scholarly journals New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Paul F. Seke Etet ◽  
M. Fawzi Mahomoodally
Keyword(s):  
Medicinal Plants ◽  
Life Quality ◽  
Sub Saharan Africa ◽  
African Trypanosomiasis ◽  
Neuroinflammatory Disease ◽  
Disease Staging ◽  
Alternative Drug ◽  
Sub Saharan ◽  
Trypanocidal Drugs ◽  
Made In

Human African trypanosomiasis (HAT) is a fatal if untreated fly-borne neuroinflammatory disease caused by protozoa of the speciesTrypanosoma brucei(T.b.). The increasing trend of HAT cases has been reversed, but according to WHO experts, new epidemics of this disease could appear. In addition, HAT is still a considerable burden for life quality and economy in 36 sub-Saharan Africa countries with 15–20 million persons at risk. Following joined initiatives of WHO and private partners, the fight against HAT was re-engaged, resulting in considerable breakthrough. We present here what is known at this day about HAT etiology and pathogenesis and the new insights in the development of accurate tools and tests for disease staging and severity monitoring in the field. Also, we elaborate herein the promising progresses made in the development of less toxic and more efficient trypanocidal drugs including the potential of medicinal plants and related alternative drug therapies.

scholarly journals HIV Status in Sero-Discordant Couples: Prevalence and Pattern among Pregnant Women in Plateau State, Nigeria

2018 ◽  
pp. 33-40
Author(s):  
Magaji FA ◽  
Ocheke AN ◽  
Ocheke AN ◽  
Pam VC ◽  
Pam VC ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Descriptive Analysis ◽  
Hiv Infections ◽  
Sub Saharan Africa ◽  
Hiv Status ◽  
Discordant Couples ◽  
Sub Saharan ◽  
Plateau State ◽  
Mother To Child ◽  
Made In

Nigeria is one of the high-burden countries in sub-Saharan Africa for HIV/AIDS and contributes to reproductive health morbidities and mortalities. This study was aimed at determining the prevalence of HIV-discordant rate among pregnant women in Plateau state Nigeria. The study sought to determine the prevalence and trend of HIV sero-discordance among pregnant women in Plateau state, Nigeria. The study was a 5-year descriptive analysis of HIV sero-discordance among pregnant women accessing prenatal care and their partners in Plateau state, Nigeria based on data generated between January 2012 and December 2016. The data was disaggregated by year, HIV concordant negative, HIV concordant positive, and HIV sero-discordant prevalence in the software and analysis were done using excel to obtained the proportions and trend of HIV sero-discordant prevalence among the antenatal population. Out of a total of 7,851 partners of pregnant women studied, 969 (16.3%) were HIV sero-discordant, 5,795 (73.8%) were HIV concordant negative, and 773 (9.9%) were HIV concordant positive. HIV sero-discordant positive males accounted for 12.3% while females were 4.0%. The prevalence of HIV sero-discordance was low with a high proportion of HIV positive male partners in Plateau state with grave public health implications for new HIV infections among partners and eroding the gains made in the Prevention of mother-to-child transmission of HIV.

scholarly journals Long-Run and Short-Run Effects of Trade Openness on Life Quality in Sub-Saharan Africa

2021 ◽  
Vol 11 (8) ◽  
pp. 72-83
Author(s):  
Guivis Zeufack Nkemgha ◽  
Aimée Viviane Mbita ◽  
Symphorin Engone Mve ◽  
Rodrigue Tchoffo
Keyword(s):  
Trade Openness ◽  
Life Quality ◽  
Sub Saharan Africa ◽  
African Countries ◽  
Pooled Mean Group ◽  
Long Run ◽  
Short Run ◽  
French Colonies ◽  
Sub Saharan ◽  
British Colonies

