scholarly journals COVID-19 in patients hospitalized and healthcare workers: what have changed after the first wave in a university hospital

2021 ◽  
Author(s):  
Luiz Vinicius Leao Moreira ◽  
Gabriela Barbosa ◽  
Luciano Kleber de Souza Luna ◽  
Alberto Fernando Oliveira Justo ◽  
Ana Paula Cunha Chaves ◽  
...  
Keyword(s):  
Viral Load ◽  
Healthcare Workers ◽  
Sao Paulo ◽  
Hospitalized Patients ◽  
University Hospital ◽  
São Paulo ◽  
The Mean ◽  
Wave Methods ◽  
The Impact ◽  
Pandemic Wave

Objective: To assess the COVID-19 frequency rates in hospitalized patients (HP) and healthcare workers (HCW), viral load inference, and the impact of vaccination and variants of concern (VOC) during the first pandemic wave. Methods: We evaluated the COVID-19 diagnostics at Hospital Sao Paulo, Brazil, from March 2020 to April 2021, in 10,202 samples (6,502 HP and 3,700 HCW) tested by RT-qPCR, inferring viral load by cycle threshold (Ct) values, and frequency rates. Results: SARS-CoV-2 was detected in 31.27% of individuals (32.23% HP and 29.80% HCW). The mean age of HP positives was 57.26 +/- 18.29 years (median = 59), with a mean Ct value of 25.55 +/- 6.07. Neither age nor Ct values in both groups have significantly differed during the first and second waves or even since the predominance of VOC P.1 on March 2021. Conclusions: The COVID-19 epidemic curves of HP and HCW accompanied the variations reported in Sao Paulo city, as well as the variation of hospitalization and occupancy of ICU beds. The VOC P.1 has no impact on the viral load, since its predominance in March 2021. The vaccination of HCW may have contributed to a decrease in the positivity rates, although more studies will provide a better understanding of the impact of immunization on the COVID-19 pandemic.

scholarly journals COVID-19 in hospitalized patients and healthcare workers: what have changed after the first wave in a university hospital

2021 ◽  
Author(s):  
Luiz Moreira ◽  
Gabriela Rodrigues Barbosa ◽  
Luciano Kleber de Souza Luna ◽  
Alberto Fernando Oliveira Justo ◽  
Ana Paula Cunha Chaves ◽  
...  
Keyword(s):  
Viral Load ◽  
Healthcare Workers ◽  
Sao Paulo ◽  
Hospitalized Patients ◽  
University Hospital ◽  
São Paulo ◽  
Cycle Threshold ◽  
Ct Value ◽  
The Mean ◽  
The Impact

Abstract ObjectiveTo assess the COVID-19 frequency rates in hospitalized patients (HP) and healthcare workers (HCW), viral load inference, and the impact of vaccination and variants of concern (VOC) during the COVID-19 pandemic.Materials and methodWe evaluated the COVID-19 diagnostics at Hospital São Paulo, Brazil, from March 2020 to April 2021, in 10,202 samples (6,502 HP and 3,700 HCW) tested by RT-qPCR, inferring viral load by cycle threshold (Ct) values, and frequency rates.ResultsSARS-CoV-2 was detected in 31.27% of individuals (32.23% HP and 29.80% HCW). The mean age of HP positives was 57.26 ± 18.29 years (median = 59), with a mean Ct value of 25.55 ± 6.07. Neither age nor Ct values in both groups have significantly differed during the first and second waves or even since the predominance of VOC P.1 on March 2021.ConclusionsThe COVID-19 epidemic curves of HP and HCW accompanied the variations reported in São Paulo city, as well as the variation of hospitalization and occupancy of ICU beds. The VOC P.1 has no impact on the viral load, since its predominance in March 2021. The vaccination of HCW may have contributed to a decrease in the positivity rates, although more studies will provide a better understanding of the impact of immunization on the COVID-19 pandemic.

scholarly journals High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

2020 ◽  
Author(s):  
Carolina Palamin Buonafine ◽  
Beatriz Nobre Monteiro Paiatto ◽  
Fabyano Leal ◽  
Samantha Matos ◽  
Camila Ohomoto Moraes ◽  
...  
Keyword(s):  
Latin America ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Medical Condition ◽  
Demographic Data ◽  
Sao Paulo ◽  
University Hospital ◽  
São Paulo ◽  
Ocular Pain ◽  
Increased Risk

Abstract Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21 st and May 22 nd , 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 (9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male) and 2 (1.6%) died. Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

scholarly journals EVALUATION OF HUMAN EXPOSURE TO HEXACHLOROBENZENE AT SAMARITÁ, SÃO VICENTE, SÃO PAULO, BRAZIL

2001 ◽  
Vol 11 ◽  
Author(s):  
AGNES S. SILVA ◽  
HELOISA H.C. BARRETTO ◽  
ODETE N.K. INOMATA ◽  
VERA R.R. LEMES
Keyword(s):  
Blood Serum ◽  
Local Population ◽  
Sao Paulo ◽  
Industrial Wastes ◽  
Determination Limit ◽  
São Paulo ◽  
Serum Samples ◽  
Baseline Information ◽  
The Mean ◽  
The Impact

