scholarly journals Genomes of Animal Mitochondria have not Evolved According to Common Models of Substitution Probabilities

2020 ◽  
Author(s):  
James Cavender

AbstractCommon probabilistic models of substitutions of bases (Jukes-Cantor, Kimura 2-parameter, Tamura-Nei, F84, HKY, and the 6-parameter models used in linear invariants methods) must be rejected, at least for mitochondrial genomes of animals. They are rejected by a new test that is simple and lenient.

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.


2020 ◽  
Vol 17 (6) ◽  
pp. 847-856
Author(s):  
Shengbing Ren ◽  
Xiang Zhang

The problem of synthesizing adequate inductive invariants lies at the heart of automated software verification. The state-of-the-art machine learning algorithms for synthesizing invariants have gradually shown its excellent performance. However, synthesizing disjunctive invariants is a difficult task. In this paper, we propose a method k++ Support Vector Machine (SVM) integrating k-means++ and SVM to synthesize conjunctive and disjunctive invariants. At first, given a program, we start with executing the program to collect program states. Next, k++SVM adopts k-means++ to cluster the positive samples and then applies SVM to distinguish each positive sample cluster from all negative samples to synthesize the candidate invariants. Finally, a set of theories founded on Hoare logic are adopted to check whether the candidate invariants are true invariants. If the candidate invariants fail the check, we should sample more states and repeat our algorithm. The experimental results show that k++SVM is compatible with the algorithms for Intersection Of Half-space (IOH) and more efficient than the tool of Interproc. Furthermore, it is shown that our method can synthesize conjunctive and disjunctive invariants automatically


2014 ◽  
Vol 14 (10) ◽  
pp. 1322-1330 ◽  
Author(s):  
C.-P. You ◽  
R.-R. Zhao ◽  
J. Hu ◽  
S.-J. Liu ◽  
M. Tao ◽  
...  

2016 ◽  
Author(s):  
Stewart M. Edie ◽  
◽  
Peter D. Smits ◽  
David Jablonski

2016 ◽  
Vol 51 (1) ◽  
pp. 469-484 ◽  
Author(s):  
Damien Octeau ◽  
Somesh Jha ◽  
Matthew Dering ◽  
Patrick McDaniel ◽  
Alexandre Bartel ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Silvia Bágeľová Poláková ◽  
Žaneta Lichtner ◽  
Tomáš Szemes ◽  
Martina Smolejová ◽  
Pavol Sulo

AbstractmtDNA recombination events in yeasts are known, but altered mitochondrial genomes were not completed. Therefore, we analyzed recombined mtDNAs in six Saccharomyces cerevisiae × Saccharomyces paradoxus hybrids in detail. Assembled molecules contain mostly segments with variable length introgressed to other mtDNA. All recombination sites are in the vicinity of the mobile elements, introns in cox1, cob genes and free standing ORF1, ORF4. The transplaced regions involve co-converted proximal exon regions. Thus, these selfish elements are beneficial to the host if the mother molecule is challenged with another molecule for transmission to the progeny. They trigger mtDNA recombination ensuring the transfer of adjacent regions, into the progeny of recombinant molecules. The recombination of the large segments may result in mitotically stable duplication of several genes.


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