This paper contributes to the understanding of the other neglected effects of trade openness by analysing how it affects life quality in sub-Saharan African countries over the period 2000–2016. We used two trade openness indicators, namely: Squalli and Wilson index and the rate of trade. The empirical evidence is based on a pooled mean group approach. With two panels differentiated by their colonial origin, the following findings are established: the trade openness variable measured by Squalli and Wilson index has no effect on life quality in the both groups of countries in the short-run. However, it has a positive and significant effect on life quality in the both group of countries in the long-run. The use of the rate of trade confirms the results in the both groups of countries in the long-run. The contribution of trade openness to life quality is 3.27 and 5.19 times higher in the Former British Colonies than that recorded in the Former French Colonies of SSA respectively to the use of Squalli and Wilson index and the rate of trade. Overall, we find strong evidence supporting the view that trade openness promotes life quality in SSA countries in the long run.

The Diagnosis of Extrapulmonary Tuberculosis in Malawi

2003 ◽  
Vol 33 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Anthony D Harries ◽  
Nicola J Hargreaves ◽  
John H Kwanjana ◽  
Felix M Salaniponi
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Smear Microscopy ◽  
Cross Sectional ◽  
Extra Pulmonary Tuberculosis ◽  
Diagnostic Practices ◽  
Hospital Resources ◽  
Sub Saharan ◽  
Made In

There is little information on a country-wide basis in sub-Saharan Africa about how the diagnosis of extra-pulmonary tuberculosis (EPTB) is made. A country-wide cross-sectional study was carried out in 40 non-private hospitals in Malawi which register and treat (TB) patients in order to assess diagnostic practices in adults registered with EPTB. All patients aged 15 years and above in hospital on treatment for EPTB were reviewed using TB registers, case note files and clinical assessment. There were 244 patients, 132 men and 112 women whose mean age was 36 years. In 138 (57%) patients, all appropriate procedures and investigations, commensurate with hospital resources, had been carried out. Of 171 EPTB patients with cough for 3 weeks or longer, 138 (81%) submitted sputum specimens for smear microscopy of acid-fast bacilli (AFB). A confirmed diagnosis of TB was made in 15 (6%) patients based on finding AFB or caseating granulomas in specimens. In 157 (64%) patients, the diagnosis of EPTB was considered to be correct. In 46 (19%) patients the diagnosis was considered to be TB, although different from the type of EPTB with which the patient was registered. In 39 (16%) patients an alternative non-TB diagnosis was made and in two (1%) patients it was not possible to make a decision. Diagnostic practices need to be improved, and ways of doing this are discussed.

scholarly journals Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

2019 ◽  
Vol 7 (5) ◽  
pp. 133 ◽  
Author(s):  
Laura I. Levi ◽  
Marco Vignuzzi
Keyword(s):  
Chikungunya Virus ◽  
Neglected Tropical Diseases ◽  
Current Knowledge ◽  
Life Quality ◽  
Sub Saharan Africa ◽  
Ross River Virus ◽  
Pacific Island ◽  
The Pacific ◽  
Sub Saharan ◽  
Mayaro Virus

Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it was responsible for two worldwide epidemics with millions of cases in the last 15 years. However, other arthritogenic alphaviruses that are as of yet restrained to specific territories are the cause of neglected tropical diseases: O’nyong’nyong virus in Sub-Saharan Africa, Mayaro virus in Latin America, and Ross River virus in Australia and the Pacific island countries and territories. This review evaluates their emerging potential in light of the current knowledge for each of them and in comparison to chikungunya virus.

