scholarly journals CSF1R inhibition by small molecule affects T-helper cell differentiation independently of microglia depletion

2021 ◽  
Author(s):  
Fengyang Lei ◽  
Naiwen Cui ◽  
Chengxin Zhou ◽  
James Chodosh ◽  
Demetrios D Vavvas ◽  
...  
Keyword(s):  
Immune Cells ◽  
Cell Activation ◽  
Bone Marrow Cells ◽  
Innate Immune ◽  
Transcriptional Profile ◽  
T Helper Cell ◽  
Helper Cell ◽  
Specific Method ◽  
Innate Immune Cells ◽  
T Helper

Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a specific method for microglia depletion. However, recent work revealed that in addition to microglia, CSF1R inhibition also affects other innate immune cells, such as peripheral monocytes and tissue-resident macrophages of the lung, liver, spleen, and peritoneum. Here, we show that this effect is not restricted to innate immune cells only, but extends to the adaptive immune compartment. CSF1R inhibition alters the transcriptional profile of bone marrow cells that control T helper cell activation. In vivo or ex vivo inhibition of CSF1R profoundly changes the transcriptional profile of CD4+ cells and suppresses Th1 and Th2 differentiation in directionally stimulated and unstimulated cells and independently of microglia depletion. Given that T cells also contribute in CNS pathology, these effects may have practical implications in the interpretation of relevant experimental data.

Mls AND THE HELPER T-CELL REPERTOIRE I. Mls as a regulator of T-helper cell activation

1988 ◽  
Vol 15 (1-3) ◽  
pp. 169-174 ◽  
Author(s):  
U. Hämmerling ◽  
M. Toulon ◽  
R. G. E. Palfree ◽  
M. K. Hoffmann
Keyword(s):  
T Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Cell Repertoire ◽  
T Helper ◽  
Helper T Cell ◽  
Cell Repertoire

scholarly journals Dendritic Cell-Independent B Cell Activation During Acute Virus Infection: A Role for Early CCR7-Driven B-T Helper Cell Collaboration

2007 ◽  
Vol 178 (3) ◽  
pp. 1468-1476 ◽  
Author(s):  
Elke Scandella ◽  
Katja Fink ◽  
Tobias Junt ◽  
Beatrice M. Senn ◽  
Evelyn Lattmann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Virus Infection ◽  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
B Cell Activation ◽  
T Helper

Integrins and T helper cell activation

1998 ◽  
Vol 30 (8) ◽  
pp. 4270-4274 ◽  
Author(s):  
G.A van Seventer ◽  
R.T Semnani ◽  
E.M Palmer ◽  
B.L McRae ◽  
J.M van Seventer
Keyword(s):  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

scholarly journals Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

2017 ◽  
Author(s):  
Johan Henriksson ◽  
Xi Chen ◽  
Tomás Gomes ◽  
Ubaid Ullah ◽  
Kerstin B Meyer ◽  
...  
Keyword(s):  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
Th2 Cells ◽  
T Helper ◽  
Cell Fates ◽  
Knock Out ◽  
Data Querying ◽  
Genome Wide ◽  
Tightly Coupled

AbstractT helper type 2 (Th2) cells are important regulators of mammalian adaptive immunity and have relevance for infection, auto-immunity and tumour immunology. Using a newly developed, genome-wide retroviral CRISPR knock-out (KO) library, combined with RNA-seq, ATAC-seq and ChIP-seq, we have dissected the regulatory circuitry governing activation (including proliferation) and differentiation of these cells. Our experiments distinguish cell activationversusdifferentiation in a quantitative framework. We demonstrate that these two processes are tightly coupled and are jointly controlled by many transcription factors, metabolic genes and cytokine/receptor pairs. There is only a small number of genes regulating differentiation without any role in activation. Our study provides an atlas for the T helper cell regulatory network, pinpointing key players of Th2 differentiation and demonstrating remarkable plasticity between the diverse T helper cell fates. We provide an online resource for interactive data querying at:http://data.teichlab.org.

T Helper Cell Activation in B-Cell Lymphomas

2002 ◽  
Vol 20 (12) ◽  
pp. 2904-2905 ◽  
Author(s):  
H. Bosshart ◽  
Stephen M. Ansell ◽  
Diane F. Jelinek ◽  
Peter J. Wettstein ◽  
Thomas E. Witzig
Keyword(s):  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
B Cell Lymphomas

scholarly journals P055 HDAC dependent regulation of the IL-6/STAT3 pathway during T helper cell activation

2013 ◽  
Vol 7 ◽  
pp. S31
Author(s):  
E. Sonnenberg ◽  
R. Glauben ◽  
P. Mascagni ◽  
B. Siegmund
Keyword(s):  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Stat3 Pathway

T helper cell‐dependent B cell activation

1991 ◽  
Vol 5 (13) ◽  
pp. 2770-2776 ◽  
Author(s):  
Randolph J. Noelle ◽  
E. Charles Snow
Keyword(s):  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
B Cell Activation ◽  
T Helper

scholarly journals Th17/Treg Imbalance and Atherosclerosis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Xin He ◽  
Bo Liang ◽  
Ning Gu
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
Regulatory T Cells ◽  
Immune Cells ◽  
Vulnerable Plaque ◽  
Plaque Rupture ◽  
Chronic Inflammatory Disease ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity. A variety of immune cells, cytokines, and transcription factors are involved in this process. Current studies found that T helper cell 17, regulatory T cells, and their cytokines play an important role in the development of atherosclerosis and vulnerable plaque rupture. Here, we provide a review of the up-to-date applications of T helper cell 17, regulatory T cells, cytokines, and their balance in the prognosis and therapy of atherosclerosis.

Sign in / Sign up

Export Citation Format

Share Document