Optimizing Flu Vaccine Planning at NorthShore University HealthSystem

2017 ◽  
pp. 1-15
Author(s):  
Sarang Deo ◽  
Ilya Kolesov ◽  
Sachin Waikar
Keyword(s):  
Supply Chain ◽  
Seasonal Influenza ◽  
Vice President ◽  
The United States ◽  
Uncertain Demand ◽  
Influenza Epidemic ◽  
Major Supplier ◽  
Secondary Objective ◽  
Flu Vaccine ◽  
Unreliable Supply

Stan Kent, vice president of pharmacy at NorthShore University HealthSystem, is faced with the challenge of seasonal planning for the influenza vaccine. The supply received by the multilocation healthcare system is unreliable in terms of timing and quantity. As part of improved planning, Kent is contemplating a new contract with NorthShore's major supplier of flu vaccines. The options under consideration include fixing either the date of delivery or the quantity delivered. The main decision involved in either option would be how much vaccine to order. The case also provides details about the seasonal influenza epidemic in the United States, illustrates operational complexities of the U.S. flu vaccine supply chain, and provides a brief description of the various channels used to distribute flu vaccine to end consumers.The main objective of the case is to illustrate supply chain decision making when there is an unreliable supply (in contrast to the usual case of uncertain demand). A secondary objective is to make students think about appropriate internal (within sector) and external (other sectors) benchmarks to evaluate the performance of a health commodity supply chain.

scholarly journals Impact of COVID-19 outbreaks and interventions on influenza in China and the United States

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Luzhao Feng ◽  
Ting Zhang ◽  
Qing Wang ◽  
Yiran Xie ◽  
Zhibin Peng ◽  
...  
Keyword(s):  
United States ◽  
Respiratory Diseases ◽  
Seasonal Influenza ◽  
Influenza Virus Infection ◽  
Northern China ◽  
The United States ◽  
Behavioral Changes ◽  
Influenza Epidemic ◽  
Lower And Upper Bounds ◽  
Influenza Activity

AbstractCoronavirus disease 2019 (COVID-19) was detected in China during the 2019–2020 seasonal influenza epidemic. Non-pharmaceutical interventions (NPIs) and behavioral changes to mitigate COVID-19 could have affected transmission dynamics of influenza and other respiratory diseases. By comparing 2019–2020 seasonal influenza activity through March 29, 2020 with the 2011–2019 seasons, we found that COVID-19 outbreaks and related NPIs may have reduced influenza in Southern and Northern China and the United States by 79.2% (lower and upper bounds: 48.8%–87.2%), 79.4% (44.9%–87.4%) and 67.2% (11.5%–80.5%). Decreases in influenza virus infection were also associated with the timing of NPIs. Without COVID-19 NPIs, influenza activity in China and the United States would likely have remained high during the 2019–2020 season. Our findings provide evidence that NPIs can partially mitigate seasonal and, potentially, pandemic influenza.

scholarly journals Contact, travel, and transmission: The impact of winter holidays on influenza dynamics in the United States

2016 ◽  
Author(s):  
Anne Ewing ◽  
Elizabeth C. Lee ◽  
Cécile Viboud ◽  
Shweta Bansal
Keyword(s):  
United States ◽  
Seasonal Influenza ◽  
Synthetic Data ◽  
The United States ◽  
Influenza Epidemic ◽  
School Closures ◽  
Future Design ◽  
Contact Patterns ◽  
Risk Of Disease ◽  
The Impact

