ADDENDUM

2001 ◽  
Vol 31 (4) ◽  
pp. 755-755

McIntosh, A. M., Forrester, A., Lawrie, S. M., Byrne, M., Harper, A., Kestelman, J. M., Best, J. J. K., Miller, P., Johnstone, E. C. & Owens, D. G. C. A factor model of the functional psychoses and the relationship of factors to clinical variables and brain morphology. Psychological Medicine 31, 159–171.The authors are very grateful to the patients and control subjects for their helpfulness in this study. Dr McIntosh was supported by the Wellcome Trust while he worked on this investigation and the help of the Veda and Theodore Stanley Foundaton in respect of the costs of the scans is gratefully acknowledged.

2001 ◽  
Vol 31 (1) ◽  
pp. 159-171 ◽  
Author(s):  
A. M. McINTOSH ◽  
A. FORRESTER ◽  
S. M. LAWRIE ◽  
M. BYRNE ◽  
A. HARPER ◽  
...  

Background. Despite more than 100 years of study, there remains no definitive diagnostic validation of the functional psychoses. Factor analysis suggests the presence of three or more psychopathological syndromes in functional psychoses as a whole. The relationship between these factors and cerebral anatomy has been investigated in schizophrenia only. This study aimed to address the relationship of symptom factors to clinically important variables and cerebral anatomy in a sample of psychotic patients with a spread of diagnoses.Methods. In a sample of patients with functional psychoses, symptom data was obtained on four consecutive admissions using the OPCRIT symptom checklist. OPCRIT data was used to generate operational diagnoses in accordance with pre-set criteria and a principle components analysis was performed on symptom data. Factor loadings were compared between each admission to examine factor stability over time. Factor scores at first admission were also correlated with clinical variables obtained from patients' case notes. From the sample of 204 patients, 64 subjects were recruited and underwent an MRI scan of the brain. Regional anatomical volumes were compared with diagnosis and factor loadings at first admission.Results. A principal components analysis gave a four-factor solution of ‘manic’, ‘depressive’, ‘disorganization’ and ‘reality distortion’ factors at each admission. Factors showed a high degree of stability over the four admissions studied. The factors were significantly associated with several clinical variables. Three of the four factors were associated with a specific pattern of cerebral anatomy.Conclusions. This study suggests that factors may correspond to relatively specific disease processes underlying functional psychotic illness. We propose that the use of symptom factors may facilitate the investigation of the underlying mechanisms of psychotic illness.


2018 ◽  
Vol 132 (23) ◽  
pp. 2509-2518 ◽  
Author(s):  
Gargi Mahapatra ◽  
S. Carrie Smith ◽  
Timothy M. Hughes ◽  
Benjamin Wagner ◽  
Joseph A. Maldjian ◽  
...  

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.


2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Bambang Supriyono ◽  
Prio Budi Leksono ◽  
Devi Erlita

<strong><em>Naval base as one of the integral components of the SSAT is the spearhead of power in carrying out support for the tasks of the operating units both in peacetime and during war. In carrying out its duties the Navy has an Integrated Fleet Weapon System (SSAT) which is the integration of strength of the capabilities of the KRI, Aircraft, Marines and Naval base components. To find out the professional level of the soldier, it is necessary to hold a Test of Combat Naval Base Task Force in order to realize, maintain and improve the skills of both individuals and groups, which in turn will increase the establishment of Operational Command and Control, Operational Procedures and the establishment of mastery of appropriate techniques and tactics. With the implementation of the test, it is expected to know about Naval Base Combat Readiness, a condition where the base can carry out its main tasks. Combat Duty Rehearsal is an exercise carried out by KRI or base to maintain the ability and professionalism of soldiers both programmed and programmed. This study aims to determine whether the relationship of human resource readiness influences the professional abilities of the Naval Base on west coast.</em></strong>


1907 ◽  
Vol XIV (3-4) ◽  
pp. 194-196
Author(s):  
V. Osipova

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.


2020 ◽  
Vol 6 (2) ◽  
pp. 29-34
Author(s):  
Metha Fahriani ◽  
Sefti Fusvita Sari ◽  
Yuni Ramadhaniati

In 2017 the number of maternal deaths was 28, consisting of 6 maternal deaths, 10 maternal deaths and 12 puerperal maternal deaths. The purpose of this study is to know the relationship of age and parity with the incidence of preeclampsia in pregnant women at dr. M. Yunus Hospital in Bengkulu year 2018. The type of research used is case control. The population in this study were all pregnant women in dr. M. Yunus Hospital in Bengkulu year 2018. The sampling technique was a case sample using total sampling, namely all pregnant women with preeclampsia and control samples using systematic random sampling technique that is sampling using multiples recorded in the hospital register of dr. M. Yunus Hospital in Bengkulu year 2018. The results of this study there is no relationship between age and the incidence of preeclampsia in pregnant women at RSUD dr. M. Yunus in 2018. With the value of p = 0.424> α = 0.05 and the value of Odds Ratio or Risk Estimate = 1.496 and there is a significant relationship between parity and the incidence of preeclampsia in pregnant women at RSUD dr. M. Yunus Bengkulu in 2018. With the value of p = 0.011 <α = 0.05 with the medium category.It is expected that the results of this study can be a program development and service improvement in reducing the prevalence of preeclampsia.


Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.


2020 ◽  
Vol 87 (9) ◽  
pp. S236 ◽  
Author(s):  
Erica Duncan ◽  
Nicholas Massa ◽  
David R. Goldsmith ◽  
Zeal H. Gandhi ◽  
Allison Hankus ◽  
...  

1990 ◽  
Vol 20 (1) ◽  
pp. 55-62 ◽  
Author(s):  
I. Harvey ◽  
M. Williams ◽  
B. K. Toone ◽  
S. W. Lewis ◽  
S. W. Turner ◽  
...  

SYNOPSISCT scans were performed on 72 consecutive patients with a functional psychosis, and compared with 50 community controls. There was a specific difference in lateral ventricular area between these two groups but it accounted for only 11% of the variance in this measure. In contrast, racial and sexual differences in the ventricular-brain ratio (VBR) related to differences in intra-cranial area. It is argued that analysis of variance, using lateral ventricular area and intra-cranial area, is more informative than VBR in examining these structural changes in functional psychoses.


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