scholarly journals Assessment of bilateral knee pain from MR imaging using deep neural networks

2018 ◽  
Author(s):  
Gary H. Chang ◽  
David T. Felson ◽  
Shangran Qiu ◽  
Terence D. Capellini ◽  
Vijaya B. Kolachalama
Keyword(s):  
Machine Learning ◽  
Risk Factors ◽  
Neural Networks ◽  
Deep Learning ◽  
Knee Pain ◽  
Deep Neural Networks ◽  
Learning Approach ◽  
Mr Images ◽  
Bilateral Knee ◽  
Machine Learning Approach

ABSTRACTBackground and objectiveIt remains difficult to characterize pain in knee joints with osteoarthritis solely by radiographic findings. We sought to understand how advanced machine learning methods such as deep neural networks can be used to analyze raw MRI scans and predict bilateral knee pain, independent of other risk factors.MethodsWe developed a deep learning framework to associate information from MRI slices taken from the left and right knees of subjects from the Osteoarthritis Initiative with bilateral knee pain. Model training was performed by first extracting features from two-dimensional (2D) sagittal intermediate-weighted turbo spin echo slices. The extracted features from all the 2D slices were subsequently combined to directly associate using a fused deep neural network with the output of interest as a binary classification problem.ResultsThe deep learning model resulted in predicting bilateral knee pain on test data with 70.1% mean accuracy, 51.3% mean sensitivity, and 81.6% mean specificity. Systematic analysis of the predictions on the test data revealed that the model performance was consistent across subjects of different Kellgren-Lawrence grades.ConclusionThe study demonstrates a proof of principle that a machine learning approach can be applied to associate MR images with bilateral knee pain.SIGNIFICANCE AND INNOVATIONKnee pain is typically considered as an early indicator of osteoarthritis (OA) risk. Emerging evidence suggests that MRI changes are linked to pre-clinical OA, thus underscoring the need for building image-based models to predict knee pain. We leveraged a state-of-the-art machine learning approach to associate raw MR images with bilateral knee pain, independent of other risk factors.

scholarly journals Harnessing deep neural networks to solve inverse problems in quantum dynamics: machine-learned predictions of time-dependent optimal control fields

2020 ◽  
Vol 22 (40) ◽  
pp. 22889-22899
Author(s):  
Xian Wang ◽  
Anshuman Kumar ◽  
Christian R. Shelton ◽  
Bryan M. Wong
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Inverse Problem ◽  
Quantum Dynamics ◽  
Deep Neural Networks ◽  
Cost Effective ◽  
Quantum Systems ◽  
Time Dependent ◽  
Learning Approach ◽  
Machine Learning Approach

Deep neural networks are a cost-effective machine-learning approach for solving the inverse problem of constructing electromagnetic fields that enable desired transitions in quantum systems.

scholarly journals Discretization and machine learning approximation of BSDEs with a constraint on the Gains-process

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Idris Kharroubi ◽  
Thomas Lim ◽  
Xavier Warin
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Neural Networks ◽  
Differential Equations ◽  
Numerical Experiments ◽  
Optimization Problem ◽  
Learning Approach ◽  
The Neural Network ◽  
Machine Learning Approach ◽  
Mesh Grid

AbstractWe study the approximation of backward stochastic differential equations (BSDEs for short) with a constraint on the gains process. We first discretize the constraint by applying a so-called facelift operator at times of a grid. We show that this discretely constrained BSDE converges to the continuously constrained one as the mesh grid converges to zero. We then focus on the approximation of the discretely constrained BSDE. For that we adopt a machine learning approach. We show that the facelift can be approximated by an optimization problem over a class of neural networks under constraints on the neural network and its derivative. We then derive an algorithm converging to the discretely constrained BSDE as the number of neurons goes to infinity. We end by numerical experiments.

scholarly journals Representing Deep Neural Networks Latent Space Geometries with Graphs

Algorithms ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 39
Author(s):  
Carlos Lassance ◽  
Vincent Gripon ◽  
Antonio Ortega
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Deep Learning ◽  
Objective Function ◽  
Learning Process ◽  
Deep Neural Networks ◽  
State Of The Art ◽  
The Core ◽  
Learning Tasks ◽  
Latent Space

Deep Learning (DL) has attracted a lot of attention for its ability to reach state-of-the-art performance in many machine learning tasks. The core principle of DL methods consists of training composite architectures in an end-to-end fashion, where inputs are associated with outputs trained to optimize an objective function. Because of their compositional nature, DL architectures naturally exhibit several intermediate representations of the inputs, which belong to so-called latent spaces. When treated individually, these intermediate representations are most of the time unconstrained during the learning process, as it is unclear which properties should be favored. However, when processing a batch of inputs concurrently, the corresponding set of intermediate representations exhibit relations (what we call a geometry) on which desired properties can be sought. In this work, we show that it is possible to introduce constraints on these latent geometries to address various problems. In more detail, we propose to represent geometries by constructing similarity graphs from the intermediate representations obtained when processing a batch of inputs. By constraining these Latent Geometry Graphs (LGGs), we address the three following problems: (i) reproducing the behavior of a teacher architecture is achieved by mimicking its geometry, (ii) designing efficient embeddings for classification is achieved by targeting specific geometries, and (iii) robustness to deviations on inputs is achieved via enforcing smooth variation of geometry between consecutive latent spaces. Using standard vision benchmarks, we demonstrate the ability of the proposed geometry-based methods in solving the considered problems.

A Machine Learning Approach to Risk Factors: A Case Study Using the Fama–French–Carhart Model

2019 ◽  
Vol 1 (1) ◽  
pp. 32-44
Author(s):  
Joseph Simonian ◽  
Chenwei Wu ◽  
Daniel Itano ◽  
Vyshaal Narayanam
Keyword(s):  
Machine Learning ◽  
Risk Factors ◽  
Learning Approach ◽  
Machine Learning Approach

A Survey on Intrusion Detection System for Software Defined Networks (SDN)

2020 ◽  
Vol 16 (1) ◽  
pp. 28-47 ◽  
Author(s):  
Yogita Hande ◽  
Akkalashmi Muddana
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Intrusion Detection ◽  
Network Architecture ◽  
Detection System ◽  
Learning Approach ◽  
Distinctive Features ◽  
Detection Systems ◽  
Security Challenges ◽  
Machine Learning Approach

Presently, the advances of the internet towards a wide-spread growth and the static nature of traditional networks has limited capacity to cope with organizational business needs. The new network architecture software defined networking (SDN) appeared to address these challenges and provides distinctive features. However, these programmable and centralized approaches of SDN face new security challenges which demand innovative security mechanisms like intrusion detection systems (IDS's). The IDS of SDN are designed currently with a machine learning approach; however, a deep learning approach is also being explored to achieve better efficiency and accuracy. In this article, an overview of the SDN with its security concern and IDS as a security solution is explained. A survey of existing security solutions designed to secure the SDN, and a comparative study of various IDS approaches based on a deep learning model and machine learning methods are discussed in the article. Finally, we describe future directions for SDN security.

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