Circulation of influenza A viruses among patients hospitalized for severe acute respiratory infection in a tertiary care hospital in Romania in the 2018/19 season

Abstract Background Sentinel surveillance for severe acute respiratory infection (SARI) in Egypt began in 2006 and occurs at eight sites. Avian influenza is endemic, and human cases of influenza A (H5N1) have been reported annually since 2006. This study aimed to describe the epidemiology of SARI at a major sentinel site in the country. Methods Data included in the study were collected from a major SARI sentinel site in Egypt during three consecutive years (2013–15). Results A total of 1254 SARI patients conforming to the WHO case definition were admitted to the sentinel site, representing 5.6% of admitted patients for all causes and 36.6% of acute respiratory infection patients. A total of 99.7% of the patients were tested, and 21.04% tested positive; 48.7% of cases involved influenza A viruses, while 25% involved influenza B. The predominant age group was under 5 years of age, accounting for 443 cases. The seasonality of the influenza data conformed to the Northern Hemisphere pattern. Conclusions The present study’s results show that SARI leads to substantial morbidity in Egypt. There is a great need for high-quality data from the SARI surveillance system in Egypt, especially with endemic respiratory threats such as influenza A (H5N1) in Egypt.

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CLINICAL CHARACTERISTICS AND OUTCOME OF PATIENTS WITH SEVERE ACUTE RESPIRATORY INFECTION (SARI) DURING COVID PANDEMIC OF A TERTIARY CARE HOSPITAL IN CHENNAI

10.36106/ijsr/9503870 ◽

2021 ◽

pp. 29-31

Author(s):

Vengada Krishnaraj S.P ◽

Roshan Kumar. M ◽

Vinod Kumar. V ◽

Reetu Singh G

Keyword(s):

Respiratory Infection ◽

Acute Respiratory Infection ◽

Clinical Characteristics ◽

Care Center ◽

Tertiary Care ◽

Clinical Manifestations ◽

Common Symptom ◽

Care Hospital ◽

Cross Sectional ◽

Severe Acute Respiratory Infection

BACKGROUND: SARI is one of the clinical manifestations of COVID-19 disease. As per WHO SARI is dened as an acute respiratory infection with a history of fever or measured fever of ≥ 38 C°; and cough with onset within the last 10 days and requires hospitalization. AIMS/OBJECTIVES: To describe clinical characteristics and factors associated with the clinical outcome of patients presenting with SARI at our hospital. METHODOLOGY: This is a record-based cross-sectional study that included all cases admitted in the SARI ward in Government Stanley Hospital, a tertiary care center in Chennai designated for the management of case denition and screened for SARS-CoV-2/COVID-19 between 15th March 2020 and 15th December 2020.RESULTS:Atotal of 246 patients were included in the study period from 15th March to 15th May 2020. The median age was 49.4 years and 56.9% were males. The most common symptom was fever (69.1%) followed by cough (62.6% ), Breathlessness (62.6%), and sore throat (52.8%) in our study. Of this 4 (1.8%) were tested positive for COVID-19. Of the 5 (2.1 %) patients who expired. CONCLUSION: In our single-center tertiary the incidence of COVID-19 among the SARI patients done between March-May 2020 showed an incidence rate of 1.8%

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Patients with influenza A/H1N1v- associated pneumonia: the perspective of a tertiary care hospital in Switzerland

Swiss Medical Weekly ◽

10.4414/smw.2010.13069 ◽

2010 ◽

Author(s):

B Bertisch ◽

P Vernazza ◽

K Boggian

Keyword(s):

Influenza A ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital

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Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014–2015 and 2015–2016

Epidemiology and Infection ◽

10.1017/s0950268818001486 ◽

2018 ◽

Vol 146 (11) ◽

pp. 1350-1358 ◽

Cited By ~ 7

Author(s):

H. E. Segaloff ◽

J. G. Petrie ◽

R. E. Malosh ◽

C. K. Cheng ◽

E. J. McSpadden ◽

...

