scholarly journals Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative data from the Dutch 100-plus Study

2018 ◽  
Author(s):  
Nina Beker ◽  
Sietske A.M. Sikkes ◽  
Marc Hulsman ◽  
Ben Schmand ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Test Performance ◽  
Normative Data ◽  
Neuropsychological Test ◽  
Cognitive Testing ◽  
Hearing Impairments ◽  
Age Related ◽  
Dementia Incidence ◽  
Sensory Impairments ◽  
Linear Regressions

ABSTRACTBackgroundThe population who reaches the extreme age of 100 years is growing. At this age, dementia incidence is high and cognitive functioning is variable and influenced by sensory impairments. Appropriate cognitive testing requires normative data generated specifically for this group. Currently, these are lacking. We set out to generate norms for neuropsychological tests in cognitively healthy centenarians while taking sensory impairments into account.MethodsWe included 235 centenarians (71.5% female) from the 100-plus Study, who self-reported to be cognitively healthy, which was confirmed by an informant and a trained researcher. Normative data were generated for 15 tests that evaluate global cognition, pre-morbid intelligence, attention, language, memory, executive and visuo-spatial functions by multiple linear regressions and/or percentiles. Centenarians with vision and/or hearing impairments were excluded for tests that required these faculties.ResultsSubjects scored on average 25.6±3.1 (range 17-30, interquartile-range 24-28) points on the MMSE. Vision problems and fatigue often complicated the ability to complete tests, and these problems explained 41% and 22% of the missing test scores respectively, whereas hearing problems (4%) and task incomprehension (6%) only rarely did. Sex and age showed a limited association with test performance, whereas educational level was associated with performance on the majority of the tests.ConclusionsNormative data for the centenarian population is provided, while taking age-related sensory impairments into consideration. Results indicate that, next to vision impairments, fatigue and education level should be taken into account when assessing cognitive functioning in centenarians.

scholarly journals Online Self-Administered Cognitive Testing Using the Amsterdam Cognition Scan: Establishing Psychometric Properties and Normative Data (Preprint)

2017 ◽  
Author(s):  
Heleen EM Feenstra ◽  
Ivar E Vermeulen ◽  
Jaap MJ Murre ◽  
Sanne B Schagen
Keyword(s):  
Psychometric Properties ◽  
Test Performance ◽  
Normative Data ◽  
Large Scale ◽  
Neuropsychological Test ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Computer Skills ◽  
Repeated Measurements ◽  
Cognitive Testing

BACKGROUND Online tests enable efficient self-administered assessments and consequently facilitate large-scale data collection for many fields of research. The Amsterdam Cognition Scan is a new online neuropsychological test battery that measures a broad variety of cognitive functions. OBJECTIVE The aims of this study were to evaluate the psychometric properties of the Amsterdam Cognition Scan and to establish regression-based normative data. METHODS The Amsterdam Cognition Scan was self-administrated twice from home—with an interval of 6 weeks—by 248 healthy Dutch-speaking adults aged 18 to 81 years. RESULTS Test-retest reliability was moderate to high and comparable with that of equivalent traditional tests (intraclass correlation coefficients: .45 to .80; .83 for the Amsterdam Cognition Scan total score). Multiple regression analyses indicated that (1) participants’ age negatively influenced all (12) cognitive measures, (2) gender was associated with performance on six measures, and (3) education level was positively associated with performance on four measures. In addition, we observed influences of tested computer skills and of self-reported amount of computer use on cognitive performance. Demographic characteristics that proved to influence Amsterdam Cognition Scan test performance were included in regression-based predictive formulas to establish demographically adjusted normative data. CONCLUSIONS Initial results from a healthy adult sample indicate that the Amsterdam Cognition Scan has high usability and can give reliable measures of various generic cognitive ability areas. For future use, the influence of computer skills and experience should be further studied, and for repeated measurements, computer configuration should be consistent. The reported normative data allow for initial interpretation of Amsterdam Cognition Scan performances.

