scholarly journals Modeling pupil responses to rapid sequential events

2019 ◽  
Author(s):  
Rachel N. Denison ◽  
Jacob A. Parker ◽  
Marisa Carrasco
Keyword(s):  
Pupil Size ◽  
Cognitive Task ◽  
Impulse Response Function ◽  
Parameter Estimates ◽  
Response Dynamics ◽  
Parameter Recovery ◽  
Pupil Response ◽  
Experimental Trial ◽  
Pupillary Responses ◽  
Model Fits

AbstractPupil size is an easily accessible, noninvasive online indicator of various perceptual and cognitive processes. Pupil measurements have the potential to reveal continuous processing dynamics throughout an experimental trial, including anticipatory responses. However, the relatively sluggish (∼2 s) response dynamics of pupil dilation make it challenging to connect changes in pupil size to events occurring close together in time. Researchers have used models to link changes in pupil size to specific trial events, but such methods have not been systematically evaluated. Here we developed and evaluated a general linear model (GLM) pipeline that estimates pupillary responses to multiple rapid events within an experimental trial. We evaluated the modeling approach using a sample dataset in which multiple sequential stimuli were presented within 2-s trials. We found: (1) Model fits improved when the pupil impulse response function (puRF) was fit for each observer. PuRFs varied substantially across individuals but were consistent for each individual. (2) Model fits also improved when pupil responses were not assumed to occur simultaneously with their associated trial events, but could have non-zero latencies. For example, pupil responses could anticipate predictable trial events. (3) Parameter recovery confirmed the validity of the fitting procedures, and we quantified the reliability of the parameter estimates for our sample dataset. (4) A cognitive task manipulation modulated pupil response amplitude. We provide our pupil analysis pipeline as open-source software (Pupil Response Estimation Toolbox: PRET) to facilitate the estimation of pupil responses and the evaluation of the estimates in other datasets.

Pupil Response: A Psychophysiological Measure of Fear during Analogue Desensitization,

1989 ◽  
Vol 69 (3-2) ◽  
pp. 1351-1367
Author(s):  
Robert S. Sturgeon ◽  
Leslie M. Cooper ◽  
Robert J. Howell
Keyword(s):  
Pupil Size ◽  
Pupillary Response ◽  
Pupil Response ◽  
Current Technology ◽  
Pupillary Responses

15 highly aroused snake phobics individually constructed fear hierarchies by selecting colored photographs of snakes. Subjects either imagined fear scenes based on their photographs or were exposed to duplicate projected slides during desensitization. Pupillary responses of the Slide Group were also recorded before, during, and after desensitization. Fear of snakes was significantly reduced for both groups within five or fewer desensitization sessions. Changes in pupil size of the Slide Group appear to reflect arousal of fear as well as reduction of fear after treatment. Current technology makes pupillary response a viable psychophysiological measure of fear.

Pupil Response: A Psychophysiological Measure of Fear during Analogue Desensitization

1989 ◽  
Vol 69 (3_suppl) ◽  
pp. 1351-1367 ◽  
Author(s):  
Robert S. Sturgeon ◽  
Leslie M. Cooper ◽  
Robert J. Howell
Keyword(s):  
Pupil Size ◽  
Pupillary Response ◽  
Pupil Response ◽  
Current Technology ◽  
Pupillary Responses

15 highly aroused snake phobics individually constructed fear hierarchies by selecting colored photographs of snakes. Subjects either imagined fear scenes based on their photographs or were exposed to duplicate projected slides during desensitization. Pupillary responses of the Slide Group were also recorded before, during, and after desensitization. Fear of snakes was significantly reduced for both groups within five or fewer desensitization sessions. Changes in pupil size of the Slide Group appear to reflect arousal of fear as well as reduction of fear after treatment. Current technology makes pupillary response a viable psychophysiological measure of fear.

scholarly journals Eye Movements in Response to Pain-Related Feelings in the Presence of Low and High Cognitive Loads