Keyword(s):

Respiratory Infection ◽

Acute Respiratory Infection ◽

Influenza A ◽

Hospital Length Of Stay ◽

Charlson Score ◽

Neuraminidase Inhibitors ◽

Icu Admission ◽

Hospitalised Patients ◽

Severe Acute Respiratory Infection ◽

The Impact

AbstractOur objective was to identify predictors of severe acute respiratory infection in hospitalised patients and understand the impact of vaccination and neuraminidase inhibitor administration on severe influenza. We analysed data from a study evaluating influenza vaccine effectiveness in two Michigan hospitals during the 2014–2015 and 2015–2016 influenza seasons. Adults admitted to the hospital with an acute respiratory infection were eligible. Through patient interview and medical record review, we evaluated potential risk factors for severe disease, defined as ICU admission, 30-day readmission, and hospital length of stay (LOS). Two hundred sixteen of 1119 participants had PCR-confirmed influenza. Frailty score, Charlson score and tertile of prior-year healthcare visits were associated with LOS. Charlson score >2 (OR 1.5 (1.0–2.3)) was associated with ICU admission. Highest tertile of prior-year visits (OR 0.3 (0.2–0.7)) was associated with decreased ICU admission. Increasing tertile of visits (OR 1.5 (1.2–1.8)) was associated with 30-day readmission. Frailty and prior-year healthcare visits were associated with 30-day readmission among influenza-positive participants. Neuraminidase inhibitors were associated with decreased LOS among vaccinated participants with influenza A (HR 1.6 (1.0–2.4)). Overall, frailty and lack of prior-year healthcare visits were predictors of disease severity. Neuraminidase inhibitors were associated with reduced severity among vaccine recipients.

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Epidemiological and virological characterization of influenza A virus subtype H1N1 at tertiary-care hospital, Ahmedabad

International Journal of Medical Science and Public Health ◽

10.5455/ijmsph.2016.0806201522 ◽

2016 ◽

Vol 5 (1) ◽

pp. 55

Author(s):

Nidhi Barot ◽

Mahendra Vegad ◽

Sumeeta Soni ◽

Lavanya V ◽

Vibhuti Patel

Keyword(s):

Influenza A Virus ◽

Influenza A ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Virus Subtype

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Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV

International Journal of STD & AIDS ◽

10.1177/0956462419882587 ◽

2020 ◽

Vol 31 (2) ◽

pp. 100-108 ◽

Cited By ~ 1

Author(s):

AC Pecego ◽

RT Amâncio ◽

DM Costa ◽

FA Bozza ◽

MM Siqueira ◽

...

Keyword(s):

Respiratory Infection ◽

Acute Respiratory Infection ◽

Influenza A ◽

People Living With Hiv ◽

Hiv Diagnosis ◽

Cd4 Cell Count ◽

Risk Of Death ◽

Severe Acute Respiratory Infection ◽

Living With Hiv ◽

Epidemiological Characteristics

People living with HIV (PLWH) are more prone to severe respiratory infections. We used the severe acute respiratory infection (SARI) definition to describe the etiology, clinical, and epidemiological characteristics in this population. This was a prospective observational study including PLWH hospitalized with fever and cough. Those with symptom onset up to 10 days were classified as severe acute respiratory infection and 11–30 days as non-severe acute respiratory infection. Blood, urine samples and nasopharyngeal swabs were collected. Data were extracted from patient charts during their hospital stay. Forty-nine patients were included, median CD4 cell count: 80 cells/mm3, median time since HIV diagnosis and hospital admission: 84 months and 80% were antiretroviral therapy exposed. Twenty-seven patients were classified as SARI. Etiology was identified in 69%, 47% were polymicrobial. Respiratory virus (9 SARI vs. 13 non-SARI), bacteria (5 SARI vs. 4 non-SARI), Mycobacterium tuberculosis (6 SARI group vs. 7 non-SARI group), Pneumocystis jirovecii (4 SARI vs. 1 non-SARI), Cryptococcus neoformans (1 SARI vs. 3 non-SARI), and influenza A (1 SARI vs. 2 non-SARI). Dyspnea was statistically more prevalent in SARI (78% vs. 36%, p = 0.011) but the risk of death was higher in the non-SARI (4% vs. 36%, p = 0.0067). In the severely immunocompromised PLWH, severe acute respiratory infection can be caused by multiple pathogens and codetection is a common feature.

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