scholarly journals Alterations in Brain Morphology by MRI in Adults with NF1

2019 ◽  
Author(s):  
Su Wang ◽  
Victor-Felix Mautner ◽  
Jan M. Friedman ◽  
Manraj K. S. Heran
Keyword(s):  
Corpus Callosum ◽  
Principal Components ◽  
Psychometric Testing ◽  
Clinical Severity ◽  
Brain Morphology ◽  
Control Subjects ◽  
Unaffected Control ◽  
And Control ◽  
Mri Measurements ◽  
Age And Sex

ABSTRACTObjectiveTo explore and characterize alterations in brain morphology by MRI in adults with neurofibromatosis 1 (NF1).MethodsMRI measurements of 29 intracranial structures were obtained for 389 adults with NF1 and 112 age- and sex-matched unaffected control subjects. A subset of NF1 patients (n = 70) was also assessed for clinical severity of NF1 features and neurological problems and received psychometric testing for attention deficiencies and IQ. Brain morphological measurements were compared between NF1 and control subjects, and correlation analyses were performed between principal components of the intracranial measurements and clinical and psychometric features.ResultsFour of nine corpus callosum measurements were significantly greater in adults with NF1 than in sex- and age-matched controls. All seven brainstem measurements were significantly greater in adults with NF1 than in controls. No robust correlations were observed between the size of these structures and clinical or neuropsychometric assessments.ConclusionsOur findings are consistent with the hypothesis that dysregulation of brain myelin production is an important manifestation of NF1 in adults.

scholarly journals Alterations in brain morphology by MRI in adults with neurofibromatosis 1

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Su Wang ◽  
Victor-Felix Mautner ◽  
Ralph Buchert ◽  
Stephane Flibotte ◽  
Per Suppa ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Psychometric Testing ◽  
Neurofibromatosis 1 ◽  
Clinical Severity ◽  
Brain Morphology ◽  
Only Children ◽  
Unaffected Control ◽  
Dominant Disease ◽  
Brain Measurements ◽  
Mri Measurements

Abstract Objective Neurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most reported studies of brain morphology in NF1 patients have included only children, and clinical implications of the observed changes later in life remain unclear. In this study, we used MRI to characterize brain morphology in adults with NF1. Methods Planar (2D) MRI measurements of 29 intracranial structures were compared in 389 adults with NF1 and 112 age- and sex-matched unaffected control subjects. The 2D measurements were correlated with volumetric (3D) brain measurements in 99 of the adults with NF1 to help interpret the 2D findings. A subset (n = 70) of these NF1 patients also received psychometric testing for attention deficits and IQ and was assessed for clinical severity of NF1 features and neurological problems. Correlation analysis was performed between the MRI measurements and clinical and psychometric features of these patients. Results Four of nine corpus callosum measurements were significantly greater in adults with NF1 than in sex- and age-matched controls. All seven brainstem measurements were significantly greater in adults with NF1 than in controls. Increased corpus callosum and brainstem 2D morphology were correlated with increased total white matter volume among the NF1 patients. No robust correlations were observed between the 2D size of these structures and clinical or neuropsychometric assessments. Conclusion Our findings are consistent with the hypothesis that dysregulation of brain myelin production is an important manifestation of NF1 in adults.

scholarly journals Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1

2021 ◽  
Author(s):  
Su Wang ◽  
Victor-Felix Mautner ◽  
Ralph Buchert ◽  
Stephane Flibotte ◽  
Per Suppa ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Psychometric Testing ◽  
Neurofibromatosis 1 ◽  
Clinical Severity ◽  
Brain Morphology ◽  
Consistent Finding ◽  
Unaffected Control ◽  
Dominant Disease ◽  
Brain Measurements ◽  
Mri Measurements

