scholarly journals Effective description of bistability and irreversibility in apoptosis

2021 ◽  
Vol 104 (6) ◽  
Author(s):  
Sol M. Fernández Arancibia ◽  
Hernán E. Grecco ◽  
Luis G. Morelli
2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Kirill Krasnov ◽  
Yuri Shtanov

Abstract We describe a new perturbation theory for General Relativity, with the chiral first-order Einstein-Cartan action as the starting point. Our main result is a new gauge-fixing procedure that eliminates the connection-to-connection propagator. All other known first-order formalisms have this propagator non-zero, which significantly increases the combinatorial complexity of any perturbative calculation. In contrast, in the absence of the connection-to-connection propagator, our formalism leads to an effective description in which only the metric (or tetrad) propagates, there are only cubic and quartic vertices, but some vertex legs are special in that they cannot be connected by the propagator. The new formalism is the gravity analog of the well-known and powerful chiral description of Yang-Mills theory.


2014 ◽  
Vol 108 (1) ◽  
pp. 14001 ◽  
Author(s):  
Michal Pecelerowicz ◽  
Agnieszka Budek ◽  
Piotr Szymczak

2005 ◽  
Vol 94 (5) ◽  
pp. 3637-3642 ◽  
Author(s):  
Romain Brette ◽  
Wulfram Gerstner

We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (±2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.


Author(s):  
Bojan B. Guzina ◽  
Shixu Meng ◽  
Othman Oudghiri-Idrissi

In this study, we establish an inclusive paradigm for the homogenization of scalar wave motion in periodic media (including the source term) at finite frequencies and wavenumbers spanning the first Brillouin zone. We take the eigenvalue problem for the unit cell of periodicity as a point of departure, and we consider the projection of germane Bloch wave function onto a suitable eigenfunction as descriptor of effective wave motion. For generality the finite wavenumber, finite frequency homogenization is pursued in R d via second-order asymptotic expansion about the apexes of ‘wavenumber quadrants’ comprising the first Brillouin zone, at frequencies near given (acoustic or optical) dispersion branch. We also consider the junctures of dispersion branches and ‘dense’ clusters thereof, where the asymptotic analysis reveals several distinct regimes driven by the parity and symmetries of the germane eigenfunction basis. In the case of junctures, one of these asymptotic regimes is shown to describe the so-called Dirac points that are relevant to the phenomenon of topological insulation. On the other hand, the effective model for nearby solution branches is found to invariably entail a Dirac-like system of equations that describes the interacting dispersion surfaces as ‘blunted cones’. For all cases considered, the effective description turns out to admit the same general framework, with differences largely being limited to (i) the eigenfunction basis, (ii) the reference cell of medium periodicity, and (iii) the wavenumber–frequency scaling law underpinning the asymptotic expansion. We illustrate the analytical developments by several examples, including Green's function near the edge of a band gap and clusters of nearby dispersion surfaces.


2018 ◽  
Vol 191 ◽  
pp. 06012
Author(s):  
Ivan Kharuk ◽  
Andrey Shkerin

We consider two theories undergoing the same spontaneous symmetry breaking pattern but with different representations of an order parameter under the Lorentz group. The effective description of the first theory includes a massive Nambu-Goldstone field, while in the second example it is absent. Based on this, we clarify the physical meaning of massive Nambu-Goldstone fields as non-radial modes needed to describe the fluctuations of an order parameter. The connection with the inverse Higgs phenomenon is also discussed.


2019 ◽  
Vol 116 (38) ◽  
pp. 18772-18776 ◽  
Author(s):  
Alfred D. Shapere ◽  
Frank Wilczek

We demonstrate that nonconvex Lagrangians, as contemplated in the theory of time crystals, can arise in the effective description of conventional, physically realizable systems. Such embeddings resolve dynamical singularities which arise in the reduced description. Microstructure featuring intervals of fixed velocity interrupted by quick resets—“Sisyphus dynamics”—is a generic consequence. In quantum mechanics, this microstructure can be blurred, leaving entirely regular behavior.


Author(s):  
Cristiano Spelta ◽  
Diego Delvecchio ◽  
Sergio M. Savaresi

This paper is devoted to the design of a novel semi-active comfort-oriented control strategy based on the “half-car” modeling of the vehicle. The half car model is an effective description of the vertical behaviors in a vehicle like a motorcycle, since it is able to represent both the heave and pitch dynamics. A recent control strategy (the “Mix-1-Sensor”) have been proven to be the quasi-optimal control strategy when the system is described with a quarter car model and the comfort objective is the control goal. This paper presents an analysis of the performances of the Mix-1-Sensor implemented in a half car: this strategy is able to guarantee a quasi optimal performance in terms of heave dynamics but it is not able to manage the pitch dynamics efficiently. A pitch-oriented extension of this strategy is proposed in order to guarantee a better filtering of the pitch dynamics.


Sign in / Sign up

Export Citation Format

Share Document