scholarly journals Reducing module size bias of participation coefficient

2019 ◽  
Author(s):  
Mangor Pedersen ◽  
Amir Omidvarnia ◽  
James M. Shine ◽  
Graeme D. Jackson ◽  
Andrew Zalesky
Keyword(s):  
New York ◽  
Working Memory ◽  
Functional Role ◽  
Network Node ◽  
Traffic Network ◽  
Mathematical Properties ◽  
Network Modules ◽  
Module Size ◽  
Size Bias ◽  
Insight Into

AbstractBoth natural and engineered networks are often modular. Whether a network node interacts with only nodes from its own module or nodes from multiple modules provides insight into its functional role. The participation coeffcient (PC) is typically used to measure this attribute although its value also depends on the size of the module it belongs to, often leading to non-intuitive identification of highly connected nodes. Here, we develop a normalized PC that overcomes the module size bias associated with the conventional PC. Using brain, C.elegans, airport and simulated networks, we show that our measure of participation alleviates the module size bias, while preserving conceptual and mathematical properties, of the classic formulation of PC. Unlike the conventional PC, we identify London and New York as high participators in the air traffic network and demonstrate stronger associations with working memory in human brain networks, yielding new insights into nodal participation across network modules.

scholarly journals Reducing the influence of intramodular connectivity in participation coefficient

2020 ◽  
Vol 4 (2) ◽  
pp. 416-431
Author(s):  
Mangor Pedersen ◽  
Amir Omidvarnia ◽  
James M. Shine ◽  
Graeme D. Jackson ◽  
Andrew Zalesky
Keyword(s):  
New York ◽  
Working Memory ◽  
Human Brain ◽  
Functional Role ◽  
Network Node ◽  
Traffic Network ◽  
C Elegans ◽  
Mathematical Properties ◽  
Network Modules ◽  
Insight Into

Both natural and engineered networks are often modular. Whether a network node interacts with only nodes from its own module or nodes from multiple modules provides insight into its functional role. The participation coefficient ( PC) is typically used to measure this attribute, although its value also depends on the size and connectedness of the module it belongs to and may lead to nonintuitive identification of highly connected nodes. Here, we develop a normalized PC that reduces the influence of intramodular connectivity compared with the conventional PC. Using brain, C. elegans, airport, and simulated networks, we show that our measure of participation is not influenced by the size or connectedness of modules, while preserving conceptual and mathematical properties, of the classic formulation of PC. Unlike the conventional PC, we identify London and New York as high participators in the air traffic network and demonstrate stronger associations with working memory in human brain networks, yielding new insights into nodal participation across network modules.

scholarly journals Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junchao Huang ◽  
Jinghui Tong ◽  
Ping Zhang ◽  
Yanfang Zhou ◽  
Yimin Cui ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Cortical Thickness ◽  
Serum Levels ◽  
Healthy Controls ◽  
Tryptophan Pathway ◽  
Liquid Chromatography Tandem Mass ◽  
Therapeutic Development ◽  
Tryptophan Metabolites ◽  
Insight Into

AbstractA number of tryptophan metabolites known to be neuroactive have been examined for their potential associations with cognitive deficits in schizophrenia. Among these metabolites, kynurenic acid (KYNA), 5-hydroxyindole (5-HI), and quinolinic acid (QUIN) are documented in their diverse effects on α-7 nicotinic acetylcholine receptor (α7nAChR) and/or N-methyl-D-aspartate receptor (NMDAR), two of the receptor types thought to contribute to cognitive impairment in schizophrenia. In this study, serum levels of KYNA, 5-HI, and QUIN were measured in 195 patients with schizophrenia and in 70 healthy controls using liquid chromatography-tandem mass spectrometry; cognitive performance in MATRICS Consensus Cognitive Battery and cortical thickness measured by magnetic resonance imaging were obtained. Patients with schizophrenia had significantly lower serum KYNA (p < 0.001) and QUIN (p = 0.02) levels, and increased 5-HI/KYNA (p < 0.001) and QUIN/KYNA ratios (p < 0.001) compared with healthy controls. Multiple linear regression showed that working memory was positively correlated with serum 5-HI levels (t = 2.10, p = 0.04), but inversely correlated with KYNA concentrations (t = −2.01, p = 0.05) in patients. Patients with high 5-HI and low KYNA had better working memory than other subgroups (p = 0.01). Higher 5-HI levels were associated with thicker left lateral orbitofrontal cortex (t = 3.71, p = 2.94 × 10−4) in patients. The different effects of 5-HI and KYNA on working memory may appear consistent with their opposite receptor level mechanisms. Our findings appear to provide a new insight into the dynamic roles of tryptophan pathway metabolites on cognition, which may benefit novel therapeutic development that targets cognitive impairment in schizophrenia.

