Evidence vs Expectations: How to validate your ligand in a protein structure
2014 ◽
Vol 70
(a1)
◽
pp. C1479-C1479
Keyword(s):
Determination of a protein-ligand complex structure is essential in many areas of structural biology. Details of the interactions between protein and a small molecule ligand often represent major findings from a crystal structure. Thorough validation of interpretation of such structural data is particularly important given high expectation of confirming prior experimental findings regarding targeted protein-ligand interaction. Modern methods of ligand validation are discussed and illustrated.
2017 ◽
Vol 73
(8)
◽
pp. 702-709
◽
2017 ◽
Vol 73
(3)
◽
pp. 279-285
2014 ◽
Vol 70
(2)
◽
pp. 451-460
◽
2017 ◽
Vol 9
(6)
◽
1994 ◽
Vol 269
(16)
◽
pp. 11703-11706