Rational use of Metoprolol: The Relationship of Its Blood Concentration to Patient Compliance, Poor Quality Medicines and Side Effects

2019 ◽  
Keyword(s):  
Side Effects ◽  
Patient Compliance ◽  
Blood Concentration ◽  
Poor Quality ◽  
Rational Use ◽  
Relationship Of ◽  
The Relationship

Toxic Effects of Anticonvulsants: General Principles

PEDIATRICS ◽  
1974 ◽  
Vol 53 (4) ◽  
pp. 551-557
Author(s):  
H. Hooshmand
Keyword(s):  
Drug Interaction ◽  
Side Effects ◽  
Toxic Effects ◽  
Multiple Drug ◽  
Severe Ataxia ◽  
Multiple Drug Therapy ◽  
Toxic Potential ◽  
Therapeutic Doses ◽  
Relationship Of ◽  
The Relationship

Any drug, regardless of how benign and well tolerated, is potentially toxic. The toxicity may be due to (1) dosage; (2) the size of the patient; (3) drug interaction; (4) drug specificity for the disease; (5) the nature of the disease for which the drug is used; and (6) the mode and frequency of medication. DOSE OF ANTICONVULSANT Dose of anficonvulsant is very important (Table I). Any anticonvulsant in higher than therapeutic doses has toxic potential. It is well known that anticonvulsants in large enough doses can act as convulsants. This is especially true for diphenylhydantoin, benzodiazepines, and lidocaine. THE SIZE OF THE PATIENT The size of the patient should be considered in dosage. It is safer and more accurate to adjust dosage to body surface than to weight (Table I). As the child grows, there may be a need to gradually increase the dose of anticonvulsants if seizure control is poor, or if the serum level of the anticonvulsant starts to decline. DRUG INTERACTION The relationship. of multiple drug therapy and its toxic effects on the brain is quite complicated, and many forms of toxicity can result. Toxicity may be the result of a combination of pharmacologically similar drugs. Such a combination may enhance the side effects of drowsiness and ataxia. The patient may suffer from these side effects without attaining therapeutic levels of individual anticonvulsants in the blood. In other words, a combination of drugs such as phenobarbital and primidone may result in severe ataxia and drowsiness.

GANGGUAN MENSTRUASI PADA AKSEPTOR DMPA TIDAK TERKAIT IMT

2021 ◽  
Vol 3 (3) ◽  
pp. 196
Author(s):  
Cicilia Valentine Simamora ◽  
Sri Ratna Dwiningsih ◽  
Ninik Darsini
Keyword(s):  
Side Effects ◽  
Fat Mass ◽  
Total Sample ◽  
The Body ◽  
Drop Out ◽  
Menstrual Disorders ◽  
Cross Sectional ◽  
Significance Level ◽  
Relationship Of ◽  
The Relationship

Abstrak Latar Belakang: Kejadian akseptor drop out tertinggi karena efek samping yaitu pada metode suntikan. KB injeksi DMPA memiliki efek samping gangguan menstruasi. Untuk menjamin lancarnya menstruasi, wanita harus mempunyai kadar lemak sebanyak 22% dari berat badannya. Kadar lemak dapat ditentukan dengan menilai berat badan seseorang melalui pengukuran Indeks Massa Tubuh (IMT). Penelitian ini bertujuan untuk mempelajari hubungan IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA di Puskesmas Jagir. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Jumlah sampel sebanyak 67 orang meliputi akseptor KB injeksi DMPA di Puskesmas Jagir sesuai dengan kriteria inklusi. Sampling dilakukan dengan total sampling. Variabel bebas dalam penelitian ini adalah IMT pada akseptor KB injeksi DMPA, sedangkan variabel tergantung adalah gangguan menstruasi pada akseptor KB injeksi DMPA. Untuk mengetahui tingkat signifikan, data yang terkumpul akan diuji dengan uji statistik Pearson pada tingkat kemaknaan α=0,05. Hasil: Hasil penelitian didapatkan bahwa sebagian besar responden memiliki IMT normal (55,2%), IMT kurus (3,0%) dan IMT overweight (41,8%). Hampir seluruhnya mengalami gangguan menstruasi (88,1%) dan yang tidak mengalami gangguan menstruasi (11,4%). Setelah uji Pearson diperoleh nilai p=0,140 (p>0,05) yang berarti bahwa tidak ada hubungan antara IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA. Kesimpulan: Tidak ada hubungan antara IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA di Puskesmas Jagir. Abstract Background: The incidence of drop out acceptors mostly due to side effects, is found on the injection method. DMPA injection has side effects of menstrual disorders. To ensure a fluent menstruation, women should have fat mass at least 22% of their body weight. Fat mass can be determined by measuring the Body Mass Index (BMI). This research aims to study the relationship of BMI with menstrual disorders in DMPA injection receiver at Puskesmas Jagir. Methods: This research is an observational analytic research with a cross sectional approach. A total sample of 67 people included DMPA injection receiver at Puskesmas Jagir corresponding for inclusion criteria. Sampling is done by total sampling. The independent variable in this study was BMI in DMPA injection receiver, while the dependent variable was menstrual disorders in DMPA injection receiver. To determine a significant level, the collected data will be tested by Pearson at the significance level of α = 0.05. Results: The results of the study showed that most of respondents had normal BMI (55.2%), thin BMI (3,0%) and overweight BMI (44.8%). Most of them experienced menstrual disorders (88.1%) and others did not experience menstrual disorders (11.4%). After the Pearson test, the value of p = 0.140 (p > 0.05) which means that there is no relationship between BMI and menstrual disorders in DMPA injection receiver. Conclusion: There is no relationship of BMI with menstrual disorders in DMPA injection receiver at Puskesmas Jagir.

