scholarly journals Psilocybin modulation of dynamic functional connectivity is associated with plasma psilocin and subjective effects

2021 ◽  
Author(s):  
Anders S Olsen ◽  
Anders Lykkebo-Valloee ◽  
Brice Ozenne ◽  
Martin K Madsen ◽  
Dea Siggaard Stenbaek ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Dwell Time ◽  
Brain State ◽  
Healthy Individuals ◽  
Acute Effects ◽  
Dynamic Functional Connectivity ◽  
Negatively Associated ◽  
State Dynamic ◽  
Brain States

Background: Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state of consciousness, evokes lasting changes in mood and personality in healthy individuals, and has potential as an antidepressant treatment. Examining the acute effects of psilocin on resting-state dynamic functional connectivity implicates network-level connectivity motifs that may underlie acute and lasting behavioral and clinical effects. Aim: Evaluate the association between resting-state dynamic functional connectivity (dFC) characteristics and plasma psilocin level (PPL) and subjective drug intensity (SDI) before and right after intake of a psychedelic dose of psilocybin in healthy humans. Methods: Fifteen healthy individuals completed the study. Before and at multiple time points after psilocybin intake, we acquired 10-minute resting-state blood-oxygen-level-dependent functional magnetic resonance imaging scans. Leading Eigenvector Dynamics Analysis (LEiDA) and diametrical clustering were applied to estimate discrete, sequentially active brain states. We evaluated associations between the fractional occurrence of brain states during a scan session and PPL and SDI using linear mixed-effects models. We examined associations between brain state dwell time and PPL and SDI using frailty Cox proportional hazards survival analysis. Results: Fractional occurrences for two brain states characterized by lateral frontoparietal and medial fronto-parietal-cingulate coherence were statistically significantly negatively associated with PPL and SDI. Dwell time for these brain states was negatively associated with SDI and, to a lesser extent, PPL. Conversely, fractional occurrence and dwell time of a fully connected brain state was positively associated with PPL and SDI. Conclusion: Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs in exchange for increases in a uniform connectivity structure. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings contribute to a more comprehensive neurobiological framework underlying acute effects of serotonergic psychedelics.

Impact of 36 h of total sleep deprivation on resting-state dynamic functional connectivity

2018 ◽  
Vol 1688 ◽  
pp. 22-32 ◽  
Author(s):  
Huaze Xu ◽  
Hui Shen ◽  
Lubin Wang ◽  
Qi Zhong ◽  
Yu Lei ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Sleep Deprivation ◽  
Resting State ◽  
Dynamic Functional Connectivity ◽  
Total Sleep Deprivation ◽  
State Dynamic

scholarly journals Modular slowing of resting-state dynamic functional connectivity as a marker of cognitive dysfunction induced by sleep deprivation

NeuroImage ◽  
2020 ◽  
Vol 222 ◽  
pp. 117155 ◽  
Author(s):  
Diego Lombardo ◽  
Catherine Cassé-Perrot ◽  
Jean-Philippe Ranjeva ◽  
Arnaud Le Troter ◽  
Maxime Guye ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Sleep Deprivation ◽  
Cognitive Dysfunction ◽  
Resting State ◽  
Dynamic Functional Connectivity ◽  
State Dynamic

scholarly journals Low-Frequency Repetitive Transcranial Magnetic Stimulation Restores Dynamic Functional Connectivity in Subcortical Stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Yin Qin ◽  
Xiaoying Liu ◽  
Xiaoping Guo ◽  
Minhua Liu ◽  
Hui Li ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
Resting State ◽  
Magnetic Stimulation ◽  
Dwell Time ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Healthy Controls ◽  
Dynamic Functional Connectivity

