Efficacy of Lyophilised Platelet-Rich Plasma Powder on Healing Rate in Patients With Deep Second Degree Burn Injury

Burn is a tissue injury due to extreme heat, electrical, radiation, corrosive chemical and friction sources. It is one of the major reasons of death and inability and accounts the fourth cause of injuries worldwide. Partial thickness burn damages the epidermis and part of the dermis. Platelet-rich plasma (PRP) has been used in several surgeries and showed a positive result regarding the healing process. In this study, 20 Wistar rats were applied the PRP and 20 others were control Histopathological analysis was done confirming the partial-thickness burn injury. The mean of weight in the control group was 276.2(±14.00) grams compared to 278.7(±11.86) grams in the PRP group, having no statistical difference (p-value 0.609)

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Treatment of burn scars in Fitzpatrick phototype III patients with a combination of pulsed dye laser and non-ablative fractional resurfacing 1550 nm erbium:glass/1927 nm thulium laser devices

Scars Burns & Healing ◽

10.1177/2059513118758510 ◽

2018 ◽

Vol 4 ◽

pp. 205951311875851 ◽

Cited By ~ 4

Author(s):

Joy Tao ◽

Amanda Champlain ◽

Charles Weddington ◽

Lauren Moy ◽

Rebecca Tung

Keyword(s):

Burn Injury ◽

Dye Laser ◽

Pulsed Dye Laser ◽

Thulium Laser ◽

Burn Scar ◽

Degree Burn ◽

Left Neck ◽

Fractional Resurfacing ◽

History Of ◽

Second Degree

Introduction: Burn scars cause cosmetic disfigurement and psychosocial distress. We present two Fitzpatrick phototype (FP) III patients with burn scars successfully treated with combination pulsed dye laser (PDL) and non-ablative fractional lasers (NAFL). Case 1: A 30-year-old, FP III woman with a history of a second-degree burn injury to the bilateral arms and legs affecting 30% body surface area (BSA) presented for cosmetic treatment. The patient received three treatments with 595 nm PDL (7 mm, 8 J, 6 ms), six with the 1550 nm erbium:glass laser (30 mJ, 14% density, 4–8 passes) and five with the 1927 nm thulium laser (10 mJ, 30% density, 4–8 passes). Treated burn scars improved significantly in thickness, texture and colour. Case 2: A 33-year-old, FP III man with a history of a second-degree burn injury of the left neck and arm affecting 7% BSA presented for cosmetic treatment. The patient received two treatments with 595 nm PDL (5 mm, 7.5 J, 6 ms), four with the 1550 nm erbium:glass laser (30 mJ, 14% density, 4–8 passes) and two with the 1927 nm thulium laser (10 mJ, 30% density, 4–8 passes). The burn scars became thinner, smoother and more normal in pigmentation and appearance. Discussion: Our patients’ burn scars were treated with a combination of PDL and NAFL (two wavelengths). The PDL targets scar hypervascularity, the 1550 nm erbium:glass stimulates collagen remodelling and the 1927 nm thulium targets epidermal processes, particularly hyperpigmentation. This combination addresses scar thickness, texture and colour with a low side effect profile and is particularly advantageous in patients at higher risk of post-procedure hyperpigmentation. Conclusion: Our cases suggest the combination of 595nm PDL plus NAFL 1550 nm erbium:glass/1927 nm thulium device is effective and well-tolerated for burn scar treatment in skin of colour.

