scholarly journals Reconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks

2022 ◽  
Author(s):  
Subham Choudhury ◽  
Michael Moret ◽  
Pierre Salvy ◽  
Daniel Weilandt ◽  
Vassily Hatzimanikatis ◽  
...  
Keyword(s):  
Deep Learning ◽  
Systems Biology ◽  
Kinetic Models ◽  
Metabolic Networks ◽  
Data Science ◽  
Dynamic Properties ◽  
Generative Adversarial Networks ◽  
Kinetic Properties ◽  
Adversarial Networks ◽  
Living Organisms

Kinetic models of metabolic networks relate metabolic fluxes, metabolite concentrations, and enzyme levels through well-defined mechanistic relations rendering them an essential tool for systems biology studies aiming to capture and understand the behavior of living organisms. However, due to the lack of information about the kinetic properties of enzymes and the uncertainties associated with available experimental data, traditional kinetic modeling approaches often yield only a few or no kinetic models with desirable dynamical properties making the computational analysis unreliable and computationally inefficient. We present REKINDLE (REconstruction of KINetic models using Deep LEarning), a deep-learning-based framework for efficiently generating large-scale kinetic models with dynamic properties matching the ones observed in living organisms. We showcase REKINDLE's efficiency and capabilities through three studies where we: (i) generate large populations of kinetic models that allow reliable in silico testing of hypotheses and systems biology designs, (ii) navigate the phenotypic space by leveraging the transfer learning capability of generative adversarial networks, demonstrating that the generators trained for one physiology can be fine-tuned for another physiology using a low amount of data, and (iii) expand upon existing datasets, making them amenable to thorough computational biology and data-science analyses. The results show that data-driven neural networks assimilate implicit kinetic knowledge and structure of metabolic networks and generate novel kinetic models with tailored properties and statistical diversity. We anticipate that our framework will advance our understanding of metabolism and accelerate future research in health, biotechnology, and systems and synthetic biology. REKINDLE is available as an open-access tool.

scholarly journals Audio-Based Drone Detection and Identification Using Deep Learning Techniques with Dataset Enhancement through Generative Adversarial Networks

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 4953
Author(s):  
Sara Al-Emadi ◽  
Abdulla Al-Ali ◽  
Abdulaziz Al-Ali
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Recurrent Neural Network ◽  
Learning Algorithms ◽  
Generative Adversarial Networks ◽  
Generative Adversarial Network ◽  
Adversarial Networks ◽  
Detection And Identification ◽  
Learning Techniques ◽  
The Impact

Drones are becoming increasingly popular not only for recreational purposes but in day-to-day applications in engineering, medicine, logistics, security and others. In addition to their useful applications, an alarming concern in regard to the physical infrastructure security, safety and privacy has arisen due to the potential of their use in malicious activities. To address this problem, we propose a novel solution that automates the drone detection and identification processes using a drone’s acoustic features with different deep learning algorithms. However, the lack of acoustic drone datasets hinders the ability to implement an effective solution. In this paper, we aim to fill this gap by introducing a hybrid drone acoustic dataset composed of recorded drone audio clips and artificially generated drone audio samples using a state-of-the-art deep learning technique known as the Generative Adversarial Network. Furthermore, we examine the effectiveness of using drone audio with different deep learning algorithms, namely, the Convolutional Neural Network, the Recurrent Neural Network and the Convolutional Recurrent Neural Network in drone detection and identification. Moreover, we investigate the impact of our proposed hybrid dataset in drone detection. Our findings prove the advantage of using deep learning techniques for drone detection and identification while confirming our hypothesis on the benefits of using the Generative Adversarial Networks to generate real-like drone audio clips with an aim of enhancing the detection of new and unfamiliar drones.

scholarly journals Independent attenuation correction of whole body [18F]FDG-PET using a deep learning approach with Generative Adversarial Networks

