scholarly journals Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM Trial Analysis

2021 ◽  
Author(s):  
reem waziry ◽  
David L corcoran ◽  
Kim M Huffman ◽  
Michael S Kobor ◽  
Meeraj Kothari ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Controlled Trial ◽  
Model Organisms ◽  
Biological Aging ◽  
Control Group ◽  
Epigenetic Clock ◽  
Long Term Effects ◽  
Cohen’S D ◽  
Cohen's D

Calorie restriction (CR) slows aging and increases healthy lifespan in model organisms. We tested if CR slowed biological aging in humans using DNA methylation analysis of blood samples from N=197 participants in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM) randomized controlled trial. We quantified CR effects on biological aging by comparing change scores for six epigenetic-clock and Pace-of-Aging measures between n=128 CR-group and n=69 ad-libitum-control-group participants at 12- and 24-month follow-ups. CR effects were strongest for DunedinPACE Pace of Aging (12-month Cohen's d=0.3; 24-month Cohen's d=0.2, p<0.01 for both), followed by DunedinPoAm and the GrimAge epigenetic clock, although effects for these measures were not statistically different from zero (p>0.08). CR effects for other epigenetic clocks were in the opposite direction (all p>0.15). CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks hypothesized to reflect longer term accumulation of aging burden.

scholarly journals Long-Term Effects of Financial Incentives for General Practitioners on Quality Indicators in the Treatment of Patients With Diabetes Mellitus in Primary Care—A Follow-Up Analysis of a Cluster Randomized Parallel Controlled Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Rahel Meier ◽  
Corinne Chmiel ◽  
Fabio Valeri ◽  
Leander Muheim ◽  
Oliver Senn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Medical Records ◽  
Financial Incentives ◽  
Controlled Trial ◽  
Intervention Group ◽  
Routine Data ◽  
Control Group ◽  
Long Term Effects ◽  
Patients With Diabetes

Background: The effect of financial incentives on the quality of primary care is of high interest, and so is its sustainability after financial incentives are withdrawn.Objective: To assess both long-term effects and sustainability of financial incentives for general practitioners (GPs) in the treatment of patients with diabetes mellitus based on quality indicators (QIs) calculated from routine data from electronic medical records.Design/Participants: Randomized controlled trial using routine data from electronic medical records of patients with diabetes mellitus of Swiss GPs.Intervention: During the study period of 24 months, all GPs received bimonthly feedback reports with information on their actual treatment as reflected in QIs. In the intervention group, the reports were combined with financial incentives for quality improvement. The incentive was stopped after 12 months.Measurements: Proportion of patients meeting the process QI of annual HbA1c measurements and the clinical QI of blood pressure levels below 140/85 mmHg.Results: A total of 71 GPs from 43 different practices were included along with 3,854 of their patients with diabetes mellitus. Throughout the study, the proportion of patients with annual HbA1c measurements was stable in the intervention group (78.8–78.9%) and decreased slightly in the control group (81.5–80.2%) [odds ratio (OR): 1.21; 95% CI: 1.04–1.42, p &lt; 0.05]. The proportion of patients achieving blood pressure levels below 140/85 mmHg decreased in the control group (51.2–47.2%) and increased in the intervention group (49.7–51.9%) (OR: 1.18; 95% CI: 1.04–1.35, p &lt; 0.05) where it peaked at 54.9% after 18 months and decreased steadily over the last 6 months.Conclusion: After the withdrawal of financial incentives for the GPs after 12 months, some QIs still improved, indicating that 1 year might be too short to observe the full effect of such interventions. The decrease in QI achievement rates after 18 months suggests that the positive effects of time-limited financial incentives eventually wane.

scholarly journals Effect of Continues Midwifery Support in Labor on the Childbirth Experience and Self-Esteem of Primipara Women: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Nasrin Soleimani ◽  
Mansoureh Refaei ◽  
Farideh Kazemi
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Intervention Group ◽  
Self Esteem ◽  
Control Group ◽  
Randomized Controlled ◽  
Childbirth Experience ◽  
Cohen’S D ◽  
The Mean ◽  
Cohen's D

