scholarly journals The Association between Macular Structure and Idiopathic Epiretinal Membrane

2020 ◽  
Author(s):  
I-Hsin Ma ◽  
Chung-May Yang ◽  
Yi-Ting Hsieh
Keyword(s):  
Regression Analysis ◽  
Epiretinal Membrane ◽  
Normal Population ◽  
Mean Value ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Structure Parameters ◽  
Idiopathic Epiretinal Membrane ◽  
And Gender ◽  
Fellow Eyes

AbstractPurposeThis study measured the anatomical characteristics of the macula in fellow eyes of patients with unilateral idiopathic epiretinal membrane (ERM) and compared them with normal control.DesignA retrospective observational study.ParticipantsA total of of 94 fellow eyes with unilateral idiopathic ERM were gathered as the study group, and their age and gender-matched subjects with no vitreomacular diseases were recruited as the control group.MethodsMacular structure parameters including foveal base width (FBW), central foveolar thickness (CFT), central subfield thickness (CST), area of foveal avascular zone (FAZ), and retinal artery trajectory (RAT) were measured using optical coherence tomography (OCT) and OCT angiography and were compared between two groups.Main outcome measuresMacular structure parameters were compared between the two groups. A wide-based foveal pit was defined as a FBW larger than the mean value plus one standard deviation of the normal population. Regression analysis was performed to evaluate factors that affect FBW.ResultsAmong the 94 fellow eyes of unilateral ERM; 71 eyes (75.5%) had a wide-based foveal pit. Both their FBW (418.9 ± 68.7 µm) and area of FAZ (0.38 ± 0.12 mm2) were significantly larger than those in the control group (323.2 ± 74.3 µm and 0.31± 0.17 mm2; p < 0.001 and p = 0.02, respectively), and they also had a thinner CFT and CST, and a wider RAT than the control group (p < 0.05 for all). In the control group, females had a wider FBW, a thinner CFT and CST, and a wider RAT than males (p < 0.05 for all). Regression analysis showed that female, a thinner CST and a larger FAZ were all associated with a larger FBW.ConclusionFellow eyes of the unilateral ERM had a larger FBW and FAZ, a thinner CFT and CST, and a wider RAT than the normal population. This implicates that centrifugal macular traction may result in the formation of idiopathic ERM. Females had a wider FBW, a thinner CST, and a wider RAT than males, which may explain the higher prevalence of idiopathic ERM in females.

scholarly journals Wide-based Foveal Pit: A Predisposition to Idiopathic Epiretinal Membrane

2020 ◽  
Author(s):  
I-Hsin Ma ◽  
Chung-May Yang ◽  
Yi-Ting Hsieh
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Normal Population ◽  
Mean Value ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Study Group ◽  
Idiopathic Epiretinal Membrane ◽  
Macular Diseases ◽  
Fellow Eyes

Aims: To report the anatomical characteristics of wide-based foveal pit and its associations with macular diseases. Methods: Wide-based foveal pit was defined as a foveal base width (FBW) larger than the mean value plus one standard deviation of normal population. Eyes with a wide-based foveal pit were retrospectively collected as the study group, and age- and sex-matched subjects with a normal FBW were recruited as the control group. FBW, area of foveal avascular zone (FAZ) and retinal artery trajectory (RAT) were compared between two groups. The characteristics of the fellow eyes in the study group were also described. Results: Fifty two eyes from 52 patients were identified as having a wide-based foveal pit; 43 (82.7%) were female. Both their FBW (474.7 ± 84.6 µm) and area of FAZ (0.50 ± 0.11mm2) were significantly larger than in the control group (297.6 ± 42.3 µm and 0.29 ± 0.10 mm2, respectively; p < 0.001 for both), and they also had a wider RAT than the control group (p < 0.001). During follow-up, three eyes had developed idiopathic epiretinal membrane. As for their fellow eyes, they either also had a wide-based foveal pit (11 eyes) or had various macular diseases including idiopathic epiretinal membrane (27 eyes), macular hole (5 eyes) and others (16 eyes). Conclusions: Eyes with a wide-based foveal pit also had a large FAZ and a wide RAT, and they might have a predisposition to idiopathic epiretinal membrane formation. Their fellow eyes also had a predisposition to epiretinal membrane and macular hole.

