scholarly journals Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood

2012 ◽  
Vol 22 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Scott T. Wilson ◽  
Barbara Stanley ◽  
David A. Brent ◽  
Maria A. Oquendo ◽  
Yung-yu Huang ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Childhood Abuse ◽  
Tryptophan Hydroxylase ◽  
Borderline Personality ◽  
Increased Risk

Suicidal and Nonsuicidal Self-Injury in Borderline Personality Disorder

2017 ◽  
Author(s):  
Margaret S. Andover ◽  
Heather T. Schatten ◽  
Blair W. Morris
Keyword(s):  
Risk Factors ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Attempted Suicide ◽  
Borderline Personality ◽  
Modifiable Risk Factors ◽  
Self Injury ◽  
Increased Risk ◽  
Suicide Attempted ◽  
Nonsuicidal Self Injury

Individuals diagnosed with borderline personality disorder (BPD) are at an elevated risk for engaging in self-injurious behaviors, including suicide, attempted suicide, and nonsuicidal self-injury (NSSI). The purpose of this chapter is to provide an overview of research on self-injurious behaviors among individuals with BPD. Definitions and prevalence rates are provided for NSSI, suicide, and attempted suicide. Clinical correlates of and risk factors for the behaviors, as well as associations between specific BPD criteria and self-injurious behaviors, are discussed, and a brief overview of treatments focused on reducing self-injurious behaviors among BPD patients is provided. By understanding risk factors for attempted suicide and NSSI in BPD, we can better identify patients who are at increased risk and focus treatment efforts on addressing modifiable risk factors.

scholarly journals Recent developments in psychosocial interventions for borderline personality disorder

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 561
Author(s):  
Christina M Temes ◽  
Mary C Zanarini
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Treatment Options ◽  
Specific Treatment ◽  
Psychosocial Interventions ◽  
Borderline Personality ◽  
Post Traumatic Stress ◽  
Treatment Needs ◽  
Specific Patient ◽  
Increased Risk

Borderline personality disorder (BPD) is a serious psychiatric disorder that affects multiple symptomatic domains and is associated with an increased risk of suicidality. Several empirically supported treatments for BPD have been developed in recent years for adults with BPD. More recent work has focused on tailoring or applying (or both) these existing treatments to specific patient populations, including patients with certain types of comorbidity (for example, BPD and post-traumatic stress disorder or antisocial personality disorder) and younger patients. Other work has involved developing treatments and models of treatment delivery that address concerns related to access of care. Relatedly, new adjunctive and technology-assisted interventions have been developed, adding to the growing repertoire of treatment options for these patients. Advances in the last several years address specific treatment needs and offer cost-efficient options for this diverse patient population.

Genetic, Developmental and Personality Correlates of Self-Mutilation in Depressed Patients

2006 ◽  
Vol 40 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Peter R. Joyce ◽  
Janice M. McKenzie ◽  
Roger T. Mulder ◽  
Suzanne E. Luty ◽  
Patrick F. Sullivan ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Childhood Abuse ◽  
Term Treatment ◽  
Borderline Personality ◽  
Depressed Patients ◽  
Self Mutilation ◽  
Long Term Treatment ◽  
History Of

Objective: To examine whether the T allele of G protein β3 (GNβ3) is associated with self-mutilation in depressed patients. Method: A history of self-mutilation was systematically inquired about when recruiting depressed patients for a long-term treatment trial. Risk factors such as borderline personality disorder and childhood abuse experiences were systematically assessed, and patients were genotyped for polymorphisms of GNβ 3. Results: The T allele of GNβ 3, borderline personality disorder and childhood sexual abuse were all significantly associated with self-mutilation in depressed patients. These associations were significant in both univariate andmultivariate analyses, and as predicted were stronger in young depressed patients than in depressed patients of all ages. Conclusions: If the association between the T allele of GNβ 3and self-mutilation can be replicated, this may provide clues to understanding the neurobiology of self-mutilation.

scholarly journals Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children

2012 ◽  
Vol 24 (1) ◽  
pp. 251-265 ◽  
Author(s):  
Daniel W. Belsky ◽  
Avshalom Caspi ◽  
Louise Arseneault ◽  
Wiebke Bleidorn ◽  
Peter Fonagy ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Family Environment ◽  
Borderline Personality ◽  
Environmental Mediation ◽  
Increased Risk ◽  
The Family ◽  
Poor Cognitive Function ◽  
History Of ◽  
Stress Models

AbstractIt has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis–stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology.

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