Media Coverage and Solidarity after Tragedies: The Reporting of School Shootings in Two Nations

2012 ◽  
Vol 11 (6) ◽  
pp. 845-874 ◽  
Author(s):  
James Hawdon ◽  
James Hawdon ◽  
Atte Oksanen ◽  
James Hawdon ◽  
Atte Oksanen ◽  
...  
Keyword(s):  
New York ◽  
Media Coverage ◽  
New York Times ◽  
Virginia Tech ◽  
School Shootings ◽  
Considerable Research ◽  
National Comparison ◽  
The Media ◽  
Insight Into ◽  
Cross National

Abstract Although considerable research analyzes the media coverage of school shootings, there is a lack of cross-national comparative studies. Yet, a cross-national comparison of the media coverage of school shootings can provide insight into how this coverage can affect communities. Our research focuses on the reporting of the school shootings at Virginia Tech in the U.S. and Jokela and Kauhajoki in Finland. Using 491 articles from the New York Times and Helsingin Sanomat published within a month of each shooting we investigate how reports vary between the nations and among the tragedies. We investigate if one style of framing a tragedy, the use of a “tragic frame,” may contribute to differences in the communities’ response to the events.

scholarly journals Designing for international law: The architecture of international organizations 1922–1952

2020 ◽  
pp. 1-22
Author(s):  
Miriam Bak McKenna
Keyword(s):  
New York ◽  
International Law ◽  
International Organizations ◽  
International Organization ◽  
International Labour Organization ◽  
The Relationship ◽  
Physical Manifestation ◽  
Insight Into ◽  
Do So

Abstract Situating itself in current debates over the international legal archive, this article delves into the material and conceptual implications of architecture for international law. To do so I trace the architectural developments of international law’s organizational and administrative spaces during the early to mid twentieth century. These architectural endeavours unfolded in three main stages: the years 1922–1926, during which the International Labour Organization (ILO) building, the first building exclusively designed for an international organization was constructed; the years 1927–1937 which saw the great polemic between modernist and classical architects over the building of the Palace of Nations; and the years 1947–1952, with the triumph of modernism, represented by the UN Headquarters in New York. These events provide an illuminating allegorical insight into the physical manifestation, modes of self-expression, and transformation of international law during this era, particularly the relationship between international law and the function and role of international organizations.

scholarly journals »Heimat im Koffer.« – »Oder über das Emigrantendasein. (Falls nicht zu traurig).«

Aschkenas ◽  
2014 ◽  
Vol 24 (2) ◽  
Author(s):  
Joachim Schlör
Keyword(s):  
United States ◽  
New York ◽  
Popular Music ◽  
Everyday Life ◽  
The United States ◽  
National Socialist ◽  
Weimar Germany ◽  
Musical Traditions ◽  
German Jewish ◽  
Insight Into

AbstractThe idea to create and stage a play called »Heimat im Koffer« – »A home in the suitcase« – emerged, I presume, in Vienna shortly before Austria became part of National Socialist Germany in 1938: the plot involved the magical translocation of a typical Viennese coffeehouse, with all its inhabitants and with the songs they sang, to New York; their confrontation with American everyday life and musical traditions would create the humorous situations the authors hoped for. Since 1933, Robert Gilbert (Robert David Winterfeld, 1899–1978), the son of a famous Jewish musician and himself a most successful writer of popular music for film and operetta in Weimar Germany, found himself in exile in Vienna where he cooperated with the journalist Rudolf Weys (1898–1978) and the piano artist Hermann Leopoldi (1888–1959). Whereas Gilbert and Leopoldi emigrated to the United States and became a part of the German-Jewish and Austrian-Jewish emigré community of New York – summarizing their experience in a song about the difficulty to acquire the new language, »Da wär’s halt gut, wenn man Englisch könnt« (1943) – Weys survived the war years in Vienna. After 1945, Gilbert and Weys renewed their contact and discussed – in letters kept today within the collection of the Viennese Rathausbibliothek – the possibility to finally put »Heimat im Koffer« on stage. The experiences of exile, it turned out, proved to be too strong, and maybe too serious, for the harmless play to be realized, but the letters do give a fascinating insight into everyday-life during emigration, including the need to learn English properly, and into the impossibility to reconnect to the former life and art.

