Address of the President Lord Adrian, O.M., at the Anniversary Meeting, 30 November 1955

1956 ◽  
Vol 144 (917) ◽  
pp. 431-440

The Copley Medal is awarded to Sir Ronald Fisher, F. R. S. The rise of quantitative biology, which has been so noteworthy a feature of this century and especially of the past thirty years or so, has been due above all to the work of R. A. Fisher. The variability of living things posed problems and raised difficulties in the interpretation of experimental and observational data which made necessary something beyond the methods of the physical sciences. They required in fact a new approach to inductive inference, and one which would provide means of drawing conclusions of assessable reliability from variable material often available only in small samples. It is to Fisher’s combination of mathematical skill and biological insight that we owe the developments, both theoretical and practical, which have done so much towards solving this problem and so making biologists of virtually every kind quantitative in their experiments, their analysis, and, most important of all, their thought. Faced with the agronomical problems of Rothamsted, whose staff he joined in 1919, Fisher began the remarkable series of statistical investigations which gave us the techniques described in Statistical methods , the tabular matter of Statistical tables (published with F. Yates) for facilitating their use, and the philosophy of Design of experiments by which they may be understood, appreciated and extended. The outcome has not merely stood the test of time in those branches of biology with which he was immediately concerned, but has had an ever-widening influence which now extends even beyond the borders of biology itself. And in building the new biometry, Fisher has given especially to the younger biologists a confidence and quantitative outlook whose full effects we have still to see.

The Copley Medal is awarded to Sir Ronald Fisher, F. R. S. The rise of quantitative biology, which has been so noteworthy a feature of this century and especially of the past thirty years or so, has been due above all to the work of R. A. Fisher. The variability of living things posed problems and raised difficulties in the inter­pretation of experimental and observational data which made necessary something beyond the methods of the physical sciences. They required in fact a new approach to inductive inference, and one which would provide means of drawing conclusions of assessable reliability from variable material often available only in small samples. It is to Fisher’s combination of mathematical skill and biological insight that we owe the developments, both theoretical and practical, which have done so much towards solving this problem and so making biologists of virtually every kind quantitative in their experiments, their analysis, and, most important of all, their thought. Faced with the agronomical problems of Rothamsted, whose staff he joined in 1919, Fisher began the remarkable series of statistical investigations which gave us the techniques described in Statistical methods , the tabular matter of Statistical tables (published with F. Yates) for facilitating their use, and the philosophy of Design of experiments by which they may be understood, appreciated and extended. The outcome has not merely stood the test of time in those branches of biology with which he was immediately concerned, but has had an ever-widening influence which now extends even beyond the borders of biology itself. And in building the new biometry, Fisher has given especially to the younger biologists a confidence and quantitative outlook whose full effects we have still to see.


Author(s):  
W. A. Chiou ◽  
N. Kohyama ◽  
B. Little ◽  
P. Wagner ◽  
M. Meshii

The corrosion of copper and copper alloys in a marine environment is of great concern because of their widespread use in heat exchangers and steam condensers in which natural seawater is the coolant. It has become increasingly evident that microorganisms play an important role in the corrosion of a number of metals and alloys under a variety of environments. For the past 15 years the use of SEM has proven to be useful in studying biofilms and spatial relationships between bacteria and localized corrosion of metals. Little information, however, has been obtained using TEM capitalizing on its higher spacial resolution and the transmission observation of interfaces. The research presented herein is the first step of this new approach in studying the corrosion with biological influence in pure copper.Commercially produced copper (Cu, 99%) foils of approximately 120 μm thick exposed to a copper-tolerant marine bacterium, Oceanospirillum, and an abiotic culture medium were subsampled (1 cm × 1 cm) for this study along with unexposed control samples.


2018 ◽  
Author(s):  
Gaolei Zhan ◽  
Younes Makoudi ◽  
Judicael Jeannoutot ◽  
Simon Lamare ◽  
Michel Féron ◽  
...  

Over the past decade, on-surface fabrication of organic nanostructures has been widely investigated for the development of molecular electronic devices, nanomachines, and new materials. Here, we introduce a new strategy to obtain alkyl oligomers in a controlled manner using on-surface radical oligomerisations that are triggered by the electrons/holes between the sample surface and the tip of a scanning tunnelling microscope. The resulting radical-mediated mechanism is substantiated by a detailed theoretical study. This electron transfer event only occurs when <i>V</i><sub>s</sub> < -3 V or <i>V</i><sub>s</sub> > + 3 V and allows access to reactive radical species under exceptionally mild conditions. This transfer can effectively ‘switch on’ a sequence leading to formation of oligomers of defined size distribution due to the on-surface confinement of reactive species. Our approach enables new ways to initiate and control radical oligomerisations with tunnelling electrons, leading to molecularly precise nanofabrication.


