This paper outlines the adaptation of a mathematical computer model used to simulate the motion of DNA particles in order to determine the best geometry and setup for a prototype cell injection system. The model predicts DNA motion due to electrophoresis near micromachined electrodes. Ten key electrode parameters are identified to test for significance, and three key test measurements are identified to help compare the various setups. A simple design of experiment is used to organize and analyze the data collected from forty-one simulations of the DNA motion within the electric field. Based on the simulations of attracting DNA to the lance for injection, it is found that a compact ring electrode placed underneath an insulated lance will yield the optimal results. Two additional areas for research are recommended.
Development and Perspective of Automatic Cell Injection System