scholarly journals Fractality of Tics as a Quantitative Assessment Tool for Diagnosis of Tourette Syndrome

2021 ◽  
Author(s):  
Payton Beeler ◽  
Nicholas O. Jensen ◽  
Soyoung Kim ◽  
Amy Viehoever-Robichaux ◽  
Bradley L. Schlaggar ◽  
...  
Keyword(s):  
Time Series ◽  
Tourette Syndrome ◽  
Assessment Tool ◽  
Treatment Effectiveness ◽  
P Value ◽  
Scale Invariant ◽  
Time Series Dataset ◽  
Tic Suppression ◽  
Power Law Exponent ◽  
Tic Severity

Tics manifest as brief, purposeless, and involuntary movements or noises that can be suppressed temporarily with effort. In 1998, Peterson and Leckman (P&L) hypothesized that the chaotic temporal nature of tics could possess an inherent fractality, that is, have neighbor-to-neighbor correlation at all levels of time scale. However, demonstrating this phenomenon has eluded researchers for more than two decades, primarily because of the challenges associated with estimating the scale-invariant, power law exponent-called the fractal dimension Df-from a fractional Brownian noise. Here, we confirm P&L's hypothesis and establish the fractality of tics by examining year-long tic time series dataset of children diagnosed with Tourette syndrome using one-dimensional random walk models. We find that Df increases from ~1.4 to 1.75 in order of decreasing tic severity, and is correlated with the conventional YGTTS total tic score (TTS) clinical measure (p-value = 0.03). We demonstrate Df to be a sensitive parameter in examining the effect of several tic suppression conditions on the tic time series. Our findings pave the way for utilizing the fractal nature of tics as a quantitative tool for estimating tic severity and treatment effectiveness, as well as a marker for differentiating typical from functional tics.

Parent and Patient Perceptions of Functional Impairment Due to Tourette Syndrome: Development of a Shortened Version of the Child Tourette Syndrome Impairment Scale

2017 ◽  
Vol 32 (8) ◽  
pp. 725-730 ◽  
Author(s):  
Kara S. Francis Barfell ◽  
Ryan R. Snyder ◽  
Kelly M. Isaacs-Cloes ◽  
Jordan F. Garris ◽  
Alyssa R. Roeckner ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Tourette Syndrome ◽  
Assessment Tool ◽  
Correlation Coefficients ◽  
Patient Perceptions ◽  
Published Data ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Hyperactivity Disorder ◽  
Tic Severity

The Child Tourette Syndrome Impairment Scale (CTIM) rates 37 problems in school, social, and home domains separately for tics and for comorbid diagnoses. However, a shorter version would be easier to implement in busy clinics. Using published data from 85 children with Tourette syndrome, 92 controls, and parents, factor analysis was used to generate a “mini-CTIM” composed of 12 items applied to tic and comorbid diagnoses. Child- and parent-rated mini-CTIM scores were compared and correlated across raters and accounting for clinician-rated tic severity and presence of attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). The mini-CTIM achieved domain Cronbach alphas ranging from 0.71 to 0.94 and intra-item correlation coefficients ranging from 0.84 to 0.96. The resulting scale correlated with clinician-rated tic severity and reflected the presence of ADHD and OCD. The mini-CTIM appears promising as a practical assessment tool for tic- and non–tic-related impairment in children with Tourette syndrome.

scholarly journals Investigation of gene–environment interactions in relation to tic severity

2021 ◽  
Author(s):  
Mohamed Abdulkadir ◽  
Dongmei Yu ◽  
Lisa Osiecki ◽  
Robert A. King ◽  
Thomas V. Fernandez ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Association Studies ◽  
Autism Spectrum ◽  
Environment Interaction ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Linear Regression Models ◽  
Compulsive Disorder ◽  
Gene Environment ◽  
Tic Severity

AbstractTourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies.

Course of Tic Severity in Tourette Syndrome: The First Two Decades

1999 ◽  
Vol 38 (4) ◽  
pp. 492
Author(s):  
James F. Leckman ◽  
Heping Zhang ◽  
Amy Vitale ◽  
Fatima Lahnin ◽  
Kimberly Lynch ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Tic Severity

scholarly journals An External Agribusiness Risk Analysis Using KBDI: A Case of Veldfires in the Northern Territory of Australia

2020 ◽  
Vol 3 (1) ◽  
pp. 37
Author(s):  
Toyi Maniki Diphagwe ◽  
Bernard Moeketsi Hlalele ◽  
Dibuseng Priscilla Mpakathi
Keyword(s):  
Time Series ◽  
Probability Distribution ◽  
Crop Production ◽  
Time Series Data ◽  
Northern Territory ◽  
Return Level ◽  
Series Data ◽  
Burned Area ◽  
Trend Test ◽  
P Value

The 2019/20 Australian bushfires burned over 46 million acres of land, killed 34 people and left 3500 individuals homeless. Majority of deaths and buildings destroyed were in New South Wales, while the Northern Territory accounted for approximately 1/3 of the burned area. Many of the buildings that were lost were farm buildings, adding to the challenge of agricultural recovery that is already complex because of ash-covered farmland accompanied by historic levels of drought. The current research therefore aimed at characterising veldfire risk in the study area using Keetch-Byram Drought Index (KBDI). A 39-year-long time series data was obtained from an online NASA database. Both homogeneity and stationarity tests were deployed using a non-parametric Pettitt’s and Dicky-Fuller tests respectively for data quality checks. Major results revealed a non-significant two-tailed Mann Kendall trend test with a p-value = 0.789 > 0.05 significance level. A suitable probability distribution was fitted to the annual KBDI time series where both Kolmogorov-Smirnov and Chi-square tests revealed Gamma (1) as a suitably fitted probability distribution. Return level computation from the Gamma (1) distribution using XLSTAT computer software resulted in a cumulative 40-year return period of moderate to high fire risk potential. With this low probability and 40-year-long return level, the study found the area less prone to fire risks detrimental to animal and crop production. More agribusiness investments can safely be executed in the Northern Territory without high risk aversion.