Abstract Background: The World Health Organization states that mothers during labor and delivery should be supported by people with whom they feel comfortable, because one of the non-pharmacological methods of relieving labor pain is the continued support of midwives in labor. The primary objectives of this study were to determine the effect of continuous midwifery support in labor on delivery experience and self-esteem of nulliparous women 6 weeks after delivery.Methods: This randomized controlled trial was performed in 2021 on 70 pregnant women admitted to the delivery ward who met the inclusion criteria. Participants were randomly allocated to two groups through balanced block randomization with a block size of 4. Participants completed a demographic and midwifery information questionnaire before entering the study. In the intervention group, in addition to routine labor care, the researcher was present at the mother's bedside and was present with the mother continuously throughout the labor and up to 2 hours after delivery and provided the necessary support. The control group received only routine labor and postpartum care. Six weeks after delivery, participants in both groups were contacted to complete the CEQ and Rosenberg self-esteem questionnaires. Finally, data were collected and analyzed. Significance level was considered 0.05.Results: By controlling the effect of duration of the first and second stages of labor as potential confounders, the mean (sd) of childbirth experience 6 weeks after delivery was 70.92 (7.07) in the intervention group and 59.69 (7.08) in the control group, and this difference was statistically significant (p <0.001). The amount of effect size indicates a very strong effect of the intervention on improving the childbirth experience (Cohen’s d = 1.69; 95% CI: 1.12, 2.26). Comparison of the mean of maternal self-esteem showed that this rate in the intervention group was 2 scores higher than the control group and this difference was statistically significant (p = 0.05). Cohen's d indicates the average effect of intervention on mothers' self-esteem score (Cohen's d = 0.56; 95% CI: 0.06, 1.05).Conclusions: Continuous support of the midwife in labor and up to 2 hours after delivery can lead to a better childbirth experience and increase the mother's self-esteem up to 6 weeks after delivery.Trial registration: IRCT ID: IRCT20201102049233N1, First Registration date: 2021-06-04

scholarly journals Acute and Chronic Periocular Massage for Ocular Blood Flow and Vision: a Randomized Controlled Trial

2021 ◽  
Vol 14 (2) ◽  
pp. 5-13
Author(s):  
Naoyuki Hayashi, PhD ◽  
Lanfei Du, MSc
Keyword(s):  
Blood Flow ◽  
Visual Acuity ◽  
Vascular Function ◽  
Controlled Trial ◽  
Ocular Blood Flow ◽  
Control Group ◽  
Long Term Effects ◽  
Short Term ◽  
Before And After

Introduction: The ocular blood flow (OBF) is responsible for supplying nutrition to the retina, which plays a fundamental role in visual function. Massage is expected to improve the blood flow and, consequently, vascular function. The aim of this study was to determine the shortterm and long-term effects of periocular massage on OBF and visual acuity. Methods: The OBF and visual acuity were measured in 40 healthy adults aged 20–30 years before and after massage, and also in control subjects. Three massage methods were used: applying periocular acupressure (“Chinese eye exercise”: CE), using a facial massage roller (MR), and using an automated eye massager (AM). The OBF and visual acuity were first measured before and after applying each type of massage for 5 min. Eye massage was then applied for 5 min once daily over a 60-day period, while the control group received no massage. The same measurements were then performed again. Results: Performing short-term periocular massage showed significant interactions in time and massage effects on visual acuity in CE and AM groups, and on OBF in AM group, while 60-day massage period exerted no significant effects. No significant relationship was found between OBF and visual acuity changes. Conclusions: These results suggest that short-term periocular massage with Chinese eye exercise and automated eye massager can improve OBF and visual acuity, although no causal relationship was supported.

scholarly journals 0506 Short and Long-Term Effects of Trazodone vs. Cognitive-Behavioral Treatment on EEG Power During NREM Sleep in Chronic Insomnia

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A193-A194
Author(s):  
Y Li ◽  
A Vgontzas ◽  
J Fernandez-Mendoza ◽  
J Fang ◽  
K Puzino ◽  
...  
Keyword(s):  
Behavioral Treatment ◽  
Slow Wave Sleep ◽  
Nrem Sleep ◽  
Chronic Insomnia ◽  
Cognitive Behavioral Treatment ◽  
Long Term Effects ◽  
Delta Power ◽  
Cohen’S D ◽  
Cohen's D

