Beam profile monitoring system for proton therapy and Monte Carlo modeling of proton beam lateral development in water in 100–400MeV

In the passive method of proton therapy, range modulation wheel is used to scatter the single energy proton beam. It rounds and scatters the single energy proton beam to the spectrum of particles that covers cancerous tissue by a change in penetration depth. Geant4 is a Monte Carlo simulation platform for studying particles behaviour in a matter. We simulated proton therapy nozzle with Geant4. Geometric properties of this nozzle have some effects on this beam absorption plot. Concerning the relation between penetration depth and proton particle energy, we have designed a range modulation wheel to have an approximately flat plot of absorption energy. An iterative algorithm programming helped us to calculate the weight and thickness of each sector of range modulation wheel. Flatness and practical range are calculated for resulting spread-out Bragg peak.

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Monte Carlo modeling of proton therapy installations: a global experimental method to validate secondary neutron dose calculations

Physics in Medicine and Biology ◽

10.1088/0031-9155/59/11/2747 ◽

2014 ◽

Vol 59 (11) ◽

pp. 2747-2765 ◽

Cited By ~ 21

Author(s):

J Farah ◽

F Martinetti ◽

R Sayah ◽

V Lacoste ◽

L Donadille ◽

...

Keyword(s):

Monte Carlo ◽

Experimental Method ◽

Proton Therapy ◽

Neutron Dose ◽

Dose Calculations ◽

Monte Carlo Modeling ◽

Secondary Neutron

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Monte Carlo Modeling and Simulation of a Passive Treatment Proton Beam Delivery System using a Modulation Wheel

Journal of the Korean Physical Society ◽

10.3938/jkps.56.153 ◽

2010 ◽

Vol 56 (1) ◽

pp. 153-163 ◽

Cited By ~ 7

Author(s):

Se Byeong Lee ◽

Jungwook Shin ◽

Dongwook Kim ◽

Young Kyung Lim ◽

Sunghwan Ahn ◽

...

Keyword(s):

Monte Carlo ◽

Modeling And Simulation ◽

Proton Beam ◽

Delivery System ◽

Passive Treatment ◽

Monte Carlo Modeling ◽

Beam Delivery ◽

Beam Delivery System

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Gold Nanoparticle Enhanced Proton Therapy: Monte Carlo Modeling of Reactive Species’ Distributions Around a Gold Nanoparticle and the Effects of Nanoparticle Proximity and Clustering

International Journal of Molecular Sciences ◽

10.3390/ijms20174280 ◽

2019 ◽

Vol 20 (17) ◽

pp. 4280 ◽

Cited By ~ 5

Author(s):

Peukert ◽

Kempson ◽

Douglass ◽

Bezak

Keyword(s):

Monte Carlo ◽

Gold Nanoparticle ◽

Proton Therapy ◽

Species Distributions ◽

Reactive Species ◽

Monte Carlo Modeling ◽

Chemical Damage ◽

Extended Range ◽

Biological Target ◽

A Cell

Gold nanoparticles (GNPs) are promising radiosensitizers with the potential to enhance radiotherapy. Experiments have shown GNP enhancement of proton therapy and indicated that chemical damage by reactive species plays a major role. Simulations of the distribution and yield of reactive species from 10 ps to 1 µs produced by a single GNP, two GNPs in proximity and a GNP cluster irradiated with a proton beam were performed using the Geant4 Monte Carlo toolkit. It was found that the reactive species distribution at 1 µs extended a few hundred nm from a GNP and that the largest enhancement occurred over 50 nm from the nanoparticle. Additionally, the yield for two GNPs in proximity and a GNP cluster was reduced by up to 17% and 60% respectively from increased absorption. The extended range of action from the diffusion of the reactive species may enable simulations to model GNP enhanced proton therapy. The high levels of absorption for a large GNP cluster suggest that smaller clusters and diffuse GNP distributions maximize the total radiolysis yield within a cell. However, this must be balanced against the high local yields near a cluster particularly if the cluster is located adjacent to a biological target.

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