The novel applications of the quantitative analysis of neutrophil cell surface FcγRI (CD64) to the diagnosis of infectious and inflammatory diseases

2010 ◽  
Vol 23 (3) ◽  
pp. 268-274 ◽  
Author(s):  
Jari Nuutila
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leila Gholami ◽  
Vajihe Taghdiri Nooshabadi ◽  
Shiva Shahabi ◽  
Marzieh Jazayeri ◽  
Rana Tarzemany ◽  
...  

AbstractOral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.


2021 ◽  
Vol 5 (7) ◽  
pp. 181
Author(s):  
Dibyani Sahu ◽  
Harekrushna Sutar ◽  
Pragyan Senapati ◽  
Rabiranjan Murmu ◽  
Debashis Roy

Graphene has accomplished huge notoriety and interest from the universe of science considering its exceptional mechanical physical and thermal properties. Graphene is an allotrope of carbon having one atom thick size and planar sheets thickly stuffed in a lattice structure resembling a honeycomb structure. Numerous methods to prepare graphene have been created throughout a limited span of time. Due to its fascinating properties, it has found some extensive applications to a wide variety of fields. So, we believe there is a necessity to produce a document of the outstanding methods and some of the novel applications of graphene. This article centres around the strategies to orchestrate graphene and its applications in an attempt to sum up the advancements that has taken place in the research of graphene.


2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sally Badawi ◽  
Bassam R. Ali

AbstractWith the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more than 65 million cases have been reported worldwide. This virus has shown high infectivity and severe symptoms in some cases, leading to over 1.5 million deaths globally. Despite the collaborative and concerted research efforts that have been made, no effective medication for COVID-19 (coronavirus disease-2019) is currently available. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) as an initial mediator for viral attachment and host cell invasion. ACE2 is widely distributed in the human tissues including the cell surface of lung cells which represent the primary site of the infection. Inhibiting or reducing cell surface availability of ACE2 represents a promising therapy for tackling COVID-19. In this context, most ACE2–based therapeutic strategies have aimed to tackle the virus through the use of angiotensin-converting enzyme (ACE) inhibitors or neutralizing the virus by exogenous administration of ACE2, which does not directly aim to reduce its membrane availability. However, through this review, we present a different perspective focusing on the subcellular localization and trafficking of ACE2. Membrane targeting of ACE2, and shedding and cellular trafficking pathways including the internalization are not well elucidated in literature. Therefore, we hereby present an overview of the fate of newly synthesized ACE2, its post translational modifications, and what is known of its trafficking pathways. In addition, we highlight the possibility that some of the identified ACE2 missense variants might affect its trafficking efficiency and localization and hence may explain some of the observed variable severity of SARS-CoV-2 infections. Moreover, an extensive understanding of these processes is necessarily required to evaluate the potential use of ACE2 as a credible therapeutic target.


1983 ◽  
Vol 57 (1-3) ◽  
pp. 381-389 ◽  
Author(s):  
Masao Iwamori ◽  
Makio Mogi ◽  
Yumi Hirano ◽  
Minori Nishio ◽  
Hiromitsu Nakauchi ◽  
...  

2021 ◽  
Author(s):  
◽  
Kerry Alistair Nitz

<p>Iris Hanika’s commercially and critically successful novel Treffen sich zwei makes use of several techniques in the characterisation of its protagonists. Many of its reviews focus on the author’s deliberate placement of links to a wider literary context. Their interest extends from questions of genre-mixing through to the identification of direct quotes from other authors’ works. The critical preoccupation with intertexts demonstrates their importance for the readers’ response to the novel. More specifically, certain reviews highlight the important role intertexts play in the characterisation of the protagonists. This study catalogues the intertexts, metaphors and parodies in Treffen sich zwei and, by means of quantitative analysis, identifies high-level patterns in the use of these techniques. In particular, patterns are identified between, on the one hand, the different narrative functions of the intertexts and, on the other hand, the different ways in which they are interwoven in the text. The data also shows that distinct patterns are associated with each of the two protagonists and that certain patterns change in the course of the novel in parallel with the changes in the relationship between them. This quantitative evidence is supported by a more detailed, qualitative approach, which examines how specific intertexts or metaphors are used for the purposes of characterisation. In addition, variations in voice are used to distinguish the two main protagonists in a manner consistent with the intertexts and metaphors. It is thanks to the combination of these techniques that the theme of meeting encapsulated in the title, Treffen sich zwei, is woven into the textual fabric of the novel.</p>


2018 ◽  
Vol 118 (07) ◽  
pp. 1167-1175 ◽  
Author(s):  
Emiel van der Vorst ◽  
Christian Weber ◽  
Marjo Donners

AbstractA disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic functions. Additionally, ADAM-mediated cleavage can render these membrane proteins inactive. This review will describe the role and association of ADAMs in various pathologies with a main focus on ADAM10 and ADAM17 in atherosclerosis, including a brief overview of atherosclerosis-related ADAM substrates. Furthermore, ADAMs involvement in other metabolic and inflammatory diseases like diabetes, sepsis, Alzheimer's disease and rheumatoid arthritis will be highlighted. Subsequently, we will briefly discuss an interesting emerging field of research, i.e. the potential implications of ADAM expression in extracellular vesicles. Finally, several ADAM-based therapeutic and diagnostic (theranostic) opportunities will be discussed, while focusing on key questions about the required specificity and selectivity.


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