scholarly journals Alcohol preferring P rats exhibit aversion resistant drinking of alcohol adulterated with quinine

2019 ◽  
Author(s):  
Nicholas M. Timme ◽  
David Linsenbardt ◽  
Maureen Timm ◽  
Taylor Galbari ◽  
Ethan Cornwell ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Genetic Risk ◽  
Alcohol Use Disorder ◽  
Home Cage ◽  
Bitter Taste ◽  
Negative Consequences ◽  
Excessive Drinking ◽  
Alcohol Access ◽  
Future Work ◽  
Quinine Solution

AbstractUnderstanding why some people continue to drink alcohol despite negative consequences and others do not is a central problem in the study of alcohol use disorder (AUD). In this study, we used alcohol preferring P rats (a strain bred to prefer to drink alcohol, a model for genetic risk for AUD) and Wistars (control) to examine drinking despite negative consequences in the form of an aversive bitter taste stimuli produced by quinine. Animals were trained to consume 10% ethanol in a simple Pavlovian conditioning task that paired alcohol access with an auditory stimulus. When the alcohol was adulterated with quinine (0.1 g/L), P rats continued to consume alcohol+quinine at the same rate as unadulterated alcohol, despite a demonstrated aversion to quinine adulterated alcohol when given a choice between adulterated and unadulterated alcohol in the home cage. Conversely, Wistars decreased consumption of quinine adulterated alcohol in the task, but continued to try the alcohol+quinine solution at similar rates to unadulterated alcohol. These results indicate that following about 8 weeks of alcohol consumption P rats exhibit aversion resistant drinking. This model could be used in future work to explore how biological basis of alcohol consumption and genetic risk for excessive drinking lead to drinking that is resistant to devaluation.

Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking

2021 ◽  
Author(s):  
Emanuela De Falco ◽  
Shelby M. White ◽  
Mitchell D. Morningstar ◽  
Baofeng Ma ◽  
Lionnel T. Nkurunziza ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cognitive Flexibility ◽  
Rodent Models ◽  
Excessive Drinking

Nalmefene against alcohol use disorder: A report of one case

2017 ◽  
Vol 41 (S1) ◽  
pp. s866-s866
Author(s):  
M. Juncal Ruiz ◽  
O. Porta Olivares ◽  
L. Sánchez Blanco ◽  
R. Landera Rodríguez ◽  
M. Gómez Revuelta ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Opioid Receptor ◽  
Treatment Option ◽  
Withdrawal Syndrome ◽  
Alcohol Use Disorder ◽  
Alcohol Intake ◽  
Family Relationship ◽  
Heavy Drinking ◽  
Alcohol Withdrawal Syndrome

IntroductionAlcohol consumption represents a significant factor for mortality in the world: 6.3% in men and 1.1% in women. Alcohol use disorder is also very common: 5.4% in men and 1.5% in women. Despite its high frequency and the seriousness of this disorder, only 8% of all alcohol-dependents are ever treated. One potentially interesting treatment option is oriented toward reducing alcohol intake.AimsTo describe one case who has improved his alcohol consumption after starting treatment with nalmefene, an opioid receptor antagonist related to naltrexone.MethodsA 35-year-old male with alcohol use disorder since 2001 came to our consult in November 2015. He was in trouble with his family and he had a liver failure. We offer a new treatment option with nalmefene 18 mg to reduce alcohol consumption.ResultsBefore to start nalmefene he drank 21 drinks/week. Six-month later, he decreased alcohol intake until 5 drinks/week with better family relationship and liver function. After starting nalmefene he complained of nausea, so we recommend to take the middle of the pill for next 7 days. After this time he returned to take one pill with good tolerance and no more side effects or withdrawal syndrome.ConclusionsNalmefene appears to be effective and safe in reducing heavy drinking and in preventing alcohol withdrawal syndrome due to its opioid receptor antagonism. This case suggests nalmefene is a potential option to help patients, who do not want or cannot get the abstinence, in reducing their alcohol consumption.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Towards the characterization and validation of alcohol use disorder subtypes: integrating consumption and symptom data

