scholarly journals Evaluation of chest X-Ray with automated interpretation algorithms for mass tuberculosis screening in prisons.

Author(s):  
Thiego Ramon Soares ◽  
Roberto Dias de Oliveira ◽  
Yiran E. Liu ◽  
Andrea da Silva Santos ◽  
Paulo C.P. Santos ◽  
...  

Rationale: The World Health Organization (WHO) recommends systematic tuberculosis (TB) screening in prisons. Evidence is lacking for accurate and scalable screening approaches in this setting. Objectives: To assess the diagnostic accuracy of artificial intelligence-based chest x-ray interpretation algorithms for TB screening in prisons. Methods: Prospective TB screening study in three prisons in Brazil from October 2017 to December 2019. We administered a standardized questionnaire, performed chest x-ray in a mobile unit, and collected sputum for confirmatory testing using Xpert MTB/RIF and culture. We evaluated x-ray images using three algorithms (CAD4TB version 6, LunitTB and qXR) and compared their diagnostic accuracy. We utilized multivariable logistic regression to assess the effect of demographic and clinical characteristics on algorithm accuracy. Finally, we investigated the relationship between abnormality scores and Xpert semi-quantitative results. Measurements and Main Results: Among 2,075 incarcerated individuals, 259 (12.5%) had confirmed TB. All three algorithms performed similarly overall with AUCs of 0.87-0.91. At 90% sensitivity, only LunitTB and qXR met the WHO Target Product Profile requirements for a triage test, with specificity of 84% and 74%, respectively. All algorithms had variable performance by age, prior TB, smoking, and presence of TB symptoms. LunitTB was the most robust to this heterogeneity, but nonetheless failed to meet the TPP for individuals with previous TB. Abnormality scores of all three algorithms were significantly correlated with sputum bacillary load. Conclusions: Automated x-ray interpretation algorithms can be an effective triage tool for TB screening in prisons. However, their specificity is insufficient in individuals with previous TB.

Proceedings ◽  
2020 ◽  
Vol 54 (1) ◽  
pp. 31
Author(s):  
Joaquim de Moura ◽  
Lucía Ramos ◽  
Plácido L. Vidal ◽  
Jorge Novo ◽  
Marcos Ortega

The new coronavirus (COVID-19) is a disease that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On 11 March 2020, the coronavirus outbreak has been labelled a global pandemic by the World Health Organization. In this context, chest X-ray imaging has become a remarkably powerful tool for the identification of patients with COVID-19 infections at an early stage when clinical symptoms may be unspecific or sparse. In this work, we propose a complete analysis of separability of COVID-19 and pneumonia in chest X-ray images by means of Convolutional Neural Networks. Satisfactory results were obtained that demonstrated the suitability of the proposed system, improving the efficiency of the medical screening process in the healthcare systems.


AI ◽  
2020 ◽  
Vol 1 (3) ◽  
pp. 418-435
Author(s):  
Khandaker Haque ◽  
Ahmed Abdelgawad

Deep Learning has improved multi-fold in recent years and it has been playing a great role in image classification which also includes medical imaging. Convolutional Neural Networks (CNNs) have been performing well in detecting many diseases including coronary artery disease, malaria, Alzheimer’s disease, different dental diseases, and Parkinson’s disease. Like other cases, CNN has a substantial prospect in detecting COVID-19 patients with medical images like chest X-rays and CTs. Coronavirus or COVID-19 has been declared a global pandemic by the World Health Organization (WHO). As of 8 August 2020, the total COVID-19 confirmed cases are 19.18 M and deaths are 0.716 M worldwide. Detecting Coronavirus positive patients is very important in preventing the spread of this virus. On this conquest, a CNN model is proposed to detect COVID-19 patients from chest X-ray images. Two more CNN models with different number of convolution layers and three other models based on pretrained ResNet50, VGG-16 and VGG-19 are evaluated with comparative analytical analysis. All six models are trained and validated with Dataset 1 and Dataset 2. Dataset 1 has 201 normal and 201 COVID-19 chest X-rays whereas Dataset 2 is comparatively larger with 659 normal and 295 COVID-19 chest X-ray images. The proposed model performs with an accuracy of 98.3% and a precision of 96.72% with Dataset 2. This model gives the Receiver Operating Characteristic (ROC) curve area of 0.983 and F1-score of 98.3 with Dataset 2. Moreover, this work shows a comparative analysis of how change in convolutional layers and increase in dataset affect classifying performances.


2020 ◽  
pp. 9-11
Author(s):  
Zohra Ahmad ◽  
Parul Dutta ◽  
Deepjyoti Das Choudhury ◽  
Satabdi Kalita ◽  
Zohaib Hussain ◽  
...  

