scholarly journals Autotomy reduces immune function and antioxidant defence

2008 ◽  
Vol 5 (1) ◽  
pp. 90-92 ◽  
Author(s):  
Stefanie Slos ◽  
Marjan De Block ◽  
Robby Stoks
Keyword(s):  
Innate Immunity ◽  
Superoxide Dismutase ◽  
Immune Function ◽  
Alternative Explanation ◽  
Indirect Interactions ◽  
Antioxidant Defence ◽  
Impaired Mobility ◽  
Antipredator Defence

Costs of autotomy, an antipredator defence, are typically explained by impaired mobility; yet physiologically mediated costs may also play a role. Given the resemblance to wounding, a decreased immune function and an associated reduction in antioxidant defence is expected after autotomy. In line with this, after lamellae autotomy, larvae of the damselfly Lestes viridis showed lower levels of innate immunity (i.e. phenoloxidase, PO) and antioxidant defence (superoxide dismutase, SOD). Levels of catalase (CAT) remained, however, unaffected. In line with its cytotoxicity, PO covaried positively with CAT, yet negatively with SOD. We identified a novel cost of autotomy in terms of a reduced innate immunity, which may provide an alternative explanation for the often observed costs of autotomy and which may generate indirect interactions between predators and parasites.

scholarly journals Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Lyudmil Terziev ◽  
Violeta Dancheva ◽  
Veneta Shopova ◽  
Galya Stavreva
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Control Group ◽  
Mice Model ◽  
Antioxidant Defence ◽  
Group 4 ◽  
Antioxidant Defence System ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.

scholarly journals The activity of the first line enzymes of the antioxidant defence in the liver of pubertal rats during stress

2012 ◽  
Vol 58 (5) ◽  
pp. 573-578 ◽  
Author(s):  
Y.V. Volkova ◽  
L.L. Sukhova ◽  
V.V. Davydov ◽  
A.V. Goloborodko
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Immobilization Stress ◽  
First Line ◽  
Short Term ◽  
Antioxidant Defence ◽  
Defence Enzymes ◽  
Antioxidant Defence Enzymes

The purpose of the work was to study the activity of the first line antioxidant defence enzymes in postmitochondrial fraction of liver of pubertal rats during immobilization stress. During short-term immobilization the activity of catalase and glutathione peroxidase (GPx) decreased. Long-term immobilization was accompanied by activation of GPx and superoxide dismutase in the liver postmitochondrial fraction of late pubertal and adult animals, but not early pubertal rats.

scholarly journals Effect of a Protein-Xanthophyll Concentrate from Alfalfa and of Genotype and Sex of Lambs on their Blood Redox Profile

2012 ◽  
Vol 56 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Katarzyna Ognik ◽  
Krzysztof Patkowski ◽  
Eugeniusz R. Grela
Keyword(s):  
Superoxide Dismutase ◽  
Vitamin C ◽  
Redox Potential ◽  
Antioxidant Potential ◽  
Defence Mechanisms ◽  
Antioxidant Defence ◽  
Total Antioxidant ◽  
Total Antioxidant Potential

Abstract The experiment was conducted on lambs of the Polish Lowland sheep (PLS) and a synthetic BCP line. The redox potential was assessed in blood of lambs with different genotype and sex, which were fed feed mixtures with various contents of a proteinxanthophyll (PX) concentrate from alfalfa (1.5% and 3%). The 1.5% addition of PX concentrate to feed stimulated the response of the antioxidant defence mechanisms of the lambs to a greater extent than the 3% addition. The study showed that sex of the lambs had no significant effect on changes in the redox parameters of blood. The PLS genotype of lambs determined higher values of superoxide dismutase (SOD), total antioxidant potential of plasma (FRAP), malondialdehyde, and vitamin C than the BCP genotype. Along with the growth of the lambs, a descending tendency was observed in SOD and catalase levels, and an ascending tendency in FRAP value.

