scholarly journals Variable bites and dynamic populations; new insights in Leishmania transmission

2020 ◽  
Author(s):  
Samuel Carmichael ◽  
Ben Powell ◽  
Thomas Hoare ◽  
Pegine Walrad ◽  
Jon Pitchford

AbstractLeishmaniasis is a neglected tropical disease which kills an estimated 50000 people each year, with its deadly impact confined mainly to lower to middle income countries. Leishmania parasites are transmitted to human hosts by sand fly vectors during blood feeding. Recent experimental work shows that transmission is modulated by the patchy landscape of infection in the host’s skin, and the parasite population dynamics within the vector. Here we assimilate these new findings into a simple probabilistic model for disease transmission which replicates recent experimental results, and assesses their relative importance. The results of subsequent simulations, describing random parasite uptake and dynamics across multiple blood meals, show that skin heterogeneity is important for transmission by short-lived flies, but that for longer-lived flies with multiple bites the population dynamics within the vector dominate transmission probability. Our results indicate that efforts to reduce fly lifespan beneath a threshold of around two weeks may be especially helpful in reducing disease transmission.

2021 ◽  
Vol 15 (1) ◽  
pp. e0009033
Author(s):  
Samuel Carmichael ◽  
Ben Powell ◽  
Thomas Hoare ◽  
Pegine B. Walrad ◽  
Jonathan W. Pitchford

Leishmaniasis is a neglected tropical disease which kills an estimated 50,000 people each year, with its deadly impact confined mainly to lower to middle income countries. Leishmania parasites are transmitted to human hosts by sand fly vectors during blood feeding. Recent experimental work shows that transmission is modulated by the patchy landscape of infection in the host’s skin, and the parasite population dynamics within the vector. Here we assimilate these new findings into a simple probabilistic model for disease transmission which replicates recent experimental results, and assesses their relative importance. The results of subsequent simulations, describing random parasite uptake and dynamics across multiple blood meals, show that skin heterogeneity is important for transmission by short-lived flies, but that for longer-lived flies with multiple bites the population dynamics within the vector dominate transmission probability. Our results indicate that efforts to reduce fly lifespan beneath a threshold of around two weeks may be especially helpful in reducing disease transmission.


2016 ◽  
Vol 18 (8) ◽  
pp. 944-955 ◽  
Author(s):  
Timothy R. Julian

Globally more than half a million children die every year from diarrheal diseases. ThisPerspectivesuggests that reductions in diarrheal disease transmission in LMICs can be achieved by accounting for site-specific factors when designing environmental interventions. This is discussed in the context of the characteristics of the most important diarrheal diseases as well as environmental reservoirs.


PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2795 ◽  
Author(s):  
Julia Robertson ◽  
James Dalton ◽  
Siouxsie Wiles ◽  
Marija Gizdavic-Nikolaidis ◽  
Simon Swift

Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis (TB), relying instead on personal protective equipment, such as facemasks, to reduce nosocomial transmission of the disease. Facemasks impregnated with an antimicrobial agent may be a cost-effective way of adding an extra level of protection against the spread of TB by reducing the risk of disease transmission. Conducting polymers, such as polyaniline (PANI), and their functionalised derivatives are a novel class of antimicrobial agents with potential as non-leaching additives to provide contamination resistant surfaces. We have investigated the antimicrobial action of PANI and a functionalised derivative, poly-3-aminobenzoic acid (P3ABA), against mycobacteria and have determined the optimal treatment time and concentration to achieve significant knockdown ofMycobacterium smegmatisandMycobacterium tuberculosison an agar surface. Results indicated that P3ABA is a potential candidate for use as an anti-tuberculoid agent in facemasks to reduce TB transmission.


2018 ◽  
Vol 48 (4) ◽  
pp. 1204-1218 ◽  
Author(s):  
Jennyfer Wolf ◽  
Richard Johnston ◽  
Matthew C Freeman ◽  
Pavani K Ram ◽  
Tom Slaymaker ◽  
...  

Abstract Background Limited data have been available on the global practice of handwashing with soap (HWWS). To better appreciate global HWWS frequency, which plays a role in disease transmission, our objectives were to: (i) quantify the presence of designated handwashing facilities; (ii) assess the association between handwashing facility presence and observed HWWS; and (iii) derive country, regional and global HWWS estimates after potential faecal contact. Methods First, using data from national surveys, we applied multilevel linear modelling to estimate national handwashing facility presence. Second, using multilevel Poisson modelling on datasets including both handwashing facility presence and observed HWWS after potential faecal contact, we estimated HWWS prevalence conditional on handwashing facility presence by region. For high-income countries, we used meta-analysis to pool handwashing prevalence of studies identified through a systematic review. Third, from the modelled handwashing facility presence and estimated HWWS prevalence conditional on the presence of a handwashing facility, we estimated handwashing practice at country, regional and global levels. Results First, approximately one in four persons did not have a designated handwashing facility in 2015, based on 115 data points for 77 countries. Second the prevalence ratio between HWWS when a designated facility was present compared with when it was absent was 1.99 (1.66, 2.39) P <0.001 for low- and middle-income countries, based on nine datasets. Third, we estimate that in 2015, 26.2% (23.1%, 29.6%) of potential faecal contacts were followed by HWWS. Conclusions Many people lack a designated handwashing facility, but even among those with access, HWWS is poorly practised. People with access to designated handwashing facilities are about twice as likely to wash their hands with soap after potential faecal contact as people who lack a facility. Estimates are based on limited data.


