Male-mediated maturation in a wild primate

AbstractIn humans, a controversial hypothesis suggests that father absence promotes early puberty in daughters. Data from rodents confirm females accelerate maturation with exposure to novel males (“Vandenbergh effect”) and delay it with exposure to male relatives. Here, we report the first case of male-mediated maturation in a wild primate, geladas (Theropithecus gelada). Females were more likely to mature after a change in the reproductive male: some matured earlier than expected (Vandenbergh effect) and some later (due to father presence). Novel males stimulated a surge in estrogens for all immature females - even females too young to mature. Although male-mediated puberty accelerated first births, the effect was modest, suggesting that alternative scenarios, such as co-evolution with the Bruce effect (male-mediated fetal loss) may explain this phenomenon.One Sentence SummaryNovel males induce an estrogen surge, male-mediated puberty, and a head-start on reproduction for immature female geladas.

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The Early Head Start Father Studies: Design, Data Collection, and Summary of Father Presence in the Lives of Infants and Toddlers

Parenting ◽

10.1207/s15327922par0602&3_1 ◽

2006 ◽

Vol 6 (2) ◽

pp. 117-143 ◽

Cited By ~ 12

Author(s):

Kimberly Boller ◽

Robert Bradley ◽

Natasha Cabrera ◽

Helen Raikes ◽

Barbara Pan ◽

...

Keyword(s):

Data Collection ◽

Head Start ◽

Early Head Start ◽

Infants And Toddlers ◽

Design Data ◽

Father Presence

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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman

Case Reports in Hematology ◽

10.1155/2020/3686584 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Claire Cochet ◽

Marion Simonet ◽

Julie Cattin ◽

Jean-Patrick Metz ◽

Ana Berceanu ◽

...

Keyword(s):

Arsenic Trioxide ◽

Acute Promyelocytic Leukemia ◽

Animal Studies ◽

Case Reports ◽

Fetal Loss ◽

Promyelocytic Leukemia ◽

University Hospital ◽

First Case ◽

Fetal Complications ◽

Medical Teams

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In March 2018 at the University Hospital of Besançon, a 22-year-old woman was diagnosed with APL at 14 weeks of gestation (WG). She received a total of 2160 mg of ATRA and 930 mg of ATO between 14 and 35 WG. The mother’s cytological remission was very fast. No maternal or fetal complications occurred during pregnancy. The pediatrics outcomes were good. Many case reports about ATRA exposure during the second and third trimesters report no serious adverse effect for pregnancy. ATO is teratogenic, genotoxic, and carcinogenic and passes through the placenta. Fetal exposure seems to be associated with bad pregnancy outcomes (preterm delivery, decreased birth weight, and fetal loss) and with lung diseases in young adults. No clinical trial is obviously possible, and the only data available are environmental exposure or animal studies. This case report may help medical teams to make hard decision for a treatment of APL during pregnancy.

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Second Trimester Fetal Loss Due to Citrobacter koseri Infection: A Rare Cause of Preterm Premature Rupture of Membranes (PPROM)

Diagnostics ◽

10.3390/diagnostics12010159 ◽

2022 ◽

Vol 12 (1) ◽

pp. 159

Author(s):

Maria Paola Bonasoni ◽

Giuseppina Comitini ◽

Mariangela Pati ◽

Giuseppe Russello ◽

Loredana Vizzini ◽

...

Keyword(s):

Fetal Loss ◽

Second Trimester ◽

Maternal Transmission ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Abdominal Organs ◽

First Case ◽

The Family ◽

Severe Infections

Citrobacter koseri is a facultative anaerobic, motile, non-spore-forming Gram-negative bacillus, which belongs to the family of Enterobacteriaceae. Severe infections due to Citrobacter spp. have been reported in the urinary tract, respiratory airways, intra-abdominal organs, skin and soft tissue, eye, bone, bloodstream, and central nervous system. In newborns, C. koseri is a well-known cause of meningitis, cerebral abscesses, brain adhesions, encephalitis, and pneumocephalus. Infection can be acquired through vertical maternal transmission or horizontal hospital settings; however, in many cases, the source is unknown. Preterm premature rupture of membranes (PPROM), caused by C. koseri, has rarely been described. Herein, we describe a case of PPROM at 16 weeks and 3 days of gestation, leading to anhydramnios. The parents opted for legal termination of the pregnancy, as the prognosis was very poor. C. koseri was isolated postmortem from a placental subamniotic swab and parenchymal sample, as well as fetal blood and lung. To the best of our knowledge, this is the first case of early second-trimester PPROM in which C. koseri infection was demonstrated.

