Role of parasitic modes in nonlinear closure via the resolvent feedback loop

Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is directed by developmental cues that include members of the TGF-β family. Our goal here was to elucidate, using the 3T3-L1 adipogenesis model, how TGF-β family growth factors and inhibitors regulate adipocyte development. We show that ligands of the Activin and TGF-β families, several ligand traps, and the SMAD1/5/8 signaling inhibitor LDN-193189 profoundly suppressed 3T3-L1 adipogenesis. Strikingly, anti-adipogenic traps and ligands engaged the same mechanism of action involving the simultaneous activation of SMAD2/3 and inhibition of SMAD1/5/8 signaling. This effect was rescued by the SMAD2/3 signaling inhibitor SB-431542. By contrast, although LDN-193189 also suppressed SMAD1/5/8 signaling and adipogenesis, its effect could not be rescued by SB-431542. Collectively, these findings reveal the fundamental role of SMAD1/5/8 for 3T3-L1 adipogenesis, and potentially identify a negative feedback loop that links SMAD2/3 activation with SMAD1/5/8 inhibition in adipogenic precursors.

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Autocrine signaling by an Aplysia neurotrophin forms a presynaptic positive feedback loop

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1810649115 ◽

2018 ◽

Vol 115 (47) ◽

pp. E11168-E11177 ◽

Cited By ~ 3

Author(s):

Iksung Jin ◽

Hiroshi Udo ◽

Russell Nicholls ◽

Huixiang Zhu ◽

Eric R. Kandel ◽

...

Keyword(s):

Positive Feedback ◽

Feedback Loop ◽

Autocrine Signaling ◽

Positive Feedback Loop ◽

Short Term Plasticity ◽

Extracellular Signaling ◽

Presynaptic Protein ◽

Long Term Facilitation

Whereas short-term plasticity is often initiated on one side of the synapse, long-term plasticity involves coordinated changes on both sides, implying extracellular signaling. We have investigated the possible signaling role of an Aplysia neurotrophin (ApNT) in facilitation induced by serotonin (5HT) at sensory-to-motor neuron synapses in culture. ApNT is an ortholog of mammalian BDNF, which has been reported to act as either an anterograde, retrograde, or autocrine signal, so that its pre- and postsynaptic sources and targets remain unclear. We now report that ApNT acts as a presynaptic autocrine signal that forms part of a positive feedback loop with ApTrk and PKA. That loop stimulates spontaneous transmitter release, which recruits postsynaptic mechanisms, and presynaptic protein synthesis during the transition from short- to intermediate-term facilitation and may also initiate gene regulation to trigger the transition to long-term facilitation. These results suggest that a presynaptic ApNT feedback loop plays several key roles during consolidation of learning-related synaptic plasticity.

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The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis

Cellular Physiology and Biochemistry ◽

10.1159/000374024 ◽

2015 ◽

Vol 35 (6) ◽

pp. 2192-2202 ◽

Cited By ~ 48

Author(s):

Guohua Lou ◽

Yanning Liu ◽

Shanshan Wu ◽

Jihua Xue ◽

Fan Yang ◽

...

Keyword(s):

Cell Apoptosis ◽

Feedback Loop ◽

Molecular Mechanisms ◽

Rt Pcr ◽

Cycle Arrest ◽

Anticancer Effects ◽

Huh7 Cells ◽

Mirnas Expression ◽

Induced Apoptosis

Background: The anti-tumor effects of quercetin have been reported, but the underlying molecular mechanisms remain to be elucidated. The aim of present study was to explore the role of miRNA in the anticancer effects of quercetin. Methods: The differential miRNAs expression between the HepG2 and Huh7 cells treated by quercetin were detected by microarray. The xCELLigence, Flow cytometry, RT-PCR and Western blot were used to analyze the cell proliferation, cell apoptosis, cell cycle arrest, anti-tumor genes, and protein expression. Results: miR-34a was up-regulated in HepG2 cells treated by quercetin exhibiting wild-type p53. When inhibiting the miR-34a, the sensitivity of the cells to quercetin decreased and the expression of the SIRT1 was up-regulated, but the acetylation of p53 and the expression of some genes related to p53 down-regulated. Conclusion: miR-34a plays an important role in the anti-tumor effects of querctin in HCC, miR-34a may be a tiemolecule between the p53 and SIRT1 and is composed of a p53/miR-34a/SIRT1 signal feedback loop, which could enhance apoptosis signal and significantly promote cell apoptosis.