Corona Virus Disease 19 or COVID-19, was first detected in Wuhan province in China in December 2019 and reported to the World Health Organization (WHO) on December 31, 2019 [1]. It was declared a pandemic on March 11th, 2020 [2] and has till now affected 40 million people all around the world resulting in 1.1 million deaths (as of 18th Oct, 2020) [3]. As the world is reeling under the burden of the disease, it has been imperative for the radiologists to be familiar with the imaging appearance of the disease. Thoracic imaging with chest X-ray and CT is the key modality for the diagnosis and management of respiratory diseases. Although CT is more sensitive, the immense challenge of disinfection control in the modality may disrupt the service availability and portable X-ray may be considered to minimize the risk [4]. Use of portable X-ray has played a vital role in all the areas around the world during this pandemic. The purpose of this pictorial review is to represent the frequently encountered features and abnormalities in chest X-ray and strengthen the knowledge of the health-care workers in this war against the pandemic.


Author(s):  
Heru Rahmat Wibawa Putra ◽  
Y Yuhandri

Corona Virus Disease 2019 (COVID-19) is an infectious respiratory disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2). This disease first appeared in Wuhan, China and spread throughout the world. COVID-19 has had a major impact on public health around the world. On March 9, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic. Early identification of people with COVID-19 can help limit the wider spread. One of the factors behind the rapid spread of the disease is the long clinical trial time. Rapid clinical testing is a challenge facing the spread of COVID-19. Most countries, including Indonesia, face the problem of lack of detection equipment and experts in diagnosing this disease. Chest X-Ray is one of the medical imaging techniques and also an alternative to identify the symptoms of pneumonia caused by COVID-19. This study aims to identify pneumonia caused by COVID-19 and other diseases based on Chest X-Ray. 107 Chest X-Ray images used as material for this study were obtained from the General Hospital of Ibnu Sina Padang Indonesia, which consisted of 27 images of pneumonia caused by COVID-19, 51 images with other diseases and 29 images of normal lungs. Then pre-processing is carried out as an initial stage and then feature extraction is carried out. Furthermore, the learning and identification process is carried out using the Backpropagation Artificial Neural Network (ANN) algorithm. In this study, 92 images were used as training data, and 15 images were used as test data. The results of calculations carried out using a network with a pattern of 16-100-100-100-2 obtained an accuracy value of 73%. The results of the identification prediction can be used as consideration in establishing a diagnosis of COVID-19 sufferers, but cannot be used as an absolute reference.


2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Tahira Nishtar ◽  
Shamsullah Burki ◽  
Fatima Sultan Ahmad ◽  
Tabish Ahmad

Background & Objectives: Pakistan ranked fifth amongst 22 high-burden Tuberculosis countries, and it is  an epidemic in Pakistan, hence screening is performed nationally, as part of the ambitious ZERO TB drive. Our objective was to assess the diagnostic accuracy of Computer Aided Detection (CAD4TB) software on chest Xray in screening for pulmonary tuberculosis in comparison with gene-Xpert. Methods: The study was conducted by Radiology Department Lady Reading Hospital Peshawar in affiliation with Indus Hospital network over a period of one year. Screening was done by using mobile Xray unit equipped with CAD4TB software with scoring system. All of those having score of more than 70 and few selected cases with strong clinical suspicion but score of less than 70 were referred to dedicated TB clinic for Gene-Xpert analysis. Results: Among 26,997 individuals screened, 2617 (9.7%) individuals were found presumptive for pulmonary TB. Sputum samples for Gene-Xpert were obtained in 2100 (80.24%) individuals, out of which 1825 (86.9%) were presumptive for pulmonary TB on CAD4TB only. Gene-Xpert was positive in 159 (8.7%) patients and negative in 1,666(91.3%). Sensitivity and specificity of CAD4TB and symptomatology with threshold score of ≥70 was 83.2% and 12.7% respectively keeping Gene-Xpert as gold standard. Conclusion: Combination of chest X-ray analysis by CAD4TB and symptomatology is of immense value to screen a large population at risk in a developing high burden country. It is significantly a more effective tool for screening and early diagnosis of TB in individuals, who would otherwise go undiagnosed. Abbreviations: TB = Tuberculosis, WHO = World Health Organization, CAD4TB = Computer aided detection for tuberculosis, CXR = Chest X-Ray, CAR = Computer aided reading. doi: https://doi.org/10.12669/pjms.38.1.4531 How to cite this:Nishtar T, Burki S, Ahmad FS, Ahmad T. Diagnostic accuracy of computer aided reading of chest x-ray in screening for pulmonary tuberculosis in comparison with Gene-Xpert. Pak J Med Sci. 2022;38(1):---------.   doi: https://doi.org/10.12669/pjms.38.1.4531 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Author(s):  
Dominic Wang ◽  
Kara Marie Ruicci

An elderly patient with a history significant for recent immigration presented with acute onset hemoptysis and a focal infiltrate on chest x-ray. A broad differential for acute hemoptysis was considered including infectious, inflammatory, and neoplastic etiologies. Sputum samples revealed the presence of drug-susceptible M. tuberculosis and treatment guidelines were reviewed. The patient demonstrated response to first-line therapy, rifampin and isoniazid, and was subsequently discharged with follow-up chest x-ray. Tuberculosis is further discussed in the broader contexts of current Canadian screening guidelines, emerging drug-resistant strains, and the initiatives of the World Health Organization (WHO) to reduce its global burden.