scholarly journals Weight Gain and Hair Loss during Anti-TNF Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Abdo Lutf ◽  
Mohammed Hammoudeh
Keyword(s):  
Adverse Effect ◽  
Weight Gain ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Side Effects ◽  
Adverse Effects ◽  
Hair Loss ◽  
Rheumatology Clinic ◽  
Relationship Of ◽  
The Relationship

Objectives. To investigate the incidence of weight gain and hair loss as adverse effects of anti-TNF therapy in rheumatic diseases.Methods. Patients using anti-TNF therapy, who are followed in rheumatology clinic, were interviewed using a questionnaire to investigate the side effects of anti-TNF therapy. Patients who complained of hair loss and weight gain were asked additional questions concerning the relationship of these adverse effects to anti-TNF use, whether therapy was stopped because of these adverse effects and if the adverse effects reversed after stopping therapy. The files were reviewed to follow the weight change before, during, and after discontinuation of anti-TNF.Results. One hundred fifty consecutive patients (82 RA, 34 ankylosing spondylitis, 32 psoriatic arthritis, and 4 for other indications) were interviewed .Weight gain was observed in 20 patients (13.3%) with average gain of 5.5 Kg. Anti-TNF was stopped in five patients because of this adverse effect. Hair loss during anti-TNf therapy was reported in five females (3.3%) and anti-TNF therapy was stopped in all of them.Conclusion. Weight gain and hair loss appear to be associated with anti-TNF therapy and may be one reason for discontinuing the therapy.

scholarly journals Pyroptosis: mechanisms and diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Pian Yu ◽  
Xu Zhang ◽  
Nian Liu ◽  
Ling Tang ◽  
Cong Peng ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Side Effects ◽  
Treatment Strategy ◽  
New Drugs ◽  
Basic Knowledge ◽  
Tumor Treatment ◽  
Dual Effect ◽  
Rational Use ◽  
The Relationship ◽  
Different Tissues

AbstractCurrently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.

scholarly journals Relationship of the quality of life and depression in the elderly

2020 ◽  
Vol 1 (2) ◽  
pp. 25-27
Author(s):  
Eka Suastika ◽  
Cokorda Bagus Jaya Lesmana ◽  
Ni Ketut Putri Ariani ◽  
Ni Ketut Sri Diniari ◽  
Luh Nyoman Alit Aryani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Life ◽  
The Elderly ◽  
Significant Negative Correlation ◽  
Poor Quality ◽  
Cross Sectional ◽  
Daily Lives ◽  
Relationship Of ◽  
The Relationship

Background: A good quality of life in the elderly must be maintained because good quality of life is an optimal condition for the elderly to live their daily lives. Depression in the elderly will have a severe impact on physical, social life where it will reduce the quality of life. This study was conducted to assess the relationship of quality of life with depression in the elderly. Method: This study uses a cross-sectional method, conducted in May-June 2019, using WHOQOL-BREf, GDS, AMT, ADL. Results: A total of 195 elderly participated, average age 67 years, married 94.4 percent, mostly 45.1 percent did not go to school, ADL was found to be normal, there was moderate cognitive impairment as much as 13.3 percent, and depression 80 percent. There was a significant relationship between quality of life and depression (OR: 1.22; 95% IK 1.02-3.97), which means that elderly people with poor quality of life have a higher risk of depression. Conclusion: There is a significant negative correlation between the quality of life with depression, where the elderly with poor quality of life have a 1.22 times greater risk of depression.

scholarly journals Asthma and obesity in children: what do we know?

