Methods for the Quantification of Salivary Cortisol and of a-amylase in Biosensors and Portable Devices

2018 ◽  
Vol 68 (12) ◽  
pp. 2857-2859
Author(s):  
Cristina Mihaela Ghiciuc ◽  
Andreea Silvana Szalontay ◽  
Luminita Radulescu ◽  
Sebastian Cozma ◽  
Catalina Elena Lupusoru ◽  
...  

There is an increasing interest in the analysis of salivary biomarkers for medical practice. The objective of this article was to identify the specificity and sensitivity of quantification methods used in biosensors or portable devices for the determination of salivary cortisol and salivary a-amylase. There are no biosensors and portable devices for salivary amylase and cortisol that are used on a large scale in clinical studies. These devices would be useful in assessing more real-time psychological research in the future.

Author(s):  
Henry Schultz ◽  
John Alexander ◽  
Jim Petersen ◽  
Thomas Hartmann ◽  
Doug Overland ◽  
...  

Automation of large-scale compound storage, biological and chemical assays, and many other biopharmaceutical R&D processes have prompted the need for immediate and regular determination of equipment performance levels. The Automatic Metric Monitoring Program (AMMP) in Amgen Research is designed to fill this need. Standardized tests are performed at regular intervals with results instantaneously retrieved, analyzed, and stored in a database. Critical information is automatically tracked using control charts allowing immediate notification via e-mail alerts when problems or nonconforming performance is discovered. System usage and errors are automatically compiled with tabulated results provided at regular intervals and e-mail alarms issued for nonconforming operation. AMMP now provides researchers with needed real-time feedback on the performance of their automation systems.


2020 ◽  
Author(s):  
Daniel Carreres-Prieto ◽  
Fernando Cerdán-Cartagena ◽  
Juan Suardiaz-Muro ◽  
Andrés Cabrera-Lozoya

BACKGROUND Constant monitoring of the heart’s state is essential for the early detection of pathologies. In the past, this analysis could only be carried out in hospitals, using sophisticated equipment handled by qualified staff. Today there is a wide range of portable monitoring devices (Holters) on the market but with a set of drawbacks (low number of leads supported and their low signal quality among others) that make it difficult to consider them as a viable replacement for the equipment used in medical practice OBJECTIVE This article describes the process of designing and implementing a Smart Holter able to record up to six leads at the same time, providing a signal quality comparable to the equipment used in medical practice, but with the dimensions, consumption and ease of use of portable devices. We also describe the workings of the expert algorithm for detecting cardiac anomalies in real time monitoring, which is embedded in the device itself, and which is capable of detecting tachycardia, bradycardia, ischemia and atrial fibrillation episodes with a high success rate. METHODS The hardware developed, performs the acquisition of 6 leads simultaneously, with a signal quality comparable to that of equipment used in medical practice. Each of the signals are processed by the algorithm described in this paper. This algorithm decomposes each lead into each heartbeat and extracts each of the segments that compose it (QRS complex) as well as a series of additional parameters. Based on the duration, amplitude and different thresholds, the system is able to detect with a high success rate, the existence of a certain cardiac pathology. RESULTS Performance evaluation shows the capacity of the Smart Holter devised to offer a high quality signal that combined with an embedded expert algorithm is capable of detecting tachycardia, bradycardia, ischemia and atrial fibrillation episodes in real time with a high success rate. CONCLUSIONS Development presented in this paper offers better characteristics, because it resolves a wide range of drawbacks inherent in that type of portable medical equipment, mainly in terms of signal quality. One aspect to highlight is the improvement in noise immunity of the equipment. Although it is not possible to compensate large artefacts produced while playing sports, which still remains a challenge for current monitoring systems, an important step has been taken in the right direction to achieve even greater attenuation in the future, through the use of dynamic filtering systems controlled digitally, unlike the systems currently present on the market.


2000 ◽  
Vol 179 ◽  
pp. 205-208
Author(s):  
Pavel Ambrož ◽  
Alfred Schroll

AbstractPrecise measurements of heliographic position of solar filaments were used for determination of the proper motion of solar filaments on the time-scale of days. The filaments have a tendency to make a shaking or waving of the external structure and to make a general movement of whole filament body, coinciding with the transport of the magnetic flux in the photosphere. The velocity scatter of individual measured points is about one order higher than the accuracy of measurements.


2014 ◽  
Vol 25 (4) ◽  
pp. 279-287 ◽  
Author(s):  
Stefan Hey ◽  
Panagiota Anastasopoulou ◽  
André Bideaux ◽  
Wilhelm Stork

Ambulatory assessment of emotional states as well as psychophysiological, cognitive and behavioral reactions constitutes an approach, which is increasingly being used in psychological research. Due to new developments in the field of information and communication technologies and an improved application of mobile physiological sensors, various new systems have been introduced. Methods of experience sampling allow to assess dynamic changes of subjective evaluations in real time and new sensor technologies permit a measurement of physiological responses. In addition, new technologies facilitate the interactive assessment of subjective, physiological, and behavioral data in real-time. Here, we describe these recent developments from the perspective of engineering science and discuss potential applications in the field of neuropsychology.


INFO ARTHA ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 17-34
Author(s):  
Fadlil Usman

Probity audit is an independence assessment activity to ensure the goods/services procurement processes have been implemented consistently appropriate with the principle of upholding integrity, uprightness, honesty and fulfill certain occur legislation aimed for improving the accountability for the use of public sector fund. Probity audit is done in real time simultaneously with the goods/services procurement process. This study aims to evaluate the suitability of the implementation of probity audit conducted by BPKP Headquarter as agency that initiated the implementation of probity audit in Indonesia compared with the Probity audit Guidelines for Procurement of Goods/Services as criteria. The results of this study indicate that the implementation of probity audit conducted by BPKP Headquarter has been implemented adequately, but there are activities that do not fit the criteria, especially in the activities of the determination of the scope of the audit, the preparation of working papers and the follow-up monitoring of the audit results. Probity audit merupakan kegiatan penilaian (independen) untuk memastikan bahwa proses pengadaan barang/jasa telah dilaksanakan secara konsisten sesuai dengan prinsip penegakan integritas, kebenaran, kejujuran dan memenuhi ketentuan perundangan yang berlaku yang bertujuan meningkatkan akuntabilitas penggunaan dana sektor publik. Probity audit dilakukan secara real time yaitu bersamaan dengan pelaksanaan pengadaan barang/jasa. Penelitian ini bertujuan untuk melakukan evaluasi kesesuaian pelaksanaan probity audit yang dilakukan oleh BPKP Pusat selaku instansi yang menginisiasi pelaksanaan probity audit di Indonesia dibandingkan dengan kriteria berupa Pedoman Probity audit Pengadaan Barang/Jasa Pemerintah. Hasil dari penelitian ini menunjukkan bahwa pelaksanaan probity audit yang dilakukan oleh BPKP Pusat sudah dilaksanakan secara memadai, namun masih terdapat hal yang belum sesuai dengan kriteria terutama dalam kegiatan penentuan ruang lingkup audit, penyusunan kertas kerja dan pemantauan terhadap tindak lanjut hasil audit.


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