Botulinum-neurotoxin-like sequences identified from anEnterococcussp. genome assembly
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AbstractBotulinum neurotoxins (BoNTs) are produced by diverse members of theClostridiaand result in a flaccid paralysis known as botulism. Exploring the diversity of BoNTs is important for the development of therapeutics and antitoxins. Here we describe a novel,bont-like gene cluster identified in a draft genome assembly forEnterococcussp. 3G1_DIV0629 by querying publicly available genomic databases. Thebont-like gene is found in a gene cluster similar to knownbontgene clusters. Protease and binding motifs conserved in known BoNT proteins are present in the newly identified BoNT-like protein; however, it is currently unknown if the BoNT-like protein described here is capable of targeting neuronal cells resulting in botulism.
2020 ◽
Vol 12
(7)
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pp. 1074-1079
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2012 ◽
Vol 71
(6)
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pp. 895-906
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2021 ◽
2021 ◽