scholarly journals Detailed patient-individual reporting of lymph node involvement in oropharyngeal squamous cell carcinoma with an online interface

2021 ◽  
Author(s):  
Roman Ludwig ◽  
Jean-Marc Hoffmann ◽  
Bertrand Pouymayou ◽  
Grégoire Morand ◽  
Martina Broglie Däppen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Lymph Node Involvement ◽  
Primary Tumors ◽  
Full Dataset ◽  
Level Ii ◽  
Hpv Status ◽  
Number Of Patients ◽  
Diagnostic Modalities ◽  
T Category

AbstractPurpose/ObjectiveWhereas the prevalence of lymph node level (LNL) involvement in head & neck squamous cell carcinomas (HNSCC) has been reported, the details of lymphatic progression patterns are insufficiently quantified. In this study, we investigate how the risk of metastases in each LNL depends on the involvement of upstream LNLs, T-category, HPV status and other risk factors.Materials/MethodsWe retrospectively analyzed patients with newly diagnosed oropharyngeal HNSCC treated at a single institution, resulting in a dataset of 287 patients. For all patients, involvement of LNLs I-VII was recorded individually based on available diagnostic modalities (PET, MR, CT, FNA) together with clinicpathological factors. To analyze the dataset, a web-based graphical user interface (GUI) was developed, which allows querying the number of patients with a certain combination of co-involved LNLs and tumor characteristics.ResultsThe full dataset and GUI is part of the publication. Selected findings are: Ipsilateral level IV was involved in 27% of patients with level II and III involvement, but only in 2% of patients with level II but not III involvement. Prevalence of involvement of ipsilateral levels II, III, IV, V was 79%, 34%, 7%, 3% for early T-category patients (T1/T2) and 85%, 50%, 17%, 9% for late T-category (T3/T4), quantifying increasing involvement with T-category. Contralateral levels II, III, IV were involved in 41%, 19%, 4% and 12%, 3%, 2% for tumors for tumors with and without midline extension, respectively. T-stage dependence of LNL involvement was more pronounced in HPV negative than positive tumors, but overall involvement was similar. Ipsilateral level VII was involved in 14% and 6% of patients with primary tumors in the tonsil and the base of tongue, respectively.ConclusionsDetailed quantification of LNL involvement in HNSCC depending on involvement of upstream LNLs and clinicopathological factors may allow for further personalization of CTV-N definition in the future.

scholarly journals Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study

2021 ◽  
Vol 10 (4) ◽  
pp. 602
Author(s):  
Antoine Tardieu ◽  
Lobna Ouldamer ◽  
François Margueritte ◽  
Lauranne Rossard ◽  
Aymeline Lacorre ◽  
...  
Keyword(s):  
Lymph Node ◽  
False Negative ◽  
False Negative Rate ◽  
Lymph Node Involvement ◽  
Accuracy Rate ◽  
Peritoneal Cancer ◽  
Negative Rate ◽  
Number Of Patients ◽  
Pet Ct ◽  
Node Involvement

The objective of our study is to evaluate the diagnostic performance of positron emission tomography/computed tomography (PET-CT) for the assessment of lymph node involvement in advanced epithelial ovarian, fallopian tubal or peritoneal cancer (EOC). This was a retrospective, bicentric study. We included all patients over 18 years of age with a histological diagnosis of advanced EOC who had undergone PET-CT at the time of diagnosis or prior to cytoreduction surgery with pelvic or para-aortic lymphadenectomy. We included 145 patients with primary advanced EOC. The performance of PET-CT was calculated from the data of 63 patients. The sensitivity of PET-CT for preoperative lymph node evaluation was 26.7%, specificity was 90.9%, PPV was 72.7%, and NPV was 57.7%. The accuracy rate was 60.3%, and the false-negative rate was 34.9%. In the case of primary cytoreduction (n = 16), the sensitivity of PET-CT was 50%, specificity was 87.5%, PPV was 80%, and NPV was 63.6%. The accuracy rate was 68.8%, and the false negative rate was 25%. After neoadjuvant chemotherapy (n = 47), the sensitivity of PET-CT was 18.2%, specificity was 92%, PPV was 66.7%, and NPV was 56.1%. The accuracy rate was 57.5%, and the false negative rate was 38.3%. Due to its high specificity, the performance of a preoperative PET-CT scan could contribute to the de-escalation and reduction of lymphadenectomy in the surgical management of advanced EOC in a significant number of patients free of lymph node metastases.

Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
Vol 37 (12) ◽  
pp. 1829-1839 ◽  
Author(s):  
Remco de Bree ◽  
Robert P. Takes ◽  
Jonas A. Castelijns ◽  
Jesus E. Medina ◽  
Sandro J. Stoeckli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Neck Squamous Cell Carcinoma ◽  
Node Metastases ◽  
Diagnostic Modalities

scholarly journals Frequency of Lympnode Metastasis in Supraglottic Ca Larynx

2019 ◽  
Vol 31 (2) ◽  
pp. 72-75
Author(s):  
Mohammad Rokan Uddin Bhuiyan ◽  
Mohammad Idris Ali ◽  
Balayet Hossain Siddiquee ◽  
Fatema Johora ◽  
Mohammad Kamal Hossain
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymphadenopathy ◽  
Female Ratio ◽  
Node Metastasis ◽  
T Stage ◽  
Supraglottic Carcinoma ◽  
Level Ii ◽  
Number Of Patients ◽  
Carcinoma Of Larynx

Introduction: To observe the association between the level of lymph node metastasis and the T- stage and to evaluate the N- stage in supraglottic carcinoma of larynx. Materials and Methods: A prospective cross-sectional study was carried out on 80 consecutive cases of supraglottic carcinoma larynx in three tertiary level hospital in Dhaka during July'2009 to March 2011. Results: The highest number of patients were in the age group 5th and 6th decades. Male to female ratio was 9:1. Topographically 70 cases (87.5%) had lesions involving epiglottis, 5 cases (6.25%) in aryepiglottic fold and 5 cases (6.25%) had lesions at false cord. Majority cases were histopathologically confirmed squamous cell carcinoma (95%) and among them 46 cases (57.5%) had well differentiated. Cervical metastatic lymph nodes were found 40% (32 cases) where level-II was most common. This was most frequent in early supraglottic(T1&T2) carcinoma of larynx (86.25%), P=0.008. A positive correlation was found between the T stage of primary tumours and frequency of cervical lymphadenopathy. Lymph node metastasis were 4.77% in T1, 37.50% in T2, 71.43% in T3 and 91.67% in T4. In early stage lymph node involved 93.75% in Level- II, 6.25% in Level- III & in advanced stage 100% in Level - II, 62.5% in Level - III and 25.0% in Level - IV. Distribution of study cases (31.25%) in stage-II, 25% in stage-I, 22.50% in stage-Ill and 21.25% were in stage-IV. Conclusion: Result of this study may help the clinician for planning of treatment of this malignant diseases as well awareness. Medicine Today 2019 Vol.31(2): 72-75

scholarly journals Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 792
Author(s):  
Jiří Novotný ◽  
Veronika Bandúrová ◽  
Hynek Strnad ◽  
Martin Chovanec ◽  
Miluše Hradilová ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Head And Neck ◽  
Squamous Cell ◽  
Normal Mucosa ◽  
Typical Feature ◽  
Cyclin D2 ◽  
Primary Tumors ◽  
Normal Tissues ◽  
Paired Samples ◽  
Hpv Status