Abstract Objective: Neurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most studies focused on brain morphology changes in NF1 were small and only included children, making clinical implications unclear. One consistent finding in children with NF1 has been increased corpus callosum area. We aimed to characterize alterations in brain morphology by MRI in adults with neurofibromatosis 1 (NF1). Methods: Planar (2D) MRI measurements of 29 intracranial structures were compared in 389 adults with NF1 and 112 age- and sex-matched unaffected control subjects. The 2D measurements were correlated to volumetric (3D) brain measurements for 99 of the adults with NF1. A subset of adults with NF1 (n = 70) was also assessed for clinical severity of NF1 features and neurological problems and received psychometric testing for attention deficits and IQ. Correlation analyses were performed between principal components of the intracranial measurements and clinical and psychometric features of these patients. Results:Four of nine corpus callosum measurements were significantly greater in adults with NF1 than in sex- and age-matched controls. All seven brainstem measurements were significantly greater in adults with NF1 than in controls. Increased corpus callosum and brainstem 2D morphology were correlated with increased total white matter volume among the NF1 patients. No robust correlations were observed between the 2D size of these structures and clinical or neuropsychometric assessments.Interpretation:Our findings are consistent with the hypothesis that dysregulation of brain myelin production is an important manifestation of NF1 in adults.

Plasma Calcitonin in Paget's Disease of Bone

1977 ◽  
Vol 52 (3) ◽  
pp. 329-332 ◽  
Author(s):  
J. A. Kanis ◽  
G. Heynen ◽  
R. J. Walton
Keyword(s):  
Alkaline Phosphatase ◽  
Plasma Levels ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Control Subjects ◽  
Plasma Alkaline Phosphatase ◽  
And Control ◽  
Age And Sex

1. Plasma levels of immunoreactive calcitonin were measured in 22 patients with untreated Paget's disease of bone and in 22 control subjects matched for age and sex. 2. No significant differences in plasma calcitonin were found between patients and control subjects, and hormone levels did not correlate significantly with activity of plasma alkaline phosphatase. 3. These results suggest that Paget's disease of bone is not due to deficient secretion of endogenous calcitonin.

scholarly journals Principal Components of Heritability From Neurocognitive Domains Differ Between Families With Schizophrenia and Control Subjects

2012 ◽  
Vol 39 (2) ◽  
pp. 464-471 ◽  
Author(s):  
Howard Wiener ◽  
Lambertus Klei ◽  
Monica Calkins ◽  
Joel Wood ◽  
Vishwajit Nimgaonkar ◽  
...  
Keyword(s):  
Principal Components ◽  
Control Subjects ◽  
And Control

ADDENDUM

2001 ◽  
Vol 31 (4) ◽  
pp. 755-755
Keyword(s):  
Factor Model ◽  
Brain Morphology ◽  
Clinical Variables ◽  
Control Subjects ◽  
Functional Psychoses ◽  
Psychological Medicine ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

McIntosh, A. M., Forrester, A., Lawrie, S. M., Byrne, M., Harper, A., Kestelman, J. M., Best, J. J. K., Miller, P., Johnstone, E. C. & Owens, D. G. C. A factor model of the functional psychoses and the relationship of factors to clinical variables and brain morphology. Psychological Medicine 31, 159–171.The authors are very grateful to the patients and control subjects for their helpfulness in this study. Dr McIntosh was supported by the Wellcome Trust while he worked on this investigation and the help of the Veda and Theodore Stanley Foundaton in respect of the costs of the scans is gratefully acknowledged.

Comparison for Aphasic and Control Subjects of Eye Movements Hypothesized in Neurolinguistic Programming

1988 ◽  
Vol 67 (1) ◽  
pp. 233-234 ◽  
Author(s):  
Kathleen O'Dea Dooley ◽  
Alvirda Farmer
Keyword(s):  
Eye Movements ◽  
Normal Subjects ◽  
Eye Position ◽  
Neurolinguistic Programming ◽  
Control Subjects ◽  
Chi Squared ◽  
Neurologically Normal ◽  
And Control ◽  
Age And Sex

Neurolinguistic programming's hypothesized eye movements were measured independently using videotapes of 10 nonfluent aphasic and 10 control subjects matched for age and sex. Chi-squared analysis indicated that eye-position responses were significantly different for the groups. Although earlier research has not supported the hypothesized eye positions for normal subjects, the present findings support the contention that eye-position responses may differ between neurologically normal and aphasic individuals.