AbstractBackgroundThe seasonality of influenza is thought to vary according to environmental factors and human behavior. During winter holidays, potential disease-causing contact and travel deviate from typical patterns, and we aim to understand these changes on age-specific and spatial flu transmission.MethodsWe characterized the changes to transmission and epidemic trajectories among children and adults in a spatial context before, during, and after the winter holidays among aggregated physician medical claims in the United States from 2001 to 2009 and among synthetic data simulated from a deterministic, age-specific spatial metapopulation model.ResultsWinter holidays reduced flu transmission and delayed the trajectory of flu season epidemics. The holiday period itself observed a shift in relative risk of disease from children towards adults. Model results indicated that holidays delay epidemic peaks and synchronize incidence across locations, and contact reductions from school closures rather than age-specific mixing and travel produce these observed holiday dynamics.ConclusionsWinter holidays delay seasonal influenza epidemic peaks due to changes in contact patterns. These findings may improve the future design of influenza intervention strategies, such as the proper timing and duration of school closures, and the spatial and demographic allocation of vaccines.

Off to a bad start: John Adams’s tussle over titles

2008 ◽  
Vol 4 ◽  
Author(s):  
James C Alexander
Keyword(s):  
United States ◽  
United States Of America ◽  
Vice President ◽  
The United States ◽  
John Adams ◽  
The Press ◽  
First Session

From the first days, of the first session, of the first Congress of the United States, the Senate was consumed by an issue that would do immense and lasting political harm to the sitting vice president, John Adams. The issue was a seemingly unimportant one: titles. Adams had strong opinions on what constituted a proper title for important officers of government and, either because he was unconcerned or unaware of the damage it would cause, placed himself in the middle of the brewing dispute. Adams hoped the president would be referred to as, “His highness, the President of the United States of America, and Protector of the Rights of the Same.” The suggestion enraged many, amused some, and was supported by few. He lost the fight over titles and made fast enemies with several of the Senators he was constitutionally obligated to preside over. Adams was savaged in the press, derided in the Senate and denounced by one of his oldest and closest friends. Not simply an isolated incident of political tone-deafness, this event set the stage for the campaign against Adams as a monarchist and provided further proof of his being woefully out of touch.

Cooperative trust and trustworthiness in China and the United States: Does guanxi make a difference?

2019 ◽  
Vol 47 (5) ◽  
pp. 1-11
Author(s):  
Hanjing Huang ◽  
Pei-Luen Patrick Rau
Keyword(s):  
United States ◽  
Supply Chain ◽  
Special Form ◽  
The United States ◽  
Personal Relationship ◽  
Personal Relationships ◽  
Business Context ◽  
Different Cultures

Our aim was to investigate and compare the effects of cooperating with either a friend or a stranger in a business context on trust and trustworthiness in 2 different cultures. In China, guanxi is a special form of personal relationship in which the exchange partners bond through reciprocal obligations. We conducted cooperation experiments based on the supply chain task in which Chinese and U.S. participants cooperated with their friends and with strangers. The results indicated that both Chinese and U.S. participants had higher levels of trust and trustworthiness for their friends than for strangers. Moreover, Chinese participants made a stronger distinction between friends and strangers than did U.S. participants. In addition, Chinese participants had lower levels of trust and trustworthiness than did U.S. participants. The cooperation experiments enrich the theoretical field of investigating the effects of personal relationships on cooperative trust and trustworthiness, and provide practical value to the management of business cooperation in different cultures.

scholarly journals Multicenter point prevalence evaluation of the utilization and safety of drug therapies for COVID-19 at the onset of the pandemic timeline in the United States

2021 ◽  
Author(s):  
Nathaniel J Rhodes ◽  
Atheer Dairem ◽  
William J Moore ◽  
Anooj Shah ◽  
Michael J Postelnick ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Drug Therapy ◽  
Supportive Care ◽  
The United States ◽  
Primary Objective ◽  
Point Prevalence ◽  
Medical Centers ◽  
Academic Medical ◽  
History Of ◽  
Secondary Objective

