scholarly journals Clinical features and outcomes of 2019 novel coronavirus–infected patients with cardiac injury

2020 ◽  
Author(s):  
Youbin Liu ◽  
Jinglong Li ◽  
Dehui Liu ◽  
Huafeng Song ◽  
Chunlin Chen ◽  
...  
Keyword(s):  
Clinical Features ◽  
Troponin I ◽  
Cardiac Injury ◽  
C Reactive Protein ◽  
Cardiac Biomarker ◽  
X Ray ◽  
Illness Onset ◽  
Reactive Protein ◽  
Chest X Ray ◽  
Novel Coronavirus

AbstractAimsTo explore the epidemiological and clinical features of 2019 novel coronavirus(2019-nCoV)-infected patients with cardiac injury.Methods and resultsData were collected from patients’ medical records, and we defined cardiac injury according to cardiac biomarker troponin I level > 0.03 μg/L. Among the 291 patients, 15 (5.2%) showed evidence of cardiac injury. Of 15 hospitalized patients with cardiac injury, the median age was 65 years, and 11/15 (73.3%) were men. Underlying cardiovascular diseases in some patients were hypertension (n=7, 46.7%), coronary heart disease (n=3, 20%) and diabetes (n=3, 20%). The most common symptoms at illness onset in patients with cardiac injury were fever (n=11, 73.3%), cough (n=7, 46.7%), headache or fatigue (n=5, 33.3%) and dyspnea (n=4, 26.7%). These patients had higher systolic pressures, white blood cell count, neutrophil count, troponin I, brain natriuretic peptide, D-dimer and lower lymphocyte count, and platelet count, compared with patients without cardiac injury, respectively. Bilateral infiltrates on chest X-ray and elevated C-reactive protein occurred in all patients with cardiac injury. Compared with patients without cardiac injury, patients with cardiac injury were more likely to develop acute respiratory distress syndrome, and receive mechanical ventilation, continuous renal replacement therapy, extracorporeal membrane oxygenation and vasopressor therapy and be admitted to the intensive care unit.ConclusionCardiac injury is a common condition among patients infected with 2019-nCoV. Compared with patients without cardiac injury, the clinical outcomes of patients with cardiac injury are relatively worse.

scholarly journals Clinical features and outcomes of 2019 novel coronavirus-infected patients with high plasma BNP levels

2020 ◽  
Author(s):  
Youbin Liu ◽  
Dehui Liu ◽  
Huafeng Song ◽  
Chunlin Chen ◽  
Mingfang Lv ◽  
...  
Keyword(s):  
Clinical Features ◽  
Troponin I ◽  
Virus Disease ◽  
Invasive Mechanical Ventilation ◽  
Severe Pneumonia ◽  
High Plasma ◽  
Illness Onset ◽  
Reactive Protein ◽  
History Of ◽  
Novel Coronavirus

AbstractAimsTo explore clinical features and outcome of 2019 novel coronavirus(2019-nCoV)-infected patients with high BNP levelsMethods and resultsData were collected from patients’ medical records, and we defined high BNP according to the plasma BNP was above > 100 pg/mL. In total,34 patients with corona virus disease 2019(COVID-19)were included in the analysis. Ten patients had high plasma BNP level. The median age for these patients was 60.5 years(interquartile range, 40-80y), and 6/10 (60%) were men. Underlying comorbidities in some patients were coronary heart disease (n=2, 20%), hypertesion (n=3,30%), heart failure (n=1,10%)and diabetes (n=2, 20%). Six (60%) patients had a history of Wuhan exposure. The most common symptoms at illness onset in patients were fever (n=7, 70%), cough (n=3, 30%), headache or fatigue(n=4,40%). These patients had higher aspartate aminotransferase(AST), troponin I, C reactive protein and lower hemoglobin, and platelet count,compared with patients with normal BNP, respectively. Compared with patients with normal BNP, patients with high BNP were more likely to develop severe pneumonia, and receive tracheal cannula, invasive mechanical ventilation, continuous renal replacement therapy, extracorporeal membrane oxygenation, and be admitted to the intensive care unit. One patient with high BNP died during the study.ConclusionHigh BNP is a common condition among patients infected with 2019-nCoV. Patients with high BNP showed poor clinical outcomes

scholarly journals Clinical Features of Maintenance Hemodialysis Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