2013 ◽  
Vol 44 (1) ◽  
pp. 143-159 ◽  
Author(s):  
K. M. Jackson ◽  
K. K. Bucholz ◽  
P. K. Wood ◽  
D. Steinley ◽  
J. D. Grant ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Model Comparison ◽  
Latent Class ◽  
Common Factor ◽  
Hybrid Approaches ◽  
Epidemiologic Survey ◽  
Alcohol Involvement ◽  
Best Fitting

BackgroundThere is evidence that measures of alcohol consumption, dependence and abuse are valid indicators of qualitatively different subtypes of alcohol involvement yet also fall along a continuum. The present study attempts to resolve the extent to which variations in alcohol involvement reflect a difference in kindversusa difference in degree.MethodData were taken from the 2001–2002 National Epidemiologic Survey of Alcohol and Related Conditions. The sample (51% male; 72% white/non-Hispanic) included respondents reporting past 12-month drinking at both waves (wave 1:n = 33644; wave 2:n = 25186). We compared factor mixture models (FMMs), a hybrid of common factor analysis (FA) and latent class analysis (LCA), against FA and LCA models using past 12-month alcohol use disorder (AUD) criteria and five indicators of alcohol consumption reflecting frequency and heaviness of drinking.ResultsModel comparison revealed that the best-fitting model at wave 1 was a one-factor four-class FMM, with classes primarily varying across dependence and consumption indices. The model was replicated using wave 2 data, and validated against AUD and dependence diagnoses. Class stability from waves 1 to 2 was moderate, with greatest agreement for the infrequent drinking class. Within-class associations in the underlying latent factor also revealed modest agreement over time.ConclusionsThere is evidence that alcohol involvement can be considered both categorical and continuous, with responses reduced to four patterns that quantitatively vary along a single dimension. Nosologists may consider hybrid approaches involving groups that vary in pattern of consumption and dependence symptomatology as well as variation of severity within group.

scholarly journals A potential sex dimorphism in the relationship between bitter taste and alcohol consumption

2017 ◽  
Vol 8 (3) ◽  
pp. 1116-1123 ◽  
Author(s):  
Emma Louise Beckett ◽  
Konsta Duesing ◽  
Lyndell Boyd ◽  
Zoe Yates ◽  
Martin Veysey ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Bitter Taste ◽  
Disease Risk ◽  
Specific Interactions ◽  
Sex Dimorphism ◽  
Taste Phenotype ◽  
The Relationship

Sex-specific interactions between bitter taste phenotype, TAS2R38 genotype and alcohol intake may explain variance is previous studies, and may have implications for disease risk.

scholarly journals Alcohol consumption and telomere length: observational and Mendelian randomization approaches

2021 ◽  
Author(s):  
Anya Topiwala ◽  
Bernd Taschler ◽  
Klaus P Ebmeier ◽  
Steve Smith ◽  
Hang Zhou ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Telomere Length ◽  
Alcohol Use Disorder ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Prevention Strategies ◽  
Genome Wide ◽  
Non Linear ◽  
Alcoholic Drinks ◽  
Potential Threshold

Alcohols impact on telomere length, a proposed marker of biological age, is unclear. We performed the largest observational study to date and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from a recent genome-wide association study (GWAS) of telomere length. Genetic variants were selected on the basis of associations with alcohol consumption and alcohol use disorder (AUD). Non-linear MR employed UK Biobank individual data. MR analyses suggest a causal relationship between alcohol and telomere length: both genetically predicted alcohol traits were inversely associated with telomere length. 1 S.D. higher genetically-predicted log-transformed alcoholic drinks weekly had a -0.07 S.D. effect on telomere length (95% confidence interval [CI]:-0.14 to -0.01); genetically-predicted AUD -0.06 S.D. effect (CI:-0.10 to -0.02). Results were consistent across methods and independent from smoking. Non-linear analyses indicated a potential threshold relationship between alcohol and telomere length. Our findings have implications for potential aging-related disease prevention strategies.