Cerium Oxide Nanoparticles Reduce X-ray Irradiation-Induced Damage to the Immune Cells by Upregulation of Superoxide Dismutase and Glutathione Peroxidase

2019 ◽  
Vol 11 (10) ◽  
pp. 1464-1469
Author(s):  
Shaoyan Si ◽  
Lindong Li ◽  
Zongye Wang ◽  
Yingying Wu ◽  
Gaixian Shan ◽  
...  
Keyword(s):  
T Cells ◽  
Superoxide Dismutase ◽  
Ionizing Radiation ◽  
Glutathione Peroxidase ◽  
Immune Function ◽  
Cerium Oxide ◽  
Immune Cells ◽  
Whole Body ◽  
X Rays ◽  
X Ray

Ionizing radiation cause serious damage to humans by inducing reactive oxygen species (ROS). Immune system is one of the most sensitive system to ionizing radiation. Cerium oxide (CeO2) nanoparticles are strong ROS scavengers. In this research we observed that whether CeO2 nanoparticles could improve immune function of X-rays irradiated mice and their antioxidant potential. The whole body of mice were once exposed to 4 Gy X-ray and treated with 5 nm CeO2 nanoparticles. Then, immune cells distribution in peripheral blood (PB), spleen T cells proliferation, spleen and thymus indexes, the concentration of Glutathione Peroxidase (GSH-Px) and the activity of Superoxide Dismutase (SOD) were analyzed. The results showed that CeO2 nanoparticles could inprove immune cells distribution in PB and increase spleen T cells proliferation, thymus and spleen indexes, concentration of GSH-Px and activity of SOD in irradiated mice. The results suggest that CeO2 nanoparticles can improve immune function by inducing the production of GSH-Px and SOD in X-ray irradiated mice.

Relationship between antioxidant defence systems and salt tolerance in Solanum tuberosum

2000 ◽  
Vol 27 (3) ◽  
pp. 273 ◽  
Author(s):  
María P. Benavídes ◽  
Patricia L. Marconi ◽  
Susana M. Gallego ◽  
María E. Comba ◽  
María L. Tomaro
Keyword(s):  
Superoxide Dismutase ◽  
Solanum Tuberosum ◽  
Salt Tolerance ◽  
Reduced Glutathione ◽  
Solanum Tuberosum L ◽  
Dehydroascorbate Reductase ◽  
Antioxidant Defence ◽  
Defence System ◽  
Sensitive Clone ◽  
Antioxidant Defence System

A relationship between the antioxidant defence system and salt tolerance in two clones of potato (Solanum tuberosum L.) differing in salt sensitivity was studied. The antioxidant defence system of the sensitive clone responded differently to 100 and 150 mM NaCl. At 100 mM NaCl, growth, dehydroascorbate reductase and catalase activities remained unaltered, but chlorophyll and reduced glutathione content decreased (23% and 35%, respectively), while ascorbate content and superoxide dismutase activity were increased 34% and 63%, with respect to the control (0 mM NaCl). The superoxide dismutase increment was higher under 150 mM NaCl treatment, while a general decrease (except for dehydroascorbate reductase and catalase activities) in all the antioxidant parameters studied was observed in the sensitive clone. Reduced glutathione and ascorbate, the main antioxidant soluble defences, and all antioxidant enzymes (except catalase) were significantly elevated in the tolerant clone compared to the sensitive one when both were grown in the absence of NaCl. Under 100 and 150 mM NaCl treatments, no changes in the antioxidant stress parameters were detected in the tolerant clone. These results suggest a relationship between salt tolerance and the antioxidant defence system in the two clones.

scholarly journals Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress

2021 ◽  
Vol 11 (5) ◽  
pp. 319-324
Author(s):  
Yurij Kryvko ◽  
Yurij Soguiko ◽  
Iryna Hot ◽  
Yuliia Antonenko ◽  
Mariana Baida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Experimental Model ◽  
Experimental Work ◽  
Guinea Pigs ◽  
Immobilization Stress ◽  
Antioxidant Systems ◽  
Conjugated Diene ◽  
Antioxidant Defence

We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd  day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.

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