Abstract Introduction Both trazodone and cognitive-behavioral treatment of insomnia (CBT-I) are widely used to treat patients with chronic insomnia. Animal studies have shown that trazodone increases slow wave sleep (i.e., increased EEG delta power). However, no study to date has compared the long term effects of trazodone vs. CBT-I on spectral EEG activity during sleep in humans. Methods We addressed this question in a sample of 19 middle-aged men and women who received either trazodone (n=8) or CBT-I (n=11) treatment for 9 months. We examined delta (0.39-3.91 Hz), theta (4.30-7.81 Hz), alpha (8.20-11.72 Hz), sigma (12.11-14.84 Hz), beta (15.23-35.16 Hz) and gamma (35.55-49.61 Hz) relative power during NREM sleep after 3-month and 9-month of treatment. Results Compared to CBT-I, trazodone significantly increased relative delta power (p=0.05) and decreased relative sigma (p=0.004) and beta (p=0.05) power during NREM sleep across 9-month treatment. Furthermore, compared to CBT-I, trazodone significantly increased relative delta power (3-month: Δ2.00 ± 3.27 vs. Δ-2.63 ± 5.88, p=0.006, Cohen’s d=0.93; 9-month: Δ2.63 ± 4.11 vs. Δ-1.10 ± 3.93, p=0.006, Cohen’s d=0.93), while decreased relative sigma power (3-month: Δ-1.55 ± 1.75 vs. Δ0.90 ± 1.82, p=0.009, Cohen’s d=1.37; 9-month: Δ-1.33 ± 1.95 vs. Δ1.05 ± 1.79, p=0.014, Cohen’s d=1.28) during NREM sleep in 3-month and 9-month, respectively. Relative beta power (3-month: Δ-0.85 ± 0.60 vs. Δ0.35 ± 1.14, p=0.016, Cohen’s d=1.03;) was significantly decreased in 3-month treatment in trazodone group compared to CBT-I. Moreover, across 9-month treatment, relative sigma (p=0.040, ω p2 = 0.29) and beta (p=0.021, ω p2 = 0.12) power during NREM sleep were significantly decreased within trazodone group, while relative sigma power (p=0.096, ω p2 = 0.230) increased within CBT-I group. Conclusion Our findings suggest that trazodone, but not CBT-I, even after 9-month of use increases slow wave sleep and decreases high-frequency EEG power during NREM sleep. This effect may explain the long-term usefulness of trazodone in chronic insomnia patients with physiologic hyperarousal i.e., activation of the stress system. Further studies should examine this effect in large samples of insomnia. Support NIH C06 RR016499, UL1 TR 000127

scholarly journals The long-term indirect effect of the early Family Check-Up intervention on adolescent internalizing and externalizing symptoms via inhibitory control

2020 ◽  
Vol 32 (4) ◽  
pp. 1544-1554 ◽  
Author(s):  
Rochelle F. Hentges ◽  
Chelsea M. Weaver Krug ◽  
Daniel S. Shaw ◽  
Melvin N. Wilson ◽  
Thomas J. Dishion ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Middle Childhood ◽  
Controlled Trial ◽  
Self Regulation ◽  
Externalizing Symptoms ◽  
Control Group ◽  
Long Term Effects ◽  
Internalizing And Externalizing ◽  
Internalizing And Externalizing Symptoms

AbstractThis study examined the long-term effects of a randomized controlled trial of the Family Check-Up (FCU) intervention initiated at age 2 on inhibitory control in middle childhood and adolescent internalizing and externalizing problems. We hypothesized that the FCU would promote higher inhibitory control in middle childhood relative to the control group, which in turn would be associated with lower internalizing and externalizing symptomology at age 14. Participants were 731 families, with half (n = 367) of the families assigned to the FCU intervention. Using an intent-to-treat design, results indicate that the FCU intervention was indirectly associated with both lower internalizing and externalizing symptoms at age 14 via its effect on increased inhibitory control in middle childhood (i.e., ages 8.5–10.5). Findings highlight the potential for interventions initiated in toddlerhood to have long-term impacts on self-regulation processes, which can further reduce the risk for behavioral and emotional difficulties in adolescence.

scholarly journals Tailored Cigarette Warning Messages: How Individualized Loss Aversion and Delay Discounting Rates Can Influence Perceived Message Effectiveness

2021 ◽  
Vol 18 (19) ◽  
pp. 10492
Author(s):  
Hollie L. Tripp ◽  
Justin C. Strickland ◽  
Melissa Mercincavage ◽  
Janet Audrain-McGovern ◽  
Eric C. Donny ◽  
...  
Keyword(s):  
Delay Discounting ◽  
Loss Aversion ◽  
Amazon Mechanical Turk ◽  
Control Group ◽  
Cross Sectional ◽  
P Values ◽  
Message Effectiveness ◽  
Cohen’S D ◽  
Cohen's D