2020 ◽  
Vol 10 (5) ◽  
pp. 92
Author(s):  
Ramtin Zargari Marandi ◽  
Camilla Ann Fjelsted ◽  
Iris Hrustanovic ◽  
Rikke Dan Olesen ◽  
Parisa Gazerani
Keyword(s):  
Eye Movements ◽  
Cognitive Load ◽  
Eye Movement ◽  
Cognitive Processing ◽  
Pain Perception ◽  
Cognitive Task ◽  
Load Level ◽  
Task Load ◽  
Pupillary Responses ◽  
Movement Characteristics

The affective dimension of pain contributes to pain perception. Cognitive load may influence pain-related feelings. Eye tracking has proven useful for detecting cognitive load effects objectively by using relevant eye movement characteristics. In this study, we investigated whether eye movement characteristics differ in response to pain-related feelings in the presence of low and high cognitive loads. A set of validated, control, and pain-related sounds were applied to provoke pain-related feelings. Twelve healthy young participants (six females) performed a cognitive task at two load levels, once with the control and once with pain-related sounds in a randomized order. During the tasks, eye movements and task performance were recorded. Afterwards, the participants were asked to fill out questionnaires on their pain perception in response to the applied cognitive loads. Our findings indicate that an increased cognitive load was associated with a decreased saccade peak velocity, saccade frequency, and fixation frequency, as well as an increased fixation duration and pupil dilation range. Among the oculometrics, pain-related feelings were reflected only in the pupillary responses to a low cognitive load. The performance and perceived cognitive load decreased and increased, respectively, with the task load level and were not influenced by the pain-related sounds. Pain-related feelings were lower when performing the task compared with when no task was being performed in an independent group of participants. This might be due to the cognitive engagement during the task. This study demonstrated that cognitive processing could moderate the feelings associated with pain perception.

scholarly journals Listener’s personality traits predict changes in pupil size during auditory language comprehension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Isabell Hubert Lyall ◽  
Juhani Järvikivi
Keyword(s):  
Personality Traits ◽  
Language Processing ◽  
Language Comprehension ◽  
Pupil Size ◽  
Pupil Dilation ◽  
Systematic Research ◽  
Cognitive Resources ◽  
Personality Profiles ◽  
Pupillary Responses ◽  
Grammatical Errors

AbstractResearch suggests that listeners’ comprehension of spoken language is concurrently affected by linguistic and non-linguistic factors, including individual difference factors. However, there is no systematic research on whether general personality traits affect language processing. We correlated 88 native English-speaking participants’ Big-5 traits with their pupillary responses to spoken sentences that included grammatical errors, "He frequently have burgers for dinner"; semantic anomalies, "Dogs sometimes chase teas"; and statements incongruent with gender stereotyped expectations, such as "I sometimes buy my bras at Hudson's Bay", spoken by a male speaker. Generalized additive mixed models showed that the listener's Openness, Extraversion, Agreeableness, and Neuroticism traits modulated resource allocation to the three different types of unexpected stimuli. No personality trait affected changes in pupil size across the board: less open participants showed greater pupil dilation when processing sentences with grammatical errors; and more introverted listeners showed greater pupil dilation in response to both semantic anomalies and socio-cultural clashes. Our study is the first one demonstrating that personality traits systematically modulate listeners’ online language processing. Our results suggest that individuals with different personality profiles exhibit different patterns of the allocation of cognitive resources during real-time language comprehension.

Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation

2003 ◽  
Vol 285 (4) ◽  
pp. G671-G680 ◽  
Author(s):  
Ole L. Munk ◽  
Susanne Keiding ◽  
Ludvik Bass
Keyword(s):  
Portal Vein ◽  
Impulse Response ◽  
Response Function ◽  
Mean Transit Time ◽  
Impulse Response Function ◽  
Parameter Estimates ◽  
Time Activity ◽  
Time Activity Curve ◽  
Transit Times ◽  
Activity Curve