2019 ◽  
Vol 18 (3) ◽  
pp. 183-191
Author(s):  
G. A. Novik ◽  
E. G. Khaleva ◽  
S. G. Makarova ◽  
M. V. Zhdanova
Keyword(s):  
Respiratory Tract ◽  
Morphological Changes ◽  
Well Being ◽  
Poor Quality ◽  
Response To Therapy ◽  
Therapeutic Interventions ◽  
Insulin Metabolism ◽  
Children With Asthma ◽  
Relationship Of ◽  
The Relationship

The results of a large number of studies indicate the relationship of obesity and bronchial asthma in children. The review highlights the mechanisms of development of the so-called obese asthma: morphological changes in the respiratory tract, systemic inflammation, adipokine production, impaired glucose and insulin metabolism, genetic and epigenetic factors, changes in the microbiome of the respiratory tract and(or) intestines. The relationship of asthma and obesity can have both a genetic basis and can occur under the influence of a complex of pathogenic factors, and they can be especially important at the “early programming” stage. Obesity increases the risk of asthma development, and in patients with existing asthma due to a number of mechanisms it increases the severity or makes it difficult to achieve control of asthma. Studies showed that patients with obese asthma are distinguished by a more severe course of the disease, poor quality of life and a decreased response to therapy for asthma. Weight loss in children with asthma can lead to an improved well-being of patients, but data on the effectiveness of therapeutic interventions in these children is limited. Comorbidity of asthma and obesity is a complex multifactorial phenotype in children, which requires further study. Being overweight or obese needs to be taken into account as part of asthma treatment in this category of patients.

scholarly journals Is monitoring mean platelet volume necessary in breast cancer patients?

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 450-455
Author(s):  
Halil Taskaynatan ◽  
Ahmet Alacacioglu ◽  
Yuksel Kucukzeybek ◽  
Umut Varol ◽  
Yasar Yildiz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Hormone Therapy ◽  
Cancer Patients ◽  
Mean Platelet Volume ◽  
Breast Cancer Patients ◽  
Platelet Volume ◽  
Adjuvant Hormone Therapy ◽  
Relationship Of ◽  
The Relationship

AbstractBackgroundMean platelet volume (MPV) is a parameter that increases during thrombotic and cardiovascular events. Tamoxifen (Tmx) and aromatase inhibitors (AIs), which are adjuvant endocrine therapies, may cause serious side effects, such as vascular thrombosis. The present study investigated the changes in MPV values of breast cancer patients receiving long-term adjuvant hormone therapy and the relationship of MPV with adverse effects of hormonotherapy.MethodsData of 261 patients who had pathologically confirmed estrogen or progesterone receptor positive invasive breast cancer and had received hormonotherapy for at least a 5-year period were retrospectively analyzed. MPV levels were measured at baseline and at the first and fifth year of hormone therapy.ResultsAll patients were females and their median age was 50 years (range, 27–78 years). The mean MPV value was significantly increased in all patients in the Tmx, AI, and switch groups over time (p<0.001).ConclusionThis is the first study evaluating the relationship between the 5-year adjuvant endocrine therapy and changes in MPV values in breast cancer patients. Monitoring changes in MPV values may be predictive for severe side effects in breast cancer patients receiving hormone therapy.

scholarly journals The System of Media Critics in the Journalistic Environment in Postmodern Conditions

2021 ◽  
Vol 12 (1) ◽  
pp. 141-151
Author(s):  
Hanna Marchuk ◽  
Galyna Prystai ◽  
Solomiia Khorob ◽  
Nataliya Marchuk ◽  
Nataliia Shoturma
Keyword(s):  
New Media ◽  
Poor Quality ◽  
Main Task ◽  
Media Criticism ◽  
Wide Range ◽  
The Media ◽  
Relationship Of ◽  
The Relationship ◽  
Mobile Complex

Media criticism is an area of modern journalism that provides critical cognition and assessment of socially significant, relevant aspects of information production in the media. Media criticism studies and evaluates the mobile complex of the diverse relationships of the print and electronic press with the media audience and society as a whole, contributes to the introduction of social and professional adjustments to the activities of the print and electronic press. Modern media criticism covers not only aspects of the functioning of the print and electronic press related to journalism, the activities of journalistic groups and editorial policies, but also invades a wide range of problems, the formulation of which involves the study and evaluation of media content, the relationship of the media and their audience, the media and society as a whole. Today in the space of the Internet the most effective mass criticism of the media. Authors of media criticism blogs set as their main task the recording and analysis of materials that do not meet accepted journalistic standards and have poor quality and ethically dubious content. Media criticism blogs in new media are becoming a platform for discussion, where the problems of the influence of the media on society and the role of the media in this society are discussed.

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