2020 ◽  
Vol 15 (8) ◽  
pp. 1139-1145 ◽  
Author(s):  
Jun Wu ◽  
Jushuang Li ◽  
Geli Zhu ◽  
Yanxia Zhang ◽  
Zhimin Bi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Troponin I ◽  
Clinical Laboratory ◽  
Cardiac Injury ◽  
Hemodialysis Patients ◽  
Hospitalized Patients ◽  
Maintenance Hemodialysis ◽  
Computed Tomographic ◽  
Risk Of Death ◽  
Novel Coronavirus

Background and objectivesPrevious reports on the outbreak of coronavirus disease 2019 were on the basis of data from the general population. Our study aimed to investigate the clinical features of patients on maintenance hemodialysis.Design, setting, participants, & measurements In this retrospective, single-center study, we included 49 hospitalized patients on maintenance hemodialysis and 52 hospitalized patients without kidney failure (controls) with confirmed coronavirus disease 2019 at Tongren Hospital of Wuhan University from January 30, 2020 to March 10, 2020. Demographic, clinical, laboratory, and radiologic characteristics and treatment and outcomes data were analyzed. The final date of follow-up was March 19, 2020.ResultsThe median age of 101 patients was 62 years (interquartile range, 49–72). All patients were local residents of Wuhan. In terms of common symptoms, there were differences between patients on hemodialysis and controls (fatigue [59% versus 83%], dry cough [49% versus 71%], and fever [47% versus 90%]). Lymphocyte counts were decreased (0.8×109/L [patients on hemodialysis] versus 0.9×109/L [controls], P=0.02). Comparing patients on hemodialysis with controls, creatine kinase–muscle and brain type, myoglobin, hypersensitive troponin I, B-type natriuretic peptide, and procalcitonin were increased, and the percentage of abnormalities in bilateral lung was higher in computed tomographic scan (82% versus 69%, P=0.15) and unilateral lung was lower (10% versus 27%, P=0.03). Common complications including shock, acute respiratory distress syndrome, arrhythmia, and acute cardiac injury in patients on hemodialysis were significantly higher. Compared with controls, more patients on hemodialysis received noninvasive ventilation (25% versus 6%, P=0.008). As of March 19, 2020, three patients on hemodialysis (6%) were transferred to the intensive care unit and received invasive ventilation. Seven patients on hemodialysis (14%) had died.ConclusionsThe main symptoms of coronavirus disease 2019 pneumonia, including fever and cough, were less common in patients on hemodialysis. Patients on hemodialysis with coronavirus disease 2019 were at higher risk of death.

scholarly journals Recurrent Empyema Thoracic Secondary to Pulmonary Nocardiosis in Immunocompetent Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Samshol Sukahri ◽  
Lily Diana Zainudin ◽  
Mohd Firdaus Hadi ◽  
Mohd Al-Baqlish Mohd Firdaus ◽  
Muhammad Imran Abdul Hafidz
Keyword(s):  
Vital Signs ◽  
C Reactive Protein ◽  
Nocardia Species ◽  
X Ray ◽  
Reactive Protein ◽  
Pulmonary Nocardiosis ◽  
Erythrocyte Sedimentation ◽  
Chest X Ray ◽  
The Right ◽  
Tomography Scan

Pulmonary nocardiosis is a rare disorder that mainly affects immune-compromised patients. We report a 37-year-old male who presented with persistent fever associated with productive cough. During this course of therapy, he had recurrent admissions for empyema thoracic. Clinically, his vital signs were normal. Blood investigations show leukocytosis with a significantly raised erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Sputum acid-fast bacilli (AFB) was scanty 1+ and sputum mycobacterium culture was negative. Chest X-ray (CXR) showed consolidative changes with mild to moderate pleural effusion on the right side. Skin biopsy was taken and showed Paecilomyces species. A computed tomography scan (CT thorax) was performed and revealed a multiloculated collection within the right hemithorax with a split pleura sign. Decortications were performed and tissue culture and sensitivity (C+S) growth of Nocardia species. And it is sensitive to sulfamethoxazole-trimethoprim and completed treatment for 4 months. This case highlights that pulmonary nocardiosis should be kept in mind in also immune-competent patients, especially in suspected cases of tuberculosis not responding to antitubercular therapy.