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Theory: Interrupting the Feedback Loop, and the Role of Expectancy

Attention and Self-Regulation ◽

10.1007/978-1-4612-5887-2_10 ◽

1981 ◽

pp. 185-201

Author(s):

Charles S. Carver ◽

Michael F. Scheier

Keyword(s):

Feedback Loop

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The Difference δ-Cells Make in Glucose Control

Physiology ◽

10.1152/physiol.00029.2018 ◽

2018 ◽

Vol 33 (6) ◽

pp. 403-411 ◽

Cited By ~ 9

Author(s):

Mark O. Huising ◽

Talitha van der Meulen ◽

Jessica L. Huang ◽

Mohammad S. Pourhosseinzadeh ◽

Glyn M. Noguchi

Keyword(s):

Glucose Control ◽

Feedback Loop ◽

Physiological Role ◽

Glucagon Secretion ◽

Negative Feedback Loop ◽

Β Cells ◽

Insulin And Glucagon Secretion ◽

The Difference ◽

Delta Cells

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

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Engagement of the CXCL12–CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis

International Journal of Molecular Sciences ◽

10.3390/ijms23020867 ◽

2022 ◽

Vol 23 (2) ◽

pp. 867

Author(s):

Sebastian F. Mause ◽

Elisabeth Ritzel ◽

Annika Deck ◽

Felix Vogt ◽

Elisa A. Liehn

Keyword(s):

Smooth Muscle ◽

Feedback Loop ◽

Cell Contact ◽

Endothelial Progenitor ◽

Vascular Homeostasis ◽

Relevant Role ◽

Direct Cell ◽

And Migration ◽

Cxcr4 Axis

Endothelial progenitor cells (EPCs) are involved in vascular repair and modulate properties of smooth muscle cells (SMCs) relevant for their contribution to neointima formation following injury. Considering the relevant role of the CXCL12–CXCR4 axis in vascular homeostasis and the potential of EPCs and SMCs to release CXCL12 and express CXCR4, we analyzed the engagement of the CXCL12–CXCR4 axis in various modes of EPC–SMC interaction relevant for injury- and lipid-induced atherosclerosis. We now demonstrate that the expression and release of CXCL12 is synergistically increased in a CXCR4-dependent mechanism following EPC–SMC interaction during co-cultivation or in response to recombinant CXCL12, thus establishing an amplifying feedback loop Additionally, mechanical injury of SMCs induces increased release of CXCL12, resulting in enhanced CXCR4-dependent recruitment of EPCs to SMCs. The CXCL12–CXCR4 axis is crucially engaged in the EPC-triggered augmentation of SMC migration and the attenuation of SMC apoptosis but not in the EPC-mediated increase in SMC proliferation. Compared to EPCs alone, the alliance of EPC–SMC is superior in promoting the CXCR4-dependent proliferation and migration of endothelial cells. When direct cell–cell contact is established, EPCs protect the contractile phenotype of SMCs via CXCL12–CXCR4 and reverse cholesterol-induced transdifferentiation toward a synthetic, macrophage-like phenotype. In conclusion we show that the interaction of EPCs and SMCs unleashes a CXCL12–CXCR4-based autoregulatory feedback loop promoting regenerative processes and mediating SMC phenotype control to potentially guard vascular homeostasis.

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Quasi-Periodic Orbits in the Five-Dimensional Nondissipative Lorenz Model: The Role of the Extended Nonlinear Feedback Loop

International Journal of Bifurcation and Chaos ◽

10.1142/s0218127418500724 ◽

2018 ◽

Vol 28 (06) ◽

pp. 1850072 ◽

Cited By ~ 7

Author(s):

Sara Faghih-Naini ◽

Bo-Wen Shen

Keyword(s):

Periodic Solution ◽

Feedback Loop ◽

Three Dimensional ◽

Nonlinear Feedback ◽

Lorenz Model ◽

Restoring Force ◽

Oscillatory Solutions ◽

Nonlinear Temperature

A recent study suggested that the nonlinear feedback loop (NFL) of the three-dimensional nondissipative Lorenz model (3D-NLM) serves as a nonlinear restoring force by producing nonlinear oscillatory solutions as well as linear periodic solutions near a nontrivial critical point. This study discusses the role of the extension of the NFL in producing quasi-periodic trajectories using a five-dimensional nondissipative Lorenz model (5D-NLM). An analytical solution to the locally linear 5D-NLM is first obtained to illustrate the association of the extended NFL and two incommensurate frequencies whose ratio is irrational, yielding a quasi-periodic solution. The quasi-periodic solution trajectory moves endlessly on a torus but never intersects itself. While the NFL of the 3D-NLM consists of a pair of downscaling and upscaling processes, the extended NFL within the 5D-NLM additionally introduces two new pairs of downscaling and upscaling processes that are enabled by two high wavenumber modes. One pair of downscaling and upscaling processes provides a two-way interaction between the original (primary) Fourier modes of the 3D-NLM and the newly-added (secondary) Fourier modes of the 5D-NLM. The other pair of downscaling and upscaling processes involves interactions amongst the secondary modes. By comparing the numerical simulations using one- and two-way interactions, we illustrate that the two-way interaction is crucial for producing the quasi-periodic solution. A follow-up study using a 7D nondissipative LM shows that a further extension of NFL, which may appear throughout the spatial mode-mode interactions rooted in the nonlinear temperature advection, is capable of producing one more incommensurate frequency.

