scholarly journals DREIMT: a drug repositioning database and prioritization tool for immunomodulation

2020 ◽  
Author(s):  
Kevin Troulé ◽  
Hugo López-Fernández ◽  
Santiago García-Martín ◽  
Miguel Reboiro-Jato ◽  
Carlos Carretero-Puche ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Cells ◽  
Drug Repositioning ◽  
Immune Gene ◽  
Immunomodulatory Drugs ◽  
Web Tool ◽  
Immune Gene Expression ◽  
Final Output ◽  
Gene Expression Signatures ◽  
New Hypothesis

AbstractMotivationDrug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.ResultsDREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ~2,6K immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables.Availabilityhttp://[email protected]; [email protected]

scholarly journals DREIMT: a drug repositioning database and prioritization tool for immunomodulation

2020 ◽  
Author(s):  
Kevin Troulé ◽  
Hugo López-Fernández ◽  
Santiago García-Martín ◽  
Miguel Reboiro-Jato ◽  
Carlos Carretero-Puche ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drug Repositioning ◽  
Supplementary Information ◽  
Immune Gene ◽  
Immunomodulatory Drugs ◽  
Web Tool ◽  
Immune Gene Expression ◽  
Final Output ◽  
Gene Expression Signatures ◽  
New Hypothesis

Abstract Motivation Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug–signature association scores, FDRs and downloadable plots and results tables. Availabilityand implementation http://www.dreimt.org. Supplementary information Supplementary data are available at Bioinformatics online.

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