Modeling physiological processes using tracer kinetic methods requires knowledge of the time course of the tracer concentration in blood supplying the organ. For liver studies, however, inaccessibility of the portal vein makes direct measurement of the hepatic dual-input function impossible in humans. We want to develop a method to predict the portal venous time-activity curve from measurements of an arterial time-activity curve. An impulse-response function based on a continuous distribution of washout constants is developed and validated for the gut. Experiments with simultaneous blood sampling in aorta and portal vein were made in 13 anesthetized pigs following inhalation of intravascular [15O]CO or injections of diffusible 3- O-[11C]methylglucose (MG). The parameters of the impulse-response function have a physiological interpretation in terms of the distribution of washout constants and are mathematically equivalent to the mean transit time ( T̄) and standard deviation of transit times. The results include estimates of mean transit times from the aorta to the portal vein in pigs: T̄ = 0.35 ± 0.05 min for CO and 1.7 ± 0.1 min for MG. The prediction of the portal venous time-activity curve benefits from constraining the regression fits by parameters estimated independently. This is strong evidence for the physiological relevance of the impulse-response function, which includes asymptotically, and thereby justifies kinetically, a useful and simple power law. Similarity between our parameter estimates in pigs and parameter estimates in normal humans suggests that the proposed model can be adapted for use in humans.

scholarly journals Is Pupil Activity Associated With the Strength of Memory Signal for Words in a Continuous Recognition Memory Paradigm?

2021 ◽  
Vol 12 ◽  
Author(s):  
Jorge Oliveira ◽  
Marta Fernandes ◽  
Pedro J. Rosa ◽  
Pedro Gamito
Keyword(s):  
Retention Interval ◽  
Recognition Memory ◽  
Pupil Size ◽  
Time Course ◽  
Recognition Performance ◽  
Recognition Task ◽  
Subjective Feeling ◽  
Consistent Finding ◽  
Pupillary Responses ◽  
Study Test

Research on pupillometry provides an increasing evidence for associations between pupil activity and memory processing. The most consistent finding is related to an increase in pupil size for old items compared with novel items, suggesting that pupil activity is associated with the strength of memory signal. However, the time course of these changes is not completely known, specifically, when items are presented in a running recognition task maximizing interference by requiring the recognition of the most recent items from a sequence of old/new items. The sample comprised 42 healthy participants who performed a visual word recognition task under varying conditions of retention interval. Recognition responses were evaluated using behavioral variables for discrimination accuracy, reaction time, and confidence in recognition decisions. Pupil activity was recorded continuously during the entire experiment. The results suggest a decrease in recognition performance with increasing study-test retention interval. Pupil size decreased across retention intervals, while pupil old/new effects were found only for words recognized at the shortest retention interval. Pupillary responses consisted of a pronounced early pupil constriction at retrieval under longer study-test lags corresponding to weaker memory signals. However, the pupil size was also sensitive to the subjective feeling of familiarity as shown by pupil dilation to false alarms (new items judged as old). These results suggest that the pupil size is related not only to the strength of memory signal but also to subjective familiarity decisions in a continuous recognition memory paradigm.

scholarly journals Differential Effects of Low-Dose Alcohol versus Acute Sleep Deprivation on Light-Evoked Pupil Response Dynamics

2019 ◽  
Vol 19 (10) ◽  
pp. 73a
Author(s):  
Terence L. Tyson ◽  
Nathan H. Feick ◽  
Patrick F. Cravalho ◽  
Erin E. Flynn-Evans ◽  
Leland S. Stone
Keyword(s):  
Sleep Deprivation ◽  
Low Dose ◽  
Response Dynamics ◽  
Pupil Response ◽  
Differential Effects ◽  
Acute Sleep Deprivation

Detecting Noneffortful Responses Based on a Residual Method Using an Iterative Purification Process

2021 ◽  
pp. 107699862199436
Author(s):  
Yue Liu ◽  
Hongyun Liu
Keyword(s):  
True Positive Rate ◽  
Item Parameter ◽  
Parameter Estimates ◽  
Detection Accuracy ◽  
Purification Process ◽  
Parameter Recovery ◽  
Residual Method ◽  
Data Contamination ◽  
Item Parameters ◽  
The Impact