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Bundling up the Role of the Actin Cytoskeleton in Primary Root Growth

Frontiers in Plant Science ◽

10.3389/fpls.2021.777119 ◽

2021 ◽

Vol 12 ◽

Author(s):

Judith García-González ◽

Kasper van Gelderen

Keyword(s):

Root Growth ◽

Actin Cytoskeleton ◽

Cell Elongation ◽

Feedback Loop ◽

Primary Root ◽

Actin Binding ◽

Actin Network ◽

Actin Organization ◽

Primary Root Growth

Primary root growth is required by the plant to anchor in the soil and reach out for nutrients and water, while dealing with obstacles. Efficient root elongation and bending depends upon the coordinated action of environmental sensing, signal transduction, and growth responses. The actin cytoskeleton is a highly plastic network that constitutes a point of integration for environmental stimuli and hormonal pathways. In this review, we present a detailed compilation highlighting the importance of the actin cytoskeleton during primary root growth and we describe how actin-binding proteins, plant hormones, and actin-disrupting drugs affect root growth and root actin. We also discuss the feedback loop between actin and root responses to light and gravity. Actin affects cell division and elongation through the control of its own organization. We remark upon the importance of longitudinally oriented actin bundles as a hallmark of cell elongation as well as the role of the actin cytoskeleton in protein trafficking and vacuolar reshaping during this process. The actin network is shaped by a plethora of actin-binding proteins; however, there is still a large gap in connecting the molecular function of these proteins with their developmental effects. Here, we summarize their function and known effects on primary root growth with a focus on their high level of specialization. Light and gravity are key factors that help us understand root growth directionality. The response of the root to gravity relies on hormonal, particularly auxin, homeostasis, and the actin cytoskeleton. Actin is necessary for the perception of the gravity stimulus via the repositioning of sedimenting statoliths, but it is also involved in mediating the growth response via the trafficking of auxin transporters and cell elongation. Furthermore, auxin and auxin analogs can affect the composition of the actin network, indicating a potential feedback loop. Light, in its turn, affects actin organization and hence, root growth, although its precise role remains largely unknown. Recently, fundamental studies with the latest techniques have given us more in-depth knowledge of the role and organization of actin in the coordination of root growth; however, there remains a lot to discover, especially in how actin organization helps cell shaping, and therefore root growth.

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When Is Poetry Political? Césaire on the Role of Knowledge in 1944

Small Axe A Caribbean Journal of Criticism ◽

10.1215/07990537-8912743 ◽

2021 ◽

Vol 25 (1) ◽

pp. 1-14

Author(s):

Yohann C. Ripert

Keyword(s):

Knowledge Production ◽

Feedback Loop ◽

International Congress ◽

Conference Paper ◽

Poetic Practice ◽

Political Actions

This essay investigates a moment for Caribbean knowledge production in which intellectuals, gathered in Haiti in 1944 for an International Congress of Philosophy, questioned whether to politicize knowledge or to seclude it from politics. Focusing on Aimé Césaire’s “Poetry and Knowledge,” the author compares the 1944 conference paper with the version published in Tropiques in 1945 to show a feedback loop between poetry and politics. The war, the isolation, and the intellectual evolution of Tropiques coalesced to form a new environment that prompted Césaire to rethink the relation between poetic practice and political relevance. Illuminating the relation between poetry and politics, “Poetry and Knowledge” is symptomatic of an epistemological shift from poetic writing geared toward political actions to poetic knowledge uncorrupted by political considerations that prepared Césaire for undertaking in 1945 a new literary and political trajectory.

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The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development

Development ◽

10.1242/dev.125.22.4417 ◽

1998 ◽

Vol 125 (22) ◽

pp. 4417-4425 ◽

Cited By ~ 6

Author(s):

M. Takahashi ◽

K. Tamura ◽

D. Buscher ◽

H. Masuya ◽

S. Yonei-Tamura ◽

...

Keyword(s):

Negative Feedback ◽

Limb Development ◽

Feedback Loop ◽

Limb Bud ◽

Negative Regulator ◽

Negative Feedback Loop ◽

Vertebrate Limb ◽

Limb Outgrowth ◽

Vertebrate Limb Development

We have determined that Strong's Luxoid (lstJ) [corrected] mice have a 16 bp deletion in the homeobox region of the Alx-4 gene. This deletion, which leads to a frame shift and a truncation of the Alx-4 protein, could cause the polydactyly phenotype observed in lstJ [corrected] mice. We have cloned the chick homologue of Alx-4 and investigated its expression during limb outgrowth. Chick Alx-4 displays an expression pattern complementary to that of shh, a mediator of polarizing activity in the limb bud. Local application of Sonic hedgehog (Shh) and Fibroblast Growth Factor (FGF), in addition to ectodermal apical ridge removal experiments suggest the existence of a negative feedback loop between Alx-4 and Shh during limb outgrowth. Analysis of polydactylous mutants indicate that the interaction between Alx-4 and Shh is independent of Gli3, a negative regulator of Shh in the limb. Our data suggest the existence of a negative feedback loop between Alx-4 and Shh during vertebrate limb outgrowth.

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