scholarly journals The influence of edema on the bisoprolol blood concentration after bisoprolol dermal patch application

Medicine ◽  
2021 ◽  
Vol 100 (38) ◽  
pp. e27354
Author(s):  
Yuji Takahashi ◽  
Tomohiro Sonoo ◽  
Hidehiko Nakano ◽  
Hiromu Naraba ◽  
Hideki Hashimoto ◽  
...  
Keyword(s):  
Blood Concentration ◽  
Patch Application ◽  
Dermal Patch

scholarly journals The Role of the Capsaicin 8 % Patch (Qutenza®) in the Treatment of Post-herpetic Neuralgia

US Neurology ◽  
2015 ◽  
Vol 11 (01) ◽  
pp. 34
Author(s):  
Gordon Irving ◽  
Keyword(s):  
Transient Receptor Potential ◽  
Rating Scale ◽  
Topical Therapy ◽  
Receptor Potential ◽  
Nerve Fibers ◽  
Transient Receptor Potential Vanilloid ◽  
Post Herpetic Neuralgia ◽  
Local Cooling ◽  
Patch Application ◽  
Dermal Patch

Post-herpetic neuralgia (PHN) occurs as a complication of acute herpes zoster. The capsaicin 8 % (w/w) dermal patch (Qutenza®) is a transient receptor potential vanilloid agonist that increases intracellular calcium concentration, triggering calcium-dependent protease enzymes to cause cytoskeletal breakdown. This action is thought to lead to loss of cellular integrity and defunctionalization of nociceptor epidermal nerve fibers. The capsaicin 8 % patch is indicated in the US for the treatment of neuropathic pain associated with PHN. In pivotal, randomized, doubleblind, multicenter trials in patients with PHN, a single 60-minute application of the capsaicin 8 % dermal patch reduced mean numeric pain rating scale scores between baseline and weeks 2–8 to a significantly greater extent than the low-dose comparator patch (capsaicin 0.04 % w/w). The capsaicin 8 % (w/w) dermal patch was found to be safe and generally well-tolerated. Most commonly reported side effects were local, comprising dermal irritation, erythema, and pain at the site of application. These effects were transient and mild to moderate in severity. Transient patch application-related pain was not a barrier to use and was managed with local cooling or oral analgesics in nearly all cases. Thus, the capsaicin 8 % dermal patch appears to have a good safety profile, is well tolerated, and offers effective topical therapy in some patients with PHN. This review aims to characterize the use of the capsaicin 8 % dermal patch in the treatment of PHN.

V500: Cystocele Repair using Porcine Dermal Patch Augmentation

2005 ◽  
Vol 173 (4S) ◽  
pp. 136-136
Author(s):  
Tara L. Frenkl ◽  
Adonis K. Hijaz ◽  
Firouz Daneshgari ◽  
Raymond R. Rackley ◽  
Sandip Vasavada
Keyword(s):  
Dermal Patch

False Prolongation of Prothrombin Time in the Presence of a High Blood Concentration of Daptomycin

2016 ◽  
Vol 119 (4) ◽  
pp. 353-359 ◽  
Author(s):  
Tomoyuki Yamada ◽  
Ryuji Kato ◽  
Kazutaka Oda ◽  
Hidema Tanaka ◽  
Kaoru Suzuki ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Blood Concentration

scholarly journals Addressing lead exposure in children in Georgia: challenges and successes of a multi-agency response

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
E Ruadze ◽  
I Khonelidze ◽  
L Sturua ◽  
P Lauriola ◽  
H Crabbe ◽  
...  
Keyword(s):  
Public Health ◽  
Blood Concentration ◽  
Tracking System ◽  
Action Plan ◽  
Blood Lead ◽  
Relevant Information ◽  
State Intervention ◽  
Intervention Programme ◽  
Public Health Action ◽  
Pb Exposure