Na área de Samaritá, cidade de São Vicente, São Paulo, Brasil, resíduos químicos industriais foram descartados por vários anos, sem proteção ambiental, contendo 55 a 85% de hexaclorobenzeno (HCB) e outros produtos em menores quantidades. Para avaliar o impacto à saúde foram analisados soro sangüíneo de 234 pessoas de diversos bairros da região, com mais de 2 anos de residência, subdivididos em 6 setores: A - Quarentenário e vizinhança do lixo industrial a 67 km; B - Jardim Rio Branco; C - Parque das Bandeiras; D - Gleba II; E - Vila Samaritá; F - Vila Ema, Vila Iolanda, Vila Mathias. Dez amostras de soro sangüíneo de habitantes de Itanhaém, área considerada não exposta, foram coletados para fornecer dados de referência. HCB não foi encontrado em nenhuma destas amostras. Resíduos de HCB foram analisados por cromatografia a gás com detetor de captura de elétrons e limite de determinação de 0,02 µg/dL. Os níveis médios de HCB no soro sanguíneo dos moradores mostraram-se significativamente diferentes (p < 0.001) entre o setor A (0.41µg/dL) e os demais setores: B (0.04 µg/dL); C (0.04 µg/ dL); D (0.03 µg/dL); E (0.04 µg/dL): F (0.04 µg/dL). Ainda que não seja possível estabelecer correlações com doenças encontradas na população, este estudo demonstra que os resíduos de HCB constituem problema para a saúde, pois além de contaminar o meio ambiente são encontrados em seres vivos, inclusive no ser humano. Abstract In the Samaritá area of São Vicente city, São Paulo State, Brazil, a chemical industry discarded for several years, with no environmental protection, a mixture of residues containing 55 to 85% of hexachlorobenzene (HCB) and others in smaller quantities. In order to evaluate the impact of these residues on the health of the local population, blood serum samples taken from 234 people dwelling at several quarters of this area for over two years were analyzed, divided into 6 sectors: A - Quarentenário and neighborhood of the industrial wastes dump at 67-km; B - Jardim Rio Branco; C - Parque das Bandeiras; D - Gleba II; E -Vila Samaritá; F -Vila Ema, Vila Iolanda, Vila Mathias. Ten blood samples from residents of an area considered no exposed from Itanhaém city were collected to provide baseline information and HCB was not found in any of the samples. HCB residues were analysed by gas chromatography with an electron capture detector, with a determination limit of 0.02 µg/dL. The mean of HCB in blood serum for the inhabitants of the affected area presented significant differences (p < 0.001) between sector A (0.41 µg/dL) and all the others sectors: B (0.04 µg/dL); C (0.04 µg/ dL); D (0.03 µg/dL); E (0.04 µg/dL): F (0.04 µg/dL). Although it has not yet been possible to correlate such findings with the presence of diseases among the area inhabitants, this study indicates that the HCB residues are a health risk, as they not only contaminate the environment, but are also present at the biota, including humans.

scholarly journals Potentially inappropriate medications among elderly Brazilian outpatients

2013 ◽  
Vol 131 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Christine Grützmann Faustino ◽  
Maria Cristina Guerra Passarelli ◽  
Wilson Jacob-Filho
Keyword(s):  
Sao Paulo ◽  
University Hospital ◽  
Potentially Inappropriate Medications ◽  
Age Group ◽  
São Paulo ◽  
Female Sex ◽  
Elderly Outpatients ◽  
The Mean ◽  
Inappropriate Medications ◽  
De Medicina

CONTEXT AND OBJECTIVESIn Brazil, few studies have investigated the prevalence of potentially inappropriate medications (PIMs) among elderly outpatients. This study aimed to determine the prevalence of PIMs prescribed for elderly outpatients, identify the PIMs most commonly involved, and investigate whether age, sex and number of medications are related to prescription of such medications.DESIGN AND SETTINGObservational descriptive study developed in the Geriatrics Service of the Central Institute of Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.METHODSPrescriptions issued to 1,270 elderly patients (≥ 60 years) were gathered from a database. These prescriptions had been written by geriatricians at a tertiary-level university hospital in São Paulo, Brazil, between February and May 2008. The prescriptions were divided according to sex and age group (60-69, 70-79 and ≥ 80). The Beers criteria were used to evaluate PIMs.RESULTSMost of the sample comprised women (77%) and the mean age was 80.1 years. The mean prevalence of PIM prescriptions was 26.9%. Female sex and number of medications prescribed were associated with prescription of PIMs. The chance of having a PIM prescription was lower among patients ≥ 70 years.CONCLUSIONThe greater prevalence of PIMs was correlated with female sex. The chance of having a PIM prescription was lower among patients ≥ 70 years and became greater with increasing numbers of medications prescribed (≥ 7).

