Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward
Keyword(s):
Drug Use
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Psychostimulant exposure alters the activity of ventral pallidum (VP) projection-neurons. However, the molecular underpinnings of these circuit dysfunctions are unclear. Using RNA-sequencing followed by circuit-specific gene expression assays, we revealed a key role for the VP to mediodorsal thalamus (VP-MDT) projection neurons in cocaine-related behaviors in mice. Our analyses demonstrated that the transcription factor Nr4a1 bidirectionally modulated dendritic spine dynamics in VP-MDT neurons and positively regulated pathological drug use.
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1997 ◽
Vol 179
(10)
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pp. 3331-3341
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2007 ◽
Vol 27
(11)
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pp. 4082-4092
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Keyword(s):
Keyword(s):
1994 ◽
Vol 14
(11)
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pp. 7517-7526
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