scholarly journals The efficacy of taking traditional Chinese medicine orally in renal interstitial fibrosis

Medicine ◽  
2020 ◽  
Vol 99 (38) ◽  
pp. e22181
Author(s):  
Guang Yu ◽  
Mao Guo ◽  
Junju Zou ◽  
Xiaotao Zhou ◽  
Yuerong Ma
2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yu Liu ◽  
Dan-qian Chen ◽  
Jing-xue Han ◽  
Ting-ting Zhao ◽  
Shu-ju Li

Renal interstitial fibrosis (RIF) is the main pathological manifestation of end-stage renal disease. Recent studies have shown that endoplasmic reticulum (ER) stress is involved in the pathogenesis and development of RIF. Traditional Chinese medicine (TCM), as an effective treatment for kidney diseases, can improve kidney damage by affecting the apoptotic signaling pathway mediated by ER stress. This article reviews the apoptotic pathways mediated by ER stress, including the three major signaling pathways of unfolded protein response, the main functions of the transcription factor C/EBP homologous protein. We also present current research on TCM treatment of RIF, focusing on medicines that regulate ER stress. A new understanding of using TCM to treat kidney disease by regulating ER stress will promote clinical application of Chinese medicine and discovery of new drugs for the treatment of RIF.


2015 ◽  
Vol 11 (4) ◽  
pp. 1067-1078 ◽  
Author(s):  
Zheng Xiang ◽  
Hao Sun ◽  
Xiaojun Cai ◽  
Dahui Chen ◽  
Xiaoyong Zheng

The cooperative material basis of the multi-component and multi-target mechanism of action of Traditional Chinese Medicine (TCM) is difficult to elucidate because of the current lack of appropriate techniques and strategies.


Sign in / Sign up

Export Citation Format

Share Document