Current text-only cigarette warning labels (long-term, loss-framed messages) may not motivate positive changes in smoking behavior. The current project was a cross-sectional study examining the effects of tailored cigarette warnings on perceived message effectiveness (PME) in adult smokers (n = 512) conducted using Amazon Mechanical Turk (M-Turk) in January–February 2020. Participants were an average age of 40.7 (SD = 11.6), with the majority of the sample being female (62.2%) and White (88.9%). Participants reported smoking an average of 14.6 cigarettes/day (SD = 9.2) with an average FTND score of 4.6 (SD = 2.2). Participants were asked to complete a tobacco use history questionnaire, and mixed gambles and delay discounting tasks before random assignment to one of five message groups. The groups were based on a 2 (gain versus loss framing) ×2 (short-term versus long-term framing) between-subject design; a fifth group served as the control group. All experimental messages reported higher PME scores than the control (p values < 0.001, Cohen’s d = 1.88–2.48). Participants with shallower delayed reward discounting and lower loss aversion rates reported higher total PME scores, p values < 0.05. Our findings also suggest that loss aversion rates vary widely among smokers and that individuals are more responsive to messages congruent with their behavioral economic profile. Specifically, smokers who viewed messages congruent with their loss aversion and delay discounting rates reported higher PME scores than those who viewed incongruent messages (p = 0.04, Cohen’s d = 0.24). These preliminary findings suggest that anti-smoking campaigns may best impact smokers by tailoring messages based on individual loss aversion and delay discounting rates versus a one-size-fits-all approach.

scholarly journals Yoga intervention and reminder e-mails for reducing cancer-related fatigue - a study protocol of a randomized controlled trial

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Teresa Zetzl ◽  
Michael Schuler ◽  
Agnes Renner ◽  
Elisabeth Jentschke ◽  
Birgitt van Oorschot
Keyword(s):  
Cancer Patients ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Routine Practice ◽  
Long Term Effects ◽  
Exercise Frequency ◽  
Yoga Therapy ◽  
Cancer Related Fatigue

Abstract Background Almost 90% of cancer patients suffer from symptoms of fatigue during treatment. Supporting treatments are increasingly used to alleviate the burden of fatigue. This study examines the short-term and long-term effects of yoga on fatigue and the effect of weekly reminder e-mails on exercise frequency and fatigue symptoms. Methods The aim of the first part of the study will evaluate the effectiveness of yoga for cancer patients with mixed diagnoses reporting fatigue. We will randomly allocate 128 patients to an intervention group (N = 64) receiving yoga and a wait-list control group (N = 64) receiving yoga 9 weeks later. The yoga therapy will be performed in weekly sessions of 60 min each for 8 weeks. The primary outcome will be self-reported fatigue symptoms. In the second part of the study, the effectiveness of reminder e-mails with regard to the exercise frequency and self-reported fatigue symptoms will be evaluated. A randomized allocated group of the participants (“email”) receives weekly reminder e-mails, the other group does not. Data will be assessed using questionnaires the beginning and after yoga therapy as well as after 6 months. Discussion Support of patients suffering from fatigue is an important goal in cancer patients care. If yoga therapy will reduce fatigue, this type of therapy may be introduced into routine practice. If the reminder e-mails prove to be helpful, new offers for patients may also develop from this. Trial registration German Clincial Trials Register (DRKS00016034, 12/2018), retrospectively registered.

Evaluation of a Decision Aid for Women with Epilepsy Who Are Considering Pregnancy: A Randomized Controlled Trial

2017 ◽  
Vol 37 (5) ◽  
pp. 589-599 ◽  
Author(s):  
Amanda McGrath ◽  
Louise Sharpe ◽  
Suncica Lah ◽  
Kaitlyn Parratt
Keyword(s):  
Randomized Controlled Trial ◽  
Decision Aid ◽  
Controlled Trial ◽  
Future Research ◽  
Control Group ◽  
Childbearing Age ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Cohen’S D ◽  
Cohen's D