scholarly journals Comparison of Macular Thickness in Patients with Keratoconus and Control Subjects Using the Cirrus HD-OCT

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
R. L. Brautaset ◽  
R. Rosén ◽  
A. Cerviño ◽  
W. L. Miller ◽  
J. Bergmanson ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Signal Strength ◽  
Macular Thickness ◽  
Control Group ◽  
Control Subjects ◽  
The Mean ◽  
And Control ◽  
Scan Pattern ◽  
One Way Anova ◽  
Age And Sex

Purpose.The aim of the present study was to compare macular thickness in patients with keratoconus (KC) with macular thickness in healthy subjects.Subjects and Methods.Twenty-six patients with KC and 52 control subjects were included. The macular structure was evaluated using a Zeiss Cirrus HD-OCT. The scan pattern used was 512 × 128, which covers an area of approximately 6 × 6 mm of the retina. The cube volume was assessed as well as macular thickness in each of the 9 sectors defined by the software.Results.The mean signal strength was significantly lower in the KC group (mean 8.4, range 6–10) compared with the control group (mean 9.7, range 7–10),P<0.0001(unpairedt-test). There were no significant differences in cube volume (unpairedt-test), cube average thickness, or macular thickness between the KC group and the control subjects in any of the retinal locations (one-way ANOVA).Conclusion.Macular structure as measured by OCT in KC subjects should be expected to lie within the range of age and sex matched controls.

scholarly journals Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients

2016 ◽  
Vol 39 (6) ◽  
pp. 21 ◽  
Author(s):  
Berin T Demir ◽  
Nezihe A Bayram ◽  
Zübeyde Ayturk ◽  
Hüsamettin Erdamar ◽  
Pelin Seven ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Structural Changes ◽  
Resonance Imaging ◽  
Brain Images ◽  
Control Subjects ◽  
Healthy Control ◽  
Magnetic Resonance Imaging Mri ◽  
Faculty Department ◽  
And Control ◽  
The Relationship

Purpose: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. Methods: This work was conducted with cooperation of the Turgut Özal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J. Data were analyzed using the planimetric method. Results: Cerebrum, cerebellum and corpus callosum volume were calculated for all subjects. The footprints of the callosum were as follows: healthy control subjects, new patients and 1-year patients: 12.8%, 5 years: 11.7% and more than 10 years: 10.7%. The cerebrum volume was as follows: healthy control subjects: 1152 cm3, 5-10 years: 1102 cm3 and more than 10 years: 1002 cm3. Discussion: The results of our study showed atrophy in the cerebrum, cerebellum and corpus callosum of chronic migraine patients. This atrophy was greater in the patients with aura migraines. Conclusion: Our study confirmed that a migraine is an episodic disease that seriously affects the CNS.

The Effects of a Neutral Stimulus (Buzzer) on Motor Responses and Disfluencies in Normal Speakers

1969 ◽  
Vol 12 (1) ◽  
pp. 179-184 ◽  
Author(s):  
Richard R. Martin ◽  
Gerald M. Siegel
Keyword(s):  
College Students ◽  
Neutral Stimulus ◽  
Motor Responses ◽  
Control Subjects ◽  
And Control ◽  
Speaking Task

Seventy-two college students were divided into three groups: Button Push-Speech (BP-S), Speech-Button Push (S-BP), and Control. BP-S subjects pushed one of two buttons on signal for 8 min. During the last 4 min, depression of the criterion button caused a buzzer to sound. After the button-push task, subjects spoke spontaneously for 30 min. During the last 20 min, the buzzer was presented contingent upon each disfluency. S-BP subjects were run under the same procedures, but the order of button-push and speech tasks was reversed. Control subjects followed the same procedures as S-BP subjects, but no buzzer signal was presented at any time. Both S-BP and BP-S subjects emitted significantly fewer disfluencies during the last 20 min (Conditioning) than during the first 10 min (Baserate) of the speaking task. The frequency of disfluencies for Control subjects did not change significantly from Baserate to Conditioning. In none of the three groups did the frequency of pushes on the criterion button change significantly from minute to minute throughout the 8-min button-push session.

Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

Sign in / Sign up

Export Citation Format

Share Document