Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus

AbstractBackgroudThe pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an emerging treatment for patients with Parkinson’s disease (PD) or multiple system atrophy (MSA) suffering gait-related atypical parkinsonian syndromes.ObjectiveIn this study, we investigated PPN activities during gait to better understand its functional role in locomotion. Specifically, we investigated whether PPN activity is rhythmically modulated during locomotion.MethodsPPN local field potential (LFP) activities were recorded from PD or MSA patients suffering from gait difficulties during stepping in place or free walking. Simultaneous measurements from force plates or accelerometers were used to determine the phase within each gait cycle at each time point.ResultsOur results showed that activities in the alpha and beta frequency bands in the PPN LFPs were rhythmically modulated by the gait phase within gait cycles, with a higher modulation index when the stepping rhythm was more regular. Meanwhile, the PPN-cortical coherence was most prominent in the alpha band. Both gait-phase related modulation in the alpha/beta power and the PPN-cortical coherence in the alpha frequency band were spatially specific to the PPN and did not extend to surrounding regions.ConclusionsThese results raise the possibility that alternating PPN stimulation in tandem with the gait rhythm may be more beneficial for gait control than continuous stimulation, although this remains to be established in future studies.

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The rate of transient beta frequency events predicts impaired function across tasks and species

10.1101/128769 ◽

2017 ◽

Cited By ~ 3

Author(s):

Hyeyoung Shin ◽

Robert Law ◽

Shawn Tsutsui ◽

Christopher I. Moore ◽

Stephanie R. Jones

Keyword(s):

High Power ◽

Brain Activity ◽

Field Potential ◽

Motor Action ◽

Attention Tasks ◽

Beta Power ◽

Beta Frequency ◽

First Time ◽

Abnormal Behaviors ◽

Local Field Potential Lfp

AbstractBeta frequency oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of many healthy and abnormal behaviors, including perception, attention and motor action. Recent evidence shows that in non-averaged signals, beta can emerge as transient high-power “events”. As such, functionally relevant differences in averaged power across time and trials can reflect accumulated changes in the number, power, duration, and/or frequency span of the events. We show for the first time that functionally relevant differences in averaged prestimulus beta power in human sensory neocortex reflects a difference in the number of high-power beta events per trial, i.e., the rate of events. Further, high power beta events close to the time of the stimulus were more likely to impair perception. This result is consistent across detection and attention tasks in human magnetoencephalography (MEG) and is conserved in local field potential (LFP) recordings of mice performing a detection task. Our findings suggest transient brain rhythms are best viewed as a “rate metric” in their impact on function, and provides a new framework for understanding and manipulating functionally relevant rhythmic events.

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Case Report: Chronic Adaptive Deep Brain Stimulation Personalizing Therapy Based on Parkinsonian State

Frontiers in Human Neuroscience ◽

10.3389/fnhum.2021.702961 ◽

2021 ◽

Vol 15 ◽

Author(s):

Asuka Nakajima ◽

Yasushi Shimo ◽

Atsuhito Fuse ◽

Joji Tokugawa ◽

Makoto Hishii ◽

...

Keyword(s):

Deep Brain Stimulation ◽

Brain Stimulation ◽

Field Potential ◽

Neural Oscillations ◽

Target Structure ◽

New Device ◽

Stimulation Method ◽

Local Field Potential Lfp ◽

Beta Oscillation ◽

Deep Brain

We describe the case of a 51-year-old man with Parkinson's disease (PD) presenting with motor fluctuations, who received bilateral subthalamic deep brain stimulation (DBS) with an adaptive DBS (aDBS) device, Percept™ PC (Medtronic, Inc. , Minneapolis, MN). This device can deliver electrical stimulations based on fluctuations of neural oscillations of the local field potential (LFP) at the target structure. We observed that the LFP fluctuations were less evident inside the hospital than outside, while the stimulation successfully adapted to beta oscillation fluctuations during the aDBS phase without any stimulation-induced side effects. Thus, this new device facilitates condition-dependent stimulation; this new stimulation method is feasible and provides new insights into the pathophysiological mechanisms of PD.

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Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

eLife ◽

10.7554/elife.19089 ◽

2016 ◽

Vol 5 ◽

Cited By ~ 17

Author(s):

Huiling Tan ◽

Alek Pogosyan ◽

Keyoumars Ashkan ◽

Alexander L Green ◽

Tipu Aziz ◽

...