2020 ◽  
pp. 119-130
Author(s):  
Shadman Q. Salih ◽  
Hawre Kh. Abdulla ◽  
Zanear Sh. Ahmed ◽  
Nigar M. Shafiq Surameery ◽  
Rasper Dh. Rashid

First outbreak of COVID-19 was in the city of Wuhan in China in Dec.2019 and then it becomes a pandemic disease all around the world. World Health Organization (WHO) confirmed more than 5.5 million cases and 341,155 deaths from the disease till the time of writing this paper. This new worldwide disease forced researchers to make more precise way to diagnose COVID-19. In the last decade, medical imaging techniques show its efficiency in helping radiologists to detect and diagnose the diseases. Deep learning and transfer learning algorithms are good techniques to detect disease from different image source types such as X-Ray and CT scan images. In this work we used a deep learning technique based on Convolution Neural Network (CNN) to detect and diagnose COVID-19 disease using Chest X-ray images.  Moreover, the modified AlexNet architecture is proposed in different scenarios were differing from each other in terms of the type of the pooling layers and/or the number of the neurons that have used in the second fully connected layer. The used chest X-ray images are gathered from two COVID-19 X-ray image datasets and one dataset includes large number of normal and pneumonia X-ray images. With the proposed models we obtained the same or even better result than the original AlexNet with having a smaller number of neurons in the second fully connected layer.


Author(s):  
Puneet Gupta

Abstract— Pneumonia is a life-threatening infectious disease affecting one or both lungs in humans commonly caused by bacteria called Streptococcus pneumoniae. One in three deaths in India is caused due to pneumonia as reported by World Health Organization (WHO). Chest X-Rays which are used to diagnose pneumonia, need expert radiotherapists for evaluation. Thus, developing an automatic system for detecting pneumonia would be beneficial for treating the disease without any delay particularly in remote areas. Due to the success of deep learning algorithms in analyzing medical images, Convolutional Neural Networks (CNNs) have gained much attention for disease classification. In addition, features learned by pre-trained CNN models on large-scale datasets are much useful in image classification tasks. In this work, we appraise the functionality of pre-trained CNN models utilized as feature-extractors followed by different classifiers for the classification of abnormal and normal chest X-Rays. We analytically determine the optimal CNN model for the purpose. Statistical results obtained demonstrates that pretrained CNN models employed along with supervised classifier algorithms can be very beneficial in analyzing chest X-ray images, specifically to detect Pneumonia. In this project Transfer learning and a CNN Model is used to detect whether the person has pneumonia or not using chest x-ray.


Author(s):  
Rajeev Kumar Gupta ◽  
Nilesh Kunhare ◽  
Rajesh Kumar Pateriya ◽  
Nikhlesh Pathik

The novel Covid-19 is one of the leading cause of death worldwide in the year 2020 and declared as a pandemic by world health organization (WHO). This virus affecting all countries across the world and 5 lakh people die as of June 2020 due to Covid-19. Due to the highly contagious nature, early detection of this virus plays a vital role to break Covid chain. Recent studies done by China says that chest CT and X-Ray image may be used as a preliminary test for Covid detection. Deep learning-based CNN model can use to detect Coronavirus automatically from the chest X-rays images. This paper proposed a transfer learning-based approach to detect Covid disease. Due to the less number of Covid chest images, we are using a pre-trained model to classify X-ray images into Covid and Normal class. This paper presents the comparative study of a various pre-trained model like VGGNet-19, ResNet50 and Inception_ResNet_V2. Experiment results show that Inception_ResNet_V2 gives the better result as compare to VGGNet and ResNet model with training and test accuracy of 99.26 and 94, respectively.


2019 ◽  
Vol 20 (3) ◽  
pp. 122-131
Author(s):  
Annette Jeanes ◽  
Fiona Henderson ◽  
Nick Drey ◽  
Dinah Gould

Introduction: Good hand hygiene practices reduce the risk of transmission of infection in healthcare. In common with other areas of healthcare, infection control knowledge and practice in radiography has potential for improvement. Regular hand hygiene compliance (HHC) monitoring indicated poor compliance in radiology which did not accurately reflect practice in one organisation. Using a quality improvement cycle, the process and context of work undertaken in radiology were examined in order to improve the validity and utility of HHC monitoring data collection process in the department. Methods: Following examination of the evidence base and with agreement from the radiology team, the chest X-ray process was observed and actions notated. This was then scored using the organisation and the World Health Organization five moments of hand hygiene tool. An alternative risk-based scoring system was developed. Results: The HHC score of 22% was obtained using standard measurements. Achievement of 100% compliance would require the radiographer to clean their hands nine times for each X-ray. The sequence of taking a chest X-ray was examined and two points in the process were identified as key points at which hand cleaning should take place to reduce the risk of transmission of infection. Conclusions: Cleaning hands frequently to achieve compliance expectations in this short low-risk process is neither feasible nor beneficial. A pragmatic risk-based approach to hand hygiene expectations in predictable procedures such as taking a chest X-ray reduces ambiguity and potentially increases compliance.


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