Simulating reference rainfall scenarios for hydrological applications using a multifractal approach

2021 ◽  
Author(s):  
Arun Ramanathan ◽  
Pierre-Antoine Versini ◽  
Daniel Schertzer ◽  
Ioulia Tchiguirinskaia ◽  
Remi Perrin ◽  
...  
Keyword(s):  
Time Series ◽  
Moment Analysis ◽  
Specific Reference ◽  
Rainfall Time Series ◽  
Time Series Dataset ◽  
Hourly Rainfall ◽  
Spatial Dimensions ◽  
Multifractal Theory ◽  
Intensity Duration Frequency ◽  
Hydrological Applications

<p><strong>Abstract</strong></p><p>Hydrological applications such as flood design usually deal with and are driven by region-specific reference rainfall regulations, generally expressed as Intensity-Duration-Frequency (IDF) values. The meteorological module of hydro-meteorological models used in such applications should therefore be capable of simulating these reference rainfall scenarios. The multifractal cascade framework, since it incorporates physically realistic properties of rainfall processes such as non-homogeneity (intermittency), scale invariance, and extremal statistics, seems to be an appropriate choice for this purpose. Here we suggest a rather simple discrete-in-scale multifractal cascade based approach. Hourly rainfall time-series datasets (with lengths ranging from around 28 to 35 years) over six cities (Paris, Marseille, Strasbourg, Nantes, Lyon, and Lille) in France that are characterized by different climates and a six-minute rainfall time series dataset (with a length of around 15  years) over Paris were analyzed via spectral analysis and Trace Moment analysis to understand the scaling range over which the universal multifractal theory can be considered valid. Then the Double Trace Moment analysis was performed to estimate the universal multifractal parameters α,C<sub>1</sub> that are required by the multifractal cascade model for simulating rainfall. A renormalization technique that estimates suitable renormalization constants based on the IDF values of reference rainfall is used to simulate the reference rainfall scenarios. Although only purely temporal simulations are considered here, this approach could possibly be generalized to higher spatial dimensions as well.</p><p><strong>Keywords</strong></p><p>Multifractals, Non-linear geophysical systems, Cascade dynamics, Scaling, Hydrology, Stochastic rainfall simulations.</p>

scholarly journals Breakdown coefficients and scaling properties of rain fields

1998 ◽  
Vol 5 (2) ◽  
pp. 93-104 ◽  
Author(s):  
D. Harris ◽  
M. Menabde ◽  
A. Seed ◽  
G. Austin
Keyword(s):  
Time Series ◽  
Parameter Estimation ◽  
Power Law ◽  
Scale Parameter ◽  
Probability Distributions ◽  
Scaling Analysis ◽  
Scaling Properties ◽  
Power Law Exponent ◽  
Scale Similarity ◽  
Parameter Estimation Techniques

Abstract. The theory of scale similarity and breakdown coefficients is applied here to intermittent rainfall data consisting of time series and spatial rain fields. The probability distributions (pdf) of the logarithm of the breakdown coefficients are the principal descriptor used. Rain fields are distinguished as being either multiscaling or multiaffine depending on whether the pdfs of breakdown coefficients are scale similar or scale dependent, respectively. Parameter  estimation techniques are developed which are applicable to both multiscaling and multiaffine fields. The scale parameter (width), σ, of the pdfs of the log-breakdown coefficients is a measure of the intermittency of a field. For multiaffine fields, this scale parameter is found to increase with scale in a power-law fashion consistent with a bounded-cascade picture of rainfall modelling. The resulting power-law exponent, H, is indicative of the smoothness of the field. Some details of breakdown coefficient analysis are addressed and a theoretical link between this analysis and moment scaling analysis is also presented. Breakdown coefficient properties of cascades are also investigated in the context of parameter estimation for modelling purposes.

scholarly journals Coronavirus (COVID-19) Pandemic in Indonesia: Cases Overview and Daily Data Time Series using Naïve Forecast Method

2021 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Annisa Puspa Kirana ◽  
Adhitya Bhawiyuga
Keyword(s):  
Time Series ◽  
Percentage Error ◽  
Forecast Method ◽  
Monthly Basis ◽  
Average Case ◽  
Monthly Average ◽  
Daily Data ◽  
Time Series Dataset ◽  
The World ◽  
Forecasting Analysis

At the end of December 2019, the virus emerges from Wuhan, China, and resulted in a severe outbreak in many cities in China and expanding globally, including Indonesia. Indonesia is the fourth most populated country globally. As of February 2021, Indonesia in the first rank of positive cases of COVID-19 in Southeast Asia, number 4 in Asia, and number 19 in the world. Our paper aims to provide detailed reporting and analysis of the COVID-19 case overview and forecasting that have hit Indonesia. Our time-series dataset from March 2020 to January 2021. Summary of cases studied included the number of positive cases and deaths due to COVID-19 on a daily or monthly basis. We use time series and forecasting analysis using the Naïve Forecast method.  The prediction is daily case prediction for six months starting from February 1, 2021, to June 30, 2021, using active cases daily COVID-19 data in all provinces in Indonesia. The highest monthly average case prediction is in June, which is 35,662 cases. Our COVID-19 prediction study has a mean absolute percentage error (MAPE) score of 15.85%.

Sign in / Sign up

Export Citation Format

Share Document