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose There are currently no FDA-approved medications for the treatment of coronavirus disease 2019 (COVID-19). At the onset of the pandemic, off-label medication use was supported by limited or no clinical data. We sought to characterize experimental COVID-19 therapies and identify safety signals during this period. Methods We conducted a non-interventional, multicenter, point prevalence study of patients hospitalized with suspected/confirmed COVID-19. Clinical and treatment characteristics within a 24-hour window were evaluated in a random sample of up to 30 patients per site. The primary objective was to describe COVID-19–targeted therapies. The secondary objective was to describe adverse drug reactions (ADRs). Results A total of 352 patients treated for COVID-19 at 15 US hospitals From April 18 to May 8, 2020, were included in the study. Most patients were treated at academic medical centers (53.4%) or community hospitals (42.6%). Sixty-seven patients (19%) were receiving drug therapy in addition to supportive care. Drug therapies used included hydroxychloroquine (69%), remdesivir (10%), and interleukin-6 antagonists (9%). Five patients (7.5%) were receiving combination therapy. The rate of use of COVID-19–directed drug therapy was higher in patients with vs patients without a history of asthma (14.9% vs 7%, P = 0.037) and in patients enrolled in clinical trials (26.9% vs 3.2%, P < 0.001). Among those receiving drug therapy, 8 patients (12%) experienced an ADR, and ADRs were recognized at a higher rate in patients enrolled in clinical trials (62.5% vs 22%; odds ratio, 5.9; P = 0.028). Conclusion While we observed high rates of supportive care for patients with COVID-19, we also found that ADRs were common among patients receiving drug therapy, including those enrolled in clinical trials. Comprehensive systems are needed to identify and mitigate ADRs associated with experimental COVID-19 treatments.

scholarly journals Perceptions of Seasonal Influenza Vaccine Among U.S. Army Civilians and Dependents in the Kaiserslautern Military Community: A Mixed-Methods Survey

2021 ◽  
Author(s):  
Veronica M Burns ◽  
Fritz M Castillo ◽  
Rodney L Coldren ◽  
Trisha Prosser ◽  
Renee L Howell ◽  
...  
Keyword(s):  
Online Survey ◽  
Seasonal Influenza ◽  
Medical Center ◽  
Vaccine Uptake ◽  
Free Text ◽  
Chi Square ◽  
Military Health ◽  
Influenza Outbreak ◽  
Flu Vaccination ◽  
Flu Vaccine

ABSTRACT Introduction Influenza is a globally occurring viral respiratory infection that can lead to hospitalizations and death. An influenza outbreak can interfere with combat readiness in a military setting, as the infection can incapacitate soldiers. Vaccination remains the most effective tool to prevent and mitigate seasonal influenza. Although influenza vaccinations for U.S. Army soldiers can be monitored through military health systems, those systems cannot capture DoD civilians and Army dependents who may not use military health services. This study aims to gauge flu vaccine uptake and perceptions in U.S. Army civilians and dependents. Materials and Methods An online survey was e-mailed to civilian and dependent enrollees of Landstuhl Regional Medical Center. The survey contained 24 questions pertaining to demographics, vaccine history, history of the flu, and beliefs toward vaccines. Chi-square tests, t-tests, and logistic regressions were performed to investigate the association between demographic, behavior, and belief factors with vaccine uptake. Free-text answers were coded and categorized by themes. Results Over 70% of respondents were vaccinated for the flu. There were differences between vaccinated and unvaccinated respondents regarding their perceptions of barriers to vaccination, benefits of the flu vaccine, severity of flu symptoms, and personal risk of getting ill with the flu. After controlling for confounders, flu vaccination in the previous season and healthcare worker status were associated with increased vaccine uptake, while perceived barriers to influenza vaccination were associated with decreased vaccine uptake. Conclusions Flu vaccine uptake may be increased by increasing access to vaccination, promoting vaccination and addressing concerns at the provider level, and engaging positively framed public messaging. Increasing flu vaccine uptake is of particular importance as the flu season approaches during the COVID-19 (Coronavirus disease 2019) pandemic.

scholarly journals Global Value Chains’ Disaggregation through Supply Chain Collaboration, Market Turbulence, and Performance Outcomes

