scholarly journals The synaptic organization in the C. elegans neural network suggests significant local compartmentalized computations

2022 ◽  
Author(s):  
Rotem Ruach ◽  
Nir Ratner ◽  
Scott W. Emmons ◽  
Alon Zaslaver
Keyword(s):  
Neural Network ◽  
Opposite Polarity ◽  
Synaptic Organization ◽  
Functional Roles ◽  
C Elegans ◽  
Guiding Principle ◽  
The Neural Network ◽  
Local Functional ◽  
Positive And Negative Feedback ◽  
Chemical Synapses

Neurons are characterized by elaborate tree-like dendritic structures that support local computations by integrating multiple inputs from upstream presynaptic neurons. It is less clear if simple neurons, consisting of a few or even a single neurite, may perform local computations as well. To address this question, we focused on the compact neural network of C. elegans animals for which the full wiring diagram is available, including the coordinates of individual synapses. We find that the positions of the chemical synapses along the neurites are not randomly distributed, nor can they be explained by anatomical constraints. Instead, synapses tend to form clusters, an organization that supports local compartmentalized computations. In mutually-synapsing neurons, connections of opposite polarity cluster separately, suggesting that positive and negative feedback dynamics may be implemented in discrete compartmentalized regions along neurites. In triple-neuron circuits, the non-random synaptic organization may facilitate local functional roles, such as signal integration and coordinated activation of functionally-related downstream neurons. These clustered synaptic topologies emerge as a guiding principle in the network presumably to facilitate distinct parallel functions along a single neurite, effectively increasing the computational capacity of the neural network.

scholarly journals Chimera-like States in Modular Neural Networks

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Johanne Hizanidis ◽  
Nikos E. Kouvaris ◽  
Gorka Zamora-López ◽  
Albert Díaz-Guilera ◽  
Chris G. Antonopoulos
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Order Parameter ◽  
Electrical Synapses ◽  
Modular Neural Networks ◽  
Common Features ◽  
C Elegans ◽  
Chaotic Bursting ◽  
Modular Networks ◽  
Chemical Synapses

Abstract Chimera states, namely the coexistence of coherent and incoherent behavior, were previously analyzed in complex networks. However, they have not been extensively studied in modular networks. Here, we consider a neural network inspired by the connectome of the C. elegans soil worm, organized into six interconnected communities, where neurons obey chaotic bursting dynamics. Neurons are assumed to be connected with electrical synapses within their communities and with chemical synapses across them. As our numerical simulations reveal, the coaction of these two types of coupling can shape the dynamics in such a way that chimera-like states can happen. They consist of a fraction of synchronized neurons which belong to the larger communities and a fraction of desynchronized neurons which are part of smaller communities. In addition to the Kuramoto order parameter ρ, we also employ other measures of coherence, such as the chimera-like χ and metastability λ indices, which quantify the degree of synchronization among communities and along time, respectively. We perform the same analysis for networks that share common features with the C. elegans neural network. Similar results suggest that under certain assumptions, chimera-like states are prominent phenomena in modular networks and might provide insight for the behavior of more complex modular networks.

Neural Network for Automatic Analysis of Motility Data

1994 ◽  
Vol 33 (01) ◽  
pp. 157-160 ◽  
Author(s):  
S. Kruse-Andersen ◽  
J. Kolberg ◽  
E. Jakobsen
Keyword(s):  
Neural Network ◽  
Muscular Activity ◽  
Recording System ◽  
Automatic Analysis ◽  
Biologically Relevant ◽  
System A ◽  
The Neural Network ◽  
Valuable Method ◽  
Motor Abnormalities ◽  
Trained Network

Abstract:Continuous recording of intraluminal pressures for extended periods of time is currently regarded as a valuable method for detection of esophageal motor abnormalities. A subsequent automatic analysis of the resulting motility data relies on strict mathematical criteria for recognition of pressure events. Due to great variation in events, this method often fails to detect biologically relevant pressure variations. We have tried to develop a new concept for recognition of pressure events based on a neural network. Pressures were recorded for over 23 hours in 29 normal volunteers by means of a portable data recording system. A number of pressure events and non-events were selected from 9 recordings and used for training the network. The performance of the trained network was then verified on recordings from the remaining 20 volunteers. The accuracy and sensitivity of the two systems were comparable. However, the neural network recognized pressure peaks clearly generated by muscular activity that had escaped detection by the conventional program. In conclusion, we believe that neu-rocomputing has potential advantages for automatic analysis of gastrointestinal motility data.