Neuropsychological Test Performance in Framingham: A Descriptive Study

1987 ◽  
Vol 60 (3_part_2) ◽  
pp. 1023-1040
Author(s):  
Mary E. Farmer ◽  
Lon R. White ◽  
Steven J. Kittner ◽  
Edith Kaplan ◽  
Elizabeth Moes ◽  
...  
Keyword(s):  
Test Performance ◽  
Neuropsychological Tests ◽  
Language Skills ◽  
Community Sample ◽  
Neuropsychological Test ◽  
Descriptive Study ◽  
Community Dwelling ◽  
Abstract Thinking ◽  
Framingham Study ◽  
Hearing Impairments

In 1976–1978, a battery of eight neuropsychologic tests was administered to 2,123 participants in the Framingham Study aged 55 to 89 yr. The battery was designed to sample multiple areas of cognitive function including language skills, memory, learning, reproduction of designs, attention, and abstract thinking. Performance is described for several groups in this population: a large community-dwelling sample, those with hearing impairments, and those with documented strokes. Performance is described by age, sex, and education strata for the community sample. This normative information should be useful for interpreting individual test performance on neuropsychological tests.

scholarly journals Effect of Age-Related Hearing Loss on Neuropsychological Test Performance

2020 ◽  
Vol 73 (3) ◽  
pp. 16
Author(s):  
Christina G. Wong ◽  
Lisa J. Rapport ◽  
Brad A. Stach ◽  
Virginia Ramachandran
Keyword(s):  
Hearing Loss ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Age Related ◽  
Age Related Hearing Loss ◽  
Effect Of Age

scholarly journals Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative Data From the Dutch 100-Plus Study

2018 ◽  
Vol 67 (4) ◽  
pp. 759-767 ◽  
Author(s):  
Nina Beker ◽  
Sietske A.M. Sikkes ◽  
Marc Hulsman ◽  
Ben Schmand ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Test Performance ◽  
Normative Data ◽  
Neuropsychological Test

Neuropsychological test performance among healthy persons in northern India: development of normative data

2015 ◽  
Vol 21 (4) ◽  
pp. 433-438 ◽  
Author(s):  
Drenna Waldrop-Valverde ◽  
Raymond L. Ownby ◽  
Deborah L. Jones ◽  
Sunil Sharma ◽  
Ritu Nehra ◽  
...  
Keyword(s):  
Test Performance ◽  
Normative Data ◽  
Neuropsychological Test ◽  
Northern India ◽  
Healthy Persons

scholarly journals The Dissociation between Early and Late Selection in Older Adults

2013 ◽  
Vol 25 (12) ◽  
pp. 2189-2206 ◽  
Author(s):  
Brittany R. Alperin ◽  
Anna E. Haring ◽  
Tatyana Y. Zhuravleva ◽  
Phillip J. Holcomb ◽  
Dorene M. Rentz ◽  
...  
Keyword(s):  
Older Adults ◽  
Information Processing ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Early Selection ◽  
Attention Task ◽  
Age Related ◽  
Different Color ◽  
Task Irrelevant ◽  
Late Selection

Older adults exhibit a reduced ability to ignore task-irrelevant stimuli; however, it remains to be determined where along the information processing stream the most salient age-associated changes occur. In the current study, ERPs provided an opportunity to determine whether age-related differences in processing task-irrelevant stimuli were uniform across information processing stages or disproportionately affected either early or late selection. ERPs were measured in young and old adults during a color-selective attention task in which participants responded to target letters in a specified color (attend condition) while ignoring letters in a different color (ignore condition). Old participants were matched to two groups of young participants on the basis of neuropsychological test performance: one using age-appropriate norms and the other using test scores not adjusted for age. There were no age-associated differences in the magnitude of early selection (attend–ignore), as indexed by the size of the anterior selection positivity and posterior selection negativity. During late selection, as indexed by P3b amplitude, both groups of young participants generated neural responses to target letters under the attend versus ignore conditions that were highly differentiated. In striking contrast, old participants generated a P3b to target letters with no reliable differences between conditions. Individuals who were slow to initiate early selection appeared to be less successful at executing late selection. Despite relative preservation of the operations of early selection, processing delays may lead older participants to allocate excessive resources to task-irrelevant stimuli during late selection.

