scholarly journals Discovering precise temporal patterns in large-scale neural recordings through robust and interpretable time warping

2019 ◽  
Author(s):  
Alex H. Williams ◽  
Ben Poole ◽  
Niru Maheswaranathan ◽  
Ashesh K. Dhawale ◽  
Tucker Fisher ◽  
...  
Keyword(s):  
Large Scale ◽  
General Purpose ◽  
Spike Time ◽  
Time Warping ◽  
Motor Sequence ◽  
Temporal Precision ◽  
Neural Recordings ◽  
Sequence Production ◽  
Time Patterns

AbstractThough the temporal precision of neural computation has been studied intensively, a data-driven determination of this precision remains a fundamental challenge. Reproducible spike time patterns may be obscured on single trials by uncontrolled temporal variability in behavior and cognition, or may not even be time locked to measurable signatures in either behavior or local field potentials (LFP). To overcome these challenges, we describe a general-purpose time warping framework that reveals precise spike-time patterns in an unsupervised manner, even when spiking is decoupled from behavior or is temporally stretched across single trials. We demonstrate this method across diverse systems: cued reaching in nonhuman primates, motor sequence production in rats, and olfaction in mice. This approach flexibly uncovers diverse dynamical firing patterns, including pulsatile responses to behavioral events, LFP-aligned oscillatory spiking, and even unanticipated patterns, like 7 Hz oscillations in rat motor cortex that are not time-locked to measured behaviors or LFP.

scholarly journals Discovering Precise Temporal Patterns in Large-Scale Neural Recordings through Robust and Interpretable Time Warping

Neuron ◽  
2020 ◽  
Vol 105 (2) ◽  
pp. 246-259.e8 ◽  
Author(s):  
Alex H. Williams ◽  
Ben Poole ◽  
Niru Maheswaranathan ◽  
Ashesh K. Dhawale ◽  
Tucker Fisher ◽  
...  
Keyword(s):  
Large Scale ◽  
Temporal Patterns ◽  
Time Warping ◽  
Neural Recordings

scholarly journals Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Lyle Muller ◽  
Giovanni Piantoni ◽  
Dominik Koller ◽  
Sydney S Cash ◽  
Eric Halgren ◽  
...  
Keyword(s):  
Large Scale ◽  
Activity Patterns ◽  
Neural Mechanism ◽  
Sleep Spindles ◽  
Sleep Spindle ◽  
Spike Time ◽  
Temporal Precision ◽  
Global Patterns ◽  
Spike Time Dependent Plasticity ◽  
Large Scale Networks

During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories.

Large-scale Motion of Solar Filaments

2000 ◽  
Vol 179 ◽  
pp. 205-208
Author(s):  
Pavel Ambrož ◽  
Alfred Schroll
Keyword(s):  
Magnetic Flux ◽  
Proper Motion ◽  
Time Scale ◽  
Large Scale ◽  
Accuracy Of Measurements ◽  
Solar Filaments ◽  
General Movement ◽  
Scale Motion ◽  
Velocity Scatter

AbstractPrecise measurements of heliographic position of solar filaments were used for determination of the proper motion of solar filaments on the time-scale of days. The filaments have a tendency to make a shaking or waving of the external structure and to make a general movement of whole filament body, coinciding with the transport of the magnetic flux in the photosphere. The velocity scatter of individual measured points is about one order higher than the accuracy of measurements.

Evidence for chunking vs. statistical learning in motor sequence production

2018 ◽  
Author(s):  
Nicola J. Popp ◽  
Neda Kordjaz ◽  
Paul Gribble ◽  
Jörn Diedrichsen
Keyword(s):  
Statistical Learning ◽  
Motor Sequence ◽  
Sequence Production

Methods for the Quantification of Salivary Cortisol and of a-amylase in Biosensors and Portable Devices

2018 ◽  
Vol 68 (12) ◽  
pp. 2857-2859
Author(s):  
Cristina Mihaela Ghiciuc ◽  
Andreea Silvana Szalontay ◽  
Luminita Radulescu ◽  
Sebastian Cozma ◽  
Catalina Elena Lupusoru ◽  
...  
Keyword(s):  
Real Time ◽  
Medical Practice ◽  
Salivary Cortisol ◽  
Clinical Studies ◽  
Large Scale ◽  
Psychological Research ◽  
Portable Devices ◽  
Salivary Amylase ◽  
Specificity And Sensitivity

There is an increasing interest in the analysis of salivary biomarkers for medical practice. The objective of this article was to identify the specificity and sensitivity of quantification methods used in biosensors or portable devices for the determination of salivary cortisol and salivary a-amylase. There are no biosensors and portable devices for salivary amylase and cortisol that are used on a large scale in clinical studies. These devices would be useful in assessing more real-time psychological research in the future.

Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform

2019 ◽  
Vol 22 (5) ◽  
pp. 346-354
Author(s):  
Yan A. Ivanenkov ◽  
Renat S. Yamidanov ◽  
Ilya A. Osterman ◽  
Petr V. Sergiev ◽  
Vladimir A. Aladinskiy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Large Scale ◽  
Underlying Mechanism ◽  
Luciferase Assay ◽  
Reporter System ◽  
E Coli ◽  
Starting Point ◽  
High Concentrations ◽  
Mic Value

Aim and Objective: Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. Materials and Methods: Using our unique double-reporter system, in-house large-scale HTS campaign was conducted for the identification of antibacterial potency of small-molecule compounds. The construction allows us to visually assess the underlying mechanism of action. After the initial HTS and rescreen procedure, luciferase assay, C14-test, determination of MIC value and PrestoBlue test were carried out. Results: HTS rounds and rescreen campaign have revealed the antibacterial activity of a series of Nsubstituted triazolo-azetidines and their isosteric derivatives that has not been reported previously. Primary hit-molecule demonstrated a MIC value of 12.5 µg/mL against E. coli Δ tolC with signs of translation blockage and no SOS-response. Translation inhibition (26%, luciferase assay) was achieved at high concentrations up to 160 µg/mL, while no activity was found using C14-test. The compound did not demonstrate cytotoxicity in the PrestoBlue assay against a panel of eukaryotic cells. Within a series of direct structural analogues bearing the same or bioisosteric scaffold, compound 2 was found to have an improved antibacterial potency (MIC=6.25 µg/mL) close to Erythromycin (MIC=2.5-5 µg/mL) against the same strain. In contrast to the parent hit, this compound was more active and selective, and provided a robust IP position. Conclusion: N-substituted triazolo-azetidine scaffold may be used as a versatile starting point for the development of novel active and selective antibacterial compounds.

Research on highly parallel embedded control system design and implementation method

Impact ◽  
2019 ◽  
Vol 2019 (10) ◽  
pp. 44-46
Author(s):  
Masato Edahiro ◽  
Masaki Gondo
Keyword(s):  
Computer Architecture ◽  
Intelligent Systems ◽  
Large Scale ◽  
General Purpose ◽  
Heterogeneous Structure ◽  
Single Chip ◽  
Powertrain Control ◽  
Processing Power ◽  
Hardware Description ◽  
Many Core

The pace of technology's advancements is ever-increasing and intelligent systems, such as those found in robots and vehicles, have become larger and more complex. These intelligent systems have a heterogeneous structure, comprising a mixture of modules such as artificial intelligence (AI) and powertrain control modules that facilitate large-scale numerical calculation and real-time periodic processing functions. Information technology expert Professor Masato Edahiro, from the Graduate School of Informatics at the Nagoya University in Japan, explains that concurrent advances in semiconductor research have led to the miniaturisation of semiconductors, allowing a greater number of processors to be mounted on a single chip, increasing potential processing power. 'In addition to general-purpose processors such as CPUs, a mixture of multiple types of accelerators such as GPGPU and FPGA has evolved, producing a more complex and heterogeneous computer architecture,' he says. Edahiro and his partners have been working on the eMBP, a model-based parallelizer (MBP) that offers a mapping system as an efficient way of automatically generating parallel code for multi- and many-core systems. This ensures that once the hardware description is written, eMBP can bridge the gap between software and hardware to ensure that not only is an efficient ecosystem achieved for hardware vendors, but the need for different software vendors to adapt code for their particular platforms is also eliminated.

Microcomputers in Political Science

1983 ◽  
Vol 38 ◽  
pp. 1-9
Author(s):  
Herbert F. Weisberg
Keyword(s):  
Data Analysis ◽  
Political Science ◽  
Large Scale ◽  
Turnaround Time ◽  
General Purpose ◽  
Batch Mode ◽  
New Era ◽  
Large Scale Data ◽  
The Social ◽  
Frequency Counts

We are now entering a new era of computing in political science. The first era was marked by punched-card technology. Initially, the most sophisticated analyses possible were frequency counts and tables produced on a counter-sorter, a machine that specialized in chewing up data cards. By the early 1960s, batch processing on large mainframe computers became the predominant mode of data analysis, with turnaround time of up to a week. By the late 1960s, turnaround time was cut down to a matter of a few minutes and OSIRIS and then SPSS (and more recently SAS) were developed as general-purpose data analysis packages for the social sciences. Even today, use of these packages in batch mode remains one of the most efficient means of processing large-scale data analysis.

scholarly journals An information theoretic approach to link prediction in multiplex networks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seyed Hossein Jafari ◽  
Amir Mahdi Abdolhosseini-Qomi ◽  
Masoud Asadpour ◽  
Maseud Rahgozar ◽  
Naser Yazdani
Keyword(s):  
Real World ◽  
Link Prediction ◽  
Large Scale ◽  
Similarity Measures ◽  
Prediction Method ◽  
General Purpose ◽  
Fast Method ◽  
Theoretic Approach ◽  
Multiplex Networks ◽  
Wide Range

AbstractThe entities of real-world networks are connected via different types of connections (i.e., layers). The task of link prediction in multiplex networks is about finding missing connections based on both intra-layer and inter-layer correlations. Our observations confirm that in a wide range of real-world multiplex networks, from social to biological and technological, a positive correlation exists between connection probability in one layer and similarity in other layers. Accordingly, a similarity-based automatic general-purpose multiplex link prediction method—SimBins—is devised that quantifies the amount of connection uncertainty based on observed inter-layer correlations in a multiplex network. Moreover, SimBins enhances the prediction quality in the target layer by incorporating the effect of link overlap across layers. Applying SimBins to various datasets from diverse domains, our findings indicate that SimBins outperforms the compared methods (both baseline and state-of-the-art methods) in most instances when predicting links. Furthermore, it is discussed that SimBins imposes minor computational overhead to the base similarity measures making it a potentially fast method, suitable for large-scale multiplex networks.

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