scholarly journals Turing patterns are common but not robust

2018 ◽  
Author(s):  
Natalie S. Scholes ◽  
David Schnoerr ◽  
Mark Isalan ◽  
Michael P. H. Stumpf

Turing patterns (TPs) underlie many fundamental developmental processes, but they operate over narrow parameter ranges, raising the conundrum of how evolution can ever discover them. Here we explore TP design space to address this question and to distill design rules. We exhaustively analyze 2- and 3-node biological candidate Turing systems: crucially, network structure alone neither determines nor guarantees emergent TPs. A surprisingly large fraction (>60%) of network design space can produce TPs, but these are sensitive to even subtle changes in parameters, network structure and regulatory mechanisms. This implies that TP networks are more common than previously thought, and evolution might regularly encounter prototypic solutions. Importantly, we deduce compositional rules for TP systems that are almost necessary and sufficient (≈96% of TP networks contain them, and ≈95% of networks implementing them produce TPs). This comprehensive network atlas provides the blueprints for identifying natural TPs, and for engineering synthetic systems.

Author(s):  
Nicolas Albarello ◽  
Jean-Baptiste Welcomme

The design of systems architectures often involve a combinatorial design-space made of technological and architectural choices. A complete or large exploration of this design space requires the use of a method to generate and evaluate design alternatives. This paper proposes an innovative approach for the design-space exploration of systems architectures. The SAMOA (System Architecture Model-based OptimizAtion) tool associated to the method is also introduced. The method permits to create a large number of various system architectures combining a set of possible components to address given system functions. The method relies on models that are used to represent the problem and the solutions and to evaluate architecture performances. An algorithm first synthesizes design alternatives (a physical architecture associated to a functional allocation) based on the functional architecture of the system, the system interfaces, a library of available components and user-defined design rules. Chains of components are sequentially added to an initially empty architecture until all functions are fulfilled. The design rules permit to guarantee the viability and validity of the chains of components and, consequently, of the generated architectures. The design space exploration is then performed in a smart way through the use of an evolutionary algorithm, the evolution mechanisms of which are specific to system architecting. Evaluation modules permit to assess the performances of alternatives based on the structure of the architecture model and the data embedded in the component models. These performances are used to select the best generated architectures considering constraints and quality metrics. This selection is based on the Pareto-dominance-based NSGA-II algorithm or, alternatively, on an interactive preference-based algorithm. Iterating over this evolution-evaluation-selection process permits to increase the quality of solutions and, thus, to highlight the regions of interest of the design-space which can be used as a base for further manual investigations. By using this method, the system designers have a larger confidence in the optimality of the adopted architecture than using a classical derivative approach as many more solutions are evaluated. Also, the method permits to quickly evaluate the trade-offs between the different considered criteria. Finally, the method can also be used to evaluate the impact of a technology on the system performances not only by a substituting a technology by another but also by adapting the architecture of the system.


2020 ◽  
Vol 10 (4) ◽  
pp. 228
Author(s):  
Rodrigo F. O. Pena ◽  
Vinicius Lima ◽  
Renan O. Shimoura ◽  
João Paulo Novato ◽  
Antonio C. Roque

In network models of spiking neurons, the joint impact of network structure and synaptic parameters on activity propagation is still an open problem. Here, we use an information-theoretical approach to investigate activity propagation in spiking networks with a hierarchical modular topology. We observe that optimized pairwise information propagation emerges due to the increase of either (i) the global synaptic strength parameter or (ii) the number of modules in the network, while the network size remains constant. At the population level, information propagation of activity among adjacent modules is enhanced as the number of modules increases until a maximum value is reached and then decreases, showing that there is an optimal interplay between synaptic strength and modularity for population information flow. This is in contrast to information propagation evaluated among pairs of neurons, which attains maximum value at the maximum values of these two parameter ranges. By examining the network behavior under the increase of synaptic strength and the number of modules, we find that these increases are associated with two different effects: (i) the increase of autocorrelations among individual neurons and (ii) the increase of cross-correlations among pairs of neurons. The second effect is associated with better information propagation in the network. Our results suggest roles that link topological features and synaptic strength levels to the transmission of information in cortical networks.


2020 ◽  
Vol 18 (12) ◽  
Author(s):  
Wan Saiful Nizam Wan Mohamad ◽  
Ismail Said ◽  
Khalilah Hassan ◽  
Siti Nurathirah Che Mohd Nasir ◽  
Mohammad Rusdi Mohd Nasir ◽  
...  

A large number of local towns with compare to another type of town in Malaysia notifying the variety which required further identification to highlight a standard in planning on this town category. Hence, this paper aims to define the basic criteria for street network of Malaysia's local town. Pasir Puteh, Baling, Rembau and Pontian were selected based on the diversity of the street network structure develop from beginning to the modern era. The towns were mapped using land use data. This study employed comparative analysis to assess similarity and differences on the principles and term of street network system. The finding suggests that local towns founded before independence retain the historical value of the street system built by the colonizer and new zone of local town is to serve the community rather than the administration. Thus, the research on how street network in local town influence vehicle or pedestrian movement is recommended.


Author(s):  
ROBERT F. WOODBURY ◽  
ANDREW L. BURROW

Design space exploration is a long-standing focus in computational design research. Its three main threads are accounts of designer action, development of strategies for amplification of designer action in exploration, and discovery of computational structures to support exploration. Chief among such structures is the design space, which is the network structure of related designs that are visited in an exploration process. There is relatively little research on design spaces to date. This paper sketches a partial account of the structure of both design spaces and research to develop them. It focuses largely on the implications of designers acting as explorers.


Author(s):  
Martin B. Reed ◽  
Stuart Nash

Given a mesh of wireless nodes for WiFi customers covering a city district, we describe a genetic algorithm-based approach to the problem of selecting a small fixed number of nodes as gateways to the internet, and linking the remaining nodes to the gateways either directly or by 'hopping', to create an efficient mesh network structure. The algorithm uses a modification of k-means clustering to allocate nodes to gateways.  


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