scholarly journals High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Carolina Palamin Buonafine ◽  
Beatriz Nobre Monteiro Paiatto ◽  
Fabyano Bruno Leal ◽  
Samantha Faria de Matos ◽  
Camila Ohomoto de Morais ◽  
...  
Keyword(s):  
Latin America ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Medical Condition ◽  
Multivariable Analysis ◽  
Sao Paulo ◽  
University Hospital ◽  
São Paulo ◽  
Ocular Pain ◽  
Increased Risk

Abstract Background Brazil became the epicenter of the COVID-19 pandemic in Latin America since May 2020, reporting the highest number of cases and deaths in the region. Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of HCWs with COVID-19 symptoms. Methods Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among HCWs with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results Overall, 125 (42.37%) of 295 symptomatic HCWs tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (95% CI 15.9–60.3%) in the second week to 55.9% (95% CI 43.2–68.6%) in the sixth week, reaching a plateau (38–46%) thereafter. Median (SD) age was 34.2 (9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariable analysis, using logistic regression, anosmia (adjusted OR 4.4 95% CI 2.21–8.74) and ocular pain (adjusted OR 1.95 95% CI 1.14–3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) HCWs were hospitalized (seven were male) and 2 (1.6%) died. Conclusions The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

scholarly journals Kangaroo Mother Care for Preterm Infants and Child Development – Evidence from São Paulo, Brazil

2019 ◽  
Author(s):  
Silas Onyango ◽  
Alexandra Brentani ◽  
Günther Fink
Keyword(s):  
Child Development ◽  
Preterm Infants ◽  
Physical Development ◽  
Sao Paulo ◽  
Kangaroo Mother Care ◽  
University Hospital ◽  
Primary Study ◽  
São Paulo ◽  
Preterm Children ◽  
The Impact

Abstract Background An estimated 15 million children are born prematurely each year globally, resulting in a high burden of under-five mortality and neurodevelopmental disability. Kangaroo Mother Care (KMC) is recognized as key intervention to support the development of preterm infants. Even though the benefits of KMC have been well documented in randomized controlled trials, evidence on the impact of KMC in routine care settings remains limited.Methods This paper examines the associations between maternal Kangaroo Mother Care efforts and child development among preterm infants born at the University Hospital of São Paulo, Brazil. Primary study outcomes were physical development (HAZ) and cognitive development at age 3.Results Practicing Kangaroo Mother Care was positively associated with physical development (+0.91 SD, 95% confidence intervals [0.126, 1.695]), and cognition (+0.37 SD, [0.034, 0.806]) of preterm children at age 3.Conclusion The results presented suggest that KMC has a large potential to improve children’s cognitive and physical development. New programs to increase KMC uptake in the setting studied may be beneficial for both mothers and their preterm children.

scholarly journals High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

2020 ◽  
Author(s):  
Carolina Palamin Buonafine ◽  
Beatriz Nobre Monteiro Paiatto ◽  
Fabyano Leal ◽  
Samantha Matos ◽  
Camila Ohomoto Moraes ◽  
...  
Keyword(s):  
Latin America ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Medical Condition ◽  
Multivariable Analysis ◽  
Sao Paulo ◽  
University Hospital ◽  
São Paulo ◽  
Ocular Pain ◽  
Increased Risk

Abstract Background: Brazil became the epicenter of the COVID-19 pandemic in Latin America since May 2020, reporting the highest number of cases and deaths in the region. Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of HCWs with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among HCWs with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic HCWs tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (95% CI 15.9% - 60.3%) in the second week to 55.9% (95% CI 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 ( 9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariable analysis, using logistic regression, anosmia (adjusted OR 4.4 95% CI 2.21 - 8.74) and ocular pain (adjusted OR 1.95 95% CI 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) HCWs were hospitalized (seven were male) and 2 (1.6%) died. Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

scholarly journals High prevalence of SARS-CoV-2 Infection Among Symptomatic Healthcare Workers in a large university tertiary hospital in São Paulo, Brazil

2020 ◽  
Author(s):  
Carolina Palamin Buonafine ◽  
Beatriz Nobre Monteiro Paiatto ◽  
Fabyano Leal ◽  
Samantha Matos ◽  
Camila Ohomoto Moraes ◽  
...  
Keyword(s):  
Latin America ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Medical Condition ◽  
Demographic Data ◽  
Sao Paulo ◽  
University Hospital ◽  
São Paulo ◽  
Ocular Pain ◽  
Increased Risk

Abstract Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 ( 9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male) and 2 (1.6%) died.Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

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