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

scholarly journals Normal Population Reference Values for the Oxford and Harris Hip Scores – Electronic Data Collection and its Implications for Clinical Practice

2016 ◽  
Vol 27 (4) ◽  
pp. 389-396 ◽  
Author(s):  
James M. McLean ◽  
Jacob Cappelletto ◽  
Jock Clarnette ◽  
Catherine L. Hill ◽  
Tiffany Gill ◽  
...  
Keyword(s):  
Data Collection ◽  
Normal Population ◽  
Country Of Origin ◽  
Age Groups ◽  
Harris Hip Score ◽  
Control Group ◽  
Electronic Data ◽  
Electronic Data Collection ◽  
Exact Test ◽  
And Gender

Background The aim of this study was to assess whether the Harris Hip Score (HHS) and the Oxford Hip Score (OHS) were comparable in normal, healthy, pathology-free individuals of different age, gender, ethnicity, handedness and nationality. The purpose of this study was to establish normal population values for the HHS and OHS using an electronic data collection system. Methods 317 Australian and 310 Canadian citizens with no active hip pain, injury or pathology in the ipsilateral hip corresponding to their dominant arm, were evaluated. Participants completed an electronically-administered questionnaire and were assessed clinically. Chi-square tests, Fisher's exact test and Poisson regression models were used where appropriate, to investigate the association between hip scores, ethnicity, nationality, gender, handedness and age. Results There was a statistically significant association between the OHS and age (p<0.0001) and the HHS and age (p = 0.0006); demonstrating that as age increased, normal hip scores decreased. There was no statistically significant association between the HHS and gender (p = 0.1389); or HSS and nationality, adjusting for age (p = 0.5698) and adjusting for gender (p = 0.6997). There was no statistically significant association between the OHS and gender (p = 0.1350). Australians reported a statistically significant 4.2% higher overall OHS value compared to Canadians (p = 0.0490). There was no statistically significant association between the OHS and nationality in age groups 18-79 years. Participants >80 years reported a statistically significant association between the OHS and nationality (p<0.0001). Conclusions Studies using an electronic control group should consider differences in gender, age, ethnicity and nationality when using the HHS and OHS to assess patient outcomes. This study has established an electronic, normal control group for studies using the HHS and OHS. When using the OHS, the control group should be sourced from the same country of origin. When using the HHS, the control group should be sourced from a pre-established control group within a database, without necessarily being sourced from the same country of origin.

Study of foveal avascular zone by OCTA before and after idiopathic epiretinal membrane removal

2017 ◽  
Vol 32 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Takayuki Baba ◽  
Masato Kakisu ◽  
Tomohiro Nizawa ◽  
Toshiyuki Oshitari ◽  
Shuichi Yamamoto
Keyword(s):  
Epiretinal Membrane ◽  
Foveal Avascular Zone ◽  
Idiopathic Epiretinal Membrane ◽  
Avascular Zone ◽  
Before And After

scholarly journals Prevalence of epiretinal membrane in the phakic eyes based on spectral-domain optical coherence tomography

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245063
Author(s):  
Boyun Kim ◽  
Ayoung Choi ◽  
Jin Heung Park ◽  
Sohee Jeon
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Epiretinal Membrane ◽  
Matched Control ◽  
Control Group ◽  
Matched Control Group ◽  
Phakic Eyes

The prevalence of epiretinal membrane (ERM) and associated factors in the phakic eyes have not been fully elucidated yet. This cross-sectional study included 2,354 phakic eyes without retinal diseases or surgical history. Ocular parameters, such as uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), intraocular pressure (IOP), white-to-white corneal diameter (WTW), mean keratometric value (Km) of total corneal refractive power at 4-mm diameter (TCRP4), astigmatism of TCRP4, total corneal irregular astigmatism (TCIA), pupil diameter, axial length (AXL), anterior chamber depth (ACD), lens thickness (LT), and posterior vitreous detachment (PVD) were compared between ERM group and control group. Additionally, an age-matched control group was selected by individual matching and compared with the ERM group to eliminate the confounders. Multiple logistic regression analysis was performed to evaluate the factors associated with the presence of ERM. Among 2,354 eyes, 429 eyes (18.2%) had ERM based on spectral-domain optical coherence tomography. The ERM group showed higher prevalence of PVD, worse CDVA, higher astigmatism of TCRP4, higher TCIA, smaller pupil size, longer AXL, and thicker LT than control group (P < 0.001, P < 0.001, P = 0.011, P < 0.001, P = 0.023, P < 0.001, and P < 0.001, respectively). Only PVD, CDVA, SE, astigmatism of TCRP4, TCIA, and AXL maintained the significance when compared with the age-matched control group (P < 0.001, P = 0.026, P < 0.001, P = 0.001, P = 0.003, and P < 0.001, respectively). Multivariate logistic regression analysis showed that age, PVD, CDVA, and TCIA were independently associated with the presence of ERM (P < 0.001, P < 0.001, P = 0.011, and P = 0.002). The prevalence of ERM detected using SD-OCT was 18.2% in the middle aged phakic population. Eyes with TCIA, in addition to older age and PVD, were more likely to have ERM.