scholarly journals Acute Myocardial Injury of Patients with Coronavirus Disease 2019

2020 ◽  
Author(s):  
Huayan Xu ◽  
Keke Hou ◽  
Hong Xu ◽  
Zhenlin Li ◽  
Huizhu Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Injury ◽  
Cardiac Injury ◽  
Cardiac Complications ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Acute Myocardial Injury ◽  
Novel Coronavirus

AbstractBackgroundSince the outbreak of the Coronavirus Disease 2019 (COVID-19) in China, respiratory manifestations of the disease have been observed. However, as a fatal comorbidity, acute myocardial injury (AMI) in COVID-19 patients has not been previously investigated in detail. We investigated the clinical characteristics of COVID-19 patients with AMI and determined the risk factors for AMI in them.MethodsWe analyzed data from 53 consecutive laboratory-confirmed and hospitalized COVID-19 patients (28 men, 25 women; age, 19–81 years). We collected information on epidemiological and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, imaging findings, management methods, and clinical outcomes.ResultsCardiac complications were found in 42 of the 53 (79.25%) patients: tachycardia (n=15), electrocardiography abnormities (n=11), diastolic dysfunction (n=20), elevated myocardial enzymes (n=30), and AMI (n=6). All the six AMI patients were aged >60 years; five of them had two or more underlying comorbidities (hypertension, diabetes, cardiovascular diseases, and chronic obstructive pulmonary disease). Novel coronavirus pneumonia (NCP) severity was higher in the AMI patients than in patients with non-definite AMI (p<0.001). All the AMI patients required care in intensive care unit; of them, three died, two remain hospitalized. Multivariate analyses showed that C-reactive protein (CRP) levels, NCP severity, and underlying comorbidities were the risk factors for cardiac abnormalities in COVID-19 patients.ConclusionsCardiac complications are common in COVID-19 patients. Elevated CRP levels, underlying comorbidities, and NCP severity are the main risk factors for cardiac complications in COVID-19 patients.

scholarly journals Risk Factors and a Scoring System to Predict ARDS in Patients with COVID-19 Pneumonia in Korea: A Multicenter Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jun-Won Seo ◽  
Seong Eun Kim ◽  
Eun Young Choi ◽  
Kyung Soo Hong ◽  
Tae Hoon Oh ◽  
...  
Keyword(s):  
Prediction Score ◽  
World Health ◽  
Case Report Form ◽  
C Reactive Protein ◽  
Multicenter Cohort Study ◽  
X Ray ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Chest X Ray ◽  
Epidemiological Characteristics

Predictive studies of acute respiratory distress syndrome (ARDS) in patients with coronavirus disease 2019 (COVID-19) are limited. In this study, the predictors of ARDS were investigated and a score that can predict progression to ARDS in patients with COVID-19 pneumonia was developed. All patients who were diagnosed with COVID-19 pneumonia between February 1, 2020, and May 15, 2020, at five university hospitals in Korea were enrolled. Their demographic, clinical, and epidemiological characteristics and the outcomes were collected using the World Health Organization COVID-19 Case Report Form. A logistic regression analysis was performed to determine the predictors for ARDS. The receiver operating characteristic (ROC) curves were constructed for the scoring model. Of the 166 patients with COVID-19 pneumonia, 37 (22.3%) patients developed ARDS. The areas under the curves for the infiltration on a chest X-ray, C-reactive protein, neutrophil/lymphocyte ratio, and age, for prediction of ARDS were 0.91, 0.90, 0.87, and 0.80, respectively (all P < 0.001 ). The COVID-19 ARDS Prediction Score (CAPS) was constructed using age (≥60 years old), C-reactive protein (≥5 mg/dL), and the infiltration on a chest X-ray (≥22%), with each predictor allocated 1 point. The area under the curve of COVID-19 ARDS prediction score (CAPS) for prediction of ARDS was 0.90 (95% CI 0.86–0.95; P < 0.001 ). It provided 100% sensitivity and 75% specificity when the CAPS score cutoff value was 2 points. CAPS, which consists of age, C-reactive protein, and the area of infiltration on a chest X-ray, was predictive of the development of ARDS in patients with COVID-19 pneumonia.

