2020 started with the outbreak of the novel coronavirus (COVID-19) virus. In this panic situation, the combination of artificial intelligence (AI) can help us in fight against the deadliest virus attack worldwide. This tool can be used to control and prevention of the outbreak disease. The AI tool can be helpful in prediction, detection, response, recovery, drug discovery of the disease. The AI-driven tools can be used in identifying the nature of outbreak as well as in forecasting the spread and coverage worldwide. In this case, so many AI-based tools can be applied and trained using active learning-based models for the detection, prevention, treatment, and recovery of the patients. Also, they can help us for identifying infected persons from the non-infected to stop the spread of the virus. This chapter mainly focuses on the AI-assisted methodology and models that can help in fighting COVID-19.