Background. For many women with epilepsy (WWE), decision making about pregnancy is complicated by considerations such as the potential teratogenicity of antiepileptic drugs, offspring risk of epilepsy, seizure occurrence during pregnancy, and the challenges of parenting amidst poorly controlled seizures. Objective. This proof-of-concept, randomized controlled trial aimed to evaluate a decision aid (DA) developed to help WWE decide if they should start or enlarge their families. Methods. Seventy-nine WWE of childbearing age were recruited from Epilepsy Action Australia between October and November 2013 and randomized to receive the intervention (the DA) or not, and to complete a set of questionnaires pre- and post- intervention. The DA, delivered as a PDF booklet, provided balanced evidence-based information about options, risks and benefits, including probabilities; as well as steps for clarifying values and considering options within one’s personal situation. Results. Compared with the control group, the DA group had statistically significant improvements in knowledge about pregnancy and epilepsy (Cohen’s d = 1.24; 95%CI = 0.77 to 1.83) and reduced decisional conflict (Cohen’s d = 0.59; 95%CI = 0.21 to 0.99). Changes in decision self-efficacy, certainty of choice, patient-practitioner communication abilities and value congruence with choice were comparable between the DA and control group. Importantly, women’s decisions about motherhood were not biased towards either direction, and there were no adverse effects on depression or anxiety. All women who received the DA indicated they would recommend it to other WWE. Conclusions. The DA has the potential to serve as a useful support tool for WWE who are considering motherhood. Future research is needed to test the DA in clinical settings with guidance from a health professional. The trial was registered with the Australian New Zealand Clinical Trials Registry (ID ACTRN12613001082796).

scholarly journals Long-term effects of daily postprandial physical activity on blood glucose: a randomized controlled trial

2017 ◽  
Vol 42 (4) ◽  
pp. 430-437
Author(s):  
Håvard Nygaard ◽  
Eirik Grindaker ◽  
Bent Ronny Rønnestad ◽  
Gerd Holmboe-Ottesen ◽  
Arne Torbjørn Høstmark
Keyword(s):  
Physical Activity ◽  
Blood Glucose ◽  
High Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Long Term Effects ◽  
Post Test

Previous studies have shown that a bout of moderate or light postprandial physical activity effectively blunts the postprandial increase in blood glucose. The objective of this study was to test whether regular light postprandial physical activity can improve glycemia in persons with hyperglycemia or with a high risk of hyperglycemia. We randomized 56 participants to an intervention or a control group. They were diagnosed as hyperglycemic, not using antidiabetics, or were categorized as high-risk individuals for type 2 diabetes. The intervention group was instructed to undertake a minimum 30 min of daily light physical activity, starting a maximum of 30 min after a meal in addition to their usual physical activity for 12 weeks. The control group maintained their usual lifestyle. Blood samples were taken pre- and post-test. Forty participants completed the study and are included in the results. The self-reported increase in daily physical activity from before to within the study period was higher in the intervention group compared with control (41 ± 25 vs. 2 ± 16 min, p < 0.001). Activity diaries and accelerometer recordings supported this observation. The activity in the intervention group started earlier after the last meal compared with control (30 ± 13 vs. 100 ± 57 min, p = 0.001). There were no within- or between-group differences in any glycemic variable from pre- to post-test. In conclusion, the present study does not seem to support the notion that regular light postprandial physical activity improves blood glucose in the long term in persons with hyperglycemia or with high risk of hyperglycemia.

scholarly journals The Feasibility and Effectiveness of a Community-Based Intervention to Reduce Sedentary Behavior in Older Adults

2021 ◽  
pp. 073346482098791
Author(s):  
Kevin M. Crombie ◽  
Brianna N. Leitzelar ◽  
Neda E. Almassi ◽  
Jane E. Mahoney ◽  
Kelli F. Koltyn
Keyword(s):  
Older Adults ◽  
Sedentary Behavior ◽  
Physical Function ◽  
Sedentary Time ◽  
Controlled Trial ◽  
Community Dwelling ◽  
Control Group ◽  
Post Intervention ◽  
Cohen’S D ◽  
Cohen's D

The purpose of this study was to examine the effectiveness and feasibility of translating a 4-week “Stand Up and Move More” (SUMM) intervention by state aging units to older adults ( N = 56, M age = 74 years). A randomized controlled trial assessed sedentary behavior, physical function, and health-related quality of life (HRQoL) before and after the intervention. Participants included healthy community-dwelling, sedentary (sit > 6 hr/day) and aged ≥ 55 years adults. For the primary outcome, the SUMM group ( n = 31) significantly ( p < .05) reduced total sedentary time post-intervention by 68 min/day on average (Cohen’s d = −0.56) compared with no change in the wait-list control group ( n = 25, Cohen’s d = 0.12). HRQoL and function also improved ( p < .05) in the SUMM group post-intervention. Workshop facilitators indicated the intervention was easy to implement, and participants expressed high satisfaction. The SUMM intervention reduced sedentary time, improved physical function and HRQoL, and was feasible to implement in community settings.

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