Keyword(s):

Basal Ganglia ◽

Subthalamic Nucleus ◽

Local Field ◽

Field Potential ◽

Field Potentials ◽

Movement Parameters ◽

Gripping Force ◽

And Control ◽

Local Field Potential Lfp ◽

Deep Brain

The basal ganglia are known to be involved in the planning, execution and control of gripping force and movement vigour. Here we aim to define the nature of the basal ganglia control signal for force and to decode gripping force based on local field potential (LFP) activities recorded from the subthalamic nucleus (STN) in patients with deep brain stimulation (DBS) electrodes. We found that STN LFP activities in the gamma (55–90 Hz) and beta (13–30m Hz) bands were most informative about gripping force, and that a first order dynamic linear model with these STN LFP features as inputs can be used to decode the temporal profile of gripping force. Our results enhance the understanding of how the basal ganglia control gripping force, and also suggest that deep brain LFPs could potentially be used to decode movement parameters related to force and movement vigour for the development of advanced human-machine interfaces.

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A Beta Oscillation Network in the Rat Olfactory System During a 2-Alternative Choice Odor Discrimination Task

Journal of Neurophysiology ◽

10.1152/jn.00166.2010 ◽

2010 ◽

Vol 104 (2) ◽

pp. 829-839 ◽

Cited By ~ 55

Author(s):

Leslie M. Kay ◽

Jennifer Beshel

Keyword(s):

Frequency Band ◽

Field Potential ◽

Gamma Oscillations ◽

Beta Band ◽

Beta Oscillations ◽

Odor Discrimination Task ◽

Beta Power ◽

Beta Frequency Band ◽

Alternative Choice ◽

Beta Frequency

We previously showed that in a two-alternative choice (2AC) task, olfactory bulb (OB) gamma oscillations (∼70 Hz in rats) were enhanced during discrimination of structurally similar odorants (fine discrimination) versus discrimination of dissimilar odorants (coarse discrimination). In other studies (mostly employing go/no-go tasks) in multiple labs, beta oscillations (15–35 Hz) dominate the local field potential (LFP) signal in olfactory areas during odor sampling. Here we analyzed the beta frequency band power and pairwise coherence in the 2AC task. We show that in a task dominated by gamma in the OB, beta oscillations are also present in three interconnected olfactory areas (OB and anterior and posterior pyriform cortex). Only the beta band showed consistently elevated coherence during odor sniffing across all odor pairs, classes (alcohols and ketones), and discrimination types (fine and coarse), with stronger effects in first than in final criterion sessions (>70% correct). In the first sessions for fine discrimination odor pairs, beta power for incorrect trials was the same as that for correct trials for the other odor in the pair. This pattern was not repeated in coarse discrimination, in which beta power was elevated for correct relative to incorrect trials. This difference between fine and coarse odor discriminations may relate to different behavioral strategies for learning to differentiate similar versus dissimilar odors. Phase analysis showed that the OB led both pyriform areas in the beta frequency band during odor sniffing. We conclude that the beta band may be the means by which information is transmitted from the OB to higher order areas, even though task specifics modify dominance of one frequency band over another within the OB.

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A Modified Miniscope System for Simultaneous Electrophysiology and Calcium Imaging in vivo

Frontiers in Integrative Neuroscience ◽

10.3389/fnint.2021.682019 ◽

2021 ◽

Vol 15 ◽

Author(s):

Xiaoting Wu ◽

Xiangyu Yang ◽

Lulu Song ◽

Yang Wang ◽

Yamin Li ◽

...

Keyword(s):

Calcium Imaging ◽

Adult Mouse ◽

Field Potential ◽

Simultaneous Recording ◽

Ca1 Region ◽

Volume Weight ◽

The Brain ◽

Local Field Potential Lfp ◽

Deep Brain

The miniscope system is one of the calcium (Ca2+) imaging tools with small size and lightweight and can realize the deep-brain Ca2+ imaging not confined to the cerebral cortex. Combining Ca2+ imaging and electrophysiology recording has been an efficient method for extracting high temporal-spatial resolution signals in the brain. In this study, a particular electrode probe was developed and assembled on the imaging lens to modify the miniscope system. The electrode probe can be tightly integrated into the lens of the miniscope without increasing the volume, weight, and implantation complexity. In vivo tests verified that the proposed modified system has realized the simultaneous recording of Ca2+ signals and local field potential (LFP) signal in the hippocampus CA1 region of an adult mouse.

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