A Novel Approach for Reversible Realization of 3:8 Decoder Circuit with Optimized Performance Parameters

Video conferencing services based on web real-time communication (WebRTC) protocol are growing in popularity among Internet users as multi-platform solutions enabling interactive communication from anywhere, especially during this pandemic era. Meanwhile, Internet service providers (ISPs) have deployed fiber links and customer premises equipment that operate according to recent 802.11ac/ax standards and promise users the ability to establish uninterrupted video conferencing calls with ultra-high-definition video and audio quality. However, the best-effort nature of 802.11 networks and the high variability of wireless medium conditions hinder users experiencing uninterrupted high-quality video conferencing. This paper presents a novel approach to estimate the perceived quality of service (PQoS) of video conferencing using only 802.11-specific network performance parameters collected from Wi-Fi access points (APs) on customer premises. This study produced datasets comprising 802.11-specific network performance parameters collected from off-the-shelf Wi-Fi APs operating at 802.11g/n/ac/ax standards on both 2.4 and 5 GHz frequency bands to train machine learning algorithms. In this way, we achieved classification accuracies of 92–98% in estimating the level of PQoS of video conferencing services on various Wi-Fi networks. To efficiently troubleshoot wireless issues, we further analyzed the machine learning model to correlate features in the model with the root cause of quality degradation. Thus, ISPs can utilize the approach presented in this study to provide predictable and measurable wireless quality by implementing a non-intrusive quality monitoring approach in the form of edge computing that preserves customers’ privacy while reducing the operational costs of monitoring and data analytics.

Download Full-text

A Robust Adiabatic Model for a Quasi-Steady Prediction of Far-Off Non-Measured Performance in Vaneless Twin-Entry or Dual-Volute Radial Turbines

Applied Sciences ◽

10.3390/app10061955 ◽

2020 ◽

Vol 10 (6) ◽

pp. 1955

Author(s):

José Ramón Serrano ◽

Francisco J. Arnau ◽

Luis Miguel García-Cuevas ◽

Vishnu Samala

Keyword(s):

Mass Flow ◽

Performance Parameters ◽

Flow Conditions ◽

Fitting Procedure ◽

Radial Turbine ◽

Novel Approach ◽

Proposed Model ◽

Double Entry ◽

Radial Turbines ◽

Fitting Parameters

The current investigation describes in detail a mass flow oriented model for extrapolation of reduced mass flow and adiabatic efficiency of double entry radial inflow turbines under any unequal and partial flow admission conditions. The model is based on a novel approach, which proposes assimilating double entry turbines to two variable geometry turbines (VGTs) using the mass flow ratio ( MFR ) between the two entries as the discriminating parameter. With such an innovative approach, the model can extrapolate performance parameters to non-measured MFR s, blade-to-jet speed ratios, and reduced speeds. Therefore, the model can be used in a quasi-steady method for predicting double entry turbines performance instantaneously. The model was validated against a dataset from two different double entry turbine types: a twin-entry symmetrical turbine and a dual-volute asymmetrical turbine. Both were tested under steady flow conditions. The proposed model showed accurate results and a coherent set of fitting parameters with physical meaning, as discussed in this paper. The obtained parameters showed very similar figures for the aforementioned turbine types, which allows concluding that they are an adequate set of values for initializing the fitting procedure of any type of double entry radial turbine.

Download Full-text

Data Driven Enhancements to the Intestinal Integrity (I2) Index: A Novel Approach to Support Poultry Sustainability

Agriculture ◽

10.3390/agriculture10080320 ◽

2020 ◽

Vol 10 (8) ◽

pp. 320

Author(s):

Alexandra L. Swirski ◽

Hind Kasab-Bachi ◽

Jocelyn Rivers ◽

Jeffrey B. Wilson

Keyword(s):

Production Efficiency ◽

Tracking System ◽

Average Daily Gain ◽

Data Driven ◽

Performance Parameters ◽

Feed Conversion ◽

Intestinal Integrity ◽

Novel Approach ◽

Comprehensive Health ◽

And Performance

Background: Optimizing the intestinal integrity of poultry flocks through a comprehensive index measure, such as the intestinal integrity (I2) index, could help to promote sustainable production in the poultry industry. The I2 index is a tool for assessing the intestinal health of flocks based on flock level health and performance data, captured by Elanco Animal Health’s global surveillance system, i.e., the Health Tracking System (HTSi). The objectives of this study were to evaluate the relationships between the proposed I2 index and each of the following four performance parameters: average daily gain (ADG), feed conversion ratio (FCR), European production efficiency factor (EPEF), and percent livability; and compare the ability of the proposed I2 index to predict these performance parameters with the current I2 index. Results: The proposed I2 index was found to produce a greater range and increased variation in flock level I2 index scores as compared with the current I2 index. The proposed I2 index was found to predict the four performance measures at least as well as the current I2 index, and the results suggested that the proposed I2 index could be superior at predicting ADG, EPEF, and percent livability. Conclusion: Our results highlight the strength of data-driven approaches in the development and improvement of comprehensive health metrics.

Download Full-text

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Download Full-text

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

Language Speech and Hearing Services in Schools ◽

10.1044/2020_lshss-19-00050 ◽

2020 ◽

Vol 51 (3) ◽

pp. 544-560 ◽

Cited By ~ 3

Author(s):

Kimberly A. Murphy ◽

Emily A. Diehm

Keyword(s):

Written Language ◽

Morphological Knowledge ◽

English Orthography ◽

Word Level ◽

Novel Approach ◽

Language Pathology ◽

The One ◽

Critical Intervention ◽

Reading And Spelling ◽

Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Download Full-text