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Effect of Combining Immersion Therapy with Shengji Ointment on Wound Healing Rate and Adverse Reaction Rate in Patients with Second-Degree Burn

Journal of Healthcare Engineering ◽

10.1155/2021/1339683 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Yun Guo ◽

Junjie Yu

Keyword(s):

Wound Healing ◽

Adverse Reaction ◽

Treatment Group ◽

Reaction Rate ◽

Healing Rate ◽

Inflammatory Factors ◽

Control Group ◽

Degree Burn ◽

Wound Healing Rate ◽

Second Degree

Objective. To explore the effect of combining immersion therapy with Shengji ointment on wound healing rate and adverse reaction rate (ARR) in patients with second-degree burn. Methods. The data of 80 patients with second-degree burn treated in our hospital from February 2019 to February 2020 were retrospectively analyzed by the means of retrospective study, and the patients were equally divided into the treatment group and the control group according to their admission order, with 40 cases each. Immersion therapy was performed to all patients (7 d); after that, patients in the control group received routine medication (7 d), and those in the treatment group were treated with Shengji ointment until the wounds were healed, so as to compare their wound healing condition, ARRs, levels of inflammatory factors, and infection incidence. Results. Compared with the control group after treatment, the treatment group presented significantly shorter wound healing time (12.14 ± 1.26 vs. 15.98 ± 1.20, P < 0.001), better wound healing rate and quality ( P < 0.05), and lower levels of inflammatory factors ( P < 0.001); no significant between-group difference in ARRs was shown ( P > 0.05); 34 patients in the treatment group (85.0%) and 26 patients in the control group (65.0%) had no infections, so the incidence rate of infections was significantly lower in the treatment group than in the control group (P < 0.05). Conclusion. Combining immersion therapy with Shengji ointment can reduce the levels of inflammatory factors in patients with second-degree burn, lower the incidence rate of infections, provide the conditions for wound healing, and increase the wound healing rate, which shall be promoted and applied in practice.

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Statistical analysis of factors affecting re-operative times in paediatric patients with scar deformity after deep second-degree burn injury

International Wound Journal ◽

10.1111/iwj.12899 ◽

2018 ◽

Vol 15 (4) ◽

pp. 565-570 ◽

Cited By ~ 1

Author(s):

Baoguo Chen ◽

Xiaotong Yue ◽

Ruijuan Zhang ◽

Huifeng Song

Keyword(s):

Statistical Analysis ◽

Burn Injury ◽

Factors Affecting ◽

Paediatric Patients ◽

Degree Burn ◽

Second Degree

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An unusual burn caused by hot argy wormwood leaf water

Clinics and Practice ◽

10.4081/cp.2011.e71 ◽

2011 ◽

Vol 1 (3) ◽

pp. 71

Author(s):

Xun Liang ◽

Xu-Lin Chen ◽

Fei Wang ◽

Feng Guo

Keyword(s):

Case Report ◽

Traditional Medicine ◽

Burn Injury ◽

Left Thigh ◽

Leaf Water ◽

Chinese Traditional Medicine ◽

Chemical Burn ◽

Prevention Measures ◽

Degree Burn ◽

Second Degree

An unusual burn case caused by hot wormwood leaf water was discussed. A 29-year-old woman sustained a 7% second-degree burn on both buttocks and left thigh. This case report highlights a rare cause of a chemical burn that may become more common with increasing use of this Chinese traditional medicine. The prevention measures of this burn injury were also presented.

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Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

Journal of Healthcare Engineering ◽

10.1155/2021/7591959 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Bingqing Li ◽

Kun Xu ◽

Xin Liu

Keyword(s):