Abstract The national response for reducing lead (Pb) exposure in Georgia is coordinated by the National Centre for Disease Control and Public Health (NCDC&PH) and implemented as a multi-agency (CDC, UNICEF, WHO, University of Emory) response. Given concerns about the extent of Pb exposure, in 2018 Multiple Indicator Cluster Surveys (MICS) of representative samples of children have been conducted to study several demographic and health aspects, including a study of the prevalence of blood Pb levels among 2 to 7 years old children (n = 1578). This survey was conducted in collaboration with the Italian Instituto Superiore di Sanita' (ISS), UNICEF and NCDC. The laboratory analyses were conducted at ISS in Italy. Initial results showed that in 41% of all children, blood Pb concentration was ≥ 5 µg/dl, a challenge which motivated public agencies to establish an initial public health action plan to assess environmental samples (paint, dust, water, soil, selected food items such as spices and imported sweets) in families where Pb concentrations were ≥ 10 µg/dL. A State intervention programme, monitoring Pb blood concentration among MICS children and their family members, provided relevant information on exposed households and led to a reduction of Pb blood concentration across the most exposed households. In collaboration with Public Health England, NCDC has conducted a small Pb isotope ratio study aimed at identifying the most relevant sources of Pb exposure contributing to elevated blood Pb in MICS children. It is expected that these data will support the design of more detailed public health interventions to reduce exposure to key sources of Pb, thus leading to further reduction of Pb-induced health effects in Georgia. In addition, this experience will clarify elements of an ongoing monitoring of environmental factors such as an Environmental Public Health Tracking system, to support national capacity to manage the risks to public health. Key messages Environmental health response requires extensive research and multi-agency approach. If State implements adequate intervention it is possible to reduce blood lead (Pb) level.

scholarly journals Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 574
Author(s):  
Xiuqing Gao ◽  
Lei Wu ◽  
Robert Y. L. Tsai ◽  
Jing Ma ◽  
Xiaohua Liu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Mycophenolic Acid ◽  
Systemic Circulation ◽  
Sprague Dawley ◽  
Anticancer Activities ◽  
Sustained Drug Release ◽  
Organ Rejection ◽  
Patch Application ◽  
Dorsal Tongue ◽  
Tongue Surface

Mycophenolic acid (MPA) is commonly used for organ rejection prophylaxis via oral administration in the clinic. Recent studies have shown that MPA also has anticancer activities. To explore new therapeutic options for oral precancerous/cancerous lesions, MPA was designed to release topically on the dorsal tongue surface via a mucoadhesive patch. The objective of this study was to establish the pharmacokinetic (PK) and tongue tissue distribution of mucoadhesive MPA patch formulation after supralingual administration in rats and also compare the PK differences between oral, intravenous, and supralingual administration of MPA. Blood samples were collected from Sprague Dawley rats before and after a single intravenous bolus injection, a single oral dose, or a mucoadhesive patch administration on the dorsal tongue surface for 4 h, all with a dose of 0.5 mg/kg of MPA. Plots of MPA plasma concentration versus time were obtained. As multiple peaks were found in all three curves, the enterohepatic recycling (EHR) model in the Phoenix software was adapted to describe their PK parameters with an individual PK analysis method. The mean half-lives of intravenous and oral administrations were 10.5 h and 7.4 h, respectively. The estimated bioavailability after oral and supralingual administration was 72.4% and 7.6%, respectively. There was a 0.5 h lag-time presented after supralingual administration. The results suggest that the systemic plasma MPA concentrations were much lower in rats receiving supralingual administration compared to those receiving doses from the other two routes, and the amount of MPA accumulated in the tongue after patch application showed a sustained drug release pattern. Studies on the dynamic of drug retention in the tongue after supralingual administration showed that ~3.8% of the dose was accumulated inside of tongue right after the patch removal, ~0.11% of the dose remained after 20 h, and ~20.6% of MPA was not released from the patches 4 h after application. The data demonstrate that supralingual application of an MPA patch can deliver a high amount of drug at the site of administration with little systemic circulation exposure, hence lowering the potential gastrointestinal side effects associated with oral administration. Thus, supralingual administration is a potential alternative route for treating oral lesions.

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