Contrasting profiles of product returners and keepers

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Dong Hwan Lee
Keyword(s):  
New York ◽  
Household Income ◽  
Field Survey ◽  
Survey Study ◽  
Content Type ◽  
Demographic Profiles ◽  
Post Purchase ◽  
Practical Implications ◽  
Insight Into ◽  
Study Offer

Purpose This paper aims to investigate whether the consumers who return a product and those who end up keeping a product after experiencing post-purchase dissonance (PPD) possess distinct underlying characteristics. Design/methodology/approach Field survey study consisting of two separate surveys conducted with consumers of New York City and neighboring areas of New York and New Jersey. Findings Product returners and keepers exhibited disparate demographic profiles regarding gender and household income, along with ethnicity to some extent. The two groups also exhibited different predispositions with regard to confidence in the purchase decision and expectations about their purchase. Finally, returners and keepers were engaged in divergent thoughts, feelings and activities to cope with PPD. Practical implications The findings of this study offer marketing practitioners new knowledge and insight into understanding product returners and keepers and will assist them in developing strategies to reduce and manage increasing product returns by consumers more effectively. Originality/value This study is the first to present empirical evidence that product returners and keepers have distinct profiles of demographic characteristics and predispositions toward purchase. The study also has found divergent PPD coping strategies used by the two types of consumers, which exposes an obsolete understanding of PPD in the marketing literature.

scholarly journals Chimeric Antibody-Binding Vitreoscilla Hemoglobin (VHb) Mediates Redox-Catalysis Reaction: New Insight into the Functional Role of VHb

2006 ◽  
pp. 208-215 ◽  
Author(s):  
Yaneenart Suwanwong ◽  
Malin Kvist ◽  
Chartchalerm Isarankura-Na-Ayudhya ◽  
Natta Tansila ◽  
Leif Bulow ◽  
...  
Keyword(s):  
Functional Role ◽  
Antibody Binding ◽  
Vitreoscilla Hemoglobin ◽  
Chimeric Antibody ◽  
Redox Catalysis ◽  
Insight Into

scholarly journals Salivary complement inhibitors from mosquitoes: Structure and mechanism of action

2020 ◽  
pp. jbc.RA120.015230
Author(s):  
Ethan C Strayer ◽  
Stephen Lu ◽  
Jose M. Ribeiro ◽  
John F. Andersen
Keyword(s):  
Functional Role ◽  
Alternative Pathway ◽  
Malaria Vectors ◽  
Salivary Proteins ◽  
Plasma Extravasation ◽  
Lower Affinity ◽  
Anopheles Mosquitoes ◽  
Highly Active ◽  
Complement Inhibitors ◽  
Insight Into

Inhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a which activate mast cells leading to plasma extravasation, pain and itching. We have previously shown that albicin, a member of the SG7 protein family from An. albimanus blocks the AP by binding to and inhibiting the function of the C3 convertase, C3bBb. Here we show that SG7.AF, the albicin homolog from An. freeborni, has a similar potency to albicin but is more active in the presence of properdin, a plasma protein that acts to stabilize C3bBb. Conversely, albicin is highly active in the absence or presence of properdin. Albicin and SG7.AF stabilize the C3bBb complex in a form that accumulates on surface plasmon resonance (SPR) surfaces coated with properdin but SG7.AF binds with lower affinity than albicin. Albicin induces oligomerization of the complex in solution, suggesting that it is oligomerization that leads to stabilization on SPR surfaces. Anophensin, the albicin ortholog from An. stephensi, is only weakly active as an inhibitor of the AP, suggesting that the SG7 family may play a different functional role in this species and other species of the subgenus Cellia, containing the major malaria vectors in Africa and Asia. Crystal structures of albicin and SG7.AF reveal a novel four-helix bundle arrangement, that is stabilized by a N-terminal hydrogen bonding network. These structures provide insight into the SG7 family and related mosquito salivary proteins including the platelet-inhibitory 30kDa family.

scholarly journals The financialisation of urban infrastructure: A framework of analysis

Urban Studies ◽  
2018 ◽  
Vol 56 (7) ◽  
pp. 1304-1325 ◽  
Author(s):  
Phillip O’Neill
Keyword(s):  
New York ◽  
Capital Structure ◽  
Balance Sheet ◽  
Urban Infrastructure ◽  
Three Dimensions ◽  
Financial Asset ◽  
Organisational Structure ◽  
Regulatory Structure ◽  
Infrastructure Investments ◽  
Insight Into

The literature on the financialisation of urban infrastructure typically traces how an infrastructure asset’s balance sheet is (re)engineered to create a financial asset. What the literature neglects are the processes by which an asset generates urban flows. Attention to these processes, we argue, not only gives better insight into the processes of financialisation of infrastructure but also exposes how the act of financing affects the operations of cities through its influence on the performance of infrastructure assets. The argument presented in the article is informed by case studies of infrastructure investments revealed in interviews conducted in New York, London and Sydney. This material is drawn on to generate a framework for understanding the relationships between infrastructure investing and the infrastructure-enabled flows of a city. This framework has three dimensions through which the financialisation process is seen to be mediated. These are capital structure, organisational structure and regulatory structure. The article argues that these mezzanine-level conceptualisations enable us to explore the to-and-fro between financing and operating cities. A key proposition is that the physical flows of a city are basic not only to the design and enactment of an investment instrument but also to its financial viability. The realisation of this relationship has changed the way investors approach infrastructure assets as investment products. Implications for urban management are drawn.

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