Background and Purpose: Strokes consistently result in brain network dysfunction. Previous studies have focused on the resting-state characteristics over the study period, while dynamic recombination remains largely unknown. Thus, we explored differences in dynamics between brain networks in patients who experienced subcortical stroke and the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on dynamic functional connectivity (dFC).Methods: A total of 41 patients with subcortical stroke were randomly divided into the LF-rTMS (n = 23) and the sham stimulation groups (n = 18). Resting-state functional MRI data were collected before (1 month after stroke) and after (3 months after stroke) treatment; a total of 20 age- and sex-matched healthy controls were also included. An independent component analysis, sliding window approach, and k-means clustering were used to identify different functional networks, estimate dFC matrices, and analyze dFC states before treatment. We further assessed the effect of LF-rTMS on dFCs in patients with subcortical stroke.Results: Compared to healthy controls, patients with stroke spent significantly more time in state I [p = 0.043, effect size (ES) = 0.64] and exhibited shortened stay in state II (p = 0.015, ES = 0.78); the dwell time gradually returned to normal after LF-rTMS treatment (p = 0.015, ES = 0.55). Changes in dwell time before and after LF-rTMS treatment were positively correlated with changes in the Fugl–Meyer Assessment for Upper Extremity (pr = 0.48, p = 0.028). Moreover, patients with stroke had decreased dFCs between the sensorimotor and cognitive control domains, yet connectivity within the cognitive control network increased. These abnormalities were partially improved after LF-rTMS treatment.Conclusion: Abnormal changes were noted in temporal and spatial characteristics of sensorimotor domains and cognitive control domains of patients who experience subcortical stroke; LF-rTMS can promote the partial recovery of dFC. These findings offer new insight into the dynamic neural mechanisms underlying effect of functional recombination and rTMS in subcortical stroke.Registration:http://www.chictr.org.cn/index.aspx, Unique.identifier: ChiCTR1800019452.

Resting state dynamic functional connectivity: Network topology analysis

2018 ◽  
Vol 23 ◽  
pp. 43-53 ◽  
Author(s):  
Irina Knyazeva ◽  
Alexey Poyda ◽  
Vyacheslav Orlov ◽  
Vitaliy Verkhlyutov ◽  
Nikolai Makarenko ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Network Topology ◽  
Resting State ◽  
Topology Analysis ◽  
Dynamic Functional Connectivity ◽  
State Dynamic

scholarly journals Dynamic functional connectivity markers of objective trait mindfulness

2018 ◽  
Author(s):  
Julian Lim ◽  
James Teng ◽  
Amiya Patanaik ◽  
Jesisca Tandi ◽  
Stijn A. A. Massar
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Network Connectivity ◽  
Resting State Fmri ◽  
Brain State ◽  
Trait Mindfulness ◽  
Five Facet Mindfulness Questionnaire ◽  
Dispositional Mindfulness ◽  
Dynamic Functional Connectivity ◽  
Objectively Measured

AbstractWhile mindfulness is commonly viewed as a skill to be cultivated through practice, untrained individuals can also vary widely in dispositional mindfulness. Prior research has identified static neural connectivity correlates of this trait. Here, we use dynamic functional connectivity (DFC) analysis of resting-state fMRI to study time-varying connectivity patterns associated with naturally varying and objectively measured trait mindfulness. Participants were selected from the top and bottom tertiles of performers on a breath-counting task to form high trait mindfulness (HTM; N = 21) and low trait mindfulness (LTM; N = 18) groups. DFC analysis of resting state fMRI data revealed that the HTM group spent significantly more time in a brain state associated with task-readiness – a state characterized by high within-network connectivity and greater anti-correlations between task-positive networks and the default-mode network (DMN). The HTM group transitioned between brain states more frequently, but the dwell time in each episode of the task-ready state was equivalent between groups. These results persisted even after controlling for vigilance. Across individuals, certain connectivity metrics were weakly correlated with self-reported mindfulness as measured by the Five Facet Mindfulness Questionnaire, though these did not survive multiple comparisons correction. In the static connectivity maps, HTM individuals had greater within-network connectivity in the DMN and the salience network, and greater anti-correlations between the DMN and task-positive networks. In sum, DFC features robustly distinguish HTM and LTM individuals, and may be useful biological markers for the measurement of dispositional mindfulness.

Functional parcellation of the hippocampus from resting-state dynamic functional connectivity

2019 ◽  
Vol 1715 ◽  
pp. 165-175 ◽  
Author(s):  
Qi Zhong ◽  
Huaze Xu ◽  
Jian Qin ◽  
Ling-Li Zeng ◽  
Dewen Hu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Dynamic Functional Connectivity ◽  
State Dynamic
Sign in / Sign up

Export Citation Format

Share Document