The prevalence and serious consequences of noneffortful responses from unmotivated examinees are well-known in educational measurement. In this study, we propose to apply an iterative purification process based on a response time residual method with fixed item parameter estimates to detect noneffortful responses. The proposed method is compared with the traditional residual method and noniterative method with fixed item parameters in two simulation studies in terms of noneffort detection accuracy and parameter recovery. The results show that when severity of noneffort is high, the proposed method leads to a much higher true positive rate with a small increase of false discovery rate. In addition, parameter estimation is significantly improved by the strategies of fixing item parameters and iteratively cleansing. These results suggest that the proposed method is a potential solution to reduce the impact of data contamination due to severe low test-taking effort and to obtain more accurate parameter estimates. An empirical study is also conducted to show the differences in the detection rate and parameter estimates among different approaches.

scholarly journals Factors Influencing Saccadic Reaction Time: Effect of Task Modality, Stimulus Saliency, Spatial Congruency of Stimuli, and Pupil Size

2020 ◽  
Vol 14 ◽  
Author(s):  
Shimpei Yamagishi ◽  
Shigeto Furukawa
Keyword(s):  
Reaction Time ◽  
Locus Coeruleus ◽  
Pupil Size ◽  
Visual Target ◽  
Cognitive Task ◽  
Saccadic Reaction Time ◽  
Auditory Target ◽  
Target Condition ◽  
Related Factors ◽  
Stimulus Saliency

It is often assumed that the reaction time of a saccade toward visual and/or auditory stimuli reflects the sensitivities of our oculomotor-orienting system to stimulus saliency. Endogenous factors, as well as stimulus-related factors, would also affect the saccadic reaction time (SRT). However, it was not clear how these factors interact and to what extent visual and auditory-targeting saccades are accounted for by common mechanisms. The present study examined the effect of, and the interaction between, stimulus saliency and audiovisual spatial congruency on the SRT for visual- and for auditory-target conditions. We also analyzed pre-target pupil size to examine the relationship between saccade preparation and pupil size. Pupil size is considered to reflect arousal states coupling with locus-coeruleus (LC) activity during a cognitive task. The main findings were that (1) the pattern of the examined effects on the SRT varied between visual- and auditory-auditory target conditions, (2) the effect of stimulus saliency was significant for the visual-target condition, but not significant for the auditory-target condition, (3) Pupil velocity, not absolute pupil size, was sensitive to task set (i.e., visual-targeting saccade vs. auditory-targeting saccade), and (4) there was a significant correlation between the pre-saccade absolute pupil size and the SRTs for the visual-target condition but not for the auditory-target condition. The discrepancy between target modalities for the effect of pupil velocity and between the absolute pupil size and pupil velocity for the correlation with SRT may imply that the pupil effect for the visual-target condition was caused by a modality-specific link between pupil size modulation and the SC rather than by the LC-NE (locus coeruleus-norepinephrine) system. These results support the idea that different threshold mechanisms in the SC may be involved in the initiation of saccades toward visual and auditory targets.

Anticipation and Stuttering: A Pupillographic Study

1969 ◽  
Vol 12 (4) ◽  
pp. 833-839 ◽  
Author(s):  
Kenneth C. Gray ◽  
Dean E. Williams
Keyword(s):  
Auditory Stimulus ◽  
Pupil Size ◽  
Free Association ◽  
Pupil Dilation ◽  
Auditory Stimuli ◽  
Physiological Changes ◽  
Single Word ◽  
Pupil Response ◽  
Association Response ◽  
Pupil Reaction

Changes in pupil size were studied in 24 stuttering and 30 nonstuttering adults during a 4-sec period following the presentation of single-word auditory stimuli and before a signal to respond. Subjects were required first to respond with a single word which was the opposite of the word presented and later to give a one-word free-association response to words of both emotional and neutral connotations. Pupil size was measured also while subjects merely listened to the word stimuli. The process of attending to an auditory stimulus was associated with pupil dilation. Pupil response was significantly greater (in absolute diameter and in dilation) when subjects were required to give an oral response to the stimulus than when they simply listened to the stimulus. Furthermore, the extent of the pupil reaction was related to the nature of the stimulus presented. Such differences in arousal did not occur to any greater degree in stutterers than in nonstutterers. Moreover, among stutterers, measures of pupil size were not predictive of stuttering. Thus, the cues which the stutterer associates with the anticipation of stuttering do not appear to be reflected in the physiological changes associated with pupillary movement.

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