scholarly journals ASSESSMENT OF ALCOHOL USE BY POPULATION AND RELATED PROBLEMS

2019 ◽  
Vol 4 (9-10) ◽  
pp. 93-99
Author(s):  
V. B. Zamkevich ◽  
M. D. Diachuk ◽  
T. S. Gruzieva
Keyword(s):  
Public Health ◽  
Information System ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Fatal Outcome ◽  
Significant Proportion ◽  
Public Health Problem ◽  
Well Being ◽  
Negative Consequences

Introduction. The development of the public health system provides for the solution of the basic operational functions of public health, including surveillance and assessment of the state of health and well-being of the population, taking into account risks to public health.Given the importance of alcohol as a risk factor for the development of diseases, the study of its prevalence in the population, consumption patterns and health effects is an important public health problem. The aim of the study. To identify current trends in alcohol consumption and the associated risk factor for health damage in Ukraine and countries of the WHO European Region.Materials and methods. Bibliographic, medical, statistical and information-analytical methods were used in the study. The key  scientific base were the European Health for All Database, the Global Information System on Alcohol and Health (GISAH) and the European Information System on Alcohol and Health (EISAH). Results. Significant differences were found in the prevalence of alcohol consumption by population in different regions of the world per capita per year, up to 16 times, with the highest rates in the WHO ER. Ukraine is characterized by high levels of alcohol consumption (8.6 liters) and negative tendencies for their growth during 1991-2016 by 45.8%. At the same time, in Ukraine the consumption of strong alcoholic drinks predominates, while in the countries of the European Union - wine and beer. The increase in alcohol consumption in Ukraine and the prevalence of strong drinks in the structure of consumed products (51.5%) is an unfavorable prognostic indicator and requires the adoption of preventive measures. The negative consequences of alcohol consumption are the prevalence of alcohol dependence (2.2%), alcohol-related disorders (6%), a significant proportion of deaths (20.5%) due to this risk factor in the overall structure of all deaths, etc. Significant is the contribution of alcohol to the formation of indicators of road traffic injuries, including those with a fatal outcome, crime rates, etc. Conclusions. Surveillance of the prevalence of alcohol use, patterns of consumption and assessment of alcohol-related public health problems is an important basis for determining directions, justification and taking countermeasures.

Effects of Familial Alcohol Consumption on Alcohol Use Disorder, Depression, Anxiety, and Stress of University Students

2021 ◽  
Vol 11 (1) ◽  
pp. 67-73
Author(s):  
Keun-Young Ryu ◽  
Kwan-Woo Park ◽  
Min-Sun Kim ◽  
Hea-Jin Lee ◽  
song yi Paek ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
University Students ◽  
Alcohol Use Disorder

Unhealthy Alcohol Use

2019 ◽  
Author(s):  
Stephen R Holt ◽  
Joseph H. Donroe
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Genetic Factors ◽  
Physical And Mental Health ◽  
Unhealthy Alcohol Use ◽  
Unhealthy Alcohol ◽  
Societal Norms ◽  
High Prevalence ◽  
Excessive Alcohol

Unhealthy alcohol use refers to a spectrum of alcohol consumption ranging from at-risk drinking to alcohol use disorder. It is associated with both a high cost to society and to individuals. Globally, alcohol is a leading cause of death and disability, and despite the high prevalence of unhealthy alcohol use, diagnosis, and treatment of alcohol use disorder remains disproportionately low. Risk for unhealthy alcohol use and alcohol related harms is multifactorial and includes genetic factors, gender, age, socioeconomic status, cultural and societal norms, and policies regulating alcohol consumption among others. Excessive alcohol use is associated with a myriad of poor physical and mental health outcomes, and screening for unhealthy alcohol use is universally recommended and effective. This review contains 1 figures, 2 tables, and 76 references.  Key Words: addiction, alcohol, cancer, diagnosis, drinking, liver disease, screening, stigma, use disorderImportant Advances

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