Snoring: a critical analysis of current treatment modalities. Does anything really work?

2007 ◽  
Vol 15 (3) ◽  
pp. 177-179 ◽  
Author(s):  
Christopher R Savage ◽  
David L Steward
Keyword(s):  
Critical Analysis ◽  
Current Treatment ◽  
Treatment Modalities

Thread Lifts: A Critical Analysis of Treatment Modalities

2020 ◽  
Vol 19 (4) ◽  
pp. 413-417
Author(s):  
Amani Adam ◽  
Dimitrios Karypidis ◽  
Ali Ghanem
Keyword(s):  
Critical Analysis ◽  
Treatment Modalities

The Use of Mesenchymal Stem Cells and their Derived Extracellular Vesicles in Cardiovascular Disease Treatment

2020 ◽  
Vol 15 (7) ◽  
pp. 623-638
Author(s):  
Saeideh Gholamzadeh Khoei ◽  
Fateme Karimi Dermani ◽  
Sara Malih ◽  
Nashmin Fayazi ◽  
Mohsen Sheykhhasan
Keyword(s):  
Cardiovascular Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Extracellular Vesicles ◽  
Adult Stem Cells ◽  
Heart Diseases ◽  
Therapeutic Option ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Cellular Source

Background: Cardiovascular disease (CVD), including disorders of cardiac muscle and vascular, is the major cause of death globally. Many unsuccessful attempts have been made to intervene in the disease's pathogenesis and treatment. Stem cell-based therapies, as a regeneration strategy, cast a new hope for CVD treatment. One of the most well-known stem cells is mesenchymal stem cells (MSCs), classified as one of the adult stem cells and can be obtained from different tissues. These cells have superior properties, such as proliferation and highly specialized differentiation. On the other hand, they have the potential to modulate the immune system and anti-inflammatory activity. One of their most important features is the secreting the extracellular vesicles (EVs) like exosomes (EXOs) as an intercellular communication system mediating the different physiological and pathophysiological affairs. Methods: In this review study, the importance of MSC and its secretory exosomes for the treatment of heart disease has been together and specifically addressed and the use of these promising natural and accessible agents is predicted to replace the current treatment modalities even faster than we imagine. Results: MSC derived EXOs by providing a pro-regenerative condition allowing innate stem cells to repair damaged tissues successfully. As a result, MSCs are considered as the appropriate cellular source in regenerative medicine. In the plethora of experiments, MSCs and MSC-EXOs have been used for the treatment and regeneration of heart diseases and myocardial lesions. Conclusions: Administration of MSCs has been provided a replacement therapeutic option for heart regeneration, obtaining great attention among the basic researcher and the medical doctors.

scholarly journals Infective Aortic Valve Endocarditis Causing Embolic Consecutive ST-Elevation Myocardial Infarctions

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Kanksha Peddi ◽  
Alexander L. Hsu ◽  
Tomas H. Ayala
Keyword(s):  
Myocardial Infarction ◽  
Infective Endocarditis ◽  
Aortic Valve ◽  
Index Case ◽  
Current Treatment ◽  
Myocardial Infarctions ◽  
Treatment Modalities ◽  
The Past ◽  
First Case ◽  
St Elevation

ST-elevation myocardial infarction (STEMI) is a rare and potentially fatal complication of infective endocarditis. We report the ninth case of embolic native aortic valve infective endocarditis causing STEMI and the first case to describe consecutive embolisms leading to infarctions of separate coronary territories. Through examination of this case in the context of the previous eight similar documented cases in the past, we find that infective endocarditis of the aortic valve can and frequently affect more than a single myocardial territory and can occur consecutively. Further, current treatment modalities for embolic infective endocarditis causing acute myocardial infarction are limited and unproven. This index case illustrates the potential severity of complications and the challenges in developing standardized management for such patients.

scholarly journals Role of Vitamin D in the Prevention of Pancreatic Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Pubudu Bulathsinghala ◽  
Kostas N. Syrigos ◽  
Muhammad W. Saif
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Dietary Intake ◽  
Sun Exposure ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Advanced Stages

Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake.

Current Treatment Modalities of JIA-associated Uveitis and its Complications: Literature Review

2016 ◽  
Vol 24 (4) ◽  
pp. 431-439 ◽  
Author(s):  
Khawla Abu Samra ◽  
Armin Maghsoudlou ◽  
Ramak Roohipoor ◽  
Manuel Valdes-Navarro ◽  
Stacey Lee ◽  
...  
Keyword(s):  
Literature Review ◽  
Current Treatment ◽  
Treatment Modalities

Pectus Excavatum in the Adult: Current Treatment Modalities

2010 ◽  
pp. 481-488
Author(s):  
Dawn E. Jaroszewski ◽  
Jason D. Fraser ◽  
David M. Notrica
Keyword(s):  
Pectus Excavatum ◽  
Current Treatment ◽  
Treatment Modalities

Therapeutic Potential of Lymphoid Infiltrates in Breast Cancer

2021 ◽  
Vol 28 ◽  
Author(s):  
Xiao-Yang Chen ◽  
Puay Hoon Tan
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Immune System ◽  
Therapeutic Potential ◽  
Antibody Therapy ◽  
Tumour Microenvironment ◽  
Current Treatment ◽  
Adoptive Cell Transfer ◽  
Treatment Modalities ◽  
Patient Specific

: Despite diagnostic and therapeutic advances in breast cancer, it remains the most frequently diagnosed malignancy in females, with the highest cancer-related mortality rate in women globally. With an improved understanding of the complex interactions between breast cancer and the immune system, immunotherapy has shown great potential in clinical management, potentially adding to current treatment modalities. These immunotherapeutic approaches include adoptive cell transfer therapy, cancer vaccination, monoclonal antibody therapy, and oncolytic virus therapy. Depending on the immune cells and cytokines present, the tumour microenvironment (TME) can be immunosuppressive or favourable for mounting an immune response. Effector lymphocytes play an essential role during an anticancer immune response, but their activities can be suppressed by the hostile TME. Many studies have made good progress in the modulation of the immune response to allow the identification and elimination of tumour cells. However, the efficacy of these immunotherapies is patient-specific and highly dependent on the immunological profile of the tumour and its TME. This review will give an overview of breast cancer, the immune system as well as their complex relationship. Strategies and approaches that can harness the potential of immunotherapy that engages lymphocytes in the treatment of breast cancer, along with their current challenges, will also be discussed.

Sneezing, Wheezing, Having Trouble Breathing

2020 ◽  
pp. 179-188
Author(s):  
Renee Quarrie
Keyword(s):  
Emergency Department ◽  
Respiratory Distress ◽  
Emergency Management ◽  
Pediatric Patient ◽  
Childhood Asthma ◽  
Early Recognition ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Key Points ◽  
Routine Chest

This chapter deals with one of the most common chronic diseases of childhood—asthma. It reviews the diagnosis of this disease and the acute emergency management of a pediatric patient who presents to the emergency department in respiratory distress from asthma. The current treatment modalities and indications for their use are discussed. Key points include that asthma diagnosis in the pediatric patient is largely clinical; early recognition and intervention are critical for successful management of asthma exacerbations; early administration of corticosteroids is important as it has been shown to reduce the rate of hospitalization; and routine chest radiographs do not play a part in the management of asthma.

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