Electroosmotic pump does not need moving mechanical parts, which can be fabricated by micromachining process and integrated with other micro-devices. Electroosmotic pump is the hydraulic actuator component and can be used in HPLC (High Pressure Liquid Chromatography), μTAS (Micro totally analysis system), chip test system, micro cooling system and micro drug delivery system, etc. The paper is to design an electroosmotic pump with low driving voltage, high pressure and high flow rate, and fabricate the samples of cascaded open-channel direct current electroosmotic pump. The three-dimensional model of one-stage parallel open-channel electroosmotic pump is established by finite element analysis software of CoventorWare. The numerical simulation of the electroosmotic pump performance has been done by CoventorWare. Compared with the equivalent circuit model, the results show that the cascaded open-channel direct current electroosmotic pump has the advantages of high flow rate and high pressure.