2021 ◽  
Vol 13 (8) ◽  
pp. 4151
Author(s):  
Amit Arora ◽  
Anshu Arora ◽  
Julius Anyu ◽  
John McIntyre
Keyword(s):  
Supply Chain ◽  
Organizational Performance ◽  
The United States ◽  
Global Value Chains ◽  
Theory And Practice ◽  
Value Chains ◽  
Supply Chain Collaboration ◽  
Doing Business ◽  
Market Turbulence ◽  
Relational Outcomes

This research examines supply chain collaboration effects on organizational performance in global value chain (GVC) infrastructure by focusing on GVC disaggregation, market turbulence, inequality, market globalization, product diversity, exploitation, and technological breakthroughs. The research strives to develop a better understanding of global value chains through relational view, behavioral, and contingency theories along with institutional and stakeholder theories of supply chains. Based on conflicting insights from these theories, this research investigates how relationships and operational outcomes of collaboration fare when market turbulence is present. Data is obtained and analyzed from focal firms that are engaged in doing business in emerging markets (e.g., India), and headquartered in the United States. We investigate relational outcomes (e.g., trust, credibility, mutual respect, and relationship commitment) among supply chain partners, and found that these relational outcomes result in better operational outcomes (e.g., profitability, market share increase, revenue generation, etc.). From managerial standpoint, supply chain managers should focus on relational outcomes that can strengthen operational outcomes in GVCs resulting in stronger organizational performance. The research offers valuable insights for theory and practice of global value chains by focusing on the GVC disaggregation through the measurement of market turbulence, playing a key role in the success of collaborative buyer–supplier relationships (with a focus on US companies doing business in India) leading to an overall improved firm performance.

You’re Fired! Donald Trump and the 2020 Congressional Elections

The Forum ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 627-650
Author(s):  
Jamie L. Carson ◽  
Spencer Hardin ◽  
Aaron A. Hitefield
Keyword(s):  
United States ◽  
Presidential Election ◽  
Descriptive Analysis ◽  
Vice President ◽  
The United States ◽  
Congressional Elections ◽  
General Election ◽  
Donald Trump ◽  
Modern Era

Abstract The 2020 elections brought to an end one of the most divisive and historic campaigns in the modern era. Former Vice President Joe Biden was elected the 46th President of the United States with the largest number of votes ever cast in a presidential election, defeating incumbent President Donald Trump in the process. The record turnout was especially remarkable in light of the ongoing pandemic surrounding COVID-19 and the roughly 236,000 Americans who had died of the virus prior to the election. This article examines the electoral context of the 2020 elections focusing on elections in both the House and Senate. More specifically, this article examines the candidates, electoral conditions, trends, and outcomes in the primaries as well as the general election. In doing so, we provide a comprehensive descriptive analysis of the climate and outcome of the 2020 congressional elections. Finally, the article closes with a discussion of the broader implications of the election outcomes on both the incoming 117th Congress as well as the upcoming 2022 midterm election.

War stimulus: The Japanese threat and rebirth of the North America Pacific Coast shipbuilding industry, 1937-1946

2021 ◽  
Vol 33 (2) ◽  
pp. 382-411
Author(s):  
Chris Madsen
Keyword(s):  
United States ◽  
Supply Chain ◽  
Pacific Coast ◽  
The United States ◽  
Pearl Harbor ◽  
Shipbuilding Industry ◽  
The North ◽  
The Pacific ◽  
Before And After ◽  
Strategic Procurement

Henry Eccles, in classic studies on logistics, describes the dynamics of strategic procurement in the supply chain stretching from home countries to military theatres of operations. Naval authorities and industrialists concerned with Japanese aggression before and after Pearl Harbor looked towards developing shipbuilding capacity on North America’s Pacific Coast. The region turned into a volume producer of merchant vessels, warships and auxiliaries destined for service in the Pacific and Indian Oceans. Shipbuilding involved four broad categories of companies in the United States and Canada that enabled the tremendous production effort.

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