Decision Support for Psychiatric Diagnosis Based on a Simple Questionnaire

1997 ◽  
Vol 36 (04/05) ◽  
pp. 349-351
Author(s):  
H. Mizuta ◽  
K. Kawachi ◽  
H. Yoshida ◽  
K. Iida ◽  
Y. Okubo ◽  
...  
Keyword(s):  
Neural Network ◽  
Decision Support ◽  
Psychiatric Diagnosis ◽  
Psychiatric Patients ◽  
Bayesian Classifier ◽  
Neural Network Classifier ◽  
Correct Decision ◽  
Neurotic Disorders ◽  
The Neural Network

Abstract:This paper compares two classifiers: Pseudo Bayesian and Neural Network for assisting in making diagnoses of psychiatric patients based on a simple yes/no questionnaire which is provided at the outpatient’s first visit to the hospital. The classifiers categorize patients into three most commonly seen ICD classes, i.e. schizophrenic, emotional and neurotic disorders. One hundred completed questionnaires were utilized for constructing and evaluating the classifiers. Average correct decision rates were 73.3% for the Pseudo Bayesian Classifier and 77.3% for the Neural Network classifier. These rates were higher than the rate which an experienced psychiatrist achieved based on the same restricted data as the classifiers utilized. These classifiers may be effectively utilized for assisting psychiatrists in making their final diagnoses.

SCORING MODELING BASED ON NEURAL NETWORKS FOR DETERMINING A BANK BORROWER'S RATING

2020 ◽  
Vol 2020 (10) ◽  
pp. 54-62
Author(s):  
Oleksii VASYLIEV ◽  
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Network Architecture ◽  
Statistical Data ◽  
Activation Function ◽  
Decision Making Process ◽  
Neural Network Architecture ◽  
Acceptable Accuracy ◽  
The Neural Network ◽  
Sigmoid Activation Function

The problem of applying neural networks to calculate ratings used in banking in the decision-making process on granting or not granting loans to borrowers is considered. The task is to determine the rating function of the borrower based on a set of statistical data on the effectiveness of loans provided by the bank. When constructing a regression model to calculate the rating function, it is necessary to know its general form. If so, the task is to calculate the parameters that are included in the expression for the rating function. In contrast to this approach, in the case of using neural networks, there is no need to specify the general form for the rating function. Instead, certain neural network architecture is chosen and parameters are calculated for it on the basis of statistical data. Importantly, the same neural network architecture can be used to process different sets of statistical data. The disadvantages of using neural networks include the need to calculate a large number of parameters. There is also no universal algorithm that would determine the optimal neural network architecture. As an example of the use of neural networks to determine the borrower's rating, a model system is considered, in which the borrower's rating is determined by a known non-analytical rating function. A neural network with two inner layers, which contain, respectively, three and two neurons and have a sigmoid activation function, is used for modeling. It is shown that the use of the neural network allows restoring the borrower's rating function with quite acceptable accuracy.

Classification and Identification of Power System Disturbances Using Wavalet and Artificial Neural Network Technique

2005 ◽  
Vol 2 (2) ◽  
pp. 25
Author(s):  
Noraliza Hamzah ◽  
Wan Nor Ainin Wan Abdullah ◽  
Pauziah Mohd Arsad
Keyword(s):  
Neural Network ◽  
Power Quality ◽  
Probabilistic Neural Network ◽  
Microsoft Excel ◽  
Waveform Data ◽  
The Neural Network ◽  
Harmonic Voltage ◽  
Power Quality Disturbances ◽  
Electronic Load ◽  
Wavelet Technique

Power Quality disturbances problems have gained widespread interest worldwide due to the proliferation of power electronic load such as adjustable speed drives, computer, industrial drives, communication and medical equipments. This paper presents a technique based on wavelet and probabilistic neural network to detect and classify power quality disturbances, which are harmonic, voltage sag, swell and oscillatory transient. The power quality disturbances are obtained from the waveform data collected from premises, which include the UiTM Sarawak, Faculty of Science Computer in Shah Alam, Jati College, Menara UiTM, PP Seksyen 18 and Putra LRT. Reliable Power Meter is used for data monitoring and the data is further processed using the Microsoft Excel software. From the processed data, power quality disturbances are detected using the wavelet technique. After the disturbances being detected, it is then classified using the Probabilistic Neural Network. Sixty data has been chosen for the training of the Probabilistic Neural Network and ten data has been used for the testing of the neural network. The results are further interfaced using matlab script code.  Results from the research have been very promising which proved that the wavelet technique and Probabilistic Neural Network is capable to be used for power quality disturbances detection and classification.

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