2018 ◽  
Vol 25 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Jan Pokorny ◽  
Lucie Borkova ◽  
Milan Urban

Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.


Author(s):  
U Neureder

Many studies of mechanisms contributing to steering wheel nibble have been carried out in the past. This paper deals with some aspects that have not yet been studied, or those that have been presented by several authors but are deemed to be controversial. Firstly, an overview of stimulation sources (disturbance factors), and the significance these have with respect to steering nibble, is given. As an example of the controversial aspects of the problem, this paper deals with the assumption of dry friction in steering gear models and its conflict with the observed transfer of vibration caused by small (realistic) amounts of imbalance or tyre force variation. After modelling the steering gear resistance correctly, it is possible to identify, in the steering gear, a natural frequency that contributes reasonably to the nibble phenomenon. Based on this new model, a CAE study on parameter sensitivity, using the ‘design of experiments’ approach, is presented.


2021 ◽  
pp. 174569162097476
Author(s):  
Danielle J. Navarro

It is commonplace, when discussing the subject of psychological theory, to write articles from the assumption that psychology differs from the physical sciences in that we have no theories that would support cumulative, incremental science. In this brief article I discuss one counterexample: Shepard’s law of generalization and the various Bayesian extensions that it inspired over the past 3 decades. Using Shepard’s law as a running example, I argue that psychological theory building is not a statistical problem, mathematical formalism is beneficial to theory, measurement and theory have a complex relationship, rewriting old theory can yield new insights, and theory growth can drive empirical work. Although I generally suggest that the tools of mathematical psychology are valuable to psychological theorists, I also comment on some limitations to this approach.


Author(s):  
Yu Hsien Wu ◽  
Kumar Srinivasan ◽  
Steven Patterson ◽  
Emmanuel Bot

The transient thermal simulation is an important part of thermal management development for new vehicle architectures. Different techniques have been studied in the past to address this coupled conduction/convection/radiation problem. In order to fully capture the transient thermal behavior of various underhood and underbody components, it is also necessary to accurately model the thermal mass of each part and the thermal links between dissimilar materials. The paper will outline a new, efficient methodology for this type of thermal analysis that shows acceptable results for complex full vehicle thermal analysis without sacrificing accuracy. The methodology is based on approximating the transient convective field with intermittent steady state solutions. The paper will present results from this new approach and compare them with fully transient simulation results as well as experimental data. The new methodology can be optimized to significantly reduce simulation run times without sacrificing accuracy and to be more practical for application in the vehicle development cycle.


1998 ◽  
Vol 8 ◽  
pp. 105-112
Author(s):  
John Barletta

Counsellors routinely work in situations with students, parents and colleagues, where they need to use interpersonal helping and counselling skills. This function has been recently compounded by the emergence of multiple demands which place a new set of challenges on counsellors. Given that many counsellor training programs do not include time-limited counselling techniques, counsellors have traditionally drawn on more problem-focussed, longer-term theories when helping others. This has not always been appropriate or successful. Traditional counselling theories suggest that only highly trained counsellors should be involved in interpersonal helping, simultaneously placing a major emphasis on the clinical nature of problems. This paper presents a relatively new approach to counselling that does not delve intrusively into the past, and is not restricted to professional counsellors. Solution-focussed brief counselling techniques lend themselves well to the education context, and with appropriate attention, can be utilised by counsellors who will become more intentional and f acilitative in their daily interactions.


2018 ◽  
Vol 285 (1888) ◽  
pp. 20180991 ◽  
Author(s):  
Patrik G. Flammer ◽  
Simon Dellicour ◽  
Stephen G. Preston ◽  
Dirk Rieger ◽  
Sylvia Warren ◽  
...  

Throughout history, humans have been afflicted by parasitic worms, and eggs are readily detected in archaeological deposits. This study integrated parasitological and ancient DNA methods with a large sample set dating between Neolithic and Early Modern periods to explore the utility of molecular archaeoparasitology as a new approach to study the past. Molecular analyses provided unequivocal species-level parasite identification and revealed location-specific epidemiological signatures. Faecal–oral transmitted nematodes ( Ascaris lumbricoides and Trichuris trichiura ) were ubiquitous across time and space. By contrast, high numbers of food-associated cestodes ( Diphyllobothrium latum and Taenia saginata ) were restricted to medieval Lübeck. The presence of these cestodes and changes in their prevalence at approximately 1300 CE indicate substantial alterations in diet or parasite availability. Trichuris trichiura ITS-1 sequences grouped into two clades; one ubiquitous and one restricted to medieval Lübeck and Bristol. The high sequence diversity of T.t .ITS-1 detected in Lübeck is consistent with its importance as a Hanseatic trading centre. Collectively, these results introduce molecular archaeoparasitology as an artefact-independent source of historical evidence.


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