P2-242: THE NEURO-NORMS CALCULATOR FOR OLDER ADULTS: DEMOGRAPHICALLY ADJUSTED NORMATIVE DATA AND STATISTICAL ANALYSIS OF NEUROPSYCHOLOGICAL TEST PERFORMANCE

2014 ◽  
Vol 10 ◽  
pp. P564-P565
Author(s):  
Nicole A. Kochan ◽  
John R. Crawford ◽  
Melissa Jane Slavin ◽  
Sarah Pont ◽  
Henry Brodaty ◽  
...  
Keyword(s):  
Older Adults ◽  
Statistical Analysis ◽  
Test Performance ◽  
Normative Data ◽  
Neuropsychological Test

Behavior Rating Inventory of Executive Function Adult Version in Patients with Neurological and Neuropsychiatric Conditions: Symptom Levels and Relationship to Emotional Distress

2016 ◽  
Vol 22 (6) ◽  
pp. 682-694 ◽  
Author(s):  
M. Løvstad ◽  
S. Sigurdardottir ◽  
S. Andersson ◽  
V.A. Grane ◽  
T. Moberget ◽  
...  
Keyword(s):  
Executive Function ◽  
Emotional Distress ◽  
Test Performance ◽  
Normative Data ◽  
Rating Scales ◽  
Neuropsychological Test ◽  
Behavior Rating ◽  
Behavior Rating Inventory ◽  
And Performance ◽  
The Relationship

AbstractObjectives:The present study explored the level of self-and informant reported executive functioning in daily living using the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) in a large sample comprising healthy adults and patient cohorts with neurological and neuropsychiatric disorders. The relationship to neuropsychological test performance and self-reported emotional distress was explored, as well as the applicability of U.S. normative data.Methods:Scores on the self- and informant reported BRIEF-A are presented, along with scores on standardized cognitive tests, and on rating scales of self-reported emotional distress in a Norwegian healthy comparison group (n=115), patients with severe traumatic brain injury (n=125), focal frontal lobe damage (n=29), focal cerebellar lesion (n=24), Parkinson’s disease (n=42), attention deficit hyperactivity disorder (n=34), type II bipolar disorder (n=21), and borderline personality disorder (n=18).Results:Strong associations were observed between the BRIEF-A and emotional distress in both the healthy group and in neurological groups, while no or weak relationships with IQ and performance-based tests of executive function were seen. The relationship between BRIEF-A and emotional distress was weaker in the neuropsychiatric patient groups, despite high symptom load in both domains. Healthy participants tended to have BRIEF-A scores 1/2–3/4SDbelow the U.S. normative mean ofTscore=50.Conclusions:The study demonstrates the need to interpret BRIEF-A results within a broad differential diagnostic context, where measures of psychological distress are included in addition to neuropsychological tests. Uncertainty about the appropriateness of U.S. normative data in non-U.S. countries adds to the need for interpretive caution. (JINS, 2016,22, 682–694)

scholarly journals Interactive effects of age and inflammation on change in ecologically-assessed cognitive functioning

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 705-706
Author(s):  
Christopher Engeland ◽  
Erik Knight ◽  
Martin Sliwinski ◽  
Jennifer Graham-Engeland
Keyword(s):  
Working Memory ◽  
Cognitive Functioning ◽  
Processing Speed ◽  
Cognitive Aging ◽  
Spatial Working Memory ◽  
Ex Vivo ◽  
Cognitive Testing ◽  
Interactive Effects ◽  
Test Accuracy ◽  
Age Related

Abstract Inflammation has been implicated as a precursor to steeper declines in age-associated cognitive decline. Here we investigated biomarkers of peripheral inflammation [basal cytokines, stimulated cytokines (ex vivo), C-reactive protein (CRP)] as moderators of age-related changes in cognitive functioning. As part of the Effects of Stress on Cognitive Aging, Physiology, and Emotion (ESCAPE) study, participants (N = 233; 65% female; 63% Black, 25% Hispanic; 25-65 years of age) completed up to four instances of ambulatory cognitive testing per day across two weeks, over three waves of annual assessments. After each 2-week ecological momentary assessment (EMA) burst, blood was collected and assayed for inflammatory biomarkers. Performance on spatial working memory (mean Euclidean distance errors), processing speed (mean symbol search reaction time), and working memory (n-back test accuracy) tasks were averaged across all instances within an EMA burst. CRP and age interactively predicted change in spatial working memory (B = 0.003, [0.000, 0.005], t(133.60) = 2.350, p = 0.020) such that higher CRP at older ages (~60 years) was associated with a loss of the expected practice effects across waves; at younger ages, CRP did not relate to change in spatial working memory. In a similar fashion, basal (B = -0.002, [-0.004, -0.000], t(103.26) = -2.399, p = 0.018) and stimulated cytokine levels (B = -0.002, [-0.004, -0.000], t(126.65) = -2.183, p = 0.031) interacted with age to predict change in processing speed across waves. These results indicate that inflammation may be critically associated with changes in cognitive functioning in older mid-life adults.

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