Managing Director's Statement to the Development Committee

Policy Papers ◽  
2005 ◽  
Vol 2005 (72) ◽  
Author(s):  
Keyword(s):  
Millennium Development Goals ◽  
Sub Saharan Africa ◽  
African Union ◽  
World Summit ◽  
Development Goals ◽  
Development Committee ◽  
Sub Saharan ◽  
Made In

Our meeting takes place at an important juncture in the international community’s efforts towards achieving the Millennium Development Goals (MDGs). It is now five years since we took up this enormous challenge, and there is a sense of renewed urgency. The recent UN World Summit on Implementing the Millennium Declaration reaffirmed the commitments made in Monterrey, but stressed the need for more progress, particularly in Sub-Saharan Africa. In addition, at the African Union and G-8 Summits, African leaders and their counterparts in the G-8 committed themselves to intensify their efforts.

scholarly journals Chemotherapy of Human African Trypanosomiasis

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Cyrus J. Bacchi
Keyword(s):  
Combination Chemotherapy ◽  
Human African Trypanosomiasis ◽  
Economic Loss ◽  
Chemotherapeutic Agents ◽  
Sub Saharan Africa ◽  
African Trypanosomiasis ◽  
Physical Suffering ◽  
Rural Clinics ◽  
Sub Saharan

Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent development of promising non-toxic combination chemotherapy suitable for use in rural clinics.

scholarly journals Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

PLoS Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. e3000796
Author(s):  
Marcos Sterkel ◽  
Lee R. Haines ◽  
Aitor Casas-Sánchez ◽  
Vincent Owino Adung’a ◽  
Raquel J. Vionette-Amaral ◽  
...  
Keyword(s):  
Degradation Pathway ◽  
Tyrosine Aminotransferase ◽  
Sub Saharan Africa ◽  
African Trypanosomiasis ◽  
Environment Friendly ◽  
Insect Pollinator ◽  
Pollinator Species ◽  
Tyrosine Metabolism ◽  
Neurotoxic Insecticides ◽  
Sub Saharan

Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they negatively impact the environment and reduce populations of insect pollinator species. Here we present a promising, environment-friendly alternative to current insecticides that targets the insect tyrosine metabolism pathway. A bloodmeal contains high levels of tyrosine, which is toxic to haematophagous insects if it is not degraded and eliminated. RNA interference (RNAi) of either the first two enzymes in the tyrosine degradation pathway (tyrosine aminotransferase (TAT) and 4-hydroxyphenylpyruvate dioxygenase (HPPD)) was lethal to tsetse. Furthermore, nitisinone (NTBC), an FDA-approved tyrosine catabolism inhibitor, killed tsetse regardless if the drug was orally or topically applied. However, oral administration of NTBC to bumblebees did not affect their survival. Using a novel mathematical model, we show that NTBC could reduce the transmission of African trypanosomiasis in sub-Saharan Africa, thus accelerating current disease elimination programmes.

Implementation Plan in Response to Board-Endorsed Recommendations Arising from the Independent Evaluation Office Report on The IMF and Aid to Sub-Saharan Africa

Policy Papers ◽  
2007 ◽  
Vol 2007 (19) ◽  
Author(s):  
Keyword(s):  
Sub Saharan Africa ◽  
Executive Board ◽  
Implementation Plan ◽  
Implementation Phase ◽  
Independent Evaluation ◽  
Sub Saharan ◽  
The Cost ◽  
Made In ◽  
The Imf

This paper sets out an implementation plan that responds to the IEO report on the Fund and Aid to Sub-Saharan Africa (the IEO Report). It sets out the recommendations made in the IEO Report and the view of the Executive Board on them (Section II), and outlines the various work streams that are being undertaken to respond substantively to the recommendations endorsed by the Board (Section III). The paper also estimates the cost of the first stage of the Fund’s response to the IEO Report, while costings for proposals in the implementation phase will be provided in the context of forthcoming Board papers. Finally, the paper solicits Directors’ feedback.

Medicinal plants: An invaluable, dwindling resource in sub-Saharan Africa

2015 ◽  
Vol 174 ◽  
pp. 595-606 ◽  
Author(s):  
Mack Moyo ◽  
Adeyemi O. Aremu ◽  
Johannes Van Staden
Keyword(s):  
Medicinal Plants ◽  
Sub Saharan Africa ◽  
Sub Saharan
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