Crystal structures of two alanylpiperidine analogues
2021 ◽
Vol 77
(11)
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Keyword(s):
X Ray
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The structure of ethyl 1-[N-(4-methylphenyl)-N-(methylsulfonyl)alanyl]piperidine-4-carboxylate, C19H28N2O5S, I, a compound of interest as activator of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1), was determined by single-crystal X-ray diffraction (SCXRD) analysis. In order to find new activators, a derivative of compound I, namely, 1-[N-(4-methylphenyl)-N-(methylsulfonyl)alanyl]piperidine-4-carboxylic acid, C17H24N2O5S, II, was studied. The synthesis and crystal structure are also reported. Despite being analogues, different crystal packings are observed. Compound II bears a carboxylic group, which favors a strong hydrogen bond. A polymorph risk assessment was carried out to study interactions in compound II.
1992 ◽
Vol 47
(10)
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pp. 1370-1376
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2015 ◽
Vol 80
(7)
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pp. 867-875
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1988 ◽
Vol 53
(11)
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pp. 2863-2876
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