Aberrant regulation of the cell cycle is a typical feature of all forms of cancer. In head and neck squamous cell carcinoma (HNSCC), it is often associated with the overexpression of cyclin D1 (CCND1). However, it remains unclear how CCND1 expression changes between tumor and normal tissues and whether human papillomavirus (HPV) affects differential CCND1 expression. Here, we evaluated the expression of D-type cyclins in a cohort of 94 HNSCC patients of which 82 were subjected to whole genome expression profiling of primary tumors and paired normal mucosa. Comparative analysis of paired samples showed that CCND1 was upregulated in 18% of HNSCC tumors. Counterintuitively, CCND1 was downregulated in 23% of carcinomas, more frequently in HPV-positive samples. There was no correlation between the change in D-type cyclin expression and patient survival. Intriguingly, among the tumors with downregulated CCND1, one-third showed an increase in cyclin D2 (CCND2) expression. On the other hand, one-third of tumors with upregulated CCND1 showed a decrease in CCND2. Collectively, we have shown that CCND1 was frequently downregulated in HNSCC tumors. Furthermore, regardless of the HPV status, our data suggested that a change in CCND1 expression was alleviated by a compensatory change in CCND2 expression.

Comparison of prognosis and specific features according to tumor size in small-sized breast cancer with extensive lymph node involvement.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 81-81 ◽  
Author(s):  
Hong-Seok Han ◽  
Hyun-June Paik ◽  
Jai Min Ryu ◽  
Sungmin Park ◽  
Ha Woo Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Tumor Size ◽  
Cancer Staging ◽  
Lymph Node Involvement ◽  
Nuclear Grade ◽  
Chi Square ◽  
Number Of Patients ◽  
Neo Adjuvant Chemotherapy ◽  
Extensive Lymph Node

81 Background: As known, larger tumor size and more extensive lymph node (LN) involvement have been considered an independent factor for poor prognosis of breast cancer. We evaluated if very small tumor size may be a factor of worse prognosis compared to larger tumor in small sized breast cancer with LN involvement. Methods: A retrospective analysis was made in a single center of all 1400 patients with small (below 2cm, T1) sized and LN involved (N1~N3) breast cancer without metastasis diagnosed between 2004 and 2014. Their ages ranged from 23 to 88 years (mean age 49.1 ± 9.9 years) and mean follow-up was 31 months. All patients were performed with surgery including axillary LN dissection without neo-adjuvant chemotherapy. We subdivided their tumor size to 4 group (T1m, T1a, T1b and T1c) grading by 7th AJCC cancer staging. The number of patients in each group is as follows: T1m = 17, T1a = 63, T1b = 214, T1c = 1106. The specific features related to mortality were analyzed according to the minor groups and they were compared with one another by Chi-square test and Kaplan-Meier analysis. Results: Total expired patients were 39 (2.8%) and the number (the rate in each group) of the minor groups is as follows: T1m = 1 (5.9%), T1a = 1 (1.6%), T1b = 7 (3.3%), T1c = 22 (2.0%). Overall survival of smaller sized tumor groups ( ≤ 1cm, T1m+T1a+T1b) are significantly decreased than the other larger sized group T1c in T1N1 staged patients (p = 0.004). There are significant differences in estrogen receptor, progesterone receptor, nuclear grade, recurrence among the 4 minor groups in whole patients group. In the analysis of nuclear grade, the results show higher grade in T1m than T1a, T1m than T1b, T1b than T1c. Especially, recurrence of T1m is significantly more frequent than T1a (17.6% vs 3.2%, P = 0.03) or T1b (17.6% vs 4.2%, p = 0.016). Conclusions: In conclusion, this study indicates smaller sized tumor with LN involvement can progress worse compared to larger tumor. This result supports very small size can be another predictive factor for prognosis in small sized breast cancer with LN involvement.

scholarly journals Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity

Cancer ◽  
2009 ◽  
Vol 115 (7) ◽  
pp. 1489-1497 ◽  
Author(s):  
Shao Hui Huang ◽  
David Hwang ◽  
Gina Lockwood ◽  
David P. Goldstein ◽  
Brian O'Sullivan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Lymph Node Involvement ◽  
Tumor Thickness ◽  
Node Involvement
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