2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Oghenowede Eyawo ◽  
A. M. Viens ◽  
Uchechukwu Chidiebere Ugoji

AbstractLockdowns can be an effective pandemic response strategy that can buy much needed time to slow disease transmission and adequately scale up preventative, diagnostic, and treatment capacities. However, the broad restrictive measures typically associated with lockdowns, though effective, also comes at a cost – imposing significant social and economic burdens on individuals and societies, especially for those in low- and middle-income countries (LMICs). Like most high-income countries (HICs), many LMICs initially adopted broad lockdown strategies for COVID-19 in the first wave of the pandemic. While many HICs experiencing subsequent waves have returned to employing lockdown strategies until they can receive the first shipments of COVID-19 vaccine, many LMICs will likely have to wait much longer to get comparable access for their own citizens. In leaving LMICs vulnerable to subsequent waves for a longer period of time without vaccines, there is a risk LMICs will be tempted to re-impose lockdown measures in the meantime. In response to the urgent need for more policy development around the contextual challenges involved in employing such measures, we propose some strategies LMICs could adopt for safe and responsible lockdown entrance/exit or to avoid re-imposing coercive restrictive lockdown measures altogether.


2020 ◽  
Author(s):  
Luisa Arroyave ◽  
Ghada E Saad ◽  
Cesar G Victora ◽  
Aluisio J D Barros

AbstractIntroductionGood quality antenatal care (ANC) helps reduce maternal and newborn mortality and morbidity, especially in low and middle-income countries (LMICs). Most studies that attempted to measure ANC quality proposed categorical indicators considering either contact with services or based on content, sometimes both. We aimed to create and validate a new indicator measured as a score, considering both contact and content.MethodsWe used Demographic and Health Surveys and Multiple Indicator Cluster Surveys. Information on ANC contact and content was used to build an adequacy score that would be applicable to all women in need of ANC. Cronbach’s alpha and factor analysis were used to assess the proposed indicator. We also used a convergent validation approach, exploring the association with neonatal mortality.ResultsThe proposed indicator (ANCq) is derived from the number of visits, timing of the first visit, skill level of the attendant, blood pressure measurement, tetanus toxoid vaccination and collection of blood and urine samples. The validity assessment showed satisfactory results with Cronbach’s alpha coefficient equal to 0.82. ANCq score ranges from 0 to 10. The overall mean of ANCq in 63 LMICs with data was 6.7, ranging from 3.5 in Afghanistan to 9.3 in Cuba and the Dominican Republic. In most countries, higher scores of ANCq were associated with lower neonatal mortality, with pooled odds ratio of 0.90 (95% CI: 0.88-0.92).ConclusionANCq allows the assessment of ANC in LMICs considering contact with services and content of care. ANCq presented good validity properties, being a useful tool for assessing ANC coverage and adequacy of care in monitoring and accountability exercises.Key questionsWhat is already known?Antenatal care (ANC) is an important part of primary healthcare, being associated with reductions in maternal and new-born morbidity and mortality, mainly in low and middle-income countries (LMICs).Several indicators have been proposed to measured ANC quality either through contacts with services or based on content of care, or sometimes both. Several of the proposed indicators are applicable only to women who had at least one ANC visit, and measured quality as a categorical indicator.Consensus on the need for a more comprehensive ANC indicator that is suitable for monitoring progress, including aspects of quality of care.What are the new findings?We proposed a content-qualified ANC indicator in the form of a score, called ANCq. It includes seven different variables related to contact with services and content of care received during pregnancy. The indicator is applicable to all pregnant women.The indicator has good validity properties and was inversely associated with neonatal mortality.There is wide variation across countries regarding the average ANCq score, and large within-country variation at individual level. Latin America and the Caribbean and East Asia and the Pacific are the best performing regions.What do the new findings imply?The proposed indicator provides a standardized and comparable measure of ANC adequacy, allowing for comparisons between and within countries.The indicator can help monitoring ANC progress to all women in need of ANC, with several advantages over currently existing indicators: it is applicable to all pregnant women independent of having accessed ANC services, it includes serval aspects of ANC content and, being a score, provides a gradation of how suitable ANC was.


2012 ◽  
Author(s):  
Joop de Jong ◽  
Mark Jordans ◽  
Ivan Komproe ◽  
Robert Macy ◽  
Aline & Herman Ndayisaba ◽  
...  

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