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The Early Head Start Father Studies: Design, Data Collection, and Summary of Father Presence in the Lives of Infants and Toddlers

Parenting: Science and Practice ◽

10.4324/9780203764169-1 ◽

2019 ◽

pp. 117-143

Author(s):

Kimberly Boiler ◽

Robert Bradley ◽

Natasha Cabrera ◽

Helen H. Raikes ◽

Barbara Pan ◽

...

Keyword(s):

Data Collection ◽

Head Start ◽

Early Head Start ◽

Infants And Toddlers ◽

Design Data ◽

Father Presence

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Retrospective Survey of Parental Marital Relations and Child Reproductive Development

International Journal of Behavioral Development ◽

10.1080/016502598384144 ◽

1998 ◽

Vol 22 (4) ◽

pp. 729-751 ◽

Cited By ~ 46

Author(s):

Kenneth Kim ◽

Peter K. Smith

Keyword(s):

Early Childhood ◽

Family Environment ◽

Marital Conflict ◽

Family Life ◽

Reproductive Behaviour ◽

Father Absence ◽

Self Report ◽

Late Childhood ◽

Early Puberty ◽

Cross Sectional

Belsky, Steinberg, and Draper (1991) predicted that early childhood stress or conflict in the family environment would be associated with childhood behavioural symptoms, early puberty, and early, less discriminate reproductive behaviour. A cross-sectional self-report survey of childhood family life and adolescent development was carried out with 357 university students aged 18 to 24 from Toronto, Canada. In women, earlier menarche was associated with more parental marital conflict in early childhood (birth to age 7), more parental marital unhappiness throughout childhood (birth to age 11), more independence from mother or father in late childhood (age 8 to 11), less anxiousness or internalising symptoms (anxiousness/depression) in late childhood (age 8 to 11), earlier age at dating men, and more boyfriends. In men, earlier spermarche was associated with father absence (birth to before spermarche), more stress in quality of family life, parental marital unhappiness, and parental marital conflict in early childhood (birth to age 7), more independence from mother or father in late childhood (age 8 to 11), earlier age at dating women, more girlfriends, and earlier age at sexual intercourse. These ndings are generally consistent with the Belsky et al. (1991) view that childhood psychosocial stresses affect puberty and reproductive life history, though they do not preclude alternative accounts.

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The Early Head Start Father Studies: Design, Data Collection, and Summary of Father Presence in the Lives of Infants and Toddlers

Parenting ◽

10.1080/15295192.2006.9681302 ◽

2006 ◽

Vol 6 (2-3) ◽

pp. 117-143 ◽

Cited By ~ 23

Author(s):

Kimberly Boller ◽

Robert Bradley ◽

Natasha Cabrera ◽

Helen Raikes ◽

Barbara Pan ◽

...

Keyword(s):

Data Collection ◽

Head Start ◽

Early Head Start ◽

Infants And Toddlers ◽

Design Data ◽

Father Presence

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Fetal Intraventricular Hemorrhage Due to Antiphospholipid Syndrome: A Case Report

Frontiers in Pediatrics ◽

10.3389/fped.2020.622597 ◽

2021 ◽

Vol 8 ◽

Author(s):

M. C. Bouw ◽

S. W. A. Nij Bijvank ◽

J. W. Bouwhuis ◽

G. van Wezel-Meijler

Keyword(s):

Antiphospholipid Syndrome ◽

Intraventricular Hemorrhage ◽

Fetal Loss ◽

Short Review ◽

Cranial Ultrasound ◽

Clinical Criteria ◽

First Case ◽

Vascular Insufficiency ◽

Uterine Growth ◽

Entire Pregnancy

Obstetric Antiphospholipid Syndrome (OAPS) is an autoimmune disease characterized by certain pregnancy complications in association with persistent antiphospholipid antibodies. These antibodies are generally known for their prothrombotic characteristics and may affect mother and fetus during the entire pregnancy. The clinical criteria for OAPS, including recurrent fetal loss, intra-uterine growth restriction and premature birth due to severe preeclampsia, all suggest uteroplacental vascular insufficiency. Although rare, thrombotic complications have been described in neonates born to mothers with OAPS, mainly ischemic stroke. We report on the first case of extensive fetal intraventricular hemorrhage related to OAPS. We share our diagnostic search and analysis for this unusual antenatal event, including cranial ultrasound findings and postmortem MRI images. We will also present a short review of the etiology and prognosis of antenatal intraventricular hemorrhage. We suggest that women with severe or early preeclampsia and/or a history of pregnancy loss should be evaluated for OAPS and carefully monitored throughout pregnancy. Further, we advise to test mothers for OAPS in the case of idiopathic fetal hemorrhage.