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Karim Armanious ◽  
Tobias Hepp ◽  
Thomas Küstner ◽  
Helmut Dittmann ◽  
Konstantin Nikolaou ◽  
...  
Keyword(s):  
Deep Learning ◽  
Attenuation Correction ◽  
Fdg Pet ◽  
Whole Body ◽  
Generative Adversarial Networks ◽  
Learning Approach ◽  
Adversarial Networks ◽  
18F Fdg

scholarly journals A deep learning approach to capture the essence of Candida albicans morphologies

2021 ◽  
Author(s):  
Van Bettauer ◽  
Anna CBP Costa ◽  
Raha Parvizi Omran ◽  
Samira Massahi ◽  
Eftyhios Kirbizakis ◽  
...  
Keyword(s):  
Deep Learning ◽  
Learning Strategy ◽  
Developmental Trajectories ◽  
Generative Adversarial Networks ◽  
Learning Approach ◽  
Adversarial Networks ◽  
Latent Space ◽  
Contrast Microscopy ◽  
Opportunistic Human Pathogen ◽  
Community Meeting

We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen C. albicans. Our system entitled Candescence automatically detects C. albicans cells from Differential Image Contrast microscopy, and labels each detected cell with one of nine vegetative, mating-competent or filamentous morphologies. The software is based upon a fully convolutional one-stage object detector and exploits a novel cumulative curriculum-based learning strategy that stratifies our images by difficulty from simple vegetative forms to more complex filamentous architectures. Candescence achieves very good performance on this difficult learning set which has substantial intermixing between the predicted classes. To capture the essence of each C. albicans morphology, we develop models using generative adversarial networks and identify subcomponents of the latent space which control technical variables, developmental trajectories or morphological switches. We envision Candescence as a community meeting point for quantitative explorations of C. albicans morphology.

Motion Imitation for Monocular Videos

2021 ◽  
pp. 118-135
Author(s):  
Priyanka Nandal
Keyword(s):  
Deep Learning ◽  
Generative Adversarial Networks ◽  
Intermediate Representation ◽  
Simple Method ◽  
Adversarial Networks ◽  
Target Subject

This work represents a simple method for motion transfer (i.e., given a source video of a subject [person] performing some movements or in motion, that movement/motion is transferred to amateur target in different motion). The pose is used as an intermediate representation to perform this translation. To transfer the motion of the source subject to the target subject, the pose is extracted from the source subject, and then the target subject is generated by applying the learned pose to-appearance mapping. To perform this translation, the video is considered as a set of images consisting of all the frames. Generative adversarial networks (GANs) are used to transfer the motion from source subject to the target subject. GANs are an evolving field of deep learning.

Deep Learning in Cybersecurity

2020 ◽  
Vol 10 (2) ◽  
pp. 82-105
Author(s):  
Yadigar N. Imamverdiyev ◽  
Fargana J. Abdullayeva
Keyword(s):  
Deep Learning ◽  
Statistical Analysis ◽  
Detection Methods ◽  
Generative Adversarial Networks ◽  
Comprehensive Overview ◽  
Adversarial Networks

In this article, a review and summarization of the emerging scientific approaches of deep learning (DL) on cybersecurity are provided, a structured and comprehensive overview of the various cyberattack detection methods is conducted, existing cyberattack detection methods based on DL is categorized. Methods covering attacks to deep learning based on generative adversarial networks (GAN) are investigated. The datasets used for the evaluation of the efficiency proposed by researchers for cyberattack detection methods are discussed. The statistical analysis of papers published on cybersecurity with the application of DL over the years is conducted. Existing commercial cybersecurity solutions developed on deep learning are described.

scholarly journals Deep learning approach to classification of lung cytological images: Two-step training using actual and synthesized images by progressive growing of generative adversarial networks

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229951 ◽  
Author(s):  
Atsushi Teramoto ◽  
Tetsuya Tsukamoto ◽  
Ayumi Yamada ◽  
Yuka Kiriyama ◽  
Kazuyoshi Imaizumi ◽  
...  
Keyword(s):  
Deep Learning ◽  
Generative Adversarial Networks ◽  
Learning Approach ◽  
Adversarial Networks
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