Important Role of B2-Glycoprotien in Females with Recurrence Abortion

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Ahmed Abbas Hasan ◽  
Radhia Hussain Fadel ◽  
Saeed Hilal Khudhair ◽  
Doaa Hashim Jawad
Keyword(s):  
Pearson Correlation ◽  
Mean Value ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
P Value ◽  
Recurrent Abortion ◽  
Significant Difference ◽  
Medical City ◽  
And Gender ◽  
Age Range

Recurrent abortion consider as one of the most common problem in world. There are different causes associated with recurrent abortion, these may be occur due to complication of microorganism infection or associated with immunological disturbance like abortion caused by Anti-phospholipid syndrome, or associated with SLE. The anti-b2glucoprotien antibodies have a role in abortion. In this study, we wish to determine whether there is a relationship between the levels of these anti-b2glucoprotien antibodies and abortion. Thirty females patients with spontaneous abortion (10 of them with Antiphospholipid syndrome,10 of them with systemic lupus erthymatosus and final 10 with toxoplasmosis with ages ranged between (20-46) where taken from (Al-Hussein Medical City/Kerbala). Control group consisted of 20 healthy people who were free from history of abortion who matched in age and gender with patients. B2gp(IgMandIgG) EASIA Kit, generic assay) and was studied using the enzyme-linked immunosorbent assay (ELISA) method. T-test and ANOVA and Pearson correlation used to analyze results by using SPSS version 24. P-value ≤ 0.05 was considered significant. The patients with age range blow 30 years show high percent(63.3%) among the other groups .most of the patients have high percent of 3 times abortion were reported in all different groups .The mean value of anti-B2gP-I IgG (45.354) show highly a significant difference results in aborted patients with APS and significant difference in patients with SLE when compared with controls groups. the Anti-B2gPI IgM not give statistically significant difference when camper to health cases. we conclude that the Anti-B2GPI IgG levels were increased significantly in aborted females with APS and SLE .

Is Emotional Congruence With Children Associated With Sexual Offending in Pedophiles and Hebephiles From the Community?

Sexual Abuse ◽  
2015 ◽  
Vol 30 (1) ◽  
pp. 3-22 ◽  
Author(s):  
Anna Konrad ◽  
Laura F. Kuhle ◽  
Till Amelung ◽  
Klaus M. Beier
Keyword(s):  
Regression Analysis ◽  
Multinomial Logistic Regression ◽  
Sexual Offending ◽  
Principal Component ◽  
Sexual Preference ◽  
Control Group ◽  
Multinomial Logistic Regression Analysis ◽  
Inherent Feature ◽  
And Gender ◽  
Group Comparisons

Although emotional congruence with children (ECWC) is a risk factor for sexual offending against children, its conceptual validity has hardly been researched. This study aims to explore the construct of ECWC by evaluating the factor structure of the Child Identification Scale (CIS-R) and its relation to facets of sexual preference and child sexual abuse behaviors. It was hypothesized that the measure comprises consistent subscales that are differently associated with aspects of sexual preference and sexual offending against children. CIS-R data of a sample of 217 adult male pedophiles from the community were used for an exploratory principal component analysis (PCA). Group comparisons and a multinomial logistic regression analysis were conducted after including a non-pedophilic control group of 22 adult men. PCA revealed a three-factor solution for the CIS-R accounting for 30% of variance. Group comparisons found differences in overall scores and the factor labeled “Attachment to Children” between subgroups of sexual age and gender preference, but not between contact, online, and non-offenders. The regression analysis showed a pedophile sexual preference and the interaction between a hebephile sexual age preference and the factor “Attachment to Children” being associated with past offending behavior. The results indicate a wish to attach to children as core feature of the CIS-R measure assessing ECWC. It is discussed whether this is an inherent feature of pedophilia or rather an independent aspect being differently distinct in pedophiles.

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