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Two alternative scenarios for easing COVID-19 lockdown measures: one reasonable and one catastrophic

10.1101/2020.05.08.20095380 ◽

2020 ◽

Cited By ~ 3

Author(s):

A.S. Fokas ◽

J. Cuevas-Maraver ◽

P. G. Kevrekidis

Keyword(s):

Time Evolution ◽

Incubation Period ◽

Epidemiological Models ◽

Sick Person ◽

Current State ◽

First Case ◽

Mathematical Equations ◽

Alternative Scenarios ◽

Two Parameters ◽

Existing Data

We consider two sub-populations consisting of individuals below or above 40 years of age, which will be referred to as “young” and “older”. A person infected with SARS-CoV-2, following an incubation period, will become either sick (with COVID-19) or will be asymptomatic; the latter will recover, whereas a sick person will either recover or will be hospitalized where they will either die or recover. We assume that the interaction between a person who is infected and a person with the capacity to be infected is described by the usual mechanism of the standard epidemiological models. We first show that by choosing appropriately the parameters of the mathematical equations describing the dynamics of the above sub-populations in data stemming from Greece, one can obtain a reasonable match of the existing data for the time evolution of the total number of deaths and infections for both subpopulations during the current state of lockdown. Then, we consider two possible alternatives: first, we keep the two parameters describing the interactions of older-older and older-young as they are now, but we increase the value of the parameter describing the interaction of young-young; this means that we allow the lockdown measures to be eased only in the young sub-population. Second, we increase the values of all the three above parameters, which means we ease the lockdown measures in both sub-populations. In the first case, the number of deaths remains relatively small, whereas in the second case the situation, upon sufficient increase of the number of contacts, may become catastrophic potentially leading to a dramatic loss of lives.

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Demand for hospitalization services for COVID-19 patients in Brazil

10.1101/2020.03.30.20047662 ◽

2020 ◽

Cited By ~ 6

Author(s):

Marcia C. Castro ◽

Lucas Resende de Carvalho ◽

Taylor Chin ◽

Rebecca Kahn ◽

Giovanny V. A. França ◽

...

Keyword(s):

Hospital Services ◽

Mechanical Ventilators ◽

Public And Private ◽

Critical Situation ◽

Brazilian Government ◽

State Delays ◽

First Case ◽

Hospital Beds ◽

Hospital Resources ◽

Alternative Scenarios

AbstractCOVID-19 is now a pandemic and many of the affected countries face severe shortages of hospital resources. In Brazil, the first case was reported on February 26. As the number of cases grows in the country, there is a concern that the health system may become overwhelmed, resulting in shortages of hospital beds, intensive care unit beds, and mechanical ventilators. The timing of shortage is likely to vary geographically depending on the observed onset and pace of transmission observed, on the availability of resources, and on the actions implemented. Here we consider the daily number of cases reported in municipalities in Brazil to simulate twelve alternative scenarios of the likely timing of shortage, based on parameters consistently reported for China and Italy, on rates of hospital occupancy for other health conditions observed in Brazil in 2019, and on assumptions of allocation of patients in public and private facilities. Results show that hospital services could start to experience shortages of hospital beds, ICU beds, and ventilators in early April, the most critical situation observed for ICU beds. Increasing the allocation of beds for COVID-19 (in lieu of other conditions) or temporarily placing all resources under the administration of the state delays the anticipated start of shortages by a week. This suggests that solutions adopted by the Brazilian government must aim at expanding the available capacity (e.g., makeshift hospitals), and not simply prioritizing the allocation of available resources to COVID-19.

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Hemoglobin crystals of the red blood cells in the human renal cortex: electron microscopic observations of the renal lithiasis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100083266 ◽

1978 ◽

Vol 36 (2) ◽

pp. 480-481

Author(s):

Kosuke Ueda ◽

Hiroto Washida ◽

Nakazo Watari

Keyword(s):

Red Blood Cells ◽

Blood Cells ◽

Renal Cortex ◽

Uranyl Acetate ◽

Osmic Acid ◽

Renal Lithiasis ◽

Electron Microscopic ◽

Hemoglobin C ◽

First Case ◽

Ultrathin Sections

IntroductionHemoglobin crystals in the red blood cells were electronmicroscopically reported by Fawcett in the cat myocardium. In the human, Lessin revealed crystal-containing cells in the periphral blood of hemoglobin C disease patients. We found the hemoglobin crystals and its agglutination in the erythrocytes in the renal cortex of the human renal lithiasis, and these patients had no hematological abnormalities or other diseases out of the renal lithiasis. Hemoglobin crystals in the human erythrocytes were confirmed to be the first case in the kidney.Material and MethodsTen cases of the human renal biopsies were performed on the operations of the seven pyelolithotomies and three ureterolithotomies. The each specimens were primarily fixed in cacodylate buffered 3. 0% glutaraldehyde and post fixed in osmic acid, dehydrated in graded concentrations of ethanol, and then embedded in Epon 812. Ultrathin sections, cut on LKB microtome, were doubly stained with uranyl acetate and lead citrate.

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