Wound Healing ◽

Adverse Reactions ◽

Healing Rate ◽

Nursing Intervention ◽

Control Group ◽

Burn Wound ◽

Degree Burn ◽

Experimental Group ◽

Wound Healing Rate ◽

Second Degree

Second-degree burn is the most common type of burn wound in the clinics, which presents a deeper wound, skin blisters, white or red bottom, and thick and clear fluid inside, is sensitive to tenderness, and turns white by compression [1, 2]. The aim of this study is to explore the efficacy of applying silver-zinc bacteriostatic cream to patients with second-degree burn under targeted nursing intervention and its effect on wound healing rate. A total of 110 patients with second-degree burn treated in our hospital from January 2019 to June 2021 were selected as the research object for the retrospective study. Between the experimental group and the control group, no statistical differences in patients’ general information were observed ( P > 0.05 ); 1 week, 2 weeks, and 3 weeks after treatment, the visual analogue scale (VAS) pain scores of the experimental group were significantly lower ( P < 0.05 ); and the total incidence rate of adverse reactions was remarkably lower in the experimental group ( P < 0.05 ). On the basis of targeted nursing intervention, applying silver-zinc bacteriostatic cream obtains an obviously better clinical efficacy than silver sulfadiazine ointment in treating second-degree burn and works better in promoting wound healing, relieving pain sensation, and reducing adverse reactions.

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Influence of Initial Moisture Content on Heat and Moisture Transfer in Firefighters’ Protective Clothing

The Scientific World JOURNAL ◽

10.1155/2017/9365814 ◽

2017 ◽

Vol 2017 ◽

pp. 1-13

Author(s):

Dongmei Huang ◽

Song He

Keyword(s):

Moisture Content ◽

Protective Clothing ◽

Moisture Transfer ◽

Burn Injury ◽

Initial Moisture Content ◽

Water Evaporation ◽

Vapor Density ◽

Degree Burn ◽

Heat And Moisture ◽

Second Degree

This paper presents a model for heat and moisture transfer through firefighters’ protective clothing (FPC) during radiation exposure. The model, which accounts for air gaps in the FPC as well as heat transfer through human skin, investigates the effect of different initial moisture contents on the thermal insulation performance of FPC. Temperature, water vapor density, and the volume fraction of liquid water profiles were monitored during the simulation, and the heat quantity absorbed by water evaporation was calculated. Then the maximum durations of heat before the wearer acquires first- and second-degree burns were calculated based on the bioheat transfer equation and the Henriques equation. The results show that both the moisture weight in each layer and the total moisture weight increase linearly within a given environmental humidity level. The initial moisture content in FPC samples significantly influenced the maximum water vapor density. The first- and second-degree burn injury time increase 16 sec and 18 sec when the RH increases from 0% to 90%. The total quantity of heat accounted for by water evaporation was about 10% when the relative humidity (RH) is 80%. Finally, a linear relationship was identified between initial moisture content and the human skin burn injury time before suffering first- and second-degree burn injuries.

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Pathophysiology and assessment of burns

10.1093/med/9780199600830.003.0346 ◽

2016 ◽

Author(s):

John A. M. Paro ◽

Geoffrey C. Gurtner

Keyword(s):

Burn Injury ◽

Subcutaneous Fat ◽

Total Body Surface Area ◽

Coagulative Necrosis ◽

Partial Thickness ◽

Degree Burn ◽

Sizing System ◽

Total Body ◽

Burn Depth ◽

Second Degree

Burn injury represents a complex clinical entity with significant associated morbidity and remains the second leading cause of trauma-related death. An understanding of the local and systemic pathophysiology of burns has led to significant improvements in mortality. Thermal insult results in coagulative necrosis of the skin and the depth or degree of injury is classified according to the skin layers involved. First-degree burns involve only epidermis and heal quickly with no scar. Second-degree burns are further classified into superficial partial thickness or deep partial thickness depending on the level of dermal involvement. Damage in a third-degree burn extends to subcutaneous fat. There is a substantial hypermetabolic response to severe burn, resulting in significant catabolism and untoward effects on the immune, gastrointestinal, and renal systems. Accurate assessment of the extent of burn injury is critical for prognosis and initiation of resuscitation. Burn size, measured in total body surface area, can be quickly estimated using the rule of nines or palmar method. A more detailed sizing system is recommended once the patient has been triaged. Appropriate diagnosis of burn depth will be important for later management. First-degree burns are erythematous and painful, like a sunburn; third-degree burns are leathery and insensate. Differentiating between second-degree burn types remains difficult. There are a number of formalized criteria during assessment that should prompt transfer to a burn centre.

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