scholarly journals SEPSIS NEONATORUM DAN PNEUMONIA PADA BAYI ATERM

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Praevilia M Salendu
Keyword(s):  
Staphylococcus Aureus ◽  
Fetal Distress ◽  
Developed Countries ◽  
C Reactive Protein ◽  
X Ray ◽  
Reactive Protein ◽  
Unpleasant Odor ◽  
Chest X Ray ◽  
Amnion Membrane ◽  
Developing And Developed Countries

Abstract: Sepsis neonatorum is the most frequent cause of admission to a hospital and of death in developing and developed countries. Microorganisms such as Gram positive and negative bacteria, viruses, parasites, and fungi can be the etiological factors. We reported a case of a female neonatus, aterm, and born with caesarean section due to fetal distress. After birth, the neonatus did not spontaneously cry and suffered from asphyxia. The risk factor of this sepsis neonatorum were the early rupture of the amnion membrane associated with an unpleasant odor. Besides that, the mother suffered from a urinary tract infection and fluor albus during pregnancy. Blood examinations showed moderate leucocytosis, slight thrombocytopenia, and a positive C-reactive protein. Chest X-ray showed infiltration in both lungs, indicating pneumonia. The blood culture confirmed Staphylococcus aureus (sensitive to meropenem). Conclusion: Based on all the tests performed, the diagnosis was an aterm neonatus with sepsis neonatorum and pneumonia. Keywords: sepsis, neonatus, pneumonia.     Abstrak: Sepsis neonatorum merupakan penyebab tersering dari perawatan di rumah sakit dan kematian neonatus baik di negara berkembang maupun negara maju. Mikroba seperti bakteri Gram positif dan negatif, virus, parasit, serta jamur dapat menjadi faktor etiologi. Kami melaporkan kasus seorang bayi perempuan, aterm, yang lahir dengan seksio sesaria oleh karena gawat janin. Setelah lahir, bayi tidak langsung menangis, dan memperlihatkan gejala asfiksia. Faktor risiko sepsis neonatorum ialah ketuban pecah dini dan air ketuban berbau. Selain itu, ibu pasien menderita infeksi saluran kemih dan fluor albus pada saat hamil. Pemeriksaan darah menunjukkan leukositosis sedang, trombositopenia ringan, dan C-reaktif protein positif. Foto toraks memperlihatkan adanya infiltrat pada kedua lapangan paru yang mengindikasikan suatu pneumonia. Kultur darah mengonfirmasikan stafilokokus aureus yang sensitif terhadap meropenem. Simpulan: Berdasarkan hasil pemeriksaan ditegakkan diagnosis bayi aterm dengan sepsis neonatorum dan pneumonia. Kata kunci: sepsis, neonatus, pneumonia.

Highly Sensitive and Fast Detection of C-Reactive Protein and Troponin Biomarkers Using Liquid-gated Single Silicon Nanowire Biosensors

MRS Advances ◽  
2020 ◽  
Vol 5 (16) ◽  
pp. 835-846 ◽  
Author(s):  
Yurii Kutovyi ◽  
Jie Li ◽  
Ihor Zadorozhnyi ◽  
Hanna Hlukhova ◽  
Nazarii Boichuk ◽  
...  
Keyword(s):  
Troponin I ◽  
Early Stage ◽  
Silicon Nanowire ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Label Free ◽  
C Reactive Protein ◽  
Force Microscopy ◽  
Reactive Protein ◽  
Detection Of Biomarkers

ABSTRACTC-reactive protein (CRP) and cardiac troponin I (cTnI) biomolecules represent the earliest enzymes that appear in the blood when a cardiac injury occurs. Real-time and selective detection of these biomarkers is essential for the prediction and detection of cardiovascular diseases at an early stage. Here we report on the label-free specific detection of both proteins at picomolar concentrations using fabricated nanowire-based biosensors. We demonstrate a novel functionalization technique based on the attachment of dibenzocyclooctyne (DBCO)-linked troponin-specific aptamers to azide-functionalized silicon (Si) nanowire (NW) surface. Due to the fast and reliable immobilization of cTnI-specific aptamers and CRP-specific antibodies on the Si NWs, the fabricated devices can rapidly detect target biomolecules demonstrating high sensitivity. We confirm the attachment of proteins to the surface of Si NWs by atomic force microscopy (AFM). Moreover, we demonstrate that nanowire structures of different sizes enable the detection of biomarkers in a wide concentration range (from 1 pg/ml to 1 µg/ml), corresponding to CRP and cTnI elevation levels during the early stage of disease formation.

scholarly journals Clinical factors, C-reactive protein point of care test and chest X-ray in patients with pneumonia: A survey in primary care

2019 ◽  
Vol 25 (4) ◽  
pp. 229-235 ◽  
Author(s):  
Geert H. Groeneveld ◽  
Robert J. van de Peppel ◽  
Margot W. M. de Waal ◽  
Theo J. M. Verheij ◽  
Jaap T. van Dissel
Keyword(s):  
Primary Care ◽  
Point Of Care ◽  
Clinical Factors ◽  
C Reactive Protein ◽  
X Ray ◽  
Reactive Protein ◽  
Point Of Care Test ◽  
Chest X Ray

scholarly journals The various prognostic scoring system used for predicting COVID-19 mortality

2021 ◽  
Vol 8 (9) ◽  
pp. 4611
Author(s):  
Khaled Mohamed Elsharkawy ◽  
Mohammed Abdulaziz Aljawi ◽  
Hani Helal Alhassani ◽  
Sadeen Essam Ezzat ◽  
Ziad Abdulmoti Alruwaithi ◽  
...  
Keyword(s):  
Scoring System ◽  
Severe Disease ◽  
Scoring Systems ◽  
Medical Attention ◽  
C Reactive Protein ◽  
X Ray ◽  
Reactive Protein ◽  
X Ray Imaging ◽  
Chest X Ray ◽  
Prognostic Scoring Systems

The widespread pandemic of Coronavirus disease 2019 (COVID-19) has been reported to affect most countries all over the world, and burden all of the affected healthcare systems. COVID-19 has first emerged in December 2019 within the district of Wuhan which is located in China. Many prognostic scoring systems have been developed to predict severe disease and death for patients with COVID-19. In this literature review, the aim to discuss the various prognostic scoring system used for predicting COVID-19 mortality. It has mainly approached the prognostic scoring systems in two main ways: The clinical and biochemical ways. In addition, the research also investigates the chest X-ray imaging findings based on scoring systems for predicting mortality for patients with COVID-19. Many scoring systems have been reported based on the biochemical and clinical parameters as age, D-dimer, presence of comorbidities, procalcitonin, C-reactive protein (CRP) and other features. Some of the reported scoring systems were recently developed in the COVID-19 pandemic while others were just modified based on the fact that patients with COVID-19 are critically ill, and usually require the same medical attention as other conditions. These scoring systems should be considered by clinicians to early predict and intervene against severe COVID-19 that might cause death. As for the imaging modalities, we have also reported many of the reported systems in the literature, including the ones that are based on chest computed tomography and X-ray findings, and are discussed in detail within this study.

The effect of C‐reactive protein on chest X‐ray interpretation: A decision‐making experiment among pediatricians

2021 ◽  
Author(s):  
Yuval Barak‐Corren ◽  
Netta Barak‐Corren ◽  
Alex Gileles‐Hillel ◽  
Eyal Heiman
Keyword(s):  
Decision Making ◽  
C Reactive Protein ◽  
X Ray ◽  
Reactive Protein ◽  
Chest X Ray
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