scholarly journals Comparison of Acupuncture and Sham Acupuncture in Migraine Treatment

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Mao Li ◽  
Weijun Wang ◽  
Wen Gao ◽  
Dongdong Yang
Keyword(s):  
Sham Acupuncture ◽  
Migraine Treatment

Formulation and Evaluation of Fish Oil-based Rizatriptan Microemulsion for Intranasal Migraine Treatment

2015 ◽  
Vol 8 (3) ◽  
pp. 2972-2978
Author(s):  
Kanchan P Upadhye ◽  
Divya Senpal ◽  
Minakshee Nimbalwar ◽  
Gouri Dixit
Keyword(s):  
Fish Oil ◽  
Nasal Cavity ◽  
Residence Time ◽  
Stability Study ◽  
Migraine Treatment ◽  
Existence Region ◽  
Microemulsion Based Gel ◽  
Micro Emulsion ◽  
Pseudoternary Phase Diagram

In the present study microemulsion based intranasal gel of rizatriptan using fish oil was prepared for treatment and management of migraine to sustain the drug release and improve the drug residence time in nasal cavity. Fish oil is reported to have antimigraine activity hence it has been used in the present formulation along with cremophore EL as surfactant and Transcutol P as co-surfactant. The pseudoternary phase diagram plotted with these components shown the microemulsion existence region in ratio of (1:9-9:1) surfactant and co-surfactant. The optimized micro-emulsion contained fish oil (45.29%), cremophore E/transcutol P (2:1) and was characterized for pH (6.3±0.02), viscosity (114 ± 3.00cp), % transmittance (99.5 ± 1.01), refractive index (1.335±0.01),). The prepared microemulsion gels were optimized and characterized for in-vitro studies, pH, drug content, rheological studies and stability study. The release of rizatriptan from micro-emulsion gel prepared from carbopol 934 (98.01%) was found to be higher and prolonged than plain gel. Thus, microemulsion based gel was able to prolong drug releaseand improve drug residence time in the nasal cavity. 

scholarly journals Efficacy of acupuncture for sciatica: study protocol for a randomized controlled pilot trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Fang-Ting Yu ◽  
Guang-Xia Ni ◽  
Guo-Wei Cai ◽  
Wen-Jun Wan ◽  
Xiao-Qing Zhou ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Lumbar Disc ◽  
Pilot Trial ◽  
Sham Acupuncture ◽  
Leg Pain ◽  
Power Calculation ◽  
Clinical Trial Registry ◽  
Randomized Controlled ◽  
Link Type

Abstract Background Acupuncture is widely used for pain diseases while evidence of its efficacy for sciatica is insufficient. We aim to explore the feasibility and efficacy of acupuncture with different acupoint selecting strategies for sciatica induced by lumbar disc herniation. Methods This is a multicenter, three-arm, patient-assessor-blinded randomized controlled pilot trial. Ninety patients will be assigned randomly into 3 groups including disease-affected meridians (DAM) group, non-affected meridians (NAM) group, and sham acupuncture (SA) group in a 1:1:1 ratio. The trial involves a 4-week treatment along with follow-up for 22 weeks. The primary outcome is the change of leg pain intensity measured by the visual analogue scale (VAS) from baseline to week 4 after randomization. Secondary outcomes include functional status, back pain intensity, and quality of life. Adverse events will also be recorded. Discussion The results will inspire the optimal acupuncture strategy for sciatica and help establish a better design as well as power calculation for a full-scale study. Trial registration ChiCTR2000030680 (Chinese Clinical Trial Registry, http://www.chictr.org.cn, registered on 9 March 2020).

scholarly journals The cerebral mechanism of acupuncture for chronic insomnia with gastrointestinal disorder: protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Wei Peng ◽  
Xiaojuan Hong ◽  
Yaru Huangfu ◽  
Zhao Sun ◽  
Wei Shen ◽  
...  
Keyword(s):  
Rating Scale ◽  
Acupuncture Treatment ◽  
Sham Acupuncture ◽  
Acupuncture Group ◽  
Chronic Insomnia ◽  
Self Rating ◽  
Real Acupuncture ◽  
Gi Symptoms ◽  
Mri Scans ◽  
Multimodal Mri

Abstract Background Many patients with chronic insomnia disorder (CID) have gastrointestinal (GI) symptoms. First-line insomnia medications do not treat GI problems. Acupuncture has a comprehensive regulative action on both CID and GI disorder and is receiving increasing attention. Recent studies indicate that both CID and GI diseases may cause abnormal brain activity. However, the neurological mechanism underlying the effect of acupuncture on such diseases is still unclear. The aim of this study is to explore the pathological mechanisms of CID with GI discomfort, as well as the main response characteristics of acupuncture treatment from multiple perspectives using multimodal magnetic resonance imaging (MRI). Methods A total of 60 participants with CID and GI disorders will be randomly divided into two groups (real acupuncture group and sham acupuncture group; ratio of 1:1). Patients will receive 20 sessions (five sessions per week) of real acupuncture treatment or sham acupuncture treatment. The primary outcome is the aggregate score on the Pittsburgh Sleep Quality Index. Secondary outcomes are scores on the Gastrointestinal Symptom Rating Scale, Self-Rating Anxiety Scale, and Self-Rating Depression Scale. Multimodal MRI scans and clinical assessments will be performed both at baseline and post-treatment. Another 30 age-, sex-, and education-matched healthy subjects will be recruited as controls and will receive MRI scans and clinical evaluations. Discussion This study aims to provide scientific evidence for the mechanism of acupuncture in treating CID with GI disorder using multimodal MRI imaging data on brain structure, function, and metabolism. Trial registration Chinese Clinical Trial Registry, ChiCTR1800017092 (URL: http://www.chictr.org.cn/showproj.aspx?proj=27173). Registered on July 11, 2018.

Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Narayanaswamy Venketasubramanian
Keyword(s):  
Motor Function ◽  
Meta Analysis ◽  
Cochrane Review ◽  
Sham Acupuncture ◽  
Stroke Recovery ◽  
Cochrane Library ◽  
Walking Ability ◽  
Alternative Interventions ◽  
Published Evidence ◽  
Complementary And Alternative

Abstract Objectives Stroke survivors dissatisfied with their progress often seek complementary and alternative interventions (CAI). This paper reviews the evidence for CAIs in stroke recovery. Methods A literature search was performed for publications until December 2019 of CAI for stroke in Pubmed, Cochrane Library, EMBASE, CINAHL, AMED. Evidence was assessed according to Oxford Centre for Evidence-based Medicine criteria. Results In a meta-analysis, acupuncture reduced death or dependency compared to control at the end of follow-up and over the long term (≥3 months), OR 0.61(95%CI 0.46–0.79) and OR 0.67(95%CI 0.53–0.85) respectively, but was neutral against sham acupuncture. A Cochrane review of acupuncture vs. sham acupuncture in subacute or chronic stroke vs. showed no differences in motor function and quality of life. Three trials found favourable effects of moxibustion on motor function (SMD=0.72, 95%CI 0.37–1.08, p<0.0001). Two trials showed cupping compared to acupuncture reduced hemiplegic shoulder pain and upper-limb ‘myodynamia’. A meta-analysis of traditional Chinese medicines for ischaemic stroke showed marked improvement in neurological deficit on stroke scales. There was no evidence for Ayurveda, homoeopathy or reiki. Tui-na reduced the Modified Ashworth Scale in some muscle groups. Marma massage improved Motricity Index and trunk control. Thai massage and herbal treatments improved the Barthel Index. On meta-analysis, Yoga improved memory and anxiety, while tai-chi improved activities of daily living, balance and walking ability. Studies were generally of poor quality. Conclusions The evidence for benefit of CAIs for stroke recovery is weak. More research is needed to justify these treatments for stroke, by well-conducted, adequately-sized, double-blinded, randomized controlled trials.

scholarly journals Migraine treatment and COVID‐19 vaccines: No cause for concern

2021 ◽  
Vol 61 (3) ◽  
pp. 409-411
Author(s):  
Amy A. Gelfand ◽  
Gregory Poland
Keyword(s):  
Migraine Treatment

CGRP-Receptor Antagonism in Migraine Treatment

2007 ◽  
Vol 6 (4) ◽  
pp. 240-246 ◽  
Author(s):  
Lars Edvinsson ◽  
Kenneth Ahrend Petersen
Keyword(s):  
Migraine Treatment ◽  
Cgrp Receptor ◽  
Receptor Antagonism

scholarly journals Triptan use after starting prophylactic migraine treatment: A retrospective cohort study in a primary care population

Cephalalgia ◽  
2014 ◽  
Vol 34 (11) ◽  
pp. 927-932 ◽  
Author(s):  
Antonia FH Smelt ◽  
Willem JJ Assendelft ◽  
Christel E van Dijk ◽  
Jeanet W Blom
Keyword(s):  
Primary Care ◽  
Clinical Trials ◽  
Cohort Study ◽  
Retrospective Cohort ◽  
Daily Practice ◽  
Rank Test ◽  
Migraine Treatment ◽  
Prophylactic Effect ◽  
Primary Care Population ◽  
Wilcoxon Rank Test

Background Clinical trials on the prophylactic effect of propranolol and metoprolol for migraine show that starting this medication leads to a decrease in the use of attack medication of 0.9–8.9 doses per month. However, studies in daily practice are lacking. Methods We compared the number of triptans prescribed in the six months before and the six months after the start of propranolol/metoprolol in a Dutch national representative primary care cohort. Results Of the 168 triptan-using patients who started with propranolol or metoprolol, the number of triptans prescribed before starting was 4.6 doses per month. The number of triptans prescribed six months before compared with six months after starting propranolol/metoprolol decreased with 1.0 dose per month (Wilcoxon rank test; p = 0.000). Conclusion In this primary care population, although the number of triptans prescribed decreased after starting propranolol